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CMP8 

Cat. No.: HY-110392
Handling Instructions

CMP8, a selective ligand for estrogen receptor, binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 exhibits IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively.

For research use only. We do not sell to patients.

CMP8 Chemical Structure

CMP8 Chemical Structure

CAS No. : 851107-28-3

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Description

CMP8, a selective ligand for estrogen receptor, binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 exhibits IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively[1][2].

IC50 & Target[2]

MGERα

29 nM (IC50)

MGRERα

41 nM (IC50)

hERα

1100 nM (IC50)

hERβ

2200 nM (IC50)

In Vivo

CMP8 (Compound 20h) is dosed in male Balb-c mice (4 mg/kg, ip). The plasma concentration after 4 h is 1.5-fold its EC50 in mammalian cells with a Cmax of 0.5 µM after 30 min[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

528.08

Formula

C₃₃H₃₄ClNO₃

CAS No.

851107-28-3

SMILES

O=C1CCC2(CC3=CC=C(Cl)C=C3)CC4=C(C=CC(O)=C4)C2=C1C5=CC=C(OCCN6CCCCC6)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CMP8CMP 8CMP-8Estrogen Receptor/ERRInhibitorinhibitorinhibit

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CMP8
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HY-110392
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