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α-Zearalenol 

Cat. No.: HY-N6710
Handling Instructions

α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects.

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α-Zearalenol Chemical Structure

α-Zearalenol Chemical Structure

CAS No. : 36455-72-8

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Description

α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects[1].

In Vitro

α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells with an IC50 of 12.5 μM[1].
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells[2].
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells[2].
α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations[2].

Cell Proliferation Assay[1]

Cell Line: MFC-7 cells
Concentration: 6.25 µM-25 µM
Incubation Time: 24 hours
Result: Observed the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells.

Cell Viability Assay[2]

Cell Line: Breast cancer cell lines: MCF-7 and MDA-MB231
Concentration: 0.001 μM, 0.1 μM and 10 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Modified the cell growth in two breast cancer cell lines.

Cell Cycle Analysis[2]

Cell Line: MCF7 cells, MDA-MB231 cells
Concentration: 0.001 μM, 0.1 μM and 10 μM
Incubation Time: 72 hours
Result: Observed an increase of cells in cell cycle in MCF7 cells.

RT-PCR[2]

Cell Line: HepG2 cells
Concentration: 1 μM, 5 μM, 10 μM
Incubation Time: 72 hours
Result: Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses.
Molecular Weight

320.38

Formula

C₁₈H₂₄O₅

CAS No.

36455-72-8

SMILES

OC1=C2C(O[[email protected]](CCC[[email protected]@H](CCC/C=C/C2=CC(O)=C1)O)C)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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α-Zearalenol
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