1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. Raloxifene

Raloxifene  (Synonyms: Keoxifene; LY156758 free base; LY139481)

Cat. No.: HY-13738 Purity: 99.62%
COA Handling Instructions

Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research.

For research use only. We do not sell to patients.

Raloxifene Chemical Structure

Raloxifene Chemical Structure

CAS No. : 84449-90-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 73 In-stock
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Solid
5 mg USD 70 In-stock
10 mg USD 120 In-stock
25 mg USD 240 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of Raloxifene:

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Description

Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[1].

IC50 & Target

Estrogen receptor

 

In Vivo

Raloxifene (4 mg/kg; intragastrically; daily for 13 weeks) significantly prevents bone loss in ovariectomized (OVX) rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female, 12-week-old, Wistar rats (OVX rats)[1]
Dosage: 4 mg/kg
Administration: Intragastrically; daily for 13 weeks
Result: Significantly increased the levels of E2 in OVX rats and significantly decreased the levels of BGP.
Clinical Trial
Molecular Weight

473.58

Formula

C28H27NO4S

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (211.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1116 mL 10.5579 mL 21.1158 mL
5 mM 0.4223 mL 2.1116 mL 4.2232 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1116 mL 10.5579 mL 21.1158 mL 52.7894 mL
5 mM 0.4223 mL 2.1116 mL 4.2232 mL 10.5579 mL
10 mM 0.2112 mL 1.0558 mL 2.1116 mL 5.2789 mL
15 mM 0.1408 mL 0.7039 mL 1.4077 mL 3.5193 mL
20 mM 0.1056 mL 0.5279 mL 1.0558 mL 2.6395 mL
25 mM 0.0845 mL 0.4223 mL 0.8446 mL 2.1116 mL
30 mM 0.0704 mL 0.3519 mL 0.7039 mL 1.7596 mL
40 mM 0.0528 mL 0.2639 mL 0.5279 mL 1.3197 mL
50 mM 0.0422 mL 0.2112 mL 0.4223 mL 1.0558 mL
60 mM 0.0352 mL 0.1760 mL 0.3519 mL 0.8798 mL
80 mM 0.0264 mL 0.1320 mL 0.2639 mL 0.6599 mL
100 mM 0.0211 mL 0.1056 mL 0.2112 mL 0.5279 mL
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Raloxifene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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