Estrogen receptor modulator 12
Estrogen receptor modulator 12 (compound 1a-(R)) is a selective estrogen receptor modulator with estrogen agonist and antagonist activities in in vivo models. Estrogen receptor modulator 12 exhibits antagonist effects on the uterus and estrogen agonist activities on bone, plasma lipids, hot flashes, and vagina in in vivo models, and is a potential compound for suppressing postmenopausal symptoms.
For research use only. We do not sell to patients.
- CAS No.: 554431-74-2
- Formula: C30H31NO5
- Molecular Weight:485.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Ishikawa | IC50 |
0.2 nM
Compound: 1a-(R), JNJ-17148066
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Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17-beta-estradiol-induced alkaline phosphatase activity after 3 days by chemiluminescence assay
Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17-beta-estradiol-induced alkaline phosphatase activity after 3 days by chemiluminescence assay
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[PMID: 19366247] |
| MCF7 | IC50 |
11 nM
Compound: 1a-(R), JNJ-17148066
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Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17-beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine incorporation assay
Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17-beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine incorporation assay
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[PMID: 19366247] |
Chemical Information
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CAS No. 554431-74-2
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Molecular Weight 485.57
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Formula C30H31NO5
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SMILES
OC1=CC=C(C([C@@H](C2=CC=C(C=C2)OCCN3CCCCC3)OC4=C5)=C(CCO6)C4=CC=C5O)C6=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Estrogen receptor modulator 12 Related Classifications
HY-119088 Related Classifications
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