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Cat. No.: HY-183187

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4H-Chromen-4-one-o-carborane

4H-Chromen-4-one-o-carborane is an estrogen receptor (ER) agonist, with an EC₅₀ of 0.9 μM for ERα and an EC₅₀ of 11.1 μM for ERβ. 4H-Chromen-4-one-o-carborane also acts as an inhibitor of COX-1 and COX-2, with an IC₅₀ of 6.6 μM for COX-1 and an IC₅₀ of 17.7 μM for COX-2.

For research use only. We do not sell to patients.

CAS No.: 3097646-96-0
Formula: C₁₁H₁₆B₁₀O₂
Molecular Weight:288.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

4H-Chromen-4-one-o-carborane Chemical Structure

CAS No.: 3097646-96-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Estrogen Receptor/ERR Isoforms :

All COX Isoforms :

In Vitro

4H-Chromen-4-one-o-carborane (compound 1) (up to 100 μM; 48 h) exhibits only weak antiproliferative activity in HepG2 hepatocellular carcinoma cells (IC₅₀ = 69.5 μM), and shows no activity even at the maximum concentration of 100 μM in Raji, Ramos or PC3 cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Raji (lymphoma), Ramos (lymphoma), PC3 (prostate cancer), HepG2 (hepatocellular carcinoma)
Concentration:

up to 100 μM
Incubation Time:

48 h
Result:

Showed negligible antiproliferative activity in Raji, Ramos, and PC3 cell lines, with IC₅₀ values greater than 100 μM for each.
Exhibited weak antiproliferative activity in HepG2 cells, with an IC₅₀ of 69.5 μM.

In Vivo

4H-Chromen-4-one-o-carborane (0.5 mg; i.p.; single dose) has a long blood half-life and slow biodistribution rate. At 3 h after a single i.p. injection, the highest boron uptake occurs in the liver (14.1 μg/g) and blood (11.5 μg/g)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

athymic mice (male, nu/nu homozygous, 4−6 weeks old)^[1]
Dosage:

0.5 mg
Administration:

i.p.; single dose
Result:

Measured boron content as 11.5 μg/g in blood.
Measured boron content as 14.1 μg/g in liver.
Showed lower boron uptake in all other tested organs (brain, bone, heart, kidney, large intestine, lung, muscle, pancreas, small intestine, spleen, stomach, tumor) than blood.

Chemical Information

CAS No. 3097646-96-0
Molecular Weight 288.35
Formula C₁₁H₁₆B₁₀O₂
SMILES

O=C1C=2C=CC=CC2OC=C1C3456[BH]789[BH]%10%11%12[BH]%13%14%15[BH]%10%169[BH]%13%17%18[BH]%14%19%20[BH]%15%11%21[BH]%1276[BH]%21%195[CH]%17%204[BH]%16%1883
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Synthesis of Carborane-Containing Flavone and Flavonol Analogues as ER Agonists and COX Inhibitors. J Nat Prod. 2026;89(4):1189-1197. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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4H-Chromen-4-one-o-carborane

All Estrogen Receptor/ERR Isoforms

All COX Isoforms