Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains

  • Bioorg Med Chem Lett. 2004 Aug 2;14(15):3865-8. doi: 10.1016/j.bmcl.2004.05.073.
Timothy A Blizzard  1 ,  Frank DiNinno ,  Jerry D Morgan 2nd ,  Jane Y Wu ,  Helen Y Chen ,  Seongkon Kim ,  Wanda Chan ,  Elizabeth T Birzin ,  Yi Tien Yang ,  Lee-Yuh Pai ,  Zhoupeng Zhang ,  Edward C Hayes ,  Carolyn A DaSilva ,  Wei Tang ,  Susan P Rohrer ,  James M Schaeffer ,  Milton L Hammond
Affiliations
  • 1. Merck Research Laboratories, Medicinal Chemistry, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. [email protected]
PMID: 15225686 DOI: 10.1016/j.bmcl.2004.05.073
Abstract

A series of benzoxathiin SERAMs with heteroatom-substituted amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue.