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  2. Estrogen Receptor/ERR
  3. Raloxifene

Raloxifene (Synonyms: Keoxifene; LY156758 free base; LY139481)

Cat. No.: HY-13738
Handling Instructions

Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research.

For research use only. We do not sell to patients.

Raloxifene Chemical Structure

Raloxifene Chemical Structure

CAS No. : 84449-90-1

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Description

Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[1].

IC50 & Target[1]

Estrogen receptor

 

In Vivo

Raloxifene (4 mg/kg; intragastrically; daily for 13 weeks) significantly prevents bone loss in ovariectomized (OVX) rats[1].

Animal Model: Female, 12-week-old, Wistar rats (OVX rats)[1]
Dosage: 4 mg/kg
Administration: Intragastrically; daily for 13 weeks
Result: Significantly increased the levels of E2 in OVX rats and significantly decreased the levels of BGP.
Molecular Weight

473.58

Formula

C₂₈H₂₇NO₄S

CAS No.

84449-90-1

SMILES

O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RaloxifeneKeoxifeneLY156758LY139481LY 156758LY-156758LY 139481LY-139481Estrogen Receptor/ERRbreastcancerosteoporosisovariectomizedratsbonelossInhibitorinhibitorinhibit

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Raloxifene
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