Aromatase-IN-8

Aromatase-IN-8 (compound 17) (72 h) displays prominent anticancer effects in ER + breast cancer cell lines (T47D and MCF-7 cells) and triple-negative breast cancer cell line (MDA-231 cells) with IC₅₀ = 42.90, 79.43 and > 100 µM^[1].
Aromatase-IN-8 (6.25-100 µM, 24 and 72 h) reduces cell viability effects correlate with increasing dosage in MCF-7 cells and MDA-MB-231 cells^[1].
Aromatase-IN-8 (0-50 μM, 24 h) reduces ERα and ERβ protein levels in MCF-7 cells^[1].
Aromatase-IN-8 (6.25-50 μM, 8 h) reveals low 17β-estradiol and estrone small suppressive effects on estrogen synthesis leads to a more abundant accumulation of testosterone at concentrations above 12.5 µM in MCF-7 cells^[1].
Aromatase-IN-8 downregulates fatty acid degradation, upregulates pantothenate and CoA biosynthesis, valine and sphingosine accumulation and has the strong anticancer effects at higher doses in MCF-7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.