1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. Raloxifene

Raloxifene  (Synonyms: Keoxifene; LY156758 free base; LY139481)

Cat. No.: HY-13738
Handling Instructions

Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research.

For research use only. We do not sell to patients.

Raloxifene Chemical Structure

Raloxifene Chemical Structure

CAS No. : 84449-90-1

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Description

Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[1].

IC50 & Target

Estrogen receptor

 

In Vivo

Raloxifene (4 mg/kg; intragastrically; daily for 13 weeks) significantly prevents bone loss in ovariectomized (OVX) rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female, 12-week-old, Wistar rats (OVX rats)[1]
Dosage: 4 mg/kg
Administration: Intragastrically; daily for 13 weeks
Result: Significantly increased the levels of E2 in OVX rats and significantly decreased the levels of BGP.
Clinical Trial
Molecular Weight

473.58

Formula

C28H27NO4S

CAS No.
SMILES

O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Raloxifene
Cat. No.:
HY-13738
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