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  3. XCT790

XCT790 

Cat. No.: HY-10426 Purity: 99.66%
Handling Instructions

XCT-790 is a potent and selective inverse agonist for ERRα with an IC50 value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ.

For research use only. We do not sell to patients.

XCT790 Chemical Structure

XCT790 Chemical Structure

CAS No. : 725247-18-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 121 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 380 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    XCT790 purchased from MCE. Usage Cited in: Oncogene. 2016 Sep 22;35(38):5033-42.

    Inhibition of the ERRα-dependent mitochondrial activity by XCT-790 is found to drastically inhibit decreased cell density and increase cell death induced by PLA2R1.

    XCT790 purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2018 Sep 5;37(1):218.

    The proliferation proteins cMyc and cyclin D1 are identified and confirmed by Western blot analysis after the colon cancer cells are treated with the indicated concentrations of XCT790 or DMSO for 48 h.

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    Description

    XCT-790 is a potent and selective inverse agonist for ERRα with an IC50 value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ[1][2].

    IC50 & Target[1][2]

    ERRα

    0.37 μM (IC50)

    In Vitro

    XCT-790 (0-40 μM; 48 hours and 72 hours) reduces the viability of MES-SA, MES-SA/DX5, and HepG2 cells in a dose-dependent manner[1].
    XCT-790 (10 μM; 24 hours and 48 hours) reduces the protein levels of ERRα in HepG2 and R-HepG2 cell lines after 24 hours and maintains these reduced levels after 48 hours[1].
    XCT-790 (10 μM; 48 hours) induces apoptosis in the two cell lines with HepG2 being more sensitive compared to R-HepG2[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: MES-SA, MES-SA/DX5, HepG2 and R-HepG2 cells
    Concentration: 0 μM, 5 μM, 10 μM, 20 μM, and 40 μM
    Incubation Time: 48 hours and 72 hours
    Result: The cells proliferation were decreased in a dose-dependent fashion.

    Western Blot Analysis[1]

    Cell Line: HepG2 and R-HepG2 cells
    Concentration: 10 μM
    Incubation Time: 24 hours and 48 hours
    Result: Reduced the protein levels of ERRα.

    Apoptosis Analysis[1]

    Cell Line: HepG2 and R-HepG2 cells
    Concentration: 10 μM
    Incubation Time: 48 hours
    Result: Induced apoptosis in HepG2 and R-HepG2 cells.
    In Vivo

    XCT-790 (XCT790; 4 mg/kg; intravenous injection; every three days; for 3 weeks; BALB/c mice) significantly inhibits tumor growth and angiogenesis, and induces apoptosis without a reduction in body weight, in xenograft models[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female BALB/c mice (4 weeks of age) with HEC-1A xenograft[3]
    Dosage: 4 mg/kg
    Administration: Intravenous injection; every three days; for 3 weeks
    Result: Suppressed endometrial cancer growth and angiogenesis, and induced apoptosis.
    Molecular Weight

    596.42

    Formula

    C₂₃H₁₃F₉N₄O₃S

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 16.67 mg/mL (27.95 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6767 mL 8.3834 mL 16.7667 mL
    5 mM 0.3353 mL 1.6767 mL 3.3533 mL
    10 mM 0.1677 mL 0.8383 mL 1.6767 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 1.67 mg/mL (2.80 mM); Suspended solution; Need ultrasonic

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.66%

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