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AZ'6421 

Cat. No.: HY-135312
Handling Instructions

AZ'6421 acts as Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor alpha. AZ'6421 has a potent anti-tumour effect to inhibit the uncontrolled cellular proliferation which arises from malignant disease. AZ'6421 can be used for the research of cancer such as breast cancer.

For research use only. We do not sell to patients.

AZ'6421 Chemical Structure

AZ'6421 Chemical Structure

CAS No. : 2361115-35-5

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Description

AZ'6421 acts as Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor alpha. AZ'6421 has a potent anti-tumour effect to inhibit the uncontrolled cellular proliferation which arises from malignant disease. AZ'6421 can be used for the research of cancer such as breast cancer[1].

IC50 & Target

IC50: 0.6 nM (ER binding); 0.4 nM (ER degradation)[1]

In Vitro

AZ'6421 (example 72) exhibits anti-tumour activity via the ability to degrade the estrogen receptor in a number of different breast cancer cell-lines (MCF-7, CAMA-I, and BT474)[1].
AZ'6421 (0.3 μM) has ER binding and ER degradation with IC50 values of 0.6 nM and 0.4 nM, respectively in MCF-7 cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

975.17

Formula

C52H65F3N6O7S

CAS No.
SMILES

C[[email protected]@H](N1CC(C)(F)C)CC2=C(NC3=C2C=CC=C3)[[email protected]]1C4=C(F)C=C(OCCCOCCCOCC(N[[email protected]@H](C(C)(C)C)C(N5[[email protected]](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[[email protected]@H](O)C5)=O)=O)C=C4F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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AZ'6421
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