PVTX-321
PVTX-321 (Compound 16a) is an orally active estrogen receptor α (ERα) degrader. PVTX-321 can potently degrade ERα (DC50=0.15 nM in MCF-7 cells) and also has inhibitory activity against mutant ERα (IC50=59 nM). PVTX-321 is promising for research of ER+/HER2- breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 3026004-38-3
- Formula: C51H55FN4O6
- Molecular Weight:839.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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ERα |
Chemical Information
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CAS No. 3026004-38-3
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Molecular Weight 839.00
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Formula C51H55FN4O6
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SMILES
OC1=CC2=C(C=C1)[C@@H](C3=CC(F)=C(N4CCC5(CC4)CC(CN6CCC7(CC6)C8=CC=C9C(CN([C@H]%10CCC(NC%10=O)=O)C9=O)=C8OC7)C5)C=C3OC)[C@@H](C%11=CC=CC=C%11)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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