Raloxifene (Synonyms: Keoxifene; LY156758 free base; LY139481)

Cat. No.: HY-13738: FAQs
Data Sheet Handling Instructions

Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research.

For research use only. We do not sell to patients.

Raloxifene Chemical Structure

CAS No. : 84449-90-1

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Other In-stock Forms of Raloxifene:

Raloxifene hydrochloride

Other Forms of Raloxifene:

Raloxifene hydrochloride In-stock

8 Publications Citing Use of MCE Raloxifene

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms

Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Estrogen receptor

In Vivo

Raloxifene (4 mg/kg; intragastrically; daily for 13 weeks) significantly prevents bone loss in ovariectomized (OVX) rats^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female, 12-week-old, Wistar rats (OVX rats)^[1]
Dosage:	4 mg/kg
Administration:	Intragastrically; daily for 13 weeks
Result:	Significantly increased the levels of E2 in OVX rats and significantly decreased the levels of BGP.

Clinical Trial

Molecular Weight

473.58

Formula

C₂₈H₂₇NO₄S

CAS No.

84449-90-1

SMILES

O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Khovidhunkit W, et al. Clinical effects of raloxifene hydrochloride in women. Ann Intern Med. 1999;130(5):431-439. [Content Brief]

[2]. Xu H, et al. Effect of caffeine on ovariectomy-induced osteoporosis in rats. Biomed Pharmacother. 2019;112:108650. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Raloxifene84449-90-1KeoxifeneLY156758 LY139481LY 156758LY-156758LY139481LY 139481LY-139481Estrogen Receptor/ERRbreastcancerosteoporosisovariectomizedratsbonelossInhibitorinhibitorinhibit

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