2361115-35-5
Chemical Structure
AZ'6421
- No. CAS: 2361115-35-5
- Formula:C52H65F3N6O7S
- Molecular Weight:975.17
IUPAC Name: (2S,4R)-1-((S)-2-(2-(3-(3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenoxy)propoxy)propoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChIKey: PMXVLCRRMGVGJX-DXALMRNBSA-N
SMILES: C[C@@H](N1CC(C)(F)C)CC2=C(NC3=C2C=CC=C3)[C@H]1C4=C(F)C=C(OCCCOCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)C=C4F
Biological Activity: AZ'6421 is an orally active ERα PROTAC degrader with a DC50 of 0.4 nM. AZ'6421 recruits the VHL E3 ligase to form a ternary complex, inducing proteasome-mediated polyubiquitination and degradation of ERα. AZ'6421 inhibits the growth of ER+ cancer cells. AZ'6421 can be used in studies related to ER+ breast cancer[1][2].
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AZ'6421 | 98.13% | AZ'6421 is an orally active ERα PROTAC degrader with a DC50 of 0.4 nM. AZ'6421 recruits the VHL E3 ligase to form a ternary complex, inducing proteasome-mediated polyubiquitination and degradation of ERα. AZ'6421 inhibits the growth of ER+ cancer cells. AZ'6421 can be used in studies related to ER+ breast cancer. | ||||||||||||||||||||
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Keywords
