57103-57-8
Chemical Structure
Glyceollin I
- CAS No.: 57103-57-8
- Formula:C20H18O5
- Molecular Weight:338.35
InChIKey: YIFYYPKWOQSCRI-AZUAARDMSA-N
SMILES: O[C@]12[C@](OC3=CC(O)=CC=C32)([H])C4=CC=C(OC(C)(C=C5)C)C5=C4OC1
Biological Activity: Glyceollin I is a pterocarpan phytoalexin and an ERα (IC50 1.68 μM) inhibitor. Glyceollin I can be induced by Phytophthora and arbuscular mycorrhizal fungi to accumulate in soybean. Glyceollin I binds ERα and inhibits ER-mediated gene expression. Glyceollin I inhibits the motility of Meloidogyne incognita. Glyceollin I inhibits colony formation, migration, and invasion of ER-positive breast/ovarian cancer cells. Glyceollin I can be used in research related to plant disease resistance, breast cancer, and ovarian cancer[1][2][3][4][5].
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Glyceollin I | Glyceollin I is a pterocarpan phytoalexin and an ERα (IC50 1.68 μM) inhibitor. Glyceollin I can be induced by Phytophthora and arbuscular mycorrhizal fungi to accumulate in soybean. Glyceollin I binds ERα and inhibits ER-mediated gene expression. Glyceollin I inhibits the motility of Meloidogyne incognita. Glyceollin I inhibits colony formation, migration, and invasion of ER-positive breast/ovarian cancer cells. Glyceollin I can be used in research related to plant disease resistance, breast cancer, and ovarian cancer. | |||||||||||||||||||||
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References
- [1]. Rao A S. Root flavonoids. The Botanical Review, 1990, 56: 1-84.
- [2]. Zimmermann MC, et al. Glyceollin I, a novel antiestrogenic phytoalexin isolated from activated soy. The Journal of pharmacology and experimental therapeutics. 2010 Jan;332(1):35-45. [Content Brief]
- [3]. Hahn MG, et al. Quantitative Localization of the Phytoalexin Glyceollin I in Relation to Fungal Hyphae in Soybean Roots Infected with Phytophthora megasperma f. sp. glycinea. Plant physiology. 1985 Mar;77(3):591-601.
- [4]. Lygin AV, et al. Glyceollin is an important component of soybean plant defense against Phytophthora sojae and Macrophomina phaseolina. Phytopathology. 2013 Oct;103(10):984-94.
- [5]. Carriere PP, et al. Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1. International journal of environmental research and public health. 2015 Dec 22;13(1):ijerph13010010.
