ER degrader 10
ER degrader 10 (Compound 51) is a selective, orally active degrader and antagonist for estrogen receptor (ER) with a DC50 of 0.43 nM and an IC50 of 0.56 nM. ER degrader 10 inhibits the proliferation of ER-positive cells with IC50s of 0-15 nM. ER degrader 10 exhibits a weak inhibitory activity against hERG channel with an IC50 >40 μM. ER degrader 10 is blood-brain barrier penetrable with a brain/plasma ratio (Kp) of 3.05. ER degrader 10 exhibits antitumor efficacy in mice model.
For research use only. We do not sell to patients.
- CAS No.: 3035311-43-1
- Formula: C28H29F2NO3S
- Molecular Weight:497.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 3035311-43-1
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Molecular Weight 497.60
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Formula C28H29F2NO3S
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SMILES
FC(C=C1)=CC(OC)=C1[C@H]2CSC3=CC(O)=CC=C3[C@H]2C4=CC=C(OCCN5CC(CF)C5)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ER degrader 10 Related Classifications
HY-170377 Related Classifications
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