(Z)-Norendoxifen
(Z)-Norendoxifen is an aromatase inhibitor and estrogen receptor modulator. The IC50 value of (Z)-Norendoxifen against aromatase is 102 nM. The EC50 values of (Z)-Norendoxifen for ER-α and ER-β are 27.0 nM and 35.2 nM, respectively. (Z)-Norendoxifen can be used in breast cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1308808-22-1
- Formula: C24H25NO2
- Molecular Weight:359.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(Z)-Norendoxifen (30 min) inhibits aromatase (CYP19), with an IC50 of 1030 nM and a Ki of 442 nM[1].
(Z)-Norendoxifen (2 h) binds competitively to ER-α and ER-β, with EC50 values of 17 nM and 28 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1308808-22-1
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Molecular Weight 359.46
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Formula C24H25NO2
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SMILES
CC/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)O)/C3=CC=C(C=C3)OCCN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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