(Z)-Norendoxifen 

(Z)-Norendoxifen is an aromatase inhibitor and estrogen receptor modulator. The IC₅₀ value of (Z)-Norendoxifen against aromatase is 102 nM. The EC₅₀ values of (Z)-Norendoxifen for ER-α and ER-β are 27.0 nM and 35.2 nM, respectively. (Z)-Norendoxifen can be used in breast cancer research^[1].

(Z)-Norendoxifen (30 min) inhibits aromatase (CYP19), with an IC₅₀ of 1030 nM and a K_i of 442 nM^[1].
(Z)-Norendoxifen (2 h) binds competitively to ER-α and ER-β, with EC₅₀ values of 17 nM and 28 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

359.46

C₂₄H₂₅NO₂

1308808-22-1

CC/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)O)/C3=CC=C(C=C3)OCCN

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lv W, et al. Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities. J Med Chem. 2015 Mar 26;58(6):2623-48.