1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. α-Zearalenol

α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects.

For research use only. We do not sell to patients.

α-Zearalenol Chemical Structure

α-Zearalenol Chemical Structure

CAS No. : 36455-72-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 308 In-stock
Solution
10 mM * 1 mL in DMSO USD 308 In-stock
Solid
1 mg USD 133 In-stock
5 mg USD 280 In-stock
10 mg USD 420 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of α-Zearalenol:

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects[1].

In Vitro

α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells with an IC50 of 12.5 μM[1].
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells[2].
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells[2].
α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MFC-7 cells
Concentration: 6.25 µM-25 µM
Incubation Time: 24 hours
Result: Observed the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells.

Cell Viability Assay[2]

Cell Line: Breast cancer cell lines: MCF-7 and MDA-MB231
Concentration: 0.001 μM, 0.1 μM and 10 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Modified the cell growth in two breast cancer cell lines.

Cell Cycle Analysis[2]

Cell Line: MCF7 cells, MDA-MB231 cells
Concentration: 0.001 μM, 0.1 μM and 10 μM
Incubation Time: 72 hours
Result: Observed an increase of cells in cell cycle in MCF7 cells.

RT-PCR[2]

Cell Line: HepG2 cells
Concentration: 1 μM, 5 μM, 10 μM
Incubation Time: 72 hours
Result: Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses.
Molecular Weight

320.38

Formula

C18H24O5

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C2C(O[C@H](CCC[C@@H](CCC/C=C/C2=CC(O)=C1)O)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (312.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1213 mL 15.6065 mL 31.2129 mL
5 mM 0.6243 mL 3.1213 mL 6.2426 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.63%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1213 mL 15.6065 mL 31.2129 mL 78.0323 mL
5 mM 0.6243 mL 3.1213 mL 6.2426 mL 15.6065 mL
10 mM 0.3121 mL 1.5606 mL 3.1213 mL 7.8032 mL
15 mM 0.2081 mL 1.0404 mL 2.0809 mL 5.2022 mL
20 mM 0.1561 mL 0.7803 mL 1.5606 mL 3.9016 mL
25 mM 0.1249 mL 0.6243 mL 1.2485 mL 3.1213 mL
30 mM 0.1040 mL 0.5202 mL 1.0404 mL 2.6011 mL
40 mM 0.0780 mL 0.3902 mL 0.7803 mL 1.9508 mL
50 mM 0.0624 mL 0.3121 mL 0.6243 mL 1.5606 mL
60 mM 0.0520 mL 0.2601 mL 0.5202 mL 1.3005 mL
80 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9754 mL
100 mM 0.0312 mL 0.1561 mL 0.3121 mL 0.7803 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

α-Zearalenol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
α-Zearalenol
Cat. No.:
HY-N6710
Quantity:
MCE Japan Authorized Agent: