AZ'6421

Cat. No.: HY-135312: FAQs
Data Sheet Handling Instructions

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AZ'6421 acts as Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor alpha. AZ'6421 has a potent anti-tumour effect to inhibit the uncontrolled cellular proliferation which arises from malignant disease. AZ'6421 can be used for the research of cancer such as breast cancer.

For research use only. We do not sell to patients.

AZ'6421 Chemical Structure

CAS No. : 2361115-35-5

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•Related Small Molecules:

•Related Proteins:

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms

Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Biological Activity
Purity & Documentation
References
Customer Review

Description	AZ'6421 acts as Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor alpha. AZ'6421 has a potent anti-tumour effect to inhibit the uncontrolled cellular proliferation which arises from malignant disease. AZ'6421 can be used for the research of cancer such as breast cancer^[1].
IC₅₀ & Target	IC50: 0.6 nM (ER binding); 0.4 nM (ER degradation)^[1]
In Vitro	AZ'6421 (example 72) exhibits anti-tumour activity via the ability to degrade the estrogen receptor in a number of different breast cancer cell-lines (MCF-7, CAMA-I, and BT474)^[1]. AZ'6421 (0.3 μM) has ER binding and ER degradation with IC₅₀ values of 0.6 nM and 0.4 nM, respectively in MCF-7 cell lines^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. AZ'6421 Related Antibodies
Molecular Weight	975.17
Formula	C₅₂H₆₅F₃N₆O₇S
CAS No.	2361115-35-5
SMILES	C[C@@H](N1CC(C)(F)C)CC2=C(NC3=C2C=CC=C3)[C@H]1C4=C(F)C=C(OCCCOCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)C=C4F
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Bin Yang, et al. Compounds and their use in treating cancer. Patent WO2019123367A1.

AZ'6421 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ'64212361115-35-5Estrogen Receptor/ERRPROTACsProtcolysis Targeting Chimeras (PROTACs)estrogen receptor alphaanti-tumourproliferationmalignant diseasecancerbreast cancerMCF-7 cellCAMA-I cellBT474 cellInhibitorinhibitorinhibit

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AZ'6421

AZ'6421 Related Antibodies