Estrogen receptor modulator 8
Estrogen receptor modulator 8 (Compound 4) down-regulates estrogen receptor with an IC50 of 0.1 nM-10 nM. Estrogen receptor modulator 8 degrades ERα (IC50: 25.7 nM in vitro, 0.136 nM in MCF-7 cell). Estrogen receptor modulator 8 also inhibits MCF-7 cell growth (IC50: 0.1 nM), and MCF-7 tumor growth.
For research use only. We do not sell to patients.
- CAS No.: 2170766-56-8
- Formula: C25H24F4N2O2
- Molecular Weight:460.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
25.7 nM (ERα)[1]
In Vitro
Estrogen receptor modulators are compounds that selectively regulate the activity of estrogen receptors (ERα/ERβ). They can exhibit estrogen agonist or antagonist effects in different tissues (i.e., tissue selectivity). For example, tamoxifen exhibits anti-estrogen effects in the breast but estrogen-like effects in bone, and is used for breast cancer prevention and osteoporosis treatment.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2170766-56-8
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Molecular Weight 460.46
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Formula C25H24F4N2O2
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SMILES
CC(C)(F)CN1[C@H](C2=C(C=C(C=C2F)/C=C/C(O)=O)F)C3=C(C[C@H]1C)C4=C(F)C=CC=C4N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Estrogen receptor modulator 8 Related Classifications
HY-153700 Related Classifications
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