Glyceollin I
Glyceollin I is a pterocarpan phytoalexin and an ERα (IC50 1.68 μM) inhibitor. Glyceollin I can be induced by Phytophthora and arbuscular mycorrhizal fungi to accumulate in soybean. Glyceollin I binds ERα and inhibits ER-mediated gene expression. Glyceollin I inhibits the motility of Meloidogyne incognita. Glyceollin I inhibits colony formation, migration, and invasion of ER-positive breast/ovarian cancer cells. Glyceollin I can be used in research related to plant disease resistance, breast cancer, and ovarian cancer.
For research use only. We do not sell to patients.
- CAS No.: 57103-57-8
- Formula: C20H18O5
- Molecular Weight:338.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[2]|
ERα 1.68 μM (IC50) |
In Vitro
Glyceollin I (0.1-25 µM; 10-14 days) inhibits E2-stimulated colony formation in MCF-7 breast cancer cells and BG-1 ovarian cancer cells[2].
Glyceollin I (0.1-10 µM; 3 weeks) reduces LTLT-Ca colony formation by 68.74% at 10 µM[5].
Glyceollin I downregulates Ki67 staining, ZEB1 protein, and TFF1/EGFR expression in LTLT-Ca cells, promoting the transition of cells from a mesenchymal morphology to an epithelial-like morphology[5].
Glyceollin I (10 µM; 24 h) increases cytoplasmic E-cadherin and decreases nuclear ZEB1 in LTLT-Ca cells[5].
Glyceollin I (10 µM; 24 h) reduces LTLT-Ca migration by 83% and invasion by more than 68%[5].
Glyceollin I (10 µM) inhibits E2-induced PgR and SDF-1 expression in BG-1 ovarian cancer cells by 86.38% and 94.4%, respectively[2].
Glyceollin I exhibits significant differences in induced accumulation in soybean after infection by different Phytophthora races: the incompatible race 1 stimulates its earlier synthesis, reaching higher local concentrations in tissues; the compatible race 3 shows low accumulation levels in the early stage, with substantial accumulation occurring only in the later stage[3].
Glyceollin I is used as an 125I-labeled tracer in cell-free RIA[3].
Glyceollin I is the predominant pterocarpan phytoalexin in the roots of the infected soybean cultivar Harosoy 63[3].
Glyceollin I (10 µM; 48 h) mediates CDH1 induction and CDH2 inhibition in LTLT-Ca cells, whereas ZEB1 overexpression abolishes this effect[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LTLT-Ca cells
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Concentration:0.1, 1.0, 10 µM
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Incubation Time:3 weeks (media replacement every 7 days)
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Result:Decreased LTLT-Ca colony formation by 68.74% at 10 µM.
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Cell Line:LTLT-Ca cells
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Concentration:10 µM
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Incubation Time:24 h
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Result:Induced cytoplasmic E-cadherin expression and decreased nuclear ZEB1 expression in LTLT-Ca cells.
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Cell Line:LTLT-Ca cells
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Concentration:10 µM
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Incubation Time:24 h
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Result:Reversed LTLT-Ca migratory behavior by as much as 83%.
Inhibited LTLT-Ca invasion by more than 68% of control values.
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Cell Line:LTLT-Ca vector and ZEB1-overexpressing cells
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Concentration:10 µM
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Incubation Time:48 h
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Result:Mediated CDH1 induction and CDH2 repression in LTLT-Ca cells, which ZEB1 overexpression abrogates.
Chemical Information
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CAS No. 57103-57-8
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Molecular Weight 338.35
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Formula C20H18O5
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SMILES
O[C@]12[C@](OC3=CC(O)=CC=C32)([H])C4=CC=C(OC(C)(C=C5)C)C5=C4OC1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glyceollin I Related Classifications
HY-N11785 Related Classifications
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Keywords
- Glyceollin I
- 57103-57-8
- Estrogen Receptor/ERR
- Parasite
- Fungal
- Endogenous Metabolite
- ER-positive breast cancer
- ERα
- Phytophthora megasperma
- antiestrogen
- epithelial-mesenchymal transition
- estrogen-induced transcription
- letrozole-resistant breast cancer
- nematode motility
- ovarian cancer
- phytoalexin
- Inhibitor
- inhibitor
- inhibit