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Cat. No.: HY-153700

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Estrogen receptor modulator 8

Estrogen receptor modulator 8 (Compound 4) down-regulates estrogen receptor with an IC₅₀ of 0.1 nM-10 nM. Estrogen receptor modulator 8 degrades ERα (IC₅₀: 25.7 nM in vitro, 0.136 nM in MCF-7 cell). Estrogen receptor modulator 8 also inhibits MCF-7 cell growth (IC₅₀: 0.1 nM), and MCF-7 tumor growth.

For research use only. We do not sell to patients.

CAS No.: 2170766-56-8
Formula: C₂₅H₂₄F₄N₂O₂
Molecular Weight:460.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Estrogen receptor modulator 8 Chemical Structure

CAS No.: 2170766-56-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

25.7 nM (ERα)^[1]

All Estrogen Receptor/ERR Isoforms :

In Vitro

Estrogen receptor modulators are compounds that selectively regulate the activity of estrogen receptors (ERα/ERβ). They can exhibit estrogen agonist or antagonist effects in different tissues (i.e., tissue selectivity). For example, tamoxifen exhibits anti-estrogen effects in the breast but estrogen-like effects in bone, and is used for breast cancer prevention and osteoporosis treatment.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2170766-56-8
Molecular Weight 460.46
Formula C₂₅H₂₄F₄N₂O₂
SMILES

CC(C)(F)CN1[C@H](C2=C(C=C(C=C2F)/C=C/C(O)=O)F)C3=C(C[C@H]1C)C4=C(F)C=CC=C4N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guan, dongliang. Acrylic acid derivative, preparation method thereof and application thereof in medicine. Patent. CN109415361.

[2]. Guan D, et al. Preparation of 3-[4-(tetrahydro-1H-pyrrolo[3,4-b]indol-1-yl)phenyl]acrylic acid compound useful as estrogen receptor down-regulator (SERD). World Intellectual Property Organization, WO2018001232 A1. 2018-01-04.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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