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  3. AZD-9833

AZD-9833 

Cat. No.: HY-136255 Purity: 98.20% ee.: 98.94%(de)
Handling Instructions

AZD-9833 is a potent and orally active estrogen receptor (ER) antagonist. AZD-9833 is used for the study of ER+ HER2-advanced breast cancer.

For research use only. We do not sell to patients.

AZD-9833 Chemical Structure

AZD-9833 Chemical Structure

CAS No. : 2222844-89-3

Size Price Stock Quantity
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2300 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3400 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

AZD-9833 is a potent and orally active estrogen receptor (ER) antagonist. AZD-9833 is used for the study of ER+ HER2-advanced breast cancer[1].

IC50 & Target

IC50: estrogen receptor (ER)[1]

In Vitro

AZD-9833 is extracted from patent US20180111931A1, example 17[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AZD-9833 (oral administration; 0.2-50 mg/kg; 20 days) exhibits anti-tumour efficacy as a dose-dependent manner in human parental MCF7 mice xenograft[1].
AZD-9833 (oral administration; 0.8-40 mg/kg; 30 days) decreases tumor growth as a dose-dependent manner. It gives almost complete tumour growth inhibition at the doses >10 mg/kg in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human ESR1 mutant breast cancer patient derived xenograft with CTC174 cells in female NSG mice[1]
Dosage: 0.8 mg/kg, 3 mg/kg, 10 mg/kg, 20 mg/kg, 40 mg/kg
Administration: Oral administration; 30 days; once daily
Result: Inhibited tumor growth in a dose-dependent manner.
Clinical Trial
Molecular Weight

476.51

Formula

C₂₄H₂₈F₄N₆

CAS No.

2222844-89-3

SMILES

FC(F)(F)CN1[[email protected]](C2=CC=C(NC3CN(CCCF)C3)C=N2)C4=C(C5=C(NN=C5)C=C4)C[[email protected]]1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (209.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0986 mL 10.4930 mL 20.9859 mL
5 mM 0.4197 mL 2.0986 mL 4.1972 mL
10 mM 0.2099 mL 1.0493 mL 2.0986 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 7.5 mg/mL (15.74 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 7.5 mg/mL (15.74 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.20% ee.: 98.94%(de)

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Keywords:

AZD-9833AZD9833AZD 9833Estrogen Receptor/ERRMCF-7breastcancertumorCTC174metastaticER+ESR1Inhibitorinhibitorinhibit

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Product Name:
AZD-9833
Cat. No.:
HY-136255
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