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  3. LY117018

LY117018 

Cat. No.: HY-116896
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LY117018, a Raloxifene analog, is a selective estrogen receptor modulator. LY117018 exerts antiproliferative effects on breast cancer cell lines.

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LY117018 Chemical Structure

LY117018 Chemical Structure

CAS No. : 63676-25-5

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Description

LY117018, a Raloxifene analog, is a selective estrogen receptor modulator. LY117018 exerts antiproliferative effects on breast cancer cell lines[1][2].

IC50 & Target[1]

Estrogen receptor

 

In Vitro

LY117018 (0.01-1000 nM; 24 hours) at lower concentrations (0.01-10 nM) caused an E2-like increase in p53 levels when compared to its effects on cells grown in the stripped medium. At a higher concentration of LY117018 (1 μM), the level of p53 appeared to decline. Treatment with 1 μM LY117018 resulted in a predominantly hypophosphorylated pRb. At lower concentrations, LY117018 did not block E2-induced pRb phosphorylation[1].
LY117018 (1 μM; 96 hours) inhibits MCF-7 cells proliferation with an IC50 of 1 μM[2].
LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway[3].

Cell Proliferation Assay[2]

Cell Line: MCF-7 cells
Concentration: 1 μM
Incubation Time: 96 hours
Result: Inhibited MCF-7 cells proliferation with an IC50 of 1 μM.
Molecular Weight

459.56

Formula

C₂₇H₂₅NO₄S

CAS No.

63676-25-5

SMILES

O=C(C1=CC=C(C=C1)OCCN2CCCC2)C3=C(SC4=CC(O)=CC=C43)C5=CC=C(C=C5)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LY117018LY 117018LY-117018Estrogen Receptor/ERRSERMbreastcancertumorsuppressorproteinsproliferationapoptosisInhibitorinhibitorinhibit

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