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  3. AZD-9833

AZD-9833 

Cat. No.: HY-136255
Handling Instructions

Estrogen receptor antagonist 2 is a potent and orally active estrogen receptor (ER) antagonist, example 17, extracted from patent US20180111931A1. Estrogen receptor antagonist 2 is used for the study of breast cancer.

For research use only. We do not sell to patients.

AZD-9833 Chemical Structure

AZD-9833 Chemical Structure

CAS No. : 2222844-89-3

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Description

Estrogen receptor antagonist 2 is a potent and orally active estrogen receptor (ER) antagonist, example 17, extracted from patent US20180111931A1. Estrogen receptor antagonist 2 is used for the study of breast cancer[1].

IC50 & Target

IC50: estrogen receptor (ER)[1]

In Vivo

Estrogen receptor antagonist 2 (oral administration; 0.2-50 mg/kg; 20 days) exhibits anti-tumour efficacy as a dose-dependent manner in human parental MCF7 mice xenograft[1].
Estrogen receptor antagonist 2 (oral administration; 0.8-40 mg/kg; 30 days) decreases tumor growth as a dose-dependent manner. It gives almost complete tumour growth inhibition at the doses >10 mg/kg in mice[1].

Animal Model: Human ESR1 mutant breast cancer patient derived xenograft with CTC174 cells in female NSG mice[1]
Dosage: 0.8 mg/kg, 3 mg/kg, 10 mg/kg, 20 mg/kg, 40 mg/kg
Administration: Oral administration; 30 days; once daily
Result: Inhibited tumor growth in a dose-dependent manner.
Molecular Weight

476.51

Formula

C₂₄H₂₈F₄N₆

CAS No.

2222844-89-3

SMILES

FC(F)(F)CN1[[email protected]](C2=CC=C(NC3CN(CCCF)C3)C=N2)C4=C(C5=C(NN=C5)C=C4)C[[email protected]]1C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AZD-9833AZD9833AZD 9833Estrogen Receptor/ERRMCF-7breastcancertumorCTC174metastaticER+ESR1Inhibitorinhibitorinhibit

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