α-Zearalenol
Based on 1 Customer Validation
α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects.
For research use only. We do not sell to patients.
- Purity: 99.73%
- CAS No.: 36455-72-8
- Formula: C18H24O5
- Molecular Weight:320.38
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Immunology/Inflammation Compound Library
HY-L007
-
Pyroptosis Compound Library
HY-L059
-
Anti-Breast Cancer Compound Library
HY-L074
-
Nuclear Receptor Compound Library
HY-L126
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Anti-Ovarian Cancer Compound Library
HY-L173
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product-like Compound Library
HY-L021L
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| KB | IC50 |
100.29 μM
Compound: 18
|
Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin microplate assay
Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin microplate assay
|
[PMID: 27311894] |
| Vero | IC50 |
60.33 μM
Compound: 18
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by green fluorescent protein-based assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by green fluorescent protein-based assay
|
[PMID: 27311894] |
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells with an IC50 of 12.5 μM[1]. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells[2]. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells[2]. α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MFC-7 cells
-
Concentration:6.25 µM-25 µM
-
Incubation Time:24 hours
-
Result:Observed the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells.
-
Cell Line:Breast cancer cell lines: MCF-7 and MDA-MB231
-
Concentration:0.001 μM, 0.1 μM and 10 μM
-
Incubation Time:24 hours, 48 hours, 72 hours
-
Result:Modified the cell growth in two breast cancer cell lines.
-
Cell Line:MCF7 cells, MDA-MB231 cells
-
Concentration:0.001 μM, 0.1 μM and 10 μM
-
Incubation Time:72 hours
-
Result:Observed an increase of cells in cell cycle in MCF7 cells.
-
Cell Line:HepG2 cells
-
Concentration:1 μM, 5 μM, 10 μM
-
Incubation Time:72 hours
-
Result:Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses.
Chemical Information
-
CAS No. 36455-72-8
-
Appearance Solid
-
Molecular Weight 320.38
-
Formula C18H24O5
-
Color White to off-white
-
SMILES
OC1=C2C(O[C@H](CCC[C@@H](CCC/C=C/C2=CC(O)=C1)O)C)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (312.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (720 KB)
- English - EN (720 KB)
- Français - FR (720 KB)
- Deutsch - DE (720 KB)
- Norwegian - NO (720 KB)
- Español - ES (720 KB)
- Swedish - SV (720 KB)
- Italian - IT (720 KB)
- Korean - KR (720 KB)
- Portuguese - PT (720 KB)
-
Handling Instructions (2659 KB)
References
[1]. .Tatay E, et al. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells. Toxicol Mech Methods. 2018 May;28(4):239-242. [Content Brief]
[2]. Marin DE, et al. Cytotoxic and inflammatory effects of individual and combined exposure of HepG2 cells to zearalenone and its metabolites. Naunyn Schmiedebergs Arch Pharmacol. 2019 Aug;392(8):937-947. [Content Brief]
[3]. Nittoli AC, et al. Effects of α-zearalenol on the metabolome of two breast cancer cell lines by 1H-NMR approach. Metabolomics. 2018 Feb 14;14(3):33. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1213 mL | 15.6065 mL | 31.2129 mL | 78.0323 mL |
| 5 mM | 0.6243 mL | 3.1213 mL | 6.2426 mL | 15.6065 mL | |
| 10 mM | 0.3121 mL | 1.5606 mL | 3.1213 mL | 7.8032 mL | |
| 15 mM | 0.2081 mL | 1.0404 mL | 2.0809 mL | 5.2022 mL | |
| 20 mM | 0.1561 mL | 0.7803 mL | 1.5606 mL | 3.9016 mL | |
| 25 mM | 0.1249 mL | 0.6243 mL | 1.2485 mL | 3.1213 mL | |
| 30 mM | 0.1040 mL | 0.5202 mL | 1.0404 mL | 2.6011 mL | |
| 40 mM | 0.0780 mL | 0.3902 mL | 0.7803 mL | 1.9508 mL | |
| 50 mM | 0.0624 mL | 0.3121 mL | 0.6243 mL | 1.5606 mL | |
| 60 mM | 0.0520 mL | 0.2601 mL | 0.5202 mL | 1.3005 mL | |
| 80 mM | 0.0390 mL | 0.1951 mL | 0.3902 mL | 0.9754 mL | |
| 100 mM | 0.0312 mL | 0.1561 mL | 0.3121 mL | 0.7803 mL |
α-Zearalenol Related Classifications
HY-N6710 Related Classifications
Powered by Bioz