HGH fragment 176-191
HGH fragment 176-191 is a fragment of Human Growth Hormone. HGH fragment 176-191 binds with high affinity to Ki-67, MiB proteins, and estrogen receptors. HGH fragment 176-191 enhances the toxicity of chitosan nanoparticles loaded with Doxorubicin (HY-15142A) against breast cancer. HGH fragment 176-191 promotes lipolysis and fat utilization in mice. HGH fragment 176-191 can be used in research related to targeted drug delivery for cancer and lipid metabolism.
For research use only. We do not sell to patients.
- Formula: C78H123N23O23S2
- Molecular Weight:1815.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HGH fragment 176-191 binds with high affinity to Ki-67, Mib protein, and estrogen receptor proteins, and enhances doxorubicin binding affinity to progesterone receptor, human epidermal growth factor receptor, and Mib protein in silico[1].
HGH fragment 176-191 (0-2.5 µg/mL; 48 h) enhances the cytotoxicity of doxorubicin-loaded chitosan nanoparticles against MCF-7 breast cancer cells, resulting in an IC50 of 1.5 µg/mL after 48 hours of treatment[1].
HGH fragment 176-191 selectively activates beta-3 adrenergic receptor-mediated lipolytic signaling in adipose tissue to promote fat breakdown and reduce fat deposition, without stimulating systemic growth or elevating IGF-1 levels[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
HGH fragment 176-191 combined with Hyaluronic acid (HY-B0633A) promotes cartilage regeneration in osteoarthritic rabbits[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1815.08
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Formula C78H123N23O23S2
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Sequence
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (Disulfide bridge: Cys7-Cys14)
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Sequence Shortening
YLRIVQCRSVEGSCGF (Disulfide bridge: Cys7-Cys14)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HGH fragment 176-191 Related Classifications
HY-P11153 Related Classifications
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