ER degrader 4
ER degrader 4 is a selective and orally active estrogen receptor degrader. ER degrader 4 has anti-tumor activity.
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- CAS. Nr.: 2913192-39-7
- Formel: C26H19FO4S
- Molecular Weight:446.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.2 μM
Compound: 22h
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Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
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[PMID: 37019030] |
In Vitro
ER degrader 4 (Compound 22h) inhibits MCF-7 cell proliferation with an IC50 of 0.20 μM[1].
ER degrader 4 (1 nM-10 μM, 24 h) degrades ER in MCF-7 cells dose-dependently[1].
ER degrader 4 (10 μM, 24 h) decreases the gene expression levels of GREB1, PGR, and TFF1 in MCF-7 cells[1].
ER degrader 4 (10 μM, 24 h) arrests MCF-7 cells in G0/G1 phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cell
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Concentration:1 nM, 100 nM, 1 μM and 10 μM
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Incubation Time:24 h
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Result:Degraded ER dose-dependently, shows maximum degradation at 10 μM.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MCF-7 xenograft model[3]
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Dosage:30 mg/kg
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Administration:Oral gavage
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Result:Significantly inhibited tumor growth with no significant body weight loss.
Reduces protein level of Ki67, ER, and PR in resected xenograft tumors.
Chemical Information
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CAS. Nr. 2913192-39-7
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Molecular Weight 446.49
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Formel C26H19FO4S
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SMILES
O=C(C1=C(C=C(C=C1)C)C)C(SC2=CC(F)=CC=C23)=C3OC4=CC=C(C=C4)/C=C/C(O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ER degrader 4 Related Classifications
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