Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers

  • Bioorg Med Chem Lett. 2005 Jan 3;15(1):107-13. doi: 10.1016/j.bmcl.2004.10.036.
Timothy A Blizzard  1 ,  Frank Dininno ,  Jerry D Morgan 2nd ,  Helen Y Chen ,  Jane Y Wu ,  Seongkon Kim ,  Wanda Chan ,  Elizabeth T Birzin ,  Yi Tien Yang ,  Lee-Yuh Pai ,  Paula M D Fitzgerald ,  Nandini Sharma ,  Ying Li ,  Zhoupeng Zhang ,  Edward C Hayes ,  Carolyn A Dasilva ,  Wei Tang ,  Susan P Rohrer ,  James M Schaeffer ,  Milton L Hammond
Affiliations
  • 1. Merck Research Laboratories, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. [email protected]
PMID: 15582421 DOI: 10.1016/j.bmcl.2004.10.036
Abstract

A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.