1244904-19-5
Chemical Structure
Aromatase-IN-8
- CAS No.: 1244904-19-5
- Formula:C17H19ClN4S
- Molecular Weight:346.88
InChIKey: ZELSQGJHFXPDPU-UHFFFAOYSA-N
SMILES: CC1=NN(C(Cl)=C1CN(CC2=CSC=C2)CC3=CN=CC=C3)C
Biological Activity: Aromatase-IN-8 is a selective Aromatase inhibitor against an IC50 of 0.05 µM. Aromatase-IN-8 exhibits selective antiproliferative effects against estrogen receptor-positive breast cancer cell lines, while showing no toxicity toward non-tumoral cells. Aromatase-IN-8 suppresses estrogen active, increases testosterone levels, and downregulates estrogen receptor expression and phosphorylation. Aromatase-IN-8 can be used for triple negative breast cancer research[1].
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Aromatase-IN-8 | Aromatase-IN-8 is a selective Aromatase inhibitor against an IC50 of 0.05 µM. Aromatase-IN-8 exhibits selective antiproliferative effects against estrogen receptor-positive breast cancer cell lines, while showing no toxicity toward non-tumoral cells. Aromatase-IN-8 suppresses estrogen active, increases testosterone levels, and downregulates estrogen receptor expression and phosphorylation. Aromatase-IN-8 can be used for triple negative breast cancer research. | |||||||||||||||||||||
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