Search Result
Results for "
Amino+Acids+and+Derivatives
" in MedChemExpress (MCE) Product Catalog:
1703
Inhibitors & Agonists
2
Biochemical Assay Reagents
4
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-134124
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Reactive Oxygen Species (ROS)
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Metabolic Disease
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Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .
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- HY-W008016
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- HY-W008371
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- HY-W008021
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- HY-W048739
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Amino Acid Derivatives
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Others
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Fmoc-α-Me-Leu-OH is a leucine derivative with an Fmoc protecting group, which can be used to synthesize peptides with oxytocin receptor agonist activity .
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- HY-W007573
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- HY-W010959
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- HY-W013968
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- HY-W011001
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- HY-W008688
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- HY-W008696
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- HY-D0885A
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Creatine phosphate disodium tetrahydrate; Creatinephosphoric acid disodium tetrahydrate
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Endogenous Metabolite
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Metabolic Disease
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Phosphocreatine disodium tetrahydrate, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction .
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- HY-P10218
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MARCKS
PKC
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Inflammation/Immunology
Cancer
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MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis .
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- HY-W007056
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- HY-W068839
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- HY-P10218A
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MARCKS
PKC
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Inflammation/Immunology
Cancer
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MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218). MANS peptide TFA is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis .
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- HY-137950
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- HY-Y1844
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- HY-42709
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Carbobenzoxy-L-valyl-L-alanine
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Amino Acid Derivatives
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Cancer
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Z-Val-Ala-OH is a dipeptide derivative of valine and alanine. Z-Val-Ala-OH undergoes cleavage by cathepsin B and other lysosomal proteases to enable payload release following lysosomal internalization. Z-Val-Ala-OH can be used for the research of antibody-drug conjugate (ADC) development[1] .
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- HY-W012713
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- HY-34597
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(S)-p-Bromophenylalanine; L-4-Bromophenylalanine; L-p-Bromophenylalanine; p-Bromo-L-phenylalanine
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Amino Acid Derivatives
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Others
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(S)-2-Amino-3-(4-bromophenyl)propanoic acid is a phenylalanine derivative .
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- HY-P10341
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GCGR
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Metabolic Disease
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ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin that has the ability to sustainably improve glycemic control. Additionally, ZP3022 can effectively increase β-cell mass, promote β-cell proliferation, and enhance the function of pancreatic islets. ZP3022 can be used in anti-diabetic research .
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- HY-W014258
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Amino Acid Derivatives
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Others
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(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a Glycine (HY-Y0966) derivative . (R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-W016835
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- HY-34738
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3-(Boc-amino)-1-propanol
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Amino Acid Derivatives
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Others
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Boc-β-Ala-ol (3-(Boc-amino)-1-propanol) is an alanine derivative with a Boc protecting group at the N-terminus, which can be used to synthesize bioactive peptide mimics, such as Nα-Benzoyl-α-azaornithine phenyl ester, which has trypsin inhibitory activity .
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- HY-W008667
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Amino Acid Derivatives
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Others
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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid hydrate is a glutamic acid derivative .
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- HY-W017501
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- HY-W011003
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- HY-W048703
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- HY-W010830
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- HY-W089229
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- HY-W013874
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- HY-W046355
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- HY-W009117
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- HY-W011722
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- HY-W107585
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- HY-W141859
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- HY-78733
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- HY-60256
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- HY-W019676
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- HY-W003225
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- HY-W010793
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- HY-W009005
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- HY-118349
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- HY-W011324
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- HY-20861
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- HY-W008233
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- HY-W009775
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- HY-W129448
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- HY-W048913
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Amino Acid Derivatives
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Others
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N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N2-(2-((5-sulfonaphthalen-1-yl)amino)ethyl)-L-glutamine is a glutamine derivative .
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- HY-W041996
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- HY-W028991
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- HY-185057
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S-Lactylglutathione; (R)-S-Lactoylglutathione
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Drug Metabolite
Glyoxalase (GLO)
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Inflammation/Immunology
Cancer
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S-D-Lactoylglutathione is a crucial intermediate metabolite of the glyoxalase (Glo) system. S-D-Lactoylglutathione acts as a "bridge molecule" for the conversion of methylglyoxal (MGO) into non-toxic D-lactic acid by continuous catalysis from Glo1 to Glo2, preventing cell damage caused by the accumulation of MGO .
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- HY-W013751
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N-Fmoc-glycyl-L-valine
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Drug Intermediate
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Others
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Fmoc-Gly-Val-OH (N-Fmoc-glycyl-L-valine) is a glycyl valine derivative, can be used for the synthesis of drugs or other compounds .
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- HY-W041983
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- HY-W052310
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- HY-42065
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- HY-W048830
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- HY-W005720
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- HY-W008787
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- HY-W018620
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- HY-Y0555
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![N-[(Phenylmethoxy)carbonyl]-L-leucine](//file.medchemexpress.com/product_pic/hy-y0555.gif)
- HY-20153
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- HY-75332
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D-Cbz phenylglycine
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Amino Acid Derivatives
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Others
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Z-D-Phg-OH (D-Cbz phenylglycine) is a N-blocked amino acids with Kd values of 390 μM and 323 μM for tBuCQN and tBuCQD, respectively .
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- HY-W011200
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- HY-W007842
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- HY-22062
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Cyclohexaneacetic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (S)-
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Amino Acid Derivatives
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Others
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Fmoc-Chg-OH is a Glycine (HY-Y0966) derivative .
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- HY-W014418
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- HY-W013824
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- HY-W009392
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- HY-P10876
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Amyloid-β
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Neurological Disease
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mcK6A1 is an inhibitor for the aggregation of amyloid-β (Aβ), that selectively binds to the 16KLVFFA21 segment of Aβ42, forms an extended β-folded structure, and inhibits the formation of Aβ42 oligomers. mcK6A1 can be used in research of Alzheimer's disease and other amyloid-related diseases .
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- HY-W051418
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- HY-79909
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Amino Acid Derivatives
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Others
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L-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-leucyl]-, phenylmethyl ester is a phenylalanine derivative .
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![L-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-leucyl]-, phenylmethyl ester](//file.medchemexpress.com/product_pic/hy-79909.gif)
- HY-79930
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Amino Acid Derivatives
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Others
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D-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-, phenylmethyl ester is a phenylalanine derivative .
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![D-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-, phenylmethyl ester](//file.medchemexpress.com/product_pic/hy-79930.gif)
- HY-W013659
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- HY-W048701
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- HY-173459
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SARS-CoV
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Infection
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N-0920 is a potent TMPRSS2 inhibitor with an IC50 of 0.35 nM. N-0920 effectively inhibits SARS-CoV-2 variants EG.5.1 and JN.1 entry in Calu-3 cells, with picomolar EC50s values of 300 pM and 90 pM, respectively .
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- HY-W021299
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- HY-W142113
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- HY-W030573
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![((4'-Chloro-[1,1'-biphenyl]-4-yl)sulfonyl)phenylalanine](//file.medchemexpress.com/product_pic/hy-w030573.gif)
- HY-W016330
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- HY-W141942
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- HY-W141771
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- HY-W065053
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Amino Acid Derivatives
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Others
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trans-N-Methyl-4-methoxyproline is a natural product that can be isolated from the stems of Petiveria alliacea and is also a Proline derivative .
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- HY-W142081
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- HY-P11759
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Drug Derivative
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Cancer
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Myr-transportan-Cys is a derivative of the cell-penetrating peptide Transportan (HY-P1732), and its conjugated myristoyl group (Myr) enhances the interaction between the peptide and cell membranes. Myr-transportan-Cys integrates three key delivery functions: nucleic acid condensation, cell penetration, and endosomal escape. Myr-transportan-Cys can form immunostimulatory tandem peptide nanocomplexes (iTPNCs) for encapsulating and delivering immunostimulatory oligonucleotide cargos to tumors .
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- HY-W051173
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Biochemical Assay Reagents
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Others
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(Methoxycarbonyl)-L-valyl-L-proline is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-P11700
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MHC
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Inflammation/Immunology
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AAPDARETA is a mutated MHC-associated peptide with reduced binding affinity to H-2D b MHC molecules. AAPDARETA activates subsets of mouse main olfactory epithelium sensory neurons and induces Ca 2+ transients .
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- HY-P3051A
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Drug Derivative
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Infection
Inflammation/Immunology
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CKS-17 (dimer) is the dimer of CKS-17 (HY-P3051). CKS-17 (dimer) can be prepared by introducing a naturally occurring cysteine at the carboxyl terminus and dimerizing via a cysteine-disulfide bond. CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has a highly conserved amino acid sequence present in the transmembrane envelope proteins of numerous animal and human retroviruses. As an immunomodulatory epitope, CKS-17 exhibits inhibitory properties on a variety of immune functions .
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- HY-P11772
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Bacterial
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Infection
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LBP-14, a peptide, is a synthetic fragment of the LPS (HY-D1056) binding protein (LBP) and is a LPS antagonist. LBP-14 interacts with LPS via electrostatic contacts between arginine/lysine residues and LPS phosphate groups, and hydrophobic contacts between aromatic/aliphatic residues and LPS acyl chains, blocking LPS binding to LBP. LBP-14 moderately inhibits LPS-induced TNF-α formation. LBP-14 can be used for the research of gram-negative sepsis .
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- HY-P11635
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Drug Derivative
MDM-2/p53
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Cancer
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ATSP-7342 is a negative control analog of ATSP-7041. ATSP-7342 exhibits lower binding affinity to both MDM2 (Ki = 536 nM) and MDMX (Ki >1000 nM), compared with ATSP-7041 .
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- HY-P11791
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- HY-W011553R
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Amino Acid Derivatives
Reference Standards
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Others
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Z-Asp(OMe)-OH (Standard) is the analytical standard of Z-Asp(OMe)-OH (HY-W011553). This product is intended for research and analytical applications. Z-Asp(OMe)-OH is an aspartic acid derivative .
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- HY-P11648
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Osteopontin
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Inflammation/Immunology
Cancer
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SVVYGLR is an osteopontin-derived peptide. SVVYGLR can promote the differentiation of fibroblasts into myofibroblast-like cells and promote the production of type III collagen by cardiac fibroblasts. SVVYGLR can activate the adhesion, migration and tubule formation of endothelial cells in vitro. SVVYGLR promotes angiogenesis and wound healing and promotes the migration of dermal fibroblasts and keratinocytes. SVVYGLR can be used for research related to angiogenesis, dermal wounds and bone regeneration .
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- HY-P11734
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Ser/Thr Protease
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Others
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Suc-AAPY-pNA is an oligptide compound and protease substrate. Suc-AAPY-pNA undergoes hydrolysis by proteases at the peptide bond between tyrosine and p-nitroaniline, releasing p-nitroaniline with an absorption peak at OD410. Suc-AAPY-pNA functions as a substrate in preclinical assays for measuring activity of acidic, neutral, and alkaline proteases .
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- HY-P11705
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Biochemical Assay Reagents
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Cancer
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PUMA2A is a PUMA BH3-only peptide. PUMA2A can be used as a negative control in Cytochrome C release assays and BH3 profiling. PUMA2A can be used in the research of chronic myeloid leukemia .
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- HY-P11716
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ERK
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Cancer
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HYD-1 is a D-amino acid tumor cell adhesion peptide. HYD-1 contains overlapping linear peptide elements required for adhesion, migration blocking, and ERK signaling activation. HYD-1 supports adhesion of breast, prostate, ovarian, and pancreatic tumor cells, and shows no effect on tumor cell cycle distribution. HYD-1 can be used for the research of prostate cancer .
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- HY-P11704
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Formyl Peptide Receptor (FPR)
Bacterial
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Neurological Disease
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f-MKKFRW is a selective mouse formyl peptide receptor 3 (Fpr3) activator and bacterial MgrB-derived peptide motif. f-MKKFRW activates Fpr3 to trigger downstream signaling and calcium responses in Fpr3-expressing cells. f-MKKFRW stimulates a subset of mouse vomeronasal sensory neurons in the accessory olfactory system to evoke calcium responses. f-MKKFRW drives innate avoidance behavior in mice via nasal contact .
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- HY-P11796
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- HY-P11811
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- HY-W040416
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- HY-W009913
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- HY-W091734
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Amino Acid Derivatives
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Cardiovascular Disease
Neurological Disease
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Methyl 4-iodo-L-phenylalaninate hydrochloride is a Phenylalaninate derivative. Methyl 4-iodo-L-phenylalaninate hydrochloride can be used for the preparation of factor XI modulators used in the research of thrombotic and thromboembolic. Methyl 4-iodo-L-phenylalaninate hydrochloride can also be used for the synthesis of compounds for the research of amyloid-related diseases, such as Alzheimer’s disease .
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- HY-W009412R
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- HY-W011002
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- HY-W004098
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- HY-W141791
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- HY-W009381
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- HY-P11706
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Bcl-2 Family
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Cancer
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MS-1 peptide is a peptide for BH3 profiling. MS-1 peptide triggers higher depolarization of mitochondrial membrane in melanoma cells pre-treated with Encorafenib (HY-15605). MS1 peptide can be used for the research of BRAF V600E melanoma .
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- HY-W009203R
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Endogenous Metabolite
Apoptosis
Keap1-Nrf2
Reactive Oxygen Species (ROS)
Ferroptosis
Reference Standards
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Metabolic Disease
Inflammation/Immunology
Cancer
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L-Cystine (dihydrochloride) (Standard) is the analytical standard of L-Cystine (dihydrochloride) (HY-W009203). This product is intended for research and analytical applications. L-Cystine dihydrochloride is the dihydrochloride salt form of L-Cystine (HY-N0394). L-Cystine dihydrochloride elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine dihydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine dihydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine dihydrochloride is promising for research of cystinuria and kidney stones
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- HY-W009003
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- HY-W008958
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- HY-W105804
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Amino Acid Derivatives
Drug Intermediate
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Others
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Selenocystamine dihydrochloride is a selenocysteine derivative that can be used in the synthesis of other active compounds. Selenocystamine dihydrochloride can also induce the aggregation of amphiphilic p-sulfonatocalixarene to form supramolecular nanoparticles .
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- HY-P10043
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MMP
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Others
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MMP-1 Substrate is a matrix metalloproteinase-1 (MMP-1) selective substrate that can be used for the fluorometric determination of MMP-1 enzymatic activity .
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- HY-W010873
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- HY-P11740
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Angiotensin-converting Enzyme (ACE)
Drug Intermediate
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Others
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VYPFPGPIHN is a precursor peptide of β-casomorphin (HY-P0179) and also an ACE inhibitor (IC50 = 123 μM). VYPFPGPIHN resists hydrolysis by peptidases associated with intestinal cell monolayers, maintaining structural integrity and ACE inhibitory activity. VYPFPGPIHN is not extensively taken up or transported by differentiated intestinal cell monolayers .
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- HY-W008254
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- HY-W002326
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- HY-W008353
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- HY-W013734
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- HY-30167
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(R)-2-Amino-3-methyl-butanol
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Biochemical Assay Reagents
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Others
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(2R)-2-Amino-3-methylbutan-1-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W050025
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- HY-W141911
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- HY-W011322
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- HY-W141814
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- HY-W072732
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- HY-W040686
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- HY-N2378
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Benzenepropanoic acid, β-amino-α-hydroxy-, hydrochloride, (αR,βS)-
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Amino Acid Derivatives
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Others
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(2R,3S)-3-Phenylisoserine hydrochloride is a serine derivative .
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- HY-W013297
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- HY-119782
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Fluorescent Dye
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Others
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L-Argininamide is a hydrophilic amino acid derivative and can be used as a compound for ligand binding DNA aptamers. L-Argininamide has the potential for fluorescent aptasensors development .
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- HY-W010734
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- HY-W013406
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- HY-W053531
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- HY-W013155
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- HY-W024554
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- HY-W019205
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- HY-20561A
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- HY-W013793
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- HY-P11646
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COX
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Metabolic Disease
Inflammation/Immunology
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Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities. Brazzein inhibits COX-2 with an IC50 of 12.62 μM. Brazzein exhibits strong antioxidant effects, showing ABTS radical scavenging activity (IC50 = 12.55 μM) . Brazzein shows no antibacterial or antifungal activity. Brazzein can be used for the research of obesity, metabolic disorder, inflammation .
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- HY-I0102
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Amino Acid Derivatives
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Others
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(2S)-Methyl 2-(2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoate is a valine derivative .
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- HY-107663
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Pro-Leu-Gly-NH2; Melanostatin
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Dopamine Receptor
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Neurological Disease
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MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) .
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- HY-W012075
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- HY-77802
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- HY-W010825
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- HY-W013373
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- HY-W010277
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- HY-79415
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L-Leucine, 4-methyl- (9CI); L-2-Amino-4,4-dimethylpentanoic acid; L-γ-Methylleucine
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Amino Acid Derivatives
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Others
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4-Methyl-L-leucine is a Glycine (HY-Y0966) derivative .
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- HY-P11649
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Integrin
VEGFR
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Cancer
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NYLTHRQ is a peptide. NYLTHRQ specifically blocks the interaction between sVEGFR1-i13 and β1 integrin, and inhibits the activation of VEGFR1 and VEGFR2. NYLTHRQ inhibits cancer cell proliferation. NYLTHRQ can be used in the research of tumors such as lung squamous cell carcinoma .
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- HY-W011321
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- HY-W141922
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- HY-W011280
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- HY-Y0134
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Amino Acid Derivatives
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Others
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(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid is a glutamic acid derivative .
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- HY-W041866
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- HY-W017200
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- HY-W012064
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- HY-W052408
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- HY-W016336
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- HY-W048671
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Amino Acid Derivatives
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Others
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Fmoc-Thr(TBDMS)-OH is a Threonine derivative. Fmoc-Thr(TBDMS)-OH can be used for the preparation of sugar ligand-tethered functional nucleic acid conjugates for targeted research .
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- HY-W141985
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- HY-W040705
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N-Methylanthranilic acid
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Drug Metabolite
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Others
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2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver .
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- HY-W002410
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- HY-W017256
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- HY-W013760
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- HY-W008694
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- HY-W010965
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- HY-W010894
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- HY-W018366
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- HY-138106
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Amino Acid Derivatives
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Others
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Fmoc-D-Cit-OH is citrulline with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as H-Dmt-D-Cit-Aba-b-Ala-NMe-30,50-(CF3)2-Bn and H-Dmt-D-Cit-Aba-b-Ala-NMe-Bn with neurokinin-1 antagonist activity .
|
-
- HY-W009562
-
-
- HY-W010591
-
-
- HY-W008487
-
-
- HY-W007599
-
|
|
Drug Derivative
|
Cancer
|
|
(S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid is a polypeptide derivative, can be used to synthesis multifunctional amphiphilic peptide dendrimer for non-viral gene delivery in cancer research. (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid can be used in the preparation of organic substances that enhance the luminescence intensity of alkaline phosphatase substrates .
|
-
- HY-W006062
-
-
- HY-W008395
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Pra-OH is a Glycine (HY-Y0966) derivative . Fmoc-D-Pra-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W009535
-
-
- HY-W008908
-
-
- HY-W011553
-
-
- HY-79709
-
|
|
Amino Acid Derivatives
|
Others
|
|
N-(Methoxycarbonyl)-D-valine methyl ester is an amino acid derivative that can be used for compound synthesis .
|
-
- HY-P11632
-
|
|
Autophagy
|
Neurological Disease
|
|
YLDLAPL is a sleep-enhancing peptide that can be isolated from truffle albumin hydrolysate. YLDLAPL exhibits sleep-promoting effects via regulation of lysosomal autophagy, neurological activity, tyrosine metabolism, and fatty acid elongation .
|
-
- HY-W012498
-
-
- HY-W142083
-
-
- HY-117141
-
-
- HY-79132
-
-
- HY-P11577
-
|
|
MMP
Biochemical Assay Reagents
|
Cancer
|
|
TGGGPLGVARGKGGC is a polypeptide that can be specifically cleaved by MMP-9. TGGGPLGVARGKGGC modifies manganese dioxide supraparticles. TGGGPLGVARGKGGC can be used in the research of early cancer diagnosis .
|
-
- HY-W013678R
-
-
- HY-W027829
-
-
- HY-W111214
-
-
- HY-W141923
-
-
![N-[2-(Fmoc-amino)-ethyl]-Gly-O-tBu hydrochloride](//file.medchemexpress.com/product_pic/hy-w141923.gif)
- HY-W002519
-
-
- HY-P11703
-
|
|
MHC
|
Others
|
|
TRVLNLGPI is an MHC motif-containing, MHC-independent nonapeptide. TRVLNLGPI is not a product of immune presentation, but a product of renal protein degradation, and its concentration is sufficiently high to be specifically recognized by vomeronasal neurons. The concentration of TRVLNLGPI in mouse urine can be six orders of magnitude higher than that of prototype MHC-dependent peptides .
|
-
- HY-W142080
-
|
α-Methyltryptophan
|
mTOR
Autophagy
Apoptosis
Amino Acid Derivatives
|
Metabolic Disease
Cancer
|
|
α-Methyl-DL-tryptophan (α-Methyltryptophan), a tryptophan derivative, is a selective SLC6A14 blocker. In estrogen receptor (ER)-positive breast cancer cells, α-Methyl-DL-tryptophan inhibits mTOR and activates autophagy and apoptosis. α-Methyl-DL-tryptophan also has the effect of reducing weight .
|
-
- HY-W014742
-
-
- HY-W008866
-
-
- HY-W012000
-
|
Boc-N-Me-Ile-OH
|
Amino Acid Derivatives
|
Others
|
|
Boc-N-methyl-L-isoleucine (Boc-N-Me-Ile-OH) is a peptide products and can be used as a precursor in organic synthesis and pharmaceuticals .
|
-
- HY-59135R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
(S)-2-(Methoxycarbonylamino)-3,3-dimethylbutanoic acid (Standard) is the analytical standard of (S)-2-(Methoxycarbonylamino)-3,3-dimethylbutanoic acid. This product is intended for research and analytical applications. (S)-2-(Methoxycarbonylamino)-3,3-dimethylbutanoic acid is a leucine derivative .
|
-
- HY-W142044
-
-
- HY-W005014
-
-
- HY-W014786
-
-
- HY-W008495
-
-
- HY-W010276
-
-
- HY-W041857
-
-
- HY-W141952
-
-
- HY-76255
-
|
|
Drug Derivative
|
Others
|
|
4-Nitrophenyl (tert-butoxycarbonyl)-L-phenylalaninate is a phenylalanine derivative .
|
-
- HY-W048918
-
-
- HY-W009412
-
-
- HY-I1111
-
-
- HY-W017788
-
-
- HY-W016031
-
-
- HY-W048724
-
-
- HY-W012871
-
-
- HY-W008426
-
-
- HY-43459
-
-
- HY-20834
-
-
- HY-Y0168
-
-
- HY-W011537
-
-
- HY-W008876
-
-
- HY-W013686
-
-
- HY-W015651
-
-
- HY-W012676
-
-
- HY-W011074
-
-
- HY-23053
-
-
- HY-W010913
-
-
- HY-W015800
-
|
|
Drug Intermediate
|
Others
|
|
L-Homoserine lactone hydrochloride is the core structural unit of the bacterial quorum-sensing signal molecule N-acyl-L-homoserine lactone (AHLs). As an important intermediate, L-Homoserine lactone hydrochloride acylated derivatives have potent immunosuppressive activity .
|
-
- HY-W016018
-
-
- HY-W009345
-
-
- HY-W009841
-
-
- HY-W005308
-
|
|
Amino Acid Derivatives
|
Cancer
|
|
N-BOC-DL-serine methyl ester is a Serine derivative. N-BOC-DL-serine methyl ester is used for the synthesis of α,β-dehydro-α-amino acid. N-BOC-DL-serine methyl ester is also used for the synthesis of anti-cancer agent, such as quinazolinone derivative that inhibits PI3K activity, and tricyclic pyrolopyranopyridines that inhibits protein kinase activity .
|
-
- HY-W283704
-
-
- HY-W015449
-
-
- HY-W011054
-
-
- HY-W088014
-
-
- HY-W048691
-
-
- HY-W010924
-
-
- HY-Z0291
-
|
Isopropyl L-alaninate; L-Alanine 2-propyl ester; L-Alanine isopropyl ester; O-Isopropyl-L-alanine
|
Amino Acid Derivatives
|
Others
|
|
L-Alanine isopropyl ester is an alanine derivative .
|
-
- HY-W008156R
-
-
- HY-P1175B
-
|
|
TRP Channel
|
Neurological Disease
|
|
L-R4W2 acetate is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC50 of 0.1 μM. L-R4W2 acetate may act as a potent analgesic .
|
-
- HY-W008359
-
-
- HY-124237
-
|
|
Bacterial
|
Others
|
|
N-Octanoyl-DL-homoserine lactone is a member of N-acyl homoserine lactones (AHLs) family, also one of the signal molecule of quorum-sensing (QS) signals. N-Octanoyl-DL-homoserine lactone can regulate the production of siderophores and present positive correlation in Aeromonas sobria strain AS7. N-Octanoyl-DL-homoserine lactone can also regulate the secretion of proteases and stimulate the production of total volatile basic nitrogen (TVB-N) .
|
-
- HY-W012485
-
-
- HY-W015946
-
-
- HY-W014304
-
-
- HY-W008255
-
-
- HY-I0393
-
-
- HY-42066
-
|
S)-3-Amino-4-(benzyloxy)-4-oxobutanoic acid; 1-Benzyl L-aspartate; Aspartic acid 1-benzyl ester; Aspartic acid α-benzyl ester
|
Amino Acid Derivatives
|
Others
|
|
L-Aspartic acid 1-benzyl ester is an aspartic acid derivative .
|
-
- HY-W007108
-
-
- HY-Z0438
-
-
- HY-W011977
-
-
- HY-139128
-
-
- HY-76204
-
-
- HY-W142071
-
-
- HY-P11708
-
|
|
Integrin
|
Cancer
|
|
Relitegatide is a cyclic peptide with selectivity for the αvβ6 integrin. Relitegatide can be used for the synthesis of Relitegatide brexetan (HY-P11276) .
|
-
- HY-W013749
-
-
- HY-75853
-
-
- HY-W010893
-
-
- HY-W019032
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with antibacterial activity .
|
-
- HY-76448
-
-
- HY-W063269
-
-
- HY-41912
-
|
N-[(1,1-Dimethylethoxy)carbonyl]-L-norleucine; BOC-L-norleucine; BOC-norleucine; N-(tert-Butoxycarbonyl)norleucine
|
Amino Acid Derivatives
|
Others
|
|
Boc-Nle-OH is a leucine derivative .
|
-
- HY-W141812
-
-
- HY-W006069
-
|
|
Protease Activated Receptor (PAR)
|
Others
|
|
H-Phe(3,5-DiF)-OH is a difluorophenylalanines in the L-configuration [L-(F2)Phe]. H-Phe(3,5-DiF)-OH can be incorporated into the thrombin receptor-tethered ligand peptide SFLLRNP to identify the phenyl hydrogens of the Phe-2 residue involved in the CH/π receptor interaction .
|
-
- HY-W014100
-
-
- HY-W013198
-
-
- HY-W002074
-
-
- HY-W008176
-
-
- HY-W012381
-
-
- HY-W011255
-
-
- HY-W112057
-
-
- HY-W022138
-
-
- HY-W011064
-
-
- HY-W037549
-
-
- HY-W067478
-
-
- HY-42356
-
-
- HY-W008382
-
-
- HY-W012889R
-
-
- HY-W012228
-
-
- HY-W009118
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-5-Ava-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize fatty acid-based dimeric peptides with PSD-95 inhibitory activity .
|
-
- HY-79908A
-
-
- HY-W141774
-
|
S-Carboxyethylcysteine
|
Amino Acid Derivatives
|
Metabolic Disease
|
|
S-(2-Carboxyethyl)-L-cysteine (S-Carboxyethylcysteine) is a non-protein (modified) sulfur amino acid. S-(2-Carboxyethyl)-L-cysteine is present in Acacia seed. S-(2-Carboxyethyl)-L-cysteine can affect the seed’s protein use in rats. S-(2-Carboxyethyl)-L-cysteine suppresses the methionine-induced growth rate, and has a negative effect on the plasma amino acid levels in rats .
|
-
- HY-W008024
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize somatostatin analogs that inhibit neointima formation induced by balloon injury in rats without altering growth hormone release. Fmoc-Dab(Boc)-OH can be used for the synthesis of peptides .
|
-
- HY-W013769
-
-
- HY-W141852
-
-
- HY-W011049
-
-
- HY-W006063
-
-
- HY-W010839
-
-
- HY-W048825
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Ala-Ala-OH is a self-assembling fluorenylmethoxycarbonyl dipeptide, a small amphiphilic building block composed of a dipeptide linked to a fluorenylmethoxycarbonyl (Fmoc) group. Under conditions of pH < 4, Fmoc-Ala-Ala-OH spontaneously assembles to form a nanofiber network, constructing a hydrogel scaffold with a water content exceeding 99% (w/w). The fibers have a diameter of approximately 22 nm, matching the size of extracellular matrix (ECM) components. Fmoc-Ala-Ala-OH supports cell adhesion, proliferation, and maintains of cell phenotype. Fmoc-Ala-Ala-OH's function is to mimic the ECM, providing a 3D growth microenvironment for cells, and Fmoc-Ala-Ala-OH is primarily used in tissue engineering and 3D cell culture, particularly suitable for in vitro culture studies of cells such as chondrocytes[1] .
|
-
- HY-P1897A
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Fibronectin active fragment control acetate is an active peptide fragment of fibronectin. Fibronectin is a glycoprotein interacting with integrins. Fibronectin active fragment control acetate can be used as a control for Gly-Arg-Gly-Asp-Ser (HY-P0295) .
|
-
- HY-P11413
-
|
|
Ser/Thr Protease
|
Cardiovascular Disease
|
|
PAI-1 is a plasminogen activator inhibitor. PAI-1 is a member of the Ser Protease inhibitor superfamily with antiprotease activity. PAI-1 is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs) .
|
-
- HY-W027230
-
-
![N-[4-(Morpholin-4-ylsulfonyl)benzoyl]glycine](//file.medchemexpress.com/product_pic/hy-w027230.gif)
- HY-20838
-
-
- HY-W017069
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(allyloxy)-4-oxobutanoic acid is an aspartic acid derivative .
|
-
- HY-Y1030
-
|
tert-Butyl (S)-2-amino-3-methylbutanoate hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
tert-Butyl L-valinate hydrochloride is a valine derivative .
|
-
- HY-42067
-
-
- HY-W012709
-
-
- HY-W011686
-
-
- HY-W013962
-
-
- HY-42364
-
-
- HY-W587803R
-
|
|
Others
Reference Standards
|
Metabolic Disease
|
|
Ergosterol (Standard) is the analytical standard of Ergosterol. This product is intended for research and analytical applications. Ergosterol is the primary sterol found in fungi, with antioxidative, anti-proliferative, and anti-inflammatory effects.
|
-
- HY-P1873B
-
|
|
Ser/Thr Protease
|
Metabolic Disease
|
|
Phosphorylase Kinase β-Subunit Fragment (420-436) acetate is the β-Subunit fragment (peptide 430-436) of phosphorylase kinase. Phosphorylase kinase is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release glucose-1-phosphate from glycogen .
|
-
- HY-W011073
-
-
- HY-P11339A
-
|
|
Integrin
|
Cancer
|
|
c-RGD-SH TFA is an Integrin αvβ3 ligand. c-RGD-SH TFA conjugated with core-crosslinked polymeric micelles (CCPM) can be used for synthesis a dual modality nanoparticle probe, and this probe labeled with both Cy7 and 111In can be used for SPECT and NIRF imaging of tumor .
|
-
- HY-W004864
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-(S)-2-(4-pentenyl) Ala-OH is an Fmoc-protected unnatural amino acid. Fmoc-(S)-2-(4-pentenyl) Ala-OH can be used for polypeptide synthesis, such as NYAD-13 (HY-P10834) .
|
-
- HY-42448
-
-
- HY-W015465
-
-
- HY-113119
-
-
- HY-W141933
-
-
- HY-75947
-
-
- HY-W013652
-
-
- HY-126169
-
-
- HY-W036322
-
-
- HY-W015241
-
-
- HY-W005226
-
-
- HY-W042006
-
-
- HY-W008467
-
-
- HY-W022823
-
-
- HY-W048700
-
-
- HY-129960
-
-
- HY-W013517
-
-
- HY-W041988
-
|
|
Bacterial
|
Infection
|
|
Fmoc-Glu-OMe is a glutamic acid derivative. Fmoc-Glu-OMe exhibits significant antibacterial activity and excellent gelation properties in silver nitrate (AgNO3) solution. Fmoc-Glu-OMe promotes wound healing in rat models and eliminates bacteria in MRSA-infected rat wound models. Fmoc-Glu-OMe can be used in studies related to wound infections and MRSA-infected wounds .
|
-
- HY-W006937
-
|
Boc-p-amino-D-Phe(Fmoc)-OH; Boc-D-phe(4-NH-fmoc)-OH
|
Amino Acid Derivatives
|
Others
|
|
Boc-D-(4-fmoc)-aminophenylalanine (Boc-p-amino-D-Phe(Fmoc)-OH) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with gonadotropin-releasing hormone antagonist activity .
|
-
- HY-W039758
-
-
- HY-P11392
-
-
- HY-30090
-
-
- HY-34540
-
|
(αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-pyridinepropanoic acid
|
Amino Acid Derivatives
|
Others
|
|
(αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-pyridinepropanoic acid is an alanine derivative .
|
-
![(αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-pyridinepropanoic acid](//file.medchemexpress.com/product_pic/hy-34540.gif)
- HY-W009244
-
-
- HY-W005759
-
-
- HY-35028
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-Glu-Ofm is a peptide. Boc-Glu-Ofm has been used for the synthesis of ester insulin and cyclic peptide mixtures .
|
-
- HY-W142019
-
-
- HY-P10065
-
-
- HY-W021482
-
|
|
Amino Acid Derivatives
Drug Intermediate
|
Others
|
|
(4S)-1-Benzoylcarbonyl-4-fluorobutylproline ((2R,4R)-1-tert-butoxycarbonyl-4-fluoropyrrolidine-2-carboxylic acid) is a derivative of fluorinated proline and can be used as a pharmaceutical intermediate for the synthesis of various active compounds .
|
-
- HY-W039180
-
-
- HY-W141889
-
-
- HY-W011279
-
-
- HY-101242
-
-
- HY-W009686
-
-
- HY-W048829
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-Phe-Gly-OH is a Boc-protected phenylalanyl glycine derivative, can be used for the synthesis of agents or other compounds .
|
-
- HY-W003318
-
-
- HY-W001954
-
-
- HY-W014824
-
-
- HY-W000795
-
-
- HY-30216AR
-
|
α-Hydroxyisocaproic acid (Standard)
|
Endogenous Metabolite
Reference Standards
|
Others
|
|
Leucic acid (Standard) is the analytical standard of Leucic acid. This product is intended for research and analytical applications. Leucic acid is an amino acid metabolite .
|
-
- HY-W012872
-
-
- HY-22297
-
-
- HY-W015595
-
|
L-2-Allylglycine hydrochloride
|
Amino Acid Decarboxylase
GABA Receptor
|
Neurological Disease
|
|
L-Allylglycine (L-2-Allylglycine) hydrochloride is an amino acid derivative. L-Allylglycine hydrochloride is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine hydrochloride exhibits convulsant activity .
|
-
- HY-W009339
-
-
- HY-Y1801
-
|
L-Aspartic acid β-methyl ester hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
β-Methyl L-aspartate hydrochloride is an aspartic acid derivative .
|
-
- HY-W013153
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg 10]HOE 140, which has bradykinin B1 antagonist activity .
|
-
- HY-W005561
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Dab(Boc)-OMe hydrochloride is an N-terminally protected diaminobutyric acid containing two protecting groups: methoxy (OMe) and tert-butyloxycarbonyl (Boc). H-Dab(Boc)-OMe hydrochloride can be used to synthesize the bifunctional chelator H3Dpaa that can rapidly complex 68Ga under physiological conditions .
|
-
- HY-W010836
-
-
- HY-107848
-
-
- HY-W716776
-
|
|
Drug Intermediate
|
Others
|
|
H-Pro-His-OH is a commonly used amino acid building block in biochemistry and peptide synthesis.
|
-
- HY-23174
-
-
- HY-W008999
-
-
- HY-W141932
-
|
Stearoylglycine; N-Octadecanoylglycine
|
Endogenous Metabolite
|
Others
|
|
N-stearoylglycine is a lipid and has a small ionizable polar headgroup whose charge is pH dependent and whose amide moiety can form H-bonded network between adjacent molecules in ordered films .
|
-
- HY-W046352
-
-
- HY-W002301
-
|
|
Amino Acid Derivatives
|
Others
|
|
(2S)-4-(benzyloxy)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-oxobutanoic acid is an aspartic acid derivative .
|
-
![(2S)-4-(benzyloxy)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-oxobutanoic acid](//file.medchemexpress.com/product_pic/hy-w002301.gif)
- HY-W053801
-
-
- HY-W010698
-
-
- HY-W007620
-
-
- HY-W141781
-
|
Cystaphos sodium
|
Phosphatase
|
Metabolic Disease
|
|
Cysteamine S-phosphate (Cystaphos) sodium can be hydroIyzed to Cysteamine by human alkaline phosphatases. Cysteamine is an orally active agent for the research of nephropathic cystinosis and an antioxidant .
|
-
- HY-W013905
-
-
- HY-Y1144
-
|
N-[(Ethoxycarbonyl)methyl]-N-methylamine hydrochloride; Sacrosine ethyl ester hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
Sarcosine ethyl ester hydrochloride is a Glycine (HY-Y0966) derivative .
|
-
- HY-W048286
-
-
- HY-Z0615
-
|
Boc-L-Asp(OBn)-OH
|
Amino Acid Derivatives
|
Others
|
|
(2S)-4-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid is an aspartic acid derivative .
|
-
![(2S)-4-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid](//file.medchemexpress.com/product_pic/hy-z0615.gif)
- HY-W092202
-
-
- HY-Y1413
-
-
- HY-W014000
-
-
- HY-W047794
-
-
- HY-P11728
-
|
|
CXCR
Apoptosis
Caspase
Akt
ERK
|
Cancer
|
|
Peptide E5 is an antagonist targeting the CXCR4/CXCL12 axis. Peptide E5 blocks the CXCR4/CXCL12 axis, downregulates CXCR4 expression, and inhibits the phosphorylation of downstream Akt and Erk. Peptide E5 induces apoptosis, suppresses migration and adhesion of breast cancer cells. Peptide E5 inhibits CXCL12-mediated endothelial progenitor cell recruitment, thereby suppressing tumor angiogenesis. Peptide E5 is applicable to relevant research on breast cancer .
|
-
- HY-W009402
-
-
- HY-W009892
-
-
- HY-P11718
-
-
- HY-W140794
-
-
- HY-122526
-
-
- HY-W004101
-
-
- HY-P11789
-
-
- HY-W011218
-
-
- HY-P11202
-
-
- HY-W022226
-
-
![N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-D-serine](//file.medchemexpress.com/product_pic/hy-w022226.gif)
- HY-W111969
-
-
- HY-W008256
-
-
- HY-I0924
-
-
- HY-78897
-
-
- HY-W013714
-
-
- HY-W794670
-
|
|
Aminopeptidase
|
Others
|
|
H-Ala-Pro-Ala-OH, tripeptide, is a substrate for Escherichia coli PepP (Xaa-Pro aminopeptidase). H-Ala-Pro-Ala-OH acts as a nitrogen source for wild-type Escherichia coli .
|
-
- HY-W008475
-
-
- HY-P11655
-
|
|
Somatostatin Receptor
|
Neurological Disease
|
|
NOTA-TATE is a somatostatin receptor 2 (SSTR2) binder. NOTA-TATE binds to SSTR2 to enable targeting of SSTR2-positive tumour cells for PET imaging. NOTA-TATE can be used for the research of neuroendocrine tumours .
|
-
- HY-137529
-
-
- HY-W005883
-
-
- HY-P11715
-
|
|
Fluorescent Dye
|
Neurological Disease
|
|
Abz-GFDPFRQ-EDDnp is a fluorogenic substrate for metallothionein oligopeptidase (λex=320 nm, λem=420 nm). Abz-GFDPFRQ-EDDnp is used to determine the enzymatic activity of metallothionein oligopeptidase in tissue extracts and for research on temporal lobe epilepsy .
|
-
- HY-W008599
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-Amino-3-methyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)butanamide 2,2,2-trifluoroacetate is a valine derivative .
|
-
- HY-P10063
-
-
- HY-30230
-
-
- HY-W018045
-
-
- HY-159703
-
|
Glutamyl-cysteine; PSSGlu-Cys
|
Endogenous Metabolite
|
Others
|
|
Glu-Cys (Glutamyl-cysteine; PSSGlu-Cys) is a dipeptide composed of L-glutamic acid (HY-14608) and L-cysteine (HY-Y0337) joined by a peptide linkage .
|
-
- HY-78907
-
-
- HY-148031
-
|
|
ADC Linker
|
Others
|
|
MC-Ala-Ala-Asn-PAB-PNP is a peptide, can be used to synthesize specifically activated micromolecular target coupling body .
|
-
- HY-I0517
-
-
- HY-66024
-
-
- HY-W097232
-
-
- HY-W011832
-
-
- HY-41267
-
-
- HY-W014303
-
-
- HY-120731
-
-
- HY-P1755A
-
|
|
MDM-2/p53
|
Cancer
|
|
p53 (17-26) acetate is a peptide derived from the P53 MDM2 binding domain, with a Kd of 50 nM for MDM2. p53 (17-26) acetate causes cell lysis by damaging cancer cells and nuclear membranes, and induces cancer cell necrosis. p53 (17-26) acetate exhibits antitumor activity and is applicable to research related to pancreatic cancer .
|
-
- HY-W007578
-
-
- HY-W014076
-
-
- HY-W141910
-
-
- HY-W045221
-
-
- HY-W012486
-
-
- HY-W141936
-
-
- HY-21983
-
|
|
Amino Acid Derivatives
|
Others
|
|
O-Acetyl-N-[(1,1-dimethylethoxy)carbonyl]-L-threonine is a compound containing both an amino group and a carboxyl group.
|
-
![O-Acetyl-N-[(1,1-dimethylethoxy)carbonyl]-L-threonine](//file.medchemexpress.com/product_pic/hy-21983.gif)
- HY-W061650
-
-
- HY-P10058
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
cpm-1285m is a cell-permeable mutated peptide analogue of cpm-1285 (Bcl-2 inhibitory peptide). cpm-1285m contains a single substitution of alanine for Leu-151, and exhibits a decrease in Bcl-2 binding affinity with a reduction in IC50 of ∼15-fold. cpm-1285m can be used as a control of cpm-1285 .
|
-
- HY-W052309
-
-
- HY-121520
-
-
- HY-W009503
-
-
- HY-W009343
-
-
- HY-20561
-
-
- HY-P4599B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
H-His-His-OH acetate is an oligopeptide. H-His-His-OH acetate can chelate with Ruthenium (II). H-His-His-OH inhibits the hydrolysis of metal ions at pH 7.4 .
|
-
- HY-W338516
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-L-Homoarginine hydrochloride is a derivative of amino acid with protecting groups. Fmoc-L-Homoarginine hydrochloride can be used for synthesis of homoarginine containing peptide .
|
-
- HY-W018849
-
-
- HY-W010209
-
-
- HY-W141820
-
-
- HY-W008273
-
-
- HY-157248
-
-
- HY-P11765
-
|
|
Adrenergic Receptor
|
Others
|
|
RESA peptide is a substrate peptide of β-adrenergic receptor kinase (βARK). RESA peptide serves as a substrate for βARK-mediated phosphorylation, and its N-terminal acidic residues enhance phosphorylation efficiency and substrate binding capacity .
|
-
- HY-W010721
-
-
- HY-W060779
-
-
- HY-W037451
-
|
|
Amino Acid Derivatives
|
Others
|
|
Methyl L-leucinate, methyl ester of L-leucine, is an alpha-amino acid ester. Methyl L-leucinate is a derivative of methyl ester and L-leucine, a class of compounds containing both amino and carboxyl groups in the molecule .
|
-
- HY-W128028
-
-
- HY-W017404
-
-
- HY-134445
-
-
- HY-P11713
-
|
|
EBV
MHC
|
Infection
Cancer
|
|
EBNA3B 399-408 is an immunodominant HLA-A11-restricted cytotoxic T-lymphocyte epitope in EBNA3B. EBNA3B 399-408 can be used in the research of EBV infection, empyema-associated lymphoma, and nasal natural killer cell lymphoma .
|
-
- HY-W015425
-
-
- HY-79333
-
-
![L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-methylethyl ester](//file.medchemexpress.com/product_pic/hy-79333.gif)
- HY-20838A
-
-
- HY-34611
-
|
N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH
|
Drug Intermediate
ASCT
|
Neurological Disease
Cancer
|
|
Boc-L-2,4-Diaminobutyric acid (N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH) is a versatile synthetic starting material with a cleavable protecting group. Boc-L-2,4-Diaminobutyric acid not only reduces the backbone cleavage rate by protecting the side-chain γ-amino group, but also triggers intramolecular cyclization of self-immolative linkers under acidic cleavage conditions, thus constructing stimuli-responsive materials. Boc-L-2,4-Diaminobutyric acid is also an important building block for bioactive molecules. It can be used in the synthesis of ASCT2 (SLC1A5) inhibitors and carboxynorspermine, and can also serve as an internal standard to support the quantitative detection of specific intracellular amino acids by UPLC-QQQ-MS .
|
-
- HY-W048215
-
|
|
Amino Acid Derivatives
|
Others
|
|
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl)-L-lysine is a lysine derivative .
|
-
- HY-115411
-
|
|
NO Synthase
|
Others
|
|
L-Hydroxy arginine acetate is an intermediate in the catabolism of L-arginine. L-Hydroxy arginine acetate is a substrate for NO synthase .
|
-
- HY-P11791A
-
-
- HY-W048207
-
-
- HY-W007408
-
-
- HY-P11739
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
ZD2 peptide is an EDB-FN-binding peptide with a Kd value of 11 μM. ZD2 peptide binds specifically to the EDB protein fragment of extradomain B fibronectin, a tumor microenvironment biomarker. ZD2 peptide can be conjugated to imaging agents. ZD2 peptide can be used for the research of cancer .
|
-
- HY-W344383
-
|
|
Ser/Thr Protease
|
Others
|
|
Boc-Phe-Ser-Arg-AMC is a trypsin peptide substrate containing a Boc protecting group. Boc-Phe-Ser-Arg-AMC can be degraded by trypsin, releasing AMC (HY-D0027) which has fluorescence activity. Boc-Phe-Ser-Arg-AMC can be used to assess the activity of trypsin .
|
-
- HY-W011773
-
-
- HY-41650
-
|
(S)-2-((tert-Butoxycarbonyl)amino)-N-methoxy-N-methylpropanamide; (S)-2-(tert-Butoxycarbonylamino)-N-methoxy-N-methylpropionamide
|
Amino Acid Derivatives
|
Others
|
|
Boc-Ala-NMe(OMe) is an alanine derivative .
|
-
- HY-75949
-
-
- HY-W141899
-
-
- HY-W006185
-
-
- HY-118535
-
-
- HY-W011614R
-
|
|
Reference Standards
Others
|
Others
|
|
L-Arginine ethyl ester dihydrochloride (Standard) is the analytical standard of L-Arginine ethyl ester dihydrochloride. This product is intended for research and analytical applications. L-Arginine ethyl ester dihydrochloride is an arginine derivative .
|
-
- HY-W010888
-
-
- HY-W026508
-
-
![1-[(3,5-Dimethylisoxazol-4-yl)sulfonyl]proline](//file.medchemexpress.com/product_pic/hy-w026508.gif)
- HY-W047901
-
-
- HY-W007136
-
-
- HY-W040024
-
-
- HY-W011021
-
-
- HY-W008872
-
-
- HY-79171
-
-
- HY-78912
-
-
- HY-W009356
-
|
|
Endogenous Metabolite
Ferroptosis
ROS Kinase
Keap1-Nrf2
Reactive Oxygen Species (ROS)
|
Others
|
|
L-Cystine hydrochloride is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine hydrochloride elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-Cystine hydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine hydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine hydrochloride is promising for research of cystinuria and kidney stones
|
-
- HY-P10541A
-
|
|
HSP
|
Others
|
|
HSP70/DnaK substrate peptide TFA is a short peptide that the HSP70/DnaK molecular chaperone can bind and act on. HSP70/DnaK substrate peptide TFA can be used to study the mechanism of action of HSP70/DnaK in molecular chaperone function .
|
-
- HY-107373A
-
-
- HY-W074889
-
-
- HY-I0172
-
-
- HY-P10838A
-
|
|
PD-1/PD-L1
Apoptosis
|
Cancer
|
|
PL120131 acetate is a PD-1 antagonist, can specifically blocking the interaction between PD-1 and PD-L1, thereby effectively inhibiting the PD-1-mediated apoptosis signaling pathway. PL120131 acetate rescues lymphocytes from apoptosis, maintains the survival and activity of T cells, and induces cytotoxic T lymphocytes to exert killing effects and recognize macrophages and dendritic cells. PL120131 acetate can be used in research related to breast cancer and various malignant tumors .
|
-
- HY-W419989
-
-
- HY-W022446
-
-
- HY-W012907
-
-
- HY-78843
-
-
- HY-W105634
-
|
|
Endogenous Metabolite
|
Others
|
|
Strombine is a imino acid produced by a dehydrogenase. Strombine is a compound present in the hemolymph that is capable of cryoprotection .
|
-
- HY-W008926
-
-
- HY-P11627
-
|
|
Endogenous Metabolite
|
Others
|
|
Cyclo(Pro-Hyp) is a collagen-derived cyclic dipeptide, and its related collagen breakdown product Gly-Pro-Hyp promotes the growth of skin fibroblasts and participates in tissue reconstruction, exhibiting biological activity.
|
-
- HY-Y0750
-
-
- HY-P11775A
-
|
|
VEGFR
|
Cardiovascular Disease
|
|
Peptide HRH acetate is a polypeptide that specifically binds to VEGF receptors. Peptide HRH acetate inhibits VEGF-stimulated endothelial cell proliferation. Peptide HRH acetate inhibits angiogenesis and suppresses corneal neovascularization. Peptide HRH acetate can be used in anti-angiogenesis related studies .
|
-
- HY-W022228
-
-
![N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methoxy-L-phenylalanine](//file.medchemexpress.com/product_pic/hy-w022228.gif)
- HY-41048
-
-
- HY-W009682
-
-
- HY-W142000
-
-
- HY-W141893
-
-
- HY-W008079
-
-
- HY-W002294
-
-
- HY-W051568
-
-
- HY-W097054
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-L-cysteic acid is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize triarylsulfonium compounds for radiolabeling of peptides .
|
-
- HY-W088100
-
|
N-Boc-N'-trityl-D-asparagine; Boc-D-Asn(Trt)-OH
|
Amino Acid Derivatives
|
Cancer
|
|
Boc-N-gamma-trityl-D-asparagin (N-Boc-N'-trityl-D-asparagine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize metastasis-inhibiting or tumor growth-inhibiting metastasis-inhibiting MS derivatives .
|
-
- HY-W018238
-
-
- HY-W205320
-
-
- HY-W097491
-
|
|
Amino Acid Derivatives
|
Others
|
|
L-Methionine sulfone is a sulfonic acid derivative of L-Methionine (HY-N0326). L-Methionine in the presence of a number of oxidizing systems is readily converted to L-Methionine sulfone .
|
-
- HY-W040723
-
-
- HY-W004861
-
-
- HY-W142008
-
-
- HY-W010957
-
-
- HY-W040804R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride (Standard) is the analytical standard of 2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride. This product is intended for research and analytical applications.
|
-
- HY-W010777
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((S)-2-((S)-2-Amino-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanoic acid is a tyrosine derivative .
|
-
- HY-W002336
-
-
- HY-136934
-
|
[Boc-Glu(Obzl)]2-Lys-Ome
|
P-glycoprotein
|
Cancer
|
|
Reversin 205 ([Boc-Glu(Obzl)]2-Lys-Ome) is a P-glycoprotein (ABCB1) inhibitor. Reversin 205 is a peptide chemosensitizer .
|
-
- HY-P10038A
-
|
Myr-FEEERA-OH TFA
|
Integrin
|
Infection
|
|
mP6 (Myr-FEEERA-OH) TFA is a myristoylated peptide. mP6 TFA inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function. mP6 TFA can block the GTP usage of Rac1, Rap1, and Rab7, effectively inhibiting the infection of CHO-A24 cells .
|
-
- HY-W016425
-
-
- HY-I0924A
-
|
Methyl (R)-phenylalaninate hydrochloride; Methyl D-phenylalaninate hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
D-Phe-OMe monohydrochloride is a phenylalanine derivative .
|
-
- HY-20167A
-
|
|
Neurokinin Receptor
|
Cancer
|
|
H-Glu(OtBu)-OtBu hydrochloride is a key intermediate that can be used to synthesize prostate-specific membrane antigen (PSMA) targeting probes. H-Glu(OtBu)-OtBu hydrochloride can reduce nonspecific background binding through negatively charged linkers, improve tumor/background contrast, and can be used in prostate cancer PET/SPECT imaging studies .
|
-
- HY-W002176
-
-
- HY-23424
-
-
- HY-W007615
-
-
- HY-W008360
-
-
- HY-W016028
-
-
- HY-W052227
-
-
- HY-W050023
-
-
- HY-W006187
-
|
(Rac)-H-Phg(4-Me)-OH
|
Glutaminase
|
Cancer
|
|
2-Amino-2-(p-tolyl)acetic acid is used for optimizing azide skeleton, and is the intermediate in the synthesis of 1,3, 4-thiadiazole compounds. 1,3,4-thiadiazole compounds exhibit potential anti-cancer activity, and inhibit glutaminase (GLSI) .
|
-
- HY-P11707
-
|
|
Apoptosis
Bcl-2 Family
|
Inflammation/Immunology
|
|
FS1 peptide is a synthetic BH3 mimetic peptide that shows potential in enhancing NK cell-mediated cancer immunity. FS1 peptide targets anti-apoptotic BCL-2 family proteins, triggers the release of cytochrome c, and thereby promotes apoptosis (Apoptosis). FS1 peptide can be used for NK cell-based immunological research .
|
-
- HY-W007942
-
-
- HY-W009329
-
-
- HY-W011210
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Pra-OH is a Glycine (HY-Y0966) derivative . Fmoc-Pra-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W038873
-
-
- HY-W009401
-
-
- HY-104004A
-
|
Fmoc-Ser-(GlcNAc(Ac)3-beta-D)-OH; Fmoc-Ser[GlcNAc(Ac)3-β-D]-OH; Fmoc-Ser(Ac3AcNH-β-Glc)-OH
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Ser(O-β-D-GlcNAc(OAc)3)-OH is a serine derivative .
|
-
- HY-W002299
-
|
Boc-D-Leu-OH hydrate
|
Amino Acid Derivatives
|
Neurological Disease
|
|
Boc-D-Leucine monohydrate (Boc-D-Leu-OH hydrate) is an N-Boc-protected form of D-Leucine. D-Leucine is an unnatural isomer of L-Leucine that acts as an auto-inhibitor of lactic streptococci. D-Leucine shows potent anti-seizure effect .
|
-
- HY-I0630R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
(R)-2-formamido-4-methylpentanoic acid (Standard) is the analytical standard of (R)-2-formamido-4-methylpentanoic acid. This product is intended for research and analytical applications.
|
-
- HY-W011056
-
-
- HY-W015987
-
|
Fmoc-NH2
|
Biochemical Assay Reagents
|
Others
|
|
9-Fluorenylmethyl carbamate (Fmoc-NH2) is an amide compound with an Fmoc protecting group, which can be used as a photobase initiator to prepare organosilane-based proton exchange membranes .
|
-
- HY-W142015
-
-
- HY-75379
-
-
- HY-W141770
-
-
- HY-P11626
-
|
|
Collagen
|
Metabolic Disease
|
|
Cyclo(Ala-Hyp) is an orally effective collagen-derived hydroxyproline-containing cyclic dipeptide that can be isolated from the culture supernatant of Lactobacillus plantarum. Cyclo(Ala-Hyp) has an AUC0-6h of 2.350 μg/mL·h, significantly higher than traditional collagen oligopeptides. Cyclo(Ala-Hyp) can be used in research related to liver and kidney function protection, skin care, and joint health.
|
-
- HY-W016032
-
-
- HY-W022630
-
-
- HY-W022593
-
-
- HY-W053503
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-3-((tert-Butoxycarbonyl)amino)-3-(3-(trifluoromethyl)phenyl)propanoic acid is a phenylalanine derivative .
|
-
- HY-W105740
-
-
- HY-141526
-
-
- HY-P11643
-
|
|
Angiotensin Receptor
Aminopeptidase
DNA/RNA Synthesis
|
Neurological Disease
|
|
LVV-hemorphin-7 is an Angiotensin IV receptor ligand and IRAP inhibitor (IC50s: 17.6 nM for sheep adrenal IRAP; 5.0 nM for sheep cerebellum IRAP). LVV-hemorphin-7 inhibits the catalytic activity of IRAP. LVV-hemorphin-7 stimulates DNA synthesis. LVV-hemorphin-7 elicits a number of physiological effects, including cellular proliferation and memory enhancement .
|
-
- HY-W023145
-
-
- HY-59135
-
-
- HY-W127783
-
-
- HY-W041990
-
-
- HY-W089230
-
|
N,N'-Di-tert-butoxycarbonyl-L-histidine
|
Amino Acid Derivatives
|
Others
|
|
Boc-His(Boc)-OH (N,N'-Di-tert-butoxycarbonyl-L-histidine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize the dodecapeptide α-mating factor of Saccharomyces cerevisiae .
|
-
- HY-W008086
-
-
- HY-W010943
-
-
- HY-P11720
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
M104 peptide is an OXA-48 carbapenemase inhibitor and antibiotic potentiator. M104 peptide effectively blocks the binding and active site cavity of OXA-48 . M104 peptide restores Meropenem (HY-13678)’s antibacterial activity against OXA-48-producing Klebsiella pneumoniae. M104 peptide can be used for the research of Carbapenem-resistant Klebsiella pneumoniae infection .
|
-
- HY-W009534
-
-
- HY-W010922
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bicyclic peptide tachykinin NK2 antagonists .
|
-
- HY-W009151
-
-
- HY-W008971
-
-
- HY-W015563R
-
|
|
Reference Standards
Others
|
Others
|
|
(R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetic acid (Standard) is the analytical standard of (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetic acid. This product is intended for research and analytical applications. (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetic acid is a Glycine (HY-Y0966) derivative .
|
-
- HY-W008077
-
-
- HY-W051350
-
-
- HY-W092107
-
-
- HY-W017350
-
-
- HY-P11714
-
|
|
EBV
MHC
|
Infection
Cancer
|
|
EBNA3 246-254 (RYSIFFDYM) is an EBV peptide. EBNA3 246-254 is submitted by HLA-A24. EBNA3 246-254 is amplified in vitro, followed by HLA multimer staining to measure EBV-specific CTLs. EBNA3 246-254 can be used for the research of lung cancer .
|
-
- HY-41318
-
|
1,2-Pyrrolidinedicarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (S)-; Methyl (S)-N-(benzyloxycarbonyl)prolinate
|
Amino Acid Derivatives
|
Others
|
|
N-Z-L-proline methyl ester is a proline derivative .
|
-
- HY-W131398
-
-
- HY-P11652
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Cardiogen is a short biologically active peptide (Ala-Glu-Asp-Arg) that does not bind single-stranded deoxyribooligonucleotides, slightly quenches fluorescence of some double-stranded deoxyribooligonucleotides, strongly quenches fluorescence of methylated and unmethylated λ phage DNA-ethidium bromide complexes .
|
-
- HY-W008269
-
-
- HY-W037441
-
-
- HY-W007223
-
|
D-5-HTP; 5-Hydroxy-D-tryptophan
|
5-HT Receptor
|
Neurological Disease
|
|
D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range .
|
-
- HY-W017413
-
-
- HY-Y1824
-
-
- HY-W101495
-
|
N-Boc-L-leucine monohydrate
|
Amino Acid Derivatives
|
Others
|
|
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .
|
-
- HY-W009592A
-
|
Glycyltyrosine dihydrate; Gly-Tyr dihydrate; H-Gly-Tyr-OH dihydrate
|
Amino Acid Derivatives
|
Others
|
|
Glycyl-L-tyrosine dihydrate is a synthetic dipeptide that can be used as a food additive for tyrosine supplementation .
|
-
- HY-76317
-
|
N-Cbz-DL-proline; DL-Cbz-Proline
|
Amino Acid Derivatives
|
Others
|
|
Z-DL-Pro-OH (N-Cbz-DL-proline) is a proline derivative, can be used for the synthesis of agents or other compounds .
|
-
- HY-W048681
-
-
- HY-W002038
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(-)-Phenylglycinol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W008887
-
-
- HY-W008134
-
-
- HY-W013145
-
-
- HY-113084
-
|
|
Drug Derivative
|
Metabolic Disease
|
|
L-Cysteine S-sulfate is an S-sulfated derivative of L-cysteine (HY-Y0337). L-Cysteine S-sulfate is the substrate for cystine lyase, it can be used in mass spectrometry and chromatography analyses .
|
-
- HY-W041986R
-
-
- HY-79294
-
-
- HY-W039756
-
|
NSC 334362
|
Amino Acid Derivatives
|
Others
|
|
Boc-Ala-Ala-OH (NSC 334362) is an Alanine derivative. Boc-Ala-Ala-OH is used in the preparation of anti-bacterial agent .
|
-
- HY-W012707
-
-
- HY-W013651
-
-
- HY-79680
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-(tert-butoxycarbonylamino)-3-(4-carbamoyl-2,6-dimethylphenyl)propanoic acid is a phenylalanine derivative .
|
-
- HY-W141912
-
-
- HY-W013906
-
-
- HY-W008972
-
-
- HY-W011325
-
-
- HY-79513
-
|
tert-Butyl [(R)-1-(methoxycarbonyl)-2-hydroxyethyl]carbamate
|
Amino Acid Derivatives
|
Others
|
|
(R)-Methyl 2-(tert-butoxycarbonylamino)-3-hydroxypropanoate is a serine derivative .
|
-
- HY-W141987
-
-
- HY-W142003
-
-
- HY-77151
-
-
- HY-P10038
-
|
Myr-FEEERA-OH
|
Integrin
|
Infection
|
|
mP6 (Myr-FEEERA-OH) is a myristoylated peptide. mP6 inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function. mP6 can block the GTP usage of Rac1, Rap1, and Rab7, effectively inhibiting the infection of CHO-A24 cells .
|
-
- HY-W011567
-
-
- HY-W007399
-
-
- HY-W009970
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
N-Benzylglycine ethyl ester is an N-substituted glycine derivative. N-Benzylglycine ethyl ester is bound to PDB code: 1B41. N-Benzylglycine ethyl ester can be used in Alzheimer's disease research .
|
-
- HY-P11742
-
|
Ac-GWW(LA)8LWWA-NH2
|
Biochemical Assay Reagents
|
Others
|
|
WALP23 is a synthetic model peptide. WALP23 induces heterogeneity in lipid bilayers, forming stripe-like microdomains in DPPC bilayers. WALP23 can be used to study protein-membrane interactions. WALP23 is also used as a model peptide to determine helical orientation during the association process .
|
-
- HY-W041076
-
-
- HY-W013936
-
-
- HY-W009006
-
-
- HY-W141934
-
-
- HY-W131866
-
-
- HY-Y0029
-
-
- HY-W042005
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-D-Phe(3,4-DiCl)-OH is D-3,4-Dichlorophenylalanine, a amino acid derivative. H-D-Phe(3,4-DiCl)-OH shows protein synthesis activity .
|
-
- HY-P11790
-
|
C-Tag peptide
|
Biochemical Assay Reagents
|
Infection
|
|
EPEA tag peptide (C-Tag peptide) is an epitope tag peptide. EPEA tag peptide enables elution of the SpaP EPEA complex. EPEA tag peptide is applicable to research related to bacterial type III secretion systems .
|
-
- HY-W011116
-
|
H-Leu-Leu-Leu-OH; Trileucine
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((S)-2-((S)-2-Amino-4-methylpentanamido)-4-methylpentanamido)-4-methylpentanoic acid is a leucine derivative .
|
-
- HY-136197
-
|
|
Ras
|
Cancer
|
|
StRIP16, bioavailable StRIP3 analogue, is a double-stapled peptide which can bind to Rab8a GTPase, with a Kd of 12.7 μM .
|
-
- HY-145512
-
|
NLT
|
Dopamine Receptor
|
Neurological Disease
|
|
N-(α-Linolenoyl) tyrosine (NLT) is a dopaminergic agonist capable of crossing the blood-brain barrier. N-(α-Linolenoyl) tyrosine increases the level, turnover rate and release amount of dopamine in the striatum. N-(α-Linolenoyl) tyrosine modulates rotational behavior in a rat model with unilateral striatal injury and alleviates excessive blinking symptoms in models induced by dopamine-depleting agents. N-(α-Linolenoyl) tyrosine can be used for research on Parkinson's disease and idiopathic blepharospasm .
|
-
- HY-W008028
-
-
- HY-W015533R
-
-
- HY-W008464
-
-
- HY-W062304
-
-
- HY-W047902
-
-
- HY-148195
-
|
NNZ-2591
|
Biochemical Assay Reagents
|
Neurological Disease
|
|
Ercanetide (NNZ 2591) is a synthetic analogue of a small peptide of cyclic glycine proline (cGP). Ercanetide shows orally active and cross the blood-brain barrier. Ercanetide shows neuroprotective after ischemic brain injury. NNZ 2591 improves motor function in a rat model of Parkinson's disease. Ercanetide has the potential for the research of ischemic brain injury and angelman syndrome .
|
-
- HY-W101889
-
|
N-Boc-N'-xanthyl-L-glutamine
|
Amino Acid Derivatives
|
Others
|
|
Boc-Gln(Xan)-OH (N-Boc-N'-xanthyl-L-glutamine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize peptides with antigenic activity .
|
-
- HY-W098273
-
-
- HY-I0749A
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-Methyl 2-((S)-2-((S)-2-amino-4-phenylbutanamido)-4-methylpentanamido)-3-phenylpropanoate 2,2,2-trifluoroacetate is a phenylalanine derivative .
|
-
- HY-W141928
-
-
- HY-W009840
-
-
- HY-101444A
-
|
MC-207,110 dihydrochloride; Phe-Arg-β-naphthylamide dihydrochloride
|
Bacterial
|
Infection
|
|
PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.
|
-
- HY-W067360
-
-
- HY-P11452A
-
|
|
LDLR
|
Endocrinology
|
|
(KKEEE)3K acetate is a kidney-targeting peptide. (KKEEE)3K enters renal tubular cells via megalin receptor-mediated endocytosis. (KKEEE)3K acetate can be used in the research of renal drug delivery .
|
-
- HY-W040438
-
-
- HY-W017617
-
-
- HY-W012921
-
-
- HY-Y1164
-
-
- HY-W005295
-
-
- HY-I0124
-
-
- HY-W006886
-
|
|
Amino Acid Derivatives
|
Others
|
Fmoc-(R)-2-(7-octenyl) Ala-OH is an unnatural Fmoc-protected amino acid and modification module. Fmoc-(R)-2-(7-octenyl) Ala-OH serves as a key building block for all-hydrocarbon cross-linking modification of antimicrobial peptides, and facilitates the generation of stapled peptide derivatives. When introduced into specific sites of the parent peptide, Fmoc-(R)-2-(7-octenyl) Ala-OH effectively increases the α-helix content of the peptide chain, thereby significantly enhancing its antimicrobial activity and proteolytic stability. Fmoc-(R)-2-(7-octenyl) Ala-OH is widely used in research on bacterial infections and the development of related antimicrobial agents . Stapled peptide is a specially chemically modified polypeptide. It locks the peptide chain into a stable α-helical structure by introducing a "staple"-like chemical bridge (usually an all-carbon backbone) at specific positions of the peptide chain.
|
-
- HY-W009693
-
-
- HY-P4613
-
|
|
Drug Derivative
Drug Intermediate
|
Others
|
|
Fmoc-D-allo-Thr-OH is a derivative of D-allothreonine (HY-W001959), which is commonly used as a building block in solid-phase peptide synthesis (SPPS) .
|
-
- HY-W022220
-
-
- HY-W008156
-
-
- HY-101444AR
-
|
MC-207,110 dihydrochloride (Standard); Phe-Arg-β-naphthylamide dihydrochloride (Standard)
|
Bacterial
Reference Standards
|
Infection
|
|
PAβN (dihydrochloride) (Standard) is the analytical standard of PAβN (dihydrochloride) (HY-101444A). This product is intended for research and analytical applications. PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.
|
-
- HY-W013152
-
-
- HY-W012791
-
-
- HY-W016075
-
-
- HY-Y1166
-
-
- HY-W000830
-
-
- HY-W053699
-
-
- HY-W003903
-
-
- HY-137002
-
|
|
Amino Acid Derivatives
Biochemical Assay Reagents
|
Others
|
|
Fmoc-N-Me-Arg(Pbf)-OH is an amino acid derivative containing a guanidinium protecting group on the arginine side chain. Fmoc-N-Me-Arg(Pbf)-OH is used in the synthesis of neurotensin-derived NTS1 ligands for PET imaging .
|
-
- HY-W019684
-
-
- HY-W012002
-
-
- HY-W051937
-
-
- HY-P11200
-
|
γ-Glutamylasparagine
|
Calcium Channel
|
Neurological Disease
|
|
γ-Glu-Asn (γ-Glutamylasparagine) is a calcium sensing receptor (CaSR) agonist. γ-Glu-Asn is a dipeptide composed of glutamic acid and asparagine .
|
-
- HY-W099247
-
-
- HY-41051
-
|
N-tert-Butoxycarbonyl-N-methyl-L-valine; N-tert-Butoxycarbonyl-N-methylvaline
|
Amino Acid Derivatives
|
Others
|
|
(2S)-2-[[(tert-Butoxy)carbonyl](methyl)amino]-3-methylbutanoic acid is a valine derivative .
|
-
amino]-3-methylbutanoic acid](//file.medchemexpress.com/product_pic/hy-41051.gif)
- HY-W023493
-
|
2-Aminopent-4-enoic acid
|
Amino Acid Decarboxylase
|
Neurological Disease
|
|
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine significantly increases mouse brain ornithine decarboxylase (ODC) activity and decreases S-adenosyl-L-methionine decarboxylase (SAM-DC) activity. DL-Allylglycine causes a marked decrease in brain GABA concentration. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .
|
-
- HY-W009257
-
-
- HY-W141940
-
-
- HY-W128037
-
-
- HY-P10060
-
-
- HY-W007020
-
-
- HY-137946
-
|
|
Aminopeptidase
|
Others
|
|
L-Leucine 4-methoxy-β-naphthylamide hydrochloride is an aminopeptidase M and leucine aminopeptidase substrate .
|
-
- HY-135113
-
|
|
Amino Acid Derivatives
|
Others
|
|
DL/meso-Lanthionine is a mixture of the racemic mixture (DL-) and meso- isomers of Lanthionine. Lanthionine is a non-protein amino acid composed of two alanine residues cross-linked by a thioether bond and is a structural component of the bacterial cell wall.
|
-
- HY-W008986
-
-
- HY-W018865
-
|
(S)-Cysteine methyl ester hydrochloride; Methyl D-cysteinate hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
Methyl D-cysteinate hydrochloride is a cysteine derivative .
|
-
- HY-78927
-
|
|
Amino Acid Derivatives
|
Others
|
|
N-Boc-L-Prolinal is a proline with a Boc protecting group, which can be used to synthesize biologically active peptide mimetics, such as the synthesis of Dolastatin 10 (HY-15580) analogs with anti-colon cancer activity .
|
-
- HY-79919
-
|
|
Amino Acid Derivatives
|
Others
|
|
D-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-leucyl]-, phenylmethyl ester is a phenylalanine derivative .
|
-
![D-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-leucyl]-, phenylmethyl ester](//file.medchemexpress.com/product_pic/hy-79919.gif)
- HY-W001158
-
|
Dimethylglycine hydrochloride; DMG hydrochloride; N-Methylsarcosine hydrochloride
|
Endogenous Metabolite
iGluR
Amino Acid Derivatives
|
Neurological Disease
Metabolic Disease
|
|
N,N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects .
|
-
- HY-138207
-
|
|
Mitochondrial Metabolism
Drug Metabolite
|
Inflammation/Immunology
|
|
N-Oleoyl-L-phenylalanine is a long-chain N-acyl-L-phenylalanine and also a mitochondrial uncoupler. N-Oleoyl-L-phenylalanine uncouples UCP1-independent respiration in mitochondria, thereby helping to regulate glucose homeostasis. As an endogenous metabolite, the level of N-Oleoyl-L-phenylalanine increases in patients with ulcerative colitis after a high-fat diet. N-Oleoyl-L-phenylalanine can be used in studies related to ulcerative colitis .
|
-
- HY-W010590R
-
-
- HY-W042478
-
-
- HY-W007750
-
-
- HY-W141890R
-
|
|
Reference Standards
Others
|
Others
|
|
2-Iodohippuric Acid (Standard) is the analytical standard of 2-Iodohippuric Acid. This product is intended for research and analytical applications. 2-Iodohippuric Acid is a Glycine (HY-Y0966) derivative .
|
-
- HY-W016948
-
-
- HY-W042013
-
-
- HY-78105
-
-
acetic acid](//file.medchemexpress.com/product_pic/hy-78105.gif)
- HY-W011830
-
-
- HY-22296
-
-
- HY-W016256
-
|
|
Bacterial
|
Infection
|
|
L-Methioninamide hydrochloride, a Methionine analogue, is Methionyl-tRNA synthetase inhibitor .
|
-
- HY-W011223
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoic acid is a phenylalanine derivative .
|
-
- HY-115393
-
-
- HY-W043473
-
-
- HY-P10062
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
Hylambatin, a tachykinin, increases both plasma glucose and plasma insulin, whereas the secretion of glucagon was not affected. Hylambatin can be used in diabetes research .
|
-
- HY-W009770
-
-
- HY-W019265
-
-
- HY-P11807
-
|
|
ADC Linker
|
Cancer
|
|
DArg-DLys-DTyr-DTyr-Gly-DTrp is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-W007354
-
-
- HY-W048839
-
-
- HY-W040804
-
-
- HY-20165
-
-
- HY-W008529
-
-
- HY-W016547
-
-
- HY-W012104
-
-
- HY-W011178
-
-
- HY-20897A
-
-
- HY-W012889
-
-
- HY-W012159
-
|
H-MET-SER-OH
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
|
Methionylserine (H-MET-SER-OH) is a methionine- and serine-containing dipeptide. Methionylserine binds to and translocation via intestinal di/tri-peptide transporter 1 (hPEPT1) with a Km value of 0.2 mM. Methionylserine inhibits ACE enzyme activity. Methionylserine can be used in the research of hypension .
|
-
- HY-W008219
-
-
- HY-W008800
-
-
- HY-P5897
-
|
|
GnRH Receptor
|
Metabolic Disease
|
|
GnRH antagonist 3 (Compound 11) is a GnRH antagonist with an IC50 of 7 nM. GnRH antagonist 3 can be used in the research of hormone-dependent diseases .
|
-
- HY-W013638
-
-
- HY-W011089
-
-
- HY-W032689
-
-
- HY-W009088
-
-
- HY-W010862R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
Fmoc-Lys(Alloc)-OH (Standard) is the analytical standard of Fmoc-Lys(Alloc)-OH (HY-W010862). This product is intended for research and analytical applications. Fmoc-Lys(Alloc)-OH is a lysine derivative.
|
-
- HY-W007941
-
-
- HY-W013719
-
-
- HY-W011203
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-(5-Amino-2-(((benzyloxy)carbonyl)amino)-5-oxopentanamido)acetic acid is a Glycine (HY-Y0966) derivative .
|
-
- HY-W018850
-
-
- HY-W089233
-
|
N-Boc-D-glutaMic acid 1-tert-butyl ester
|
Amino Acid Derivatives
|
Others
|
|
Boc-D-Glu-OtBu (N-Boc-D-glutaMic acid 1-tert-butyl ester) is an amino acid derivative with a Boc protecting group, which can be used to synthesize Adamant-1-yl tripeptide with immunostimulatory activity .
|
-
- HY-W030321
-
-
- HY-P10057
-
|
|
Apoptosis
|
Cancer
|
|
cpm-1285 induces apoptosis by functionally blocking intracellular Bcl-2 and related death antagonists. cpm-1285 shows strong binding potency to Bcl-2 with an IC50 value of 130 nM. cpm-1285 reduces tumor burden in mice .
|
-
- HY-W010747
-
-
- HY-P11187A
-
|
|
Bacterial
Endogenous Metabolite
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Bactofencin A acetate is a class IId bacteriocin and Antibacterial agent. Bactofencin A acetate is produced by Lactobacillus salivarius DPC6502, an isolate derived from the intestine. Bactofencin A acetate exhibits activity against Staphylococcus and Listeria species. Bactofencin A acetate slightly modulates the intestinal flora. Bactofencin A acetate can be used in research related to staphylococcal infections, listerial infections, and mastitis .
|
-
- HY-W010729
-
-
- HY-W125501
-
-
![(2R)-2-[(3,5-Dinitrobenzoyl)amino]-2-phenyl-acetic acid](//file.medchemexpress.com/product_pic/hy-w125501.gif)
- HY-Y0028
-
|
N-(tert-Butoxycarbonyl)aspartic acid 1-benzyl ester; N-(tert-Butoxycarbonyl)aspartic acid benzyl ester
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-(tert-Butoxycarbonylamino)succinic acid benzyl ester is an aspartic acid derivative .
|
-
- HY-W008733
-
-
- HY-W015279
-
-
- HY-P11085A
-
|
|
Bacterial
|
Infection
|
|
WLBU2 acetate is a engineered cationic antimicrobial peptide (eCAP) that overcomes the environmental sensitivity of natural antimicrobial peptides (AMPs). WLBU2 acetate exhibits rapid bactericidal effect, with the MIC values of ≤ 10 μM against both Gram-negative and Gram-positive bacteria including MRSA, vancomycin-resistant enterococci, K. pneumoniae, E.aerogenes, E. cloacae, Escherichia coli, et, al. WLBU2 acetate prevents P. aeruginosa biofilm growth and retains its activity in an environment rich in mucus, low pH and high salt concentrations without negative effects on human airway epithelial cells. WLBU2 acetate can be used for the studies of cystic fibrosis (CF) and Pseudomonas aeruginosa infections .
|
-
- HY-W141801
-
-
- HY-W343771
-
|
|
Drug Intermediate
|
Others
|
|
H-Tyr-Gly-OH is an amino acid building block commonly used in biochemical and peptide synthesis.
|
-
- HY-W008064
-
|
Fmoc-L-Citrulline
|
Amino Acid Derivatives
|
Cancer
|
|
Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif .
|
-
- HY-W142139
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-Boc-2-amino-5-azido-pentanoic acid (dicyclohexylammonium) is an amino acid derivative, can be used for the synthesis of compounds .
|
-
- HY-W111382
-
-
- HY-W013998
-
-
- HY-Y1091
-
|
|
Endogenous Metabolite
|
Others
|
|
D-Lysine is a useful raw material employed as an analog of lutenizing-hormone-releasing hormone and as a agent carrier in the form of polylysine. D-Lysine decreases renal uptake of radioactivity during scintigraphy and PRRT with low toxicity. D-Lysine not interferes with the natural amino acid metabolic balance .
|
-
- HY-W018489
-
-
- HY-W006205
-
-
- HY-W028793
-
-
- HY-W008370
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Z-Hyp-OMe is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-20582
-
-
- HY-P11203
-
-
- HY-W005117
-
-
- HY-W141845
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-3-(3-quinolyl)-DL-Ala-OH is a Boc-protected quinolyl Alanine derivative, can be used to synthesis compounds.
|
-
- HY-W009762
-
-
- HY-W012487
-
-
- HY-W011126
-
-
- HY-W009038
-
-
- HY-79288
-
|
(S)-2-[(tert-Butoxycarbonyl)amino]-3-(3-fluorophenyl)propionic acid; tert-Butoxycarbonyl-L-3-fluorophenylalanine
|
Amino Acid Derivatives
|
Others
|
|
(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3-fluorophenyl)propionic acid is a phenylalanine derivative .
|
-
![(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3-fluorophenyl)propionic acid](//file.medchemexpress.com/product_pic/hy-79288.gif)
- HY-P10945A
-
-
- HY-W048334
-
-
- HY-W330469
-
-
- HY-W013210
-
-
- HY-60265
-
-
- HY-32688
-
-
- HY-P10999A
-
|
P55 acetate
|
Drug Derivative
Biochemical Assay Reagents
|
Others
|
|
INF7TAT-P55 acetate (P55 acetate) is a polypeptide derived from INF7TAT (HY-P11000) with G1K, G20L and Y22N mutations. INF7TAT-P55 acetate serves as a delivery carrier to deliver preassembled CRISPR ribonucleases into cells for genome editing .
|
-
- HY-W022796
-
-
![(S)-2-Amino-3-(benzo[b]thiophen-3-yl)propanoic acid](//file.medchemexpress.com/product_pic/hy-w022796.gif)
- HY-79404A
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-beta-t-butyl-d-alanine is an intermediate, can be used in the synthesis of peptides and other amino acids .
|
-
- HY-W010366
-
-
- HY-W012706
-
-
- HY-W013664
-
|
|
PROTAC Linkers
|
Cancer
|
|
Glycyl-l-serine is a PROTAC linker composed of glycine and serine. Glycyl-l-serine can be used in the synthesis of PROTACs, such as FPP29 (HY-P11228) .
|
-
- HY-W015424
-
-
- HY-44070
-
-
- HY-W001037
-
-
- HY-77894
-
-
- HY-W008560
-
-
- HY-W019683
-
-
- HY-W096171
-
|
3-Hydroxy-D-tyrosine
|
Carboxypeptidase
|
Infection
Neurological Disease
|
|
D-Dopa (3-Hydroxy-D-tyrosine) is a potent, orally active, non-competitive and allosteric inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 200 nM. D-Dopa elevates brain dopamine and produce turning behavior in rats. D-Dopa inhibit severe fever with thrombocytopenia syndrome (SFTS) virus infection. D-Dopa can be used for neurological disease and virus infection research .
|
-
- HY-W142162
-
-
- HY-W141795
-
-
- HY-W002588
-
-
- HY-W053701
-
|
|
Amino Acid Derivatives
|
Others
|
|
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-((5-(dimethylamino)naphthalen-1-yl)sulfonyl)-L-lysine is a lysine derivative .
|
-
- HY-W009477
-
-
- HY-W018050
-
-
- HY-W048680
-
-
- HY-59260
-
-
- HY-W040803
-
-
- HY-W014553
-
-
- HY-W039102
-
|
|
Amino Acid Derivatives
|
Cancer
|
|
N-Fmoc-N,O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells .
|
-
- HY-W005846
-
-
- HY-W009144
-
-
- HY-79131
-
-
- HY-W048668
-
-
- HY-W002237
-
-
- HY-Z0615R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
(2S)-4-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid (Standard) is the analytical standard of (2S)-4-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid. This product is intended for research and analytical applications.
|
-
![(2S)-4-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid (Standard)](//file.medchemexpress.com/product_pic/hy-z0615r.gif)
- HY-W008297
-
-
- HY-79271
-
|
Butanamide, 2-amino-N,3,3-trimethyl-, (S)-; (S)-2-Amino-N-methyl-3,3-dimethylbutanamide; L-tert-Leucine methylamide; L-tert-Leucine-N-methylamide
|
Amino Acid Derivatives
|
Others
|
|
S-tert-Leucine N-methylamide is a leucine derivative .
|
-
- HY-W337644
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-L-Homoarg(Et)2-OH hydrochloride is a derivative of amino acid with protecting groups. Fmoc-L-Dap(Boc,Me)-OH can be used for synthesis of homoarginine containing peptide .
|
-
- HY-W141945
-
-
- HY-W013416
-
-
- HY-W010955
-
|
NSC 334018
|
Carboxypeptidase
|
Others
|
|
Z-Phe-Leu-OH (NSC 334018) is a dipeptide acid. Z-Phe-Leu-OH undergoes hydrolysis by carboxypeptidase Y to release L-leucine. Z-Phe-Leu-OH acts as a substrate to assay carboxypeptidase Y peptidase activity .
|
-
- HY-W142107
-
-
- HY-W011154
-
-
- HY-N7831
-
-
- HY-W004153
-
-
- HY-P11785
-
|
|
Claudin
|
Cancer
|
|
Cpe30 MT2 is a short peptide that binds tightly junction protein Claudin‑4 (CLDN4) with high affinity, with a Kd value of 1.97 nM. Cpe30 MT2 can be used for the synthesis of PET molecular imaging probes targeting pancreatic cancer .
|
-
- HY-151641
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3-Azido-L-alanine is an aliphatic functionalized amino acid with side chain lengths of up to four carbons . 3-Azido-L-alanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-116073
-
|
|
Acyltransferase
|
Infection
Cancer
|
|
L-Penicillamine is an orally active serine palmitoyltransferase (SPT) inhibitor. L-Penicillamine inactivates the PLP cofactor by forming adducts, thereby inhibiting SPT activity and reducing sphingolipid biosynthesis. L-Penicillamine not only blocks tumor access to vitamin B6, but also stabilizes the human papillomavirus 16 E6 oncoprotein monomer and inhibits its polymerization, exhibiting a unique anticancer mechanism. L-Penicillamine effectively delays the growth of Sarcoma-180, induces tumor necrosis and prolongs survival (though long-term use may lead to Pyridoxine (HY-B1328) deficiency and weight loss) .
|
-
- HY-W013292
-
-
- HY-W142009
-
-
- HY-41121
-
|
Boc-Ala-OH
|
Amino Acid Derivatives
|
Cancer
|
|
Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma .
|
-
- HY-I0775
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-methyl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoate is a phenylalanine derivative .
|
-
- HY-Y1250
-
|
Fmoc-glycine
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds .
|
-
- HY-W039695
-
-
- HY-W018386
-
-
- HY-W214058
-
|
(S)-N-Acetyl-2-naphthylalanine
|
Biochemical Assay Reagents
|
Others
|
|
Ac-2-Nal-OH ((S)-N-Acetyl-2-naphthylalanine), the S-enantiomer of N-Acetyl-2-naphthylalanine, is used as a biochemical assay reagent .
|
-
- HY-106187B
-
|
|
|
Cancer
|
|
MART-1 (27-35) (human) (TFA) is the amino acid fragment spanning positions 27 to 35 of the MART-1 protein, and it represents an immunogenic epitope recognizable by HLA-A2-restricted melanoma-specific tumor-infiltrating lymphocytes (TILs). MART-1 (27-35) (human) (TFA) can be used in studies related to melanoma .
|
-
- HY-W036329
-
-
- HY-W129587
-
-
- HY-W011186
-
-
- HY-W008183
-
-
- HY-W009403
-
-
- HY-W105884
-
-
- HY-W010197
-
-
- HY-W044620
-
-
- HY-P11751A
-
|
|
Endogenous Metabolite
Endothelin Receptor
|
Cardiovascular Disease
Infection
|
|
RES-701-3 peptide TFA is a class II lasso peptide. RES-701-3 peptide TFA can be isolated from the fermentation broth of Streptomyces species. RES-701-3 peptide TFA potently inhibits the binding of ET-1 to ETB, with an IC50 of approximately 5-10 nM. RES-701-3 peptide TFA is applicable to research related to systemic hypertension, myocardial infarction, and myocardial ischemia .
|
-
- HY-W045072
-
-
- HY-W044285
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-4-Aph(cBm)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active peptide mimetics, such as Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph/4Amf(P)-D4Aph/D4Amf(Q)-Leu-ILys-Pro-DAla-NH2 with gonadotropin-releasing hormone (GnRH) antagonist activity .
|
-
- HY-W013300
-
-
- HY-W042057
-
-
- HY-W009472
-
-
- HY-W007798
-
-
- HY-W022255
-
|
D-Fmoc-glutamic acid
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Glu-OH (D-Fmoc-glutamic acid) is a derivative of glutamate, can be used to prepare supramolecular hydrogels .
|
-
- HY-W720703
-
|
|
Drug Intermediate
|
Others
|
|
H-Ser-Val-OH is a commonly used amino acid building block in biochemistry and peptide synthesis.
|
-
- HY-W017499
-
-
- HY-W010835
-
|
Boc-S-trityl-D-cysteine
|
Amino Acid Derivatives
|
Others
|
|
Boc-D-Cys(Trt)-OH (Boc-S-trityl-D-cysteine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize the bicyclic depsipeptide histone deacetylase inhibitor spirocysteine .
|
-
- HY-41309
-
-
- HY-W009204
-
-
- HY-W009085
-
-
- HY-W048733
-
-
- HY-131894
-
-
- HY-W002235
-
-
- HY-W008446
-
|
|
Amino Acid Derivatives
|
Others
|
|
(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid is a proline derivative .
|
-
- HY-W008997
-
-
- HY-76205
-
-
- HY-W141975
-
-
- HY-Y1080
-
|
N-Acetyl-D-leucine
|
Amino Acid Derivatives
Monocarboxylate Transporter
|
Endocrinology
|
|
N-Acetyl-R-leucine is an amino-protecting group N-substituted chiral amino acid. N-Acetyl-R-leucine is a PepT1 and MCT1 inhibitor with IC50 of 0.74 and 11 mM, respectively. N-Acetyl-R-leucine can be used for LysoTracker signaling studies .
|
-
- HY-20838B
-
-
- HY-W015177
-
-
- HY-W010028
-
-
- HY-W006093R
-
-
- HY-W010984
-
-
- HY-W036324
-
-
- HY-W008383
-
-
- HY-W014373
-
-
- HY-W022134
-
-
![N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methylalanine](//file.medchemexpress.com/product_pic/hy-w022134.gif)
- HY-77635
-
-
- HY-W008942
-
-
- HY-W004083
-
-
- HY-W072598
-
-
- HY-WAA0112
-
|
|
Amino Acid Derivatives
|
Others
|
|
Ethyl 2-((2-((tert-butoxycarbonyl)amino)ethyl)amino)acetate hydrochloride is a Glycine (HY-Y0966) derivative .
|
-
- HY-W012214
-
-
- HY-W002578
-
-
- HY-W142119
-
|
|
Ser/Thr Protease
|
Neurological Disease
|
|
α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine .
|
-
- HY-W036333
-
-
- HY-121705
-
-
- HY-W142161
-
|
Fmoc-MeHis(Trt)-OH
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-N-Me-His(Trt)-OH (Fmoc-MeHis(Trt)-OH) is an Amino acid derivative containing a carboxyl group. Fmoc-N-Me-His(Trt)-OH can be used for the synthesis of Fmoc-MeHis (Trt)-Leu-OH and N-methyl peptides .
|
-
- HY-W026072
-
-
- HY-W040417
-
|
|
PI3K
|
Others
|
|
Boc-L-cyclobutylglycine is a Boc-protected L-cyclic amino acid and synthetic intermediate in the preparation of purinyl quinazolinone PI3Kδ inhibitors .
|
-
- HY-W008527
-
-
- HY-W013678
-
-
- HY-P11638
-
|
|
Mitochondrial Metabolism
|
Neurological Disease
Inflammation/Immunology
|
|
Mitochondrial-targeted peptide BP29 is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 can be used for the research of Friedreich's ataxia .
|
-
- HY-23122
-
-
- HY-W141815
-
-
- HY-W048828
-
-
- HY-P10929
-
|
|
Drug Intermediate
|
Others
|
|
Fmoc-Lys(tBuO-Ara-Glu(AEEA-AEEA)-OtBu)-OH is a drug intermediate in the synthesis of Tirzepatide. Tirzepatide is a dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor (GLP-1R) agonist .
|
-
- HY-W039763
-
-
- HY-77132
-
-
- HY-W012519
-
-
- HY-W011337
-
-
- HY-W018628
-
-
- HY-77757
-
-
- HY-W142140
-
|
N-Methylvaline
|
Amino Acid Derivatives
|
Others
|
|
N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability .
|
-
- HY-W015450
-
|
D-Alanyl-D-alanine; H-D-Ala-D-Ala-OH
|
Endogenous Metabolite
|
Others
|
|
D-Ala-D-Ala is a bacterial endogenous metabolite. D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase .
|
-
- HY-141447
-
|
α-N-Carbobenzoxy-L-lysine thiobenzyl ester monohydrochloride
|
Amino Acid Derivatives
|
Others
|
|
Z-LYS-SBZL (monohydrochloride) is a lysine derivative .
|
-
- HY-W014505
-
-
- HY-W057465
-
-
- HY-W004064
-
-
- HY-P2089
-
|
|
MMP
|
Others
|
|
Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm .
|
-
- HY-W050785
-
-
- HY-30231
-
-
- HY-W141786
-
|
|
Amino Acid Derivatives
|
Others
|
|
Magnesium L-glutamate is a cysteine derivative. Magnesium L-glutamate s a flavor enhancer used to reduce the amount of salt needed in meat products .
|
-
- HY-W013163
-
-
- HY-W011026
-
-
- HY-W142023
-
-
- HY-P11805
-
|
|
ADC Linker
|
Cancer
|
|
Gly-Gly-DTyr-Gly-Gly is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-W002481
-
-
- HY-23861
-
|
Fmoc-N,N-dimethyl-L-Glutamine
|
Amino Acid Derivatives
|
Others
|
|
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N5,N5-dimethyl-L-glutamine is a glutamine derivative .
|
-
- HY-W008182
-
-
- HY-W077223
-
-
- HY-W008075
-
-
- HY-W052493
-
-
- HY-W011913
-
-
- HY-W009794
-
-
- HY-30216A
-
|
α-Hydroxyisocaproic acid
|
Drug Metabolite
Hydroxycarboxylic Acid Receptor (HCAR)
AMPK
ERK
|
Metabolic Disease
Inflammation/Immunology
|
|
Leucic acid (α-Hydroxyisocaproic acid) is an orally active end-product of the microbial metabolism of leucine. Leucic acid can bind to HCAR2, alters AMPK and ERK1/2 phosphorylation status, suppresses lipid synthesis, promotes catabolism, reduces adiposity, enhances lean mass and exercise capacity. Leucic acid suppresses pro-inflammatory cytokine secretion, inflammation-related gene mRNA expression. Leucic acid decreases basal protein synthesis, attenuates myotube atrophy. Leucic acid can be used for the research of obesity .
|
-
- HY-Y0007
-
|
L-Alanine, N-carboxy-, N-benzyl ester (6CI,7CI); (S)-2-(Benzyloxycarbonylamino)propanoic acid
|
Amino Acid Derivatives
|
Others
|
|
N-[(Benzyloxy)carbonyl]-L-alanine is an alanine derivative .
|
-
![N-[(Benzyloxy)carbonyl]-L-alanine](//file.medchemexpress.com/product_pic/hy-y0007.gif)
- HY-15400
-
-
- HY-W008029
-
-
- HY-W048693
-
-
- HY-20167
-
-
- HY-W041864
-
-
- HY-W042002
-
-
- HY-W142035
-
-
- HY-I0591R
-
-
- HY-W072147
-
|
Fmoc-L-Ser-OMe
|
Amino Acid Derivatives
Drug Intermediate
|
Others
|
|
Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is an Fmoc-protected L-serine methyl ester and also a solid-phase peptide synthesis intermediate. Fmoc-Ser-OMe is linked to Ellman resin via its hydroxyl side chain. Fmoc-Ser-OMe is used in peptide synthesis .
|
-
- HY-W141821
-
-
- HY-W009648
-
-
- HY-W011472
-
-
- HY-W013123
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Phe(4-CF3)-OH is Phenylalanine derivative. Fmoc-D-Phe(4-CF3)-OH can be used for the research of peptide inhibitors of protein-protein interactions .
|
-
- HY-W000843
-
-
- HY-P10056
-
|
Human ezrin peptide (324-337)
|
HIV
HCV
HPV
Influenza Virus
Interleukin Related
|
Infection
Inflammation/Immunology
|
|
HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases .
|
-
- HY-W562116
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-Lys(ivdde)-OH is a derivative of amino acid. Boc-Lys(ivdde)-OH can be used for synthesis of lysine containing peptide .
|
-
- HY-14743
-
|
SCV 07; Gamma-D-glutamyl-L-tryptophan
|
Bacterial
STAT
|
Infection
Inflammation/Immunology
Cancer
|
|
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .
|
-
- HY-W014097
-
-
- HY-W142169
-
|
Formyl-L-histidine
|
Aminoacyl-tRNA Synthetase
|
Others
|
|
N-Formyl-L-histidine shows binding affinity to histidyl-tRNA synthetase with a Ki value of 4.6 μM. N-Formyl-L-histidine shows a competitive inhibition against L-histidine ammonia-lyase, inhibits urocanic acid formation from L-histidine with a Ki value of 4.26 mM .
|
-
- HY-W099254
-
-
- HY-W017255
-
|
L-R-(3-Thieyl)glycie; L-α-3-Thieylglycie
|
Amino Acid Derivatives
|
Others
|
|
(S)-3-Thienylglycine (L-R-(3-Thieyl)glycie; L-α-3-Thieylglycie) is aamino acids and their derivatives.
|
-
- HY-I1107
-
-
- HY-P10458
-
|
Human/rat 5-LO (130-149)
|
Lipoxygenase
|
Others
|
|
5-Lipoxygenase blocking peptide (Human/rat 5-LO 130-149) is a specific sequence fragment of 5-lipoxygenase (5-LOX), which can be utilized to prepare an antibody against 5-LOX .
|
-
- HY-75331
-
-
- HY-79295
-
|
N-BOC-3-Fluoro-D-phenylalanine; N-tert-Butoxycarbonyl-3-fluoro-D-phenylalanine
|
Amino Acid Derivatives
|
Others
|
|
N-BOC-3-Fluoro-D-phenylalanine is a phenylalanine derivative .
|
-
- HY-W092111
-
-
- HY-P11782
-
|
|
GSK-3
CDK
Apoptosis
|
Cancer
|
|
GTGKT is a CAGE inhibitor. GTGKT binds to CAGE and blocks the binding of CAGE to GSK3β. GTGKT alters the localization of CAGE and inhibits the binding of CAGE to the promoter sequence of Cyclin D1. GTGKT enhances the Apoptotic effect of anticancer agents. GTGKT reduces the expression of Cyclin D1. GTGKT decreases the tumorigenic potential of melanoma and hepatocellular carcinoma cells .
|
-
- HY-W010838
-
-
- HY-W015233
-
-
- HY-W012030
-
-
- HY-W036320
-
|
|
Amino Acid Derivatives
|
Others
|
|
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-Nw-((4-methoxy-2,3,6-trimethylphenyl)sulfonyl)-N2-methyl-L-arginine is an arginine derivative .
|
-
- HY-W002450
-
|
|
Drug Derivative
|
Cardiovascular Disease
|
|
L-Cyclohexylalanine is an amino acid derivative. L-Cyclohexylalanine modifies an atrial natriuretic peptide, regulates homeostasis of body fluid and blood pressure homeostasis and vasodilation activity .
|
-
- HY-W042008
-
-
- HY-41631
-
|
(S)-Ethyl-N-Boc-pyroglutamate
|
Amino Acid Derivatives
Drug Intermediate
|
Others
|
|
Boc-Pyr-Oet ((S)-Ethyl-N-Boc-pyroglutamate) is a derivative of L-Pyroglutamic acid (HY-76082). Boc-Pyr-Oet can be used for the synthesis of agents or other compounds.
|
-
- HY-W067091
-
-
- HY-138815
-
|
|
Glycosidase
|
Metabolic Disease
|
|
(S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a Tryptophan derivative that weakly inhibits β-D-glucosidase .
|
-
- HY-W041992
-
-
- HY-W048831
-
-
- HY-79165
-
-
![(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3,4-difluorophenyl)propionic acid](//file.medchemexpress.com/product_pic/hy-79165.gif)
- HY-W053705
-
-
- HY-W040432
-
-
- HY-W027251
-
-
- HY-W050803
-
-
- HY-W098059
-
-
- HY-W009124
-
-
- HY-I0591
-
-
- HY-W008633
-
-
- HY-W012906
-
|
L-2-Allylglycine
|
Amino Acid Decarboxylase
GABA Receptor
|
Neurological Disease
|
|
L-Allylglycine (L-2-Allylglycine) is an amino acid derivative. L-Allylglycine is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine exhibits convulsant activity .
|
-
- HY-Y1856
-
-
- HY-P11770
-
|
|
Microtubule/Tubulin
|
Others
|
|
α-Tubulin (residues 440-451) (α-Tubulin Tail) is a Microtubule growth inhibitor. α-Tubulin (residues 440-451) transiently interacts with the longitudinal polymerization interface of α-tubulin, regulating the apparent association and dissociation rates of tubulin at the microtubule growing end. α-Tubulin (residues 440-451) inhibits microtubule growth .
|
-
- HY-W009284
-
-
- HY-23185
-
-
- HY-W142073
-
|
7-Methyltryptophan
|
Amino Acid Derivatives
|
Infection
|
|
7-Methyl-DL-tryptophan (7-Methyltryptophan) is an amino acid derivative, which is a key precursor for biosynthesis of many non-ribosomal peptide antibiotics. 7-Methyl-DL-tryptophan plays an important role in synthesis of high-efficiency antibacterial agents and analogues thereof .
|
-
- HY-W008996
-
-
- HY-W142086
-
-
- HY-W003222
-
|
|
Drug Intermediate
|
Metabolic Disease
|
|
N-tert-Boc-cis-4-fluoro-L-proline (Compound 11) is a drug intermediate for the synthesis of 4-fluoropyrrolidine-2-carbonitrile DPP-4 inhibitor. N-tert-Boc-cis-4-fluoro-L-proline can be used to study type 2 diabetes .
|
-
- HY-W042001
-
-
- HY-W008685
-
-
- HY-W009630
-
-
- HY-P11699
-
|
|
|
Inflammation/Immunology
|
|
AAPDNRETF is a dominant minor histocompatibility antigen presented by H-2D b， which antigen is expressed in C57BL/6 mice and can be recognized by T cells from C3H.SW mice, thereby inducing a strong immune response. AAPDNRETF can induce graft-versus-host disease in irradiated C57BL/6 recipient mice via transfer of sensitized T lymphocytes. AAPDNRETF is applicable to the research of graft-versus-host disease .
|
-
- HY-W003985
-
-
- HY-W141842
-
-
- HY-42938
-
-
- HY-P11201
-
-
- HY-W587803
-
-
- HY-W030771
-
-
- HY-W111211
-
-
- HY-W007706
-
-
- HY-W010927
-
-
- HY-W012133
-
-
- HY-W142047
-
-
![Boc-(R)-4-[4-(trifluoromethyl)benzyl]-L-proline](//file.medchemexpress.com/product_pic/hy-w142047.gif)
- HY-W145762
-
-
- HY-W009343R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
(S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoic acid (Standard) is the analytical standard of (S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoic acid. This product is intended for research and analytical applications. (S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoic acid is an alanine derivative .
|
-
- HY-77519R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
N-(4-Cyanophenyl)glycine (Standard) is the analytical standard of N-(4-Cyanophenyl)glycine. This product is intended for research and analytical applications. N-(4-Cyanophenyl)glycine is a Glycine (HY-Y0966) derivative .
|
-
- HY-W141918
-
-
- HY-P11774
-
|
|
Integrin
|
Cancer
|
|
HYNIC-3P-RGD2 is a dimeric cyclic RGD peptide with high binding affinity for integrin αvβ3 (IC50 = 33 nM). HYNIC-3P-RGD2 acts as a precursor molecule for radiotracers and is used to detect tumor angiogenesis .
|
-
- HY-W009321
-
-
- HY-W048722
-
|
Fmoc-D-2-Thienylalanine
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Thi-OH (Fmoc-D-2-Thienylalanine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize AS-Z-P with thrombin inhibitory activity .
|
-
- HY-P10061
-
|
|
Cathepsin
|
Cancer
|
|
Cathepsin K inhibitor 4 is a potent carbohydrazide Cathepsin K inhibitor with IC50s of 13 nM, 269 nM, 296 nM for human, rat, mouse Cathepsin K, respectively .
|
-
- HY-Y0555A
-
|
N-(Benzyloxycarbonyl)-D-leucine; N-Carbobenzoxy-D-leucine; N-Carbobenzyloxy-D-leucine; NSC 523826
|
Amino Acid Derivatives
|
Others
|
|
D-N-(Benzyloxycarbonyl)leucine is a leucine derivative .
|
-
- HY-W007875
-
-
- HY-113214R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
3,5-Diiodo-L-tyrosine (Standard) is the analytical standard of 3,5-Diiodo-L-tyrosine. This product is intended for research and analytical applications. 3,5-Diiodo-L-tyrosine is a tyrosine derivative .
|
-
- HY-W016340
-
-
- HY-W650842
-
|
|
Caspase
|
Cancer
|
|
Boc-Asp(OBzl)-CMK is an inhibitor for IL-1 converting enzyme (ICE, caspase1). Boc-Asp(OBzl)-CMK prevents death of CHP100 neuroblastoma cell, and IL-1β release elicited by the viral coat protein .
|
-
- HY-114932
-
-
- HY-W019263
-
-
- HY-W061614
-
|
|
Amino Acid Derivatives
|
Others
|
|
(4R)-1-Boc-4-fluoro-D-proline is an amino acid derivative that can be used for preparation of peptidomimetics, dihydropyridopyrimidines and pyridopyrimidines .
|
-
- HY-100047
-
|
|
Taste Receptor
|
Others
|
|
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .
|
-
- HY-W009049
-
-
- HY-W129194
-
-
- HY-P11736
-
|
|
NF-κB
|
Metabolic Disease
|
|
mcIRBP-9 is an orally active NF-κB inhibitor. mcIRBP-9 reduces the levels of TNF-α, IL-1β and TGF-β1 in renal tissues, and decreases LPS-induced IL-1β production. mcIRBP-9 can be used in research related to diabetic nephropathy and type 2 diabetes mellitus .
|
-
- HY-W016035
-
-
- HY-W011019
-
-
- HY-W142126
-
-
- HY-W044573
-
-
- HY-W015449R
-
-
- HY-W015231
-
-
- HY-W014917
-
-
- HY-79417
-
|
Carbamic acid, [(1S)-1-[(methoxymethylamino)carbonyl]-3-methylbutyl]-, 1,1-dimethylethyl ester (9CI); Carbamic acid, [1-[(methoxymethylamino)carbonyl]-3-methylbutyl]-, 1,1-dimethylethyl ester, (S)-
|
Amino Acid Derivatives
|
Others
|
|
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide is a leucine derivative .
|
-
- HY-W010712
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-His(Trt)-OH is a histidine derivative with a trityl (Trt) group protecting the His side chain. Fmoc-His(Trt)-OH also has an Fmoc group protecting the α-NH2 group. Fmoc-His(Trt)-OH can be used in solid-phase peptide synthesis to prevent racemization and byproduct formation. Fmoc-His(Trt)-OH acts as a protected histidine precursor in solid-phase peptide synthesis (SPPS), participating in peptide chain construction through amide bond formation. Fmoc-His(Trt)-OH can be precisely incorporated into the target peptide sequence, ensuring correct peptide chain synthesis and reducing impurity formation. Fmoc-His(Trt)-OH is mainly used in the solid-phase synthesis research of pharmaceutical peptides and bioactive peptides, and is particularly suitable for the preparation of peptide drugs requiring precise control of histidine configuration .
|
-
- HY-W015359
-
-
- HY-W042016
-
-
- HY-45894
-
|
Semaglutide side chain
|
GLP Receptor
|
Metabolic Disease
Inflammation/Immunology
|
|
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is an intermediate in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist Semaglutide (HY-114118). tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu exhibits a strong binding affinity to albumin and can be used to modify SN38 prodrugs to improve tumor distribution .
|
-
- HY-W047788
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Dab(Boc)-OH is an amino acid derivative with a Boc protecting group, which can be used to synthesize methotrexate (MTX) analogs with antitumor and antifolate activities .
|
-
- HY-W009379
-
-
- HY-W011342
-
-
- HY-P11701
-
|
|
MHC
|
Others
|
|
SEIDLILGY is a nonapeptide identified as a peptide ligand derived from mouse major histocompatibility complex class I (MHC). SEIDLILGY serves as a tool chemical stimulant for the specific activation of sensory neurons expressing the particular vomeronasal receptor (V2rf2) .
|
-
- HY-W011444
-
-
- HY-W014238
-
-
- HY-W019028
-
-
- HY-W141990
-
-
- HY-W008995
-
-
- HY-W141962
-
-
- HY-W013810
-
-
- HY-P11650
-
|
|
p38 MAPK
JNK
|
Cardiovascular Disease
|
|
HE4-1 leech peptide is a p38 MAPK inhibitor with an additional c-Jun N-terminal kinase (JNK) inhibitory role. HE4-1 leech peptide suppresses macrophage migration, and does not significantly affect macrophage immunological activities including phagocytic ability, lysozyme activity, and expression levels of most inflammatory factors. HE4-1 leech peptide can be used for the research of atherosclerosis .
|
-
- HY-P11800A
-
|
|
Exosomes
MMP
|
Inflammation/Immunology
|
|
GPLGVRGC is a cysteine-tagged variant of GPLGVRG (HY-P11800). GPLGVRGC is hydrolyzable by MMP13. GPLGVRGC mediates the disassembly of micelle-exosome systems, enhances chondrocyte endocytosis, and promotes responsive system uptake. GPLGVRGC confers targeted delivery and responsive release properties to micelle-exosome systems. GPLGVRGC is applicable to the research of osteoarthritis .
|
-
- HY-Y1875
-
-
- HY-34346
-
|
[[[Hydrazino]carbonyl]methyl]carbamic acid tert-butyl ester; tert-Butyl (2-hydrazinyl-2-oxoethyl)carbamate; tert-Butyl (2-hydrazinyl-2-oxoethyl)carbamate
|
Amino Acid Derivatives
|
Others
|
|
tert-Butyl (2-hydrazinyl-2-oxoethyl)carbamate is a Glycine (HY-Y0966) derivative .
|
-
- HY-P11638A
-
|
|
Mitochondrial Metabolism
|
Neurological Disease
Inflammation/Immunology
|
|
Mitochondrial-targeted peptide BP29 acetate is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 acetate protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 acetate prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 acetate can be used for the research of Friedreich's ataxia .
|
-
- HY-W141930
-
-
- HY-P11741
-
|
|
Exosomes
Biochemical Assay Reagents
|
Neurological Disease
|
|
BV2 is a delivery peptide that binds to BVES, with a Ka of 2.03 μM for the BVES target. BV2 specifically binds to the extracellular domain of BVES, achieving muscle homing and cellular internalization via caveolae-mediated endocytosis. When BV2 is modified on the surface of exosomes by PMO, it enhances dystrophin restoration in the peripheral muscles and myocardium of dystrophin-deficient mice. BV2 is applicable to research related to Duchenne muscular dystrophy and muscle atrophy .
|
-
- HY-W019599
-
|
L-PCPA
|
5-HT Receptor
Tryptophan Hydroxylase
|
Neurological Disease
|
|
4-Chloro-L-phenylalanine (L-PCPA) is a tryptophan hydroxylase inhibitor targeting TPH1 and TPH2, with the activity of blocking serotonin biosynthesis. 4-Chloro-L-phenylalanine reduces the levels of serotonin and its metabolites in the brain without impairing the survival of serotonergic neurons. 4-Chloro-L-phenylalanine enhances anhedonic, depression-like and anxiety-like behaviors in mice with depleted noradrenergic and dopaminergic neurons. 4-Chloro-L-phenylalanine acts as a decarboxylation substrate for aromatic L-amino acid decarboxylase from Bacillus atrophaeus. 4-Chloro-L-phenylalanine can be used in studies related to Parkinson's disease .
|
-
- HY-P11088A
-
-
- HY-20841
-
|
(S)-2-((tert-Butoxycarbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid; Boc-4-Pyranoyl-Gly-OH
|
Amino Acid Derivatives
|
Others
|
|
Boc-(2S)-Gly-4-pyranoyl ((S)-2-((tert-Butoxycarbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid) is an amino-terminally protected glycine derivative that can be used to synthesize dipeptidyl peptidase IV with antidiabetic activity .
|
-
- HY-W008179
-
-
- HY-W048677
-
-
- HY-P5407A
-
|
|
SARS-CoV
Angiotensin-converting Enzyme (ACE)
|
Infection
Cancer
|
|
HD5 TFA is an innate immune effector peptide and SARS-CoV Inhibitor. HD5 TFA binds to the ligand-binding domain of angiotensin-converting enzyme-2 (ACE2) via multiple hydrogen bonds to competitively block the receptor, shielding it from viral recognition. HD5 TFA can be used for the research of COVID-19, HPV16 infection, epithelial ovarian cancer, small-cell lung cancer, and colon cancer .
|
-
- HY-W009197
-
-
- HY-W014663
-
-
- HY-41912B
-
|
Boc-D-Nle-OH; N-BOC-D-norleucine
|
Amino Acid Derivatives
|
Others
|
|
Boc-D-norleucine (Boc-D-Nle-OH) is a leucine derivative that can be used for peptide synthesis .
|
-
- HY-W040441
-
-
- HY-P11810
-
|
|
GnRH Receptor
Neuropeptide FF Receptor
|
Metabolic Disease
|
|
GUB08248 is a full GPR10 agonist and a partial NPFF2R agonist, with EC50 values of 0.5 nM and 2.5 nM, respectively. GUB08248 inhibits food intake and induces sustained weight loss. GUB08248 can be used in obesity-related research .
|
-
- HY-P0281B
-
|
TAT(47-57) acetate; HIV-1 TAT protein (47-57) acetate
|
HIV
|
Infection
|
|
TAT (TAT(47-57)) acetate is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT acetate can increase the yields and the solubility of heterologous proteins .
|
-
- HY-W013844
-
-
- HY-14743R
-
|
SCV 07 (Standard); Gamma-D-glutamyl-L-tryptophan (Standard)
|
Bacterial
STAT
Reference Standards
|
Infection
Inflammation/Immunology
Cancer
|
|
Golotimod (Standard) is the analytical standard of Golotimod. This product is intended for research and analytical applications. Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .
|
-
- HY-W048911
-
-
- HY-W008379
-
-
- HY-W012705
-
-
- HY-P11764
-
-
- HY-P2682
-
|
|
MMP
|
Metabolic Disease
|
|
MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a matrix metalloproteinase-8 (MMP-8) fluorogenic substrate. MMP-8/MMP-26 Fluorogenic substrate can be used for the research of atherosclerosis, pulmonary fibrosis, and sepsis .
|
-
- HY-B1732R
-
|
DLPA (Standard); NSC 9959 (Standard)
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
DL-3-Phenylalanine (Standard) is the analytical standard of DL-3-Phenylalanine. This product is intended for research and analytical applications. DL-3-Phenylalanine is a phenylalanine derivative .
|
-
- HY-W012003
-
-
- HY-N0473A
-
-
- HY-W011004
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-4-Amino-5-(((S)-1-(((S)-1-carboxy-2-phenylethyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-5-oxopentanoic acid is a phenylalanine derivative .
|
-
- HY-W026894
-
-
- HY-W038703
-
-
- HY-W015230
-
-
- HY-W011892
-
-
- HY-W111226
-
|
|
Amyloid-β
Amino Acid Derivatives
|
Cardiovascular Disease
Neurological Disease
|
|
Fmoc-His (3-Me)-OH is a histidine derivative with a methylated imidazole group. Fmoc-His (3-Me)-OH can be used for the synthesis of the chemically modified tripeptide His (3-methyl)-Arg-Trp (H (3-Me)-RW). Fmoc-His (3-Me)-OH serves as a resin in Fmoc solid-phase synthesis for the generation of the His-(3-Me)-Gly-Lys peptide. Fmoc-His (3-Me)-OH is a building block for the synthesis of NAHIS02-(p-Met). Fmoc-His (3-Me)-OH can be applied in research related to Alzheimer's disease .
|
-
- HY-W008140
-
-
- HY-P10005A
-
-
- HY-W141907
-
-
- HY-W014259
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a Glycine (HY-Y0966) derivative . (S)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W016342
-
-
- HY-W141885
-
-
- HY-W013162
-
-
- HY-W011713R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
(4-Aminobenzoyl)-L-glutamic acid (Standard) is the analytical standard of (4-Aminobenzoyl)-L-glutamic acid. This product is intended for research and analytical applications. (4-Aminobenzoyl)-L-glutamic acid is a glutamic acid derivative .
|
-
- HY-Y1167
-
-
- HY-W048217
-
-
- HY-W013185
-
-
- HY-W013048
-
-
- HY-W018717
-
-
- HY-W007986
-
-
- HY-113014
-
-
- HY-W041867
-
-
- HY-W007931
-
-
- HY-W010997
-
-
- HY-W101772
-
-
- HY-W012485R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
H-D-Phe(4-Cl)-OH (Standard) is the analytical standard of H-D-Phe(4-Cl)-OH. This product is intended for research and analytical applications. H-D-Phe(4-Cl)-OH is a phenylalanine derivative .
|
-
- HY-W011606
-
-
- HY-66026
-
-
- HY-W010732
-
-
- HY-79676
-
-
- HY-W002236
-
-
- HY-W029652
-
-
- HY-W010931
-
-
- HY-W041991
-
-
- HY-W101935
-
|
N-Boc-D-arginine hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
N-Boc-D-Arg hydrochloride (N-Boc-D-arginine hydrochloride) is an amino acid derivative with a Boc protecting group, which can be used to synthesize desmopressin with the effects of improving nocturia, urinary incontinence and enuresis .
|
-
- HY-W040734
-
-
- HY-134852
-
-
- HY-W140881
-
-
- HY-139006
-
|
|
TRP Channel
|
Neurological Disease
|
|
N-oleoyl-glutamine is a PM20D1-regulated N-acyl amino acids (NAAs). N-oleoyl-glutamine is a transient receptor potential (TRP) antagonist .
|
-
- HY-W010974
-
-
- HY-41257A
-
-
- HY-W025811
-
-
- HY-W009322
-
-
- HY-W005913
-
-
- HY-W141881
-
|
|
Environmental Pollutants
Biochemical Assay Reagents
HSV
|
Infection
|
|
N-lauroylsarcosine is an anionic surfactant. N-lauroylsarcosine has antiviral activity against HSV-2 strain 333 and HSV-1 strain F. N-lauroylsarcosine synergistically increases skin permeability with 25-50% ethanol. N-lauroylsarcosine can be used to study HSV-2 infection .
|
-
- HY-Z0424
-
|
Methyl (2S)-2-(tert-butoxycarbonylamino)-3-iodopropanoate; Methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-iodopropanoate
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-[(tert-Butoxycarbonyl)amino]-3-iodopropionic acid methyl ester is an alanine derivative .
|
-
![(S)-2-[(tert-Butoxycarbonyl)amino]-3-iodopropionic acid methyl ester](//file.medchemexpress.com/product_pic/hy-z0424.gif)
- HY-79106
-
|
[1,1'-Biphenyl]-4-propanoic acid, α-amino-, (S)-; 4-Biphenylyl-L-alanine; 4-Phenyl-L-phenylalanine; Biphenylalanine
|
Amino Acid Derivatives
|
Others
|
|
L-Biphenylalanine is a phenylalanine derivative .
|
-
- HY-W010386
-
-
- HY-W022227
-
-
- HY-W011081
-
-
- HY-79775
-
-
- HY-W419374
-
|
|
Amino Acid Derivatives
|
Others
|
|
ivDde-Lys(Fmoc)-OH is a derivative of amino acid with protecting groups. ivDde-Lys(Fmoc)-OH can be used for peptide synthesis .
|
-
- HY-P11637
-
|
|
Fluorescent Dye
|
Neurological Disease
|
|
Mitochondrial-targeted peptide BP19 is a fluorescent probe for the selective measurement of labile iron in the mitochondriairon. Mitochondrial-targeted peptide BP19 exhibits iron-selective sensing activity with mitochondrial accumulation, reduced fluorescence in iron-loaded cells, and fluorescence reinstatement upon iron chelation. Mitochondrial-targeted peptide BP19 evaluates mitochondrial labile iron levels in cultured fibroblasts with Friedreich's ataxia .
|
-
- HY-W007618
-
-
- HY-P10768B
-
|
|
PACAP Receptor
|
Inflammation/Immunology
|
|
Ro 25-1553 acetate is a selective VIP2 receptor (VPAC2 receptor) agonist. Ro 25-1553 acetate exhibits bronchodilatory effects on tracheal smooth muscle contractions induced by nerve stimulation or Carbachol (HY-B1208). Ro 25-1553 acetate produces a superimposed effect when combined with Formoterol and Salmeterol (HY-14302). Ro 25-1553 acetate can be used for the study of bronchoconstriction .
|
-
- HY-Z0711
-
-
- HY-Y1394
-
-
- HY-W050493
-
-
- HY-W040801
-
-
- HY-W042010
-
-
- HY-P1544A
-
|
|
Calcium Channel
PKA
Endogenous Metabolite
Adenylate Cyclase
|
Neurological Disease
Metabolic Disease
|
|
Cerebellin TFA is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation. Cerebellin TFA stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway. Cerebellin TFA reduces insulin secretion from pancreatic islets under high-glucose conditions. Cerebellin TFA also regulates synaptic structure formation and controls catecholamine secretion in peripheral tissues. Cerebellin TFA can be used in neurological research .
|
-
- HY-W017150
-
-
- HY-P10945B
-
|
|
Radionuclide-Drug Conjugates (RDCs)
FAP
|
Cancer
|
|
Cys-FAP targeting peptide for FXX489 TFA is the polypeptide part of Unlabeled FXX489 (HY-P10944). Unlabeled FXX489 is a fibroblast activation protein (FAP)-targeting ligand .
|
-
- HY-W016749
-
-
- HY-W010794
-
-
- HY-W009110
-
-
- HY-W017254
-
-
- HY-W048209
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Lys(Palmitoyl)-OH is a Fmoc-amino acid with long alkyl chains. Fmoc-Lys(Palmitoyl)-OH can be used for peptide synthesis .
|
-
- HY-N7403
-
-
- HY-W009911
-
-
- HY-P11647
-
|
|
Complement System
|
Cancer
|
|
RPARPAR is a CendR tumor-penetrating peptide. RPARPAR directly binds to the NRP-1 and NRP-2 receptors on the surface of tumor cells, triggering cellular internalization, vascular extravasation, and penetration into tumor tissues. RPARPAR serves as an efficient ligand for targeting nanocarriers to NRP-1-positive tumors. RPARPAR is applicable in research on tumor targeting and drug delivery .
|
-
- HY-W010499
-
|
|
Biochemical Assay Reagents
|
Others
|
|
H-D-Homoser-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-79404
-
|
L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl- (9CI); (S)-2-(tert-Butoxycarbonylamino)-4,4-dimethylpentanoic acid
|
Amino Acid Derivatives
|
Others
|
|
N-(Tert-Butoxycarbonyl)-L-neopentylglycine is a Glycine (HY-Y0966) derivative .
|
-
- HY-W011155
-
-
- HY-W014405
-
-
- HY-59121
-
-
- HY-W013870
-
-
- HY-W005143
-
-
- HY-W012098
-
-
- HY-W010930
-
|
|
Amino Acid Derivatives
|
Others
|
|
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-chlorophenyl)propanoic acid is a phenylalanine derivative .
|
-
- HY-P5107A
-
|
LMWP acetate; TDSP5 acetate
|
VEGFR
|
Cancer
|
|
Low molecular weight protamine acetate (LMWP acetate;TDSP5 acetate) is a truncated arginine-rich protamine peptide, which also acts as an antidote for heparin/low molecular weight heparin and a cell-penetrating delivery vector. Low molecular weight protamine acetate neutralizes heparin-induced anticoagulant activities, including aPTT, anti-Xa and anti-IIa activities. Low molecular weight protamine acetate translocates across mammalian cell membranes, delivers conjugated impermeable molecules through tumor tissues, enhances the skin permeability of conjugated epidermal growth factor, and accelerates wound healing when conjugated with epidermal growth factor. Low molecular weight protamine acetate retains the in vitro cell proliferation activity of conjugated EGF, and also enables site-specific conjugation with peptides or proteins via genetic recombination. Low molecular weight protamine acetate can be used in studies related to colon cancer, skin wounds and diabetic skin wounds .
|
-
- HY-W090626
-
-
- HY-W007720
-
-
- HY-W100942
-
-
- HY-W141946
-
-
- HY-120791A
-
|
L-Lysyl-L-lysine trihydrochloride
|
Drug Intermediate
|
Others
|
|
Lysyllysine (L-Lysyl-L-lysine) trihydrochloride is a dipeptide composed of two L-lysine amino acids linked together. Lysyllysine trihydrochloride is often used as an enzyme cleavage linker for connecting bioactive peptides, or as a component of more complex antibacterial agents .
|
-
- HY-W007766
-
-
- HY-W010249
-
-
- HY-W010714
-
-
- HY-W011701
-
-
- HY-Y1636
-
-
- HY-W009631
-
-
- HY-W042000
-
-
- HY-W022447
-
-
- HY-W013305
-
-
- HY-I0377
-
-
- HY-P11797
-
|
|
Transmembrane Glycoprotein
|
Cardiovascular Disease
|
|
EP9 is a 7-amino acid peptide targeting CD63. EP9 binds specifically to the extracellular region of CD63, including a groove in the large extracellular loop (EC2) or the extracellular end of CD63’s central cavity, triggering endocytosis of decorated nanoemulsions/liposomes into cells. EP9 promotes cellular uptake of decorated nanoemulsions/liposomes into activated cardiac fibroblasts and epicardial stromal cells via caveolae and/or clathrin-coated pits. EP9 can be used for the research of myocardial infarction, cardiac fibrosis .
|
-
- HY-W142133
-
-
- HY-W013118
-
-
- HY-P11639
-
|
|
Biochemical Assay Reagents
|
Others
|
|
ppTG21 is an endosomolytic agent and inducer. ppTG21 can facilitate endosomal escape of Cas9-2lig-1NLS and Cas9-ASGPrL ribonucleoproteins (RNPs) to enable receptor-facilitated, cell-type specific gene editing in cancer cells without electroporation or transfection reagents. ppTG21 can be used for the research of gene editing .
|
-
- HY-W011458
-
|
|
Amino Acid Derivatives
|
Others
|
|
3,5-Dinitro-L-tyrosine sodium is a tyrosine derivative. 3,5-Dinitro-L-tyrosine sodium as artificial substrate, has zero activity relative to tyrosine as a substrate for tyrosine aminotransferase .
|
-
- HY-W011391A
-
-
- HY-W010156
-
-
- HY-79648
-
-
- HY-W141879
-
-
- HY-W048199
-
-
- HY-W015340
-
-
- HY-W010837
-
-
- HY-W011983
-
-
- HY-P11773
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Integrin
|
Others
|
|
3P-RGD2 is a dimeric cyclic RGD (Arg-Gly-Asp) peptide. When radiolabeled with 99mTc, 3P-RGD2 serves as a selective radiotracer for integrin αvβ3. When radiolabeled with 99mTc, 3P-RGD2 enables single-photon emission computed tomography imaging of integrin αvβ3 .
|
-
- HY-W009320
-
-
- HY-W008386
-
-
- HY-W016424
-
-
- HY-W212029
-
-
- HY-W141810
-
|
H-Phe(4-NH2)-OH hydrochloride
|
Endogenous Metabolite
|
Others
|
|
4-Amino-L-phenylalanine (H-Phe(4-NH2)-OH) hydrochloride is an endogenous metabolite.
|
-
- HY-W055811
-
-
- HY-P11806
-
|
|
ADC Linker
|
Cancer
|
|
DLeu-DTyr-Gly-DTrp-Gly-DTyr-DTrp is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-79130
-
|
Benzeneacetic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (S)-; (S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]phenylethanoic acid; (S)-N-Fmoc-α-phenylglycine; N-9-Fluorenylmethoxycarbonyl-L-phenylglycine
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-(S)-phenylglycine is a Glycine (HY-Y0966) derivative .
|
-
- HY-W010871
-
-
- HY-W012908
-
|
|
Biochemical Assay Reagents
|
Infection
Cancer
|
|
DL-Proline is a racemic mixture of D-Proline and L-Prolin. DL-Proline is a cyclic imino acid with a five-membered ring structure. DL-Proline is a key structural unit in peptide synthesis. DL-Proline can stabilize the β-turn conformation and affect the secondary structure of the peptide. DL-Proline has biological activities such as regulating peptide conformation and enhancing the stability of cyclic peptides. DL-Proline can be used to study diseases related to peptide structure and function, such as cancer and bacterial infection .
|
-
- HY-W005891
-
-
- HY-W012379
-
-
- HY-W141949
-
-
- HY-W012572A
-
|
|
Mitochondrial Metabolism
Bacterial
|
Infection
Metabolic Disease
|
|
D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu 2+) .
|
-
- HY-P11416
-
|
|
Integrin
|
Cardiovascular Disease
|
|
Ac-RGDS-NH2, a tetrapeptide, is an integrin antagonist. Ac-RGDS-NH2 competitively binds to the GPIIb/IIIa receptor (Ki = 4.2 μM), inhibiting the binding of fibrinogen to platelets and thereby effectively suppressing platelet aggregation. Ac-RGDS-NH2 can be used for research on thrombosis .
|
-
- HY-W018077
-
-
- HY-W142025
-
-
- HY-W011993
-
-
- HY-W008559
-
-
- HY-W141986
-
-
- HY-34663
-
|
(2R)-2-(tert-Butoxycarbonylamino)-2-phenylethanoic acid; (R)-2-((tert-Butoxycarbonyl)amino)-2-phenylacetic acid; (R)-2-[(tert-Butoxycarbonyl)amino]-2-phenylacetic acid
|
Amino Acid Derivatives
|
Others
|
|
(αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzeneacetic acid is a Glycine (HY-Y0966) derivative .
|
-
![(αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzeneacetic acid](//file.medchemexpress.com/product_pic/hy-34663.gif)
- HY-W002170
-
-
- HY-W013280
-
-
- HY-W010862
-
-
- HY-P3501A
-
|
NX-1207 TFA
|
Apoptosis
|
Cancer
|
|
Fexapotide (NX-1207) TFA induces apoptosis selectively, reducing prostate volume at a cellular level. Fexapotide can be used in lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) research .
|
-
- HY-W017202
-
-
- HY-100047R
-
|
|
Taste Receptor
Reference Standards
|
Others
|
|
Nα,Nα-Bis(carboxymethyl)-L-lysine (Standard) is the analytical standard of Nα,Nα-Bis(carboxymethyl)-L-lysine (HY-100047). This product is intended for research and analytical applications. Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .
|
-
- HY-W088097
-
-
- HY-W008269R
-
-
- HY-P11108A
-
|
|
NF-κB
Apoptosis
TNF Receptor
Caspase
|
Inflammation/Immunology
Cancer
|
|
RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (Kd = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 acetate induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 high TAMs. RP-182 acetate has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 acetate is used in pancreatic cancer and melanoma research .
|
-
- HY-W013864
-
-
- HY-W008869
-
-
- HY-W729138
-
|
|
ADC Linker
|
Others
|
|
Fmoc-D-homoArg(Et)2-OH (hydrochloride) is a Fmoc-protected derivative of D-Homoarginine (HArg) that renders peptides and proteins resistant to proteolysis by trypsin. Fmoc-D-homoArg(Et)2-OH (hydrochloride) can be used as a cleavable ADC linker to synthesize antibody-drug conjugates (ADCs) .
|
-
- HY-W005144
-
-
- HY-W091365
-
|
N-Boc-N'-xanthyl-L-asparagine
|
Amino Acid Derivatives
|
Others
|
|
Boc-Asn(Xan)-OH (N-Boc-N'-xanthyl-L-asparagine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize locust fat growth hormone .
|
-
- HY-I1044
-
-
- HY-I0115
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((S)-2-Cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid is a valine derivative .
|
-
- HY-Y1153
-
|
CarnoSyn; Ethyl 3-aminopropanoate hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
Ethyl 3-aminopropionate hydrochloride is an alanine derivative .
|
-
- HY-W053678
-
-
- HY-W002302
-
-
- HY-77801
-
-
- HY-W048332
-
-
- HY-W141779
-
-
- HY-W007706R
-
-
- HY-W010324
-
-
- HY-66025
-
-
- HY-W142171
-
-
- HY-P11781
-
|
|
Drug Derivative
|
Cancer
|
|
HW12 is a random peptide containing an N-terminal cysteine and is not an EGFR ligand. HW12 can serve as a control for GE11 (HY-P10128)-conjugated mixed micelles targeting EGFR. HW12 is applicable to pancreatic cancer-related research .
|
-
- HY-I0917
-
-
- HY-W003605
-
|
N-Boc-D-pyroglutamic acid ethyl ester
|
Biochemical Assay Reagents
|
Others
|
|
Boc-D-Pyr-Oet (N-Boc-D-pyroglutamic acid ethyl ester) is used as a biochemical assay reagent .
|
-
- HY-W016319
-
-
- HY-105305A
-
|
ABT-719 acetate; AP-214 acetate
|
Melanocortin Receptor
|
Endocrinology
|
|
Modimelanotide (ABT-719) acetate is an α-melanocyte-stimulating hormone analog. Modimelanotide acetate has high specific binding ability to melanocortin receptors (MCR1, 3, 4, 5). Modimelanotide acetate possesses anti-inflammatory and organ-protective effects. Modimelanotide acetate can be used in the research of diseases such as acute kidney injury .
|
-
- HY-60040
-
-
- HY-P60234A
-
|
|
Dipeptidyl Peptidase
GLP Receptor
|
Metabolic Disease
|
|
AGFAGDDAPR is a bioactive peptide that is a competitive and orally effective inhibitor of dipeptidyl peptidase-IV (DPP-IV). AGFAGDDAPR can enhance the level of GLP-1 in the body by inhibiting DPP-IV, thereby stimulating insulin secretion, improving β-cell function, and inhibiting abnormal proliferation of α-cells, exerting anti-diabetic effects. AGFAGDDAPR can be used for research on type 2 diabetes .
|
-
- HY-W008022
-
-
- HY-W016012
-
|
H-Glu-Glu-OH; Glutamyl-glutamic acid
|
Amino Acid Derivatives
|
Others
|
|
Glu-Glu is a glutamic acid derivative containing amino and carboxyl groups. Glu-Glu is an analogs of acidic tripeptide and can contribute to calcium absorption .
|
-
- HY-W009908
-
-
- HY-W006152
-
-
- HY-W010946
-
-
- HY-W043423
-
-
- HY-W050444
-
-
- HY-W011931
-
-
- HY-W032681
-
-
- HY-W009211
-
-
- HY-W419324
-
-
- HY-W011167
-
-
- HY-P3918
-
|
|
p38 MAPK
|
Others
|
|
EGF-R (661-681) T669 Peptide is a MAPK substrate that can used to measure MAPK catalytic activity .
|
-
- HY-78008
-
-
![N-[(1,1-Dimethylethoxy)carbonyl]-L-leucyl-L-leucine](//file.medchemexpress.com/product_pic/hy-78008.gif)
- HY-P11633
-
|
|
Autophagy
|
Neurological Disease
|
|
YLRPEGDW is an orally active sleep-promoting peptide. YLRPEGDW upregulates Autophagy-related genes, increase Autophagy activity. YLRPEGDW could improve Caffeine-induced sleep reduction .
|
-
- HY-W048708
-
-
- HY-19821
-
-
- HY-W051351
-
-
- HY-W014329
-
-
- HY-W024485
-
|
|
SARS-CoV
Drug Derivative
|
Infection
|
|
SARS-CoV-2-IN-86 (Compound 2734589) is SARS-CoV-2 methyltransferases nsp14 and nsp16 inhibitor, Andrographolide (HY-N0191) derivative. SARS-CoV-2-IN-86 has low toxicity, and according to toxicity analysis, the predicted LD50 is 700 mg/kg .
|
-
- HY-W019714
-
-
- HY-P5502A
-
|
|
Influenza Virus
MHC
|
Infection
Inflammation/Immunology
|
|
Influenza NP (311-325) TFA is an Influenza A nucleoprotein peptide. Influenza NP (311-325) TFA is a class II restricted epitope. Influenza NP (311-325) Influenza NP (311-325) TFA fused to OVA protein can be used for immunological response studies .
|
-
- HY-W013144
-
-
- HY-W104862
-
|
4-NH2-d-Phe
|
CXCR
|
Inflammation/Immunology
|
|
4-Amino-D-phenylalanine ([D-Phe(4-NH2)), a cyclic pentapeptide, inhibits CXCL12 binding to CXCR4 in FC131, with an IC50 of 0.1 μM .
|
-
- HY-W014168
-
-
- HY-W142092
-
|
|
Bacterial
Endogenous Metabolite
|
Others
|
|
N-Acetyl-DL-serine is a hydrophobic amino acid that is synthesized in the body and can be found as a free form or as a salt with malonate, phosphate, or acetate. N-Acetyl-DL-serine has antimicrobial activity against Bacillus cereus and Staphylococcus aureus. N-Acetyl-DL-serine has also been used for the immobilization of DNA fragments on solid surfaces and can be used for protein synthesis and optical detection of DNA strands .
|
-
- HY-W046071
-
|
|
Drug Intermediate
|
Others
|
|
N-Boc-trans-4-fluoro-L-proline is a non-natural amino acid substitute used to construct monoclonal antibodies that specifically target the seed conformation of tau protein .
|
-
- HY-W011354
-
-
- HY-W041986
-
-
- HY-77630
-
-
- HY-W141835
-
-
- HY-W013735
-
-
- HY-W013781
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Boc-Glu(OBzl)-OH (Compound 9) is a glutamic acid derivative commonly used in Boc SPPS. Glutamic acid residues increase the hydrophilicity of the polypeptide and play an important structural and receptor binding role .
|
-
- HY-W101377
-
-
- HY-Y1661
-
-
- HY-W048704
-
|
|
Amino Acid Derivatives
|
Others
|
|
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-((4-methoxyphenyl)diphenylmethyl)-L-lysine is a lysine derivative .
|
-
- HY-20897AR
-
-
- HY-W012967
-
-
- HY-W012850
-
-
- HY-W013622
-
-
- HY-W013407
-
|
|
Tyrosine Hydroxylase
Thyroid Hormone Receptor
|
Neurological Disease
|
|
α-Methyltyrosine methyl ester hydrochloride is an orally active and competitive tyrosine hydroxylase inhibitor. α-Methyltyrosine methyl ester hydrochloride can inhibit the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride causes kidney damage and urethral calculi in rats. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research .
|
-
- HY-I0109
-
-
- HY-W011000
-
-
- HY-115411A
-
|
|
NO Synthase
|
Others
|
|
L-Hydroxy arginine dihydrochloride is an intermediate in the catabolism of L-arginine, and is a substrate for NO synthase .
|
-
- HY-P11143A
-
|
|
Interleukin Related
Liposome
|
Cancer
|
|
IL4RPep-1 acetate is an interleukin-4 receptor (IL-4R) binding agent. IL4RPep-1 acetate preferentially binds to cells with high levels of IL-4R expression compared to those with low levels of expression. IL4RPep-1-labeled liposomes containing Doxorubicin (HY-15142A) are internalized by cells more efficiently. IL4RPep-1-labeled liposomes accumulate more effectively within H226 tumors .
|
-
- HY-Y0978
-
-
- HY-65000
-
-
- HY-78906
-
-
- HY-W040067
-
-
- HY-W098060
-
-
- HY-W011652
-
-
- HY-W010958
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-cyanophenyl)propanoic acid is a phenylalanine derivative .
|
-
- HY-W013239
-
-
- HY-W016427
-
-
- HY-W013108
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxycarbonyl)amino)phenyl)propanoic acid is a phenylalanine derivative .
|
-
- HY-W005388
-
-
- HY-W141858
-
|
Indoleacetylalanine; IAA-ala
|
Amino Acid Derivatives
|
Others
|
|
N-(3-Indolylacetyl)-L-alanine (Indoleacetylalanine) is an indoleacetylamino acid. N-(3-Indolylacetyl)-L-alanine appears to increase callus growth and reduces the ability of growths to differentiate into shoots of Phalaenopsis orchids .
|
-
- HY-113064
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .
|
-
- HY-W141963
-
-
- HY-W008326
-
-
- HY-76205R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid (Standard) is the analytical standard of 2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid. This product is intended for research and analytical applications. 2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid is a phenylalanine derivative .
|
-
- HY-W010788
-
-
- HY-W142120
-
-
- HY-Y0533
-
|
L-Aspartic acid β-tert-butyl ester; β-tert-Butyl L-aspartate
|
Amino Acid Derivatives
|
Others
|
|
L-Aspartic acid 4-tert-butyl ester is an aspartic acid derivative .
|
-
- HY-W011137
-
|
|
Drug Derivative
|
Others
|
|
(S)-4-Nitrophenyl 4-amino-2-((tert-butoxycarbonyl)amino)-4-oxobutanoate is an asparagine derivative .
|
-
- HY-W048283
-
-
- HY-W010590
-
-
- HY-W050782
-
-
- HY-Y0749A
-
|
Glutamic acid, dimethyl ester, hydrochloride, D-
|
Amino Acid Derivatives
|
Others
|
|
Dimethyl D-glutamate hydrochloride is a glutamic acid derivative .
|
-
- HY-W011488
-
-
- HY-W016555
-
-
- HY-W092115
-
-
- HY-32687A
-
-
- HY-Y0920
-
-
- HY-77519
-
-
- HY-P11775
-
|
|
VEGFR
|
Cardiovascular Disease
|
|
Peptide HRH is a polypeptide that specifically binds to VEGF receptors. Peptide HRH inhibits VEGF-stimulated endothelial cell proliferation. Peptide HRH inhibits angiogenesis and suppresses corneal neovascularization. Peptide HRH can be used in anti-angiogenesis related studies .
|
-
- HY-W001210
-
-
- HY-P11280A
-
|
|
Melanocortin Receptor
|
Cancer
|
|
PRAME peptide (425-433) acetate is a proteasome-degraded peptide derived from the cancer-testis antigen PRAME (Preferentially Expressed Antigen in Melanoma). PRAME peptide (425-433) acetate is restricted by HLA-A*02:01 and can serve as a target for bispecific T cell engager therapy in the context of major histocompatibility complex I presentation. PRAME peptide (425-433) acetate shows application potential in various malignant tumors and is widely suitable for research related to solid tumors, melanoma, ovarian cancer, endometrial cancer, and lung cancer (including lung adenocarcinoma and lung squamous cell carcinoma). PRAME peptide (425-433) acetate can be used to explore disease of triple-negative breast cancer, diffuse large B-cell lymphoma, and head and neck squamous cell carcinoma .
|
-
- HY-W016339
-
-
- HY-W002416
-
-
- HY-W130212
-
|
|
Amino Acid Derivatives
|
Others
|
|
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-(trifluoromethyl)phenyl)propanoic acid is a phenylalanine derivative .
|
-
- HY-W011201
-
-
- HY-W013154
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as the biotinylated derivative of the opioid receptor antagonist TIPP .
|
-
- HY-P3343
-
|
|
Estrogen Receptor/ERR
|
Endocrinology
|
|
hFSH-β-(33-53) is a polypeptide corresponding to residues 33-53 of hFSH-β, and also a follicle-stimulating hormone (FSH) antagonist. hFSH-β-(33-53) stimulates basal estradiol synthesis in cells. hFSH-β-(33-53) prolongs vaginal estrus in mice with normal estrous cycles .
|
-
- HY-W010745
-
-
- HY-W050494
-
-
- HY-W041985
-
-
- HY-W008389
-
-
- HY-B1732
-
-
- HY-201283A
-
-
- HY-W011374
-
-
- HY-W053702
-
-
- HY-P10704A
-
|
|
Integrin
|
Cancer
|
|
C16Y acetate is a short peptide and an inhibitor of integrins αvβ3 and α5β1. C16Y acetate acts on the cell membrane and exerts its anticancer activity by inhibiting angiogenesis .
|
-
- HY-W142030
-
-
- HY-P11768
-
|
|
Bombesin Receptor
|
Cancer
|
|
AMBA is a gastrin-releasing peptide receptor (GRPR, BB2, BRS-2) ligand. AMBA binds to GRPR with high specificity and high affinity, and undergoes receptor-mediated endocytosis, which retains the conjugated radiometal in target cells. AMBA is applicable for the research of prostate cancer .
|
-
- HY-W002169
-
-
- HY-W013850
-
-
- HY-W015897
-
-
- HY-W090421
-
-
- HY-43973
-
-
- HY-W011903
-
-
- HY-W011703
-
-
- HY-W003499
-
-
- HY-60264
-
-
- HY-P11781B
-
|
|
Drug Derivative
|
Cancer
|
|
Cys-HW12 TFA is a random peptide containing an N-terminal cysteine and derivative of HW12 (HY-P11781). Cys-HW12 TFA can be coupled via the thiol group of Cys. Cys-HW12 TFA can serve as a control for GE11 (HY-P10128)-conjugated mixed micelles targeting EGFR, and also functions as a cytotoxic agent, cellular uptake inhibitor, and tumor growth inhibitor. Cys-HW12 TFA is applicable to pancreatic cancer-related research .
|
-
- HY-W142115
-
-
- HY-W014599
-
-
- HY-124081
-
|
|
Apoptosis
|
Metabolic Disease
|
|
N-Oleoyl-L-Serine is an endogenous amide of long-chain fatty acids with ethanolamine (N-acyl amides). N-Oleoyl-L-Serine is a lipid regulator of bone remodeling and stimulates osteoclast apoptosis. N-Oleoyl-L-Serine can be used for antiosteoporotic drug discovery development .
|
-
- HY-W141788
-
|
|
Bacterial
|
Infection
|
|
N-Butyryl-DL-homocysteine thiolactone is an N-acyl homoserine lactone (AHL) analogue. AHLs are potent inhibitors of biofilm formation and virulence factors, and has been used for degrading microbial communities, reducing bacterial pathogenicity .
|
-
- HY-W011278
-
-
- HY-W008544
-
-
- HY-W015450R
-
|
D-Alanyl-D-alanine (Standard); H-D-Ala-D-Ala-OH (Standard)
|
Reference Standards
Endogenous Metabolite
|
Others
|
|
D-Ala-D-Ala (Standard) is the analytical standard of D-Ala-D-Ala. This product is intended for research and analytical applications. D-Ala-D-Ala is a bacterial endogenous metabolite. D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase .
|
-
- HY-W041862
-
-
- HY-P11812
-
-
- HY-W011084
-
-
- HY-W010775
-
-
- HY-W003991
-
-
- HY-W008113
-
-
- HY-P11769
-
|
|
CGRP Receptor
|
Cancer
|
|
RM2 is a GRPr antagonist. RM2 selectively binds to GRPr, blocks agonist-induced receptor internalization, and inhibits agonist-triggered intracellular calcium mobilization. RM2 can be used in studies related to prostate cancer .
|
-
- HY-W009502
-
-
- HY-W051299
-
-
- HY-I1061
-
-
- HY-P10587B
-
|
JNJ-77242113 (hydrochloride); JNJ-2113 (hydrochloride); PN-235 (hydrochloride)
|
Interleukin Related
STAT
IFNAR
|
Inflammation/Immunology
|
|
Icotrokinra (JNJ-77242113) hydrochloride is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra hydrochloride inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC50=5.6 pM) and inhibits IL-23-induced interferon IFN-γ production in NK cells with an IC50 of 18.4 pM. Icotrokinra hydrochloride exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra hydrochloride can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease .
|
-
- HY-W022223
-
-
- HY-126809
-
|
Bz-PFR-pNA
|
Kallikrein
Ser/Thr Protease
Parasite
Factor Xa
|
Others
|
|
Bz-Pro-Phe-Arg-pNA (Bz-PFR-pNA) is a chromogenic peptide substrate for plasma and glandular Kallikrein, cysteine proteinase (Cruzipain) and Trypsin. Bz-Pro-Phe-Arg-pNA can be used in Factor XII assay .
|
-
- HY-W035886
-
-
- HY-I0630
-
-
- HY-W013207
-
-
- HY-34519
-
|
L-Tyrosine tert-butyl ester; tert-Butyl (S)-2-amino-3-(4-hydroxyphenyl)propanoate; tert-Butyl L-tyrosinate
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid tert-butyl ester is a tyrosine derivative .
|
-
- HY-W012255
-
-
- HY-W010895
-
-
- HY-59140
-
-
- HY-W009337
-
-
- HY-P11776
-
-
- HY-W012220
-
-
- HY-W008486
-
-
- HY-W008522
-
-
- HY-W010976
-
-
- HY-139093
-
|
APAP-Cys
|
Drug Derivative
|
Others
|
|
Paracetamol-cysteine is a Paracetamol (HY-66005)-cysteine Paracetamol protein (HY-139093A) adduct (PPA), which is formed when Paracetamol is oxidized to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) .
|
-
- HY-W010209R
-
-
- HY-W013726
-
|
|
Biochemical Assay Reagents
Amino Acid Derivatives
|
Others
|
|
Fmoc-Phe(4-Br)-OH is a widely used amino acid derivative. Fmoc-Phe(4-Br)-OH can be used in the synthesis of compounds and for the study of protein-protein interactions and the development of biomaterials. Fmoc-Phe(4-Br)-OH can be used in peptide synthesis to incorporate phenylalanine bromide into the peptide chain .
|
-
- HY-W102709
-
-
- HY-W012451
-
-
- HY-W018062
-
-
- HY-W012139
-
-
- HY-W025807
-
-
- HY-W035914
-
-
- HY-W141955
-
-
- HY-76962
-
-
- HY-W129585
-
-
- HY-W013923
-
-
- HY-W092110
-
-
- HY-W013097
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-Arg(di-Z)-OH can be used for the synthesis of amino acid. Boc-Arg(di-Z)-OH can be used for the research of inhibitors for processing proteinases. Boc-Arg(di-Z)-OH is coupled via the mixed anhydride (MA) with HGlu(OBzl)-Lys(Z)-Arg(Z,Z)-CH2Cl .
|
-
- HY-W130397
-
|
|
Drug Derivative
|
Others
|
|
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-4-oxo-4-(tritylamino)butanoic acid is an asparagine derivative .
|
-
- HY-W142156
-
-
- HY-Y0735
-
-
- HY-41060
-
-
- HY-W022536
-
-
- HY-W002173
-
-
- HY-W011020
-
-
- HY-W141817
-
-
- HY-W018650
-
-
- HY-W012137
-
-
- HY-W141944
-
-
- HY-W021790
-
-
- HY-W269700
-
|
L-Isoleucyl-L-leucine
|
Drug Intermediate
|
Neurological Disease
|
|
Ile-Leu-OH (L-Isoleucyl-L-leucine) is a hydrophobic dipeptide fragment and is a component of the neurotensin C-terminal heptapeptide Pro-Arg-Arg-Pro-Tyr-Ile-LeuOH .
|
-
- HY-W724905
-
|
γ-Glu-Ile; H-γ-Glu-Ile-OH
|
Amino Acid Derivatives
|
Others
|
|
gamma-Glutamylisoleucine (γ-Glu-Ile; H-γ-Glu-Ile-OH) is a dipeptide composed of γ-glutamic acid and isoleucine, and it is also a degradation product of macromolecular proteins after proteolysis .
|
-
- HY-W014048
-
-
- HY-W010758
-
-
- HY-34470
-
-
![N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-phenylalanine](//file.medchemexpress.com/product_pic/hy-34470.gif)
- HY-W099255
-
-
- HY-W011199
-
-
- HY-W008867
-
-
- HY-W041999
-
-
- HY-W097163
-
-
- HY-79708A
-
|
Methyl (R)-2-amino-3-methylbutanoate hydrochloride; Methyl D-valinate hydrochloride; NSC 22921
|
Amino Acid Derivatives
|
Others
|
|
O-Methyl-D-valine (hydrochloride) is a valine derivative .
|
-
- HY-W053550
-
-
- HY-W008731
-
-
- HY-W014692
-
|
N-t-Boc-amino-D-alanine; Boc-D-Dap-OH
|
Amino Acid Derivatives
|
Others
|
|
Boc-D-2,3-diaminopropionic acid (N-t-Boc-amino-D-alanine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize a potent NMDA receptor glycine site agonist with GluN2 subunit-specific activity .
|
-
- HY-W014406
-
-
- HY-W010724
-
-
- HY-W040333
-
-
- HY-100838
-
|
L-CCG III
|
EAAT
|
Neurological Disease
|
|
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na +-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes .
|
-
- HY-W004110
-
-
- HY-W142093
-
-
- HY-W010249R
-
-
- HY-77584
-
|
|
Amino Acid Derivatives
|
Others
|
|
(2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)non-8-enoyl)-4-hydroxypyrrolidine-2-carboxylic acid is a proline derivative .
|
-
- HY-33259
-
-
- HY-W008261
-
-
- HY-134450
-
-
- HY-W011443
-
-
- HY-W077219
-
|
Boc-Arg(Mtr)-OH
|
Amino Acid Derivatives
|
Others
|
|
Boc-L-Arg(Mtr)-OH (Boc-Arg(Mtr)-OH) is an amino acid derivative with a Boc protecting group, which can be used to synthesize peptides with antithrombotic activity .
|
-
- HY-22002
-
-
![N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-methyl-L-norleucine](//file.medchemexpress.com/product_pic/hy-22002.gif)
- HY-W291634
-
-
- HY-W022137
-
-
- HY-P3730A
-
|
|
CDK
|
Cancer
|
|
Cdk2/Cyclin Inhibitory Peptide I (Tat-LFG) acetate, a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner .
|
-
- HY-42069
-
-
- HY-W010880
-
-
- HY-W111209
-
-
- HY-Y0754
-
-
- HY-W345421
-
-
- HY-W141789
-
-
- HY-W008308
-
-
- HY-79128
-
-
- HY-W141831
-
-
- HY-W141863
-
-
- HY-30167A
-
|
(S)-2-Amino-3-methyl-butanol
|
Biochemical Assay Reagents
|
Others
|
|
L-Valinol ((S)-2-Amino-3-methyl-butanol) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W109214
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-L-Dap(Boc,Me)-OH is a derivative of amino acid with protecting groups. Fmoc-L-Dap(Boc,Me)-OH can be used for synthesis of diaminopropionic acid containing peptide .
|
-
- HY-W018741
-
-
- HY-P2278A
-
-
- HY-W128408
-
-
- HY-W011033
-
-
- HY-134449
-
-
- HY-W041987
-
-
- HY-42354
-
|
(R)-2-Cyclohexyl-2-aminoethanoic acid; D-Cyclohexylglycine; D-α-Aminocyclohexaneacetic acid
|
Amino Acid Derivatives
|
Others
|
|
D-α-Aminocyclohexylacetic acid is a Glycine (HY-Y0966) derivative .
|
-
- HY-W041989
-
-
- HY-W142163
-
-
- HY-W015926
-
-
- HY-W048718
-
|
Fmoc-D-α-t-butylglycine
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Tle-OH (Fmoc-D-α-t-butylglycine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize chelating agents that can form a single stereoisomer-enriched form after coordination with metal centers .
|
-
- HY-P10046
-
|
|
Vasopressin Receptor
|
Metabolic Disease
|
|
[Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an arginine-vasopressin (AVP) antagonist. AVP-A can significantly lower plasma aldosterone concentration in rats. AVP-A can be used for the research of the growth and steroidogenic capacity of rat adrenal zona glomerulosa .
|
-
![[Deamino-Pen1,Val4,D-Arg8]-vasopressin](//file.medchemexpress.com/product_pic/hy-p10046.gif)
- HY-W015533
-
-
- HY-W141927
-
-
- HY-W013780
-
-
- HY-W141948
-
-
- HY-W013460
-
-
- HY-W016363
-
-
- HY-W041982
-
-
- HY-W012883
-
-
- HY-I0519
-
-
- HY-N7403R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
3-Phenylpropionylglycine (Standard) is the analytical standard of 3-Phenylpropionylglycine. This product is intended for research and analytical applications. 3-Phenylpropionylglycine is a Glycine (HY-Y0966) derivative .
|
-
- HY-W008977
-
-
![N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(phenylmethyl)-L-serine](//file.medchemexpress.com/product_pic/hy-w008977.gif)
- HY-W745139
-
-
- HY-W012138
-
-
- HY-P11702
-
|
|
Bacterial
|
Others
|
|
f-MFFINTLTL is a formylated nonapeptide and a natural ligand from mitochondria or bacteria. f-MFFINTLTL serves as a tool chemical stimulant for the specific activation of sensory neurons expressing the specific vomeronasal receptor (V2rf2) .
|
-
- HY-134935
-
-
- HY-W009215
-
|
L-Met-L-Ala-L-Ser
|
Amino Acid Derivatives
|
Others
|
|
H-Met-Ala-Ser-OH (L-Met-L-Ala-L-Ser) is a tripeptide. H-Met-Ala-Ser-OH can act as a formyl receptor .
|
-
- HY-W009008
-
-
- HY-W010770
-
-
![Fmoc-Thr[PO(OBzl)OH]-OH](//file.medchemexpress.com/product_pic/hy-w010770.gif)
- HY-W022471
-
-
- HY-W013182
-
-
- HY-P10036
-
|
|
PKG
|
Others
|
|
G-Subtide is a G-substrate peptide localized in Purkinje cells of the cerebellum. G-Subtide has little activity distinct from background and is a preferentially phosphorylated peptide substrate of recombinant PfPKG2 protein .
|
-
- HY-W010850
-
-
- HY-P10055
-
|
PSMA-1
|
PSMA
|
Cancer
|
|
PSMA-1 is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells. PSMA-1 is selected and polyarginine sequences R6 or R9 were added at the C terminus to generate the CTPs. FITC labeling of the peptide with an aminohexanoic acid (Ahx) linker at the N terminus produced FITC-PSMA-1，to track PSMA binding on PCa cells .
|
-
- HY-W018528
-
-
- HY-W013201
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-1-((S)-2-Amino-4-methylpentanoyl)pyrrolidine-2-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:1) is a proline derivative .
|
-
- HY-W141880
-
-
- HY-W013083
-
-
- HY-W008530
-
-
- HY-W010719
-
-
- HY-W010782
-
-
- HY-114118C
-
|
|
GLP Receptor
Insulin Receptor
α-synuclein
Apoptosis
p38 MAPK
Autophagy
Bcl-2 Family
|
Neurological Disease
Metabolic Disease
Cancer
|
|
Semaglutide sodium is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide sodium promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide sodium also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide sodium has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide sodium can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .
|
-
- HY-W016996
-
-
- HY-W016731
-
-
- HY-W013745
-
-
- HY-W008178
-
-
- HY-Y0749
-
|
Dimethyl (S)-2-aminopentanedioate hydrochloride; Dimethyl L-glutamate hydrochloride; Dimethyl glutamate hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
Glutamic acid dimethyl ester hydrochloride is a glutamic acid derivative .
|
-
- HY-W013322
-
-
- HY-W018847
-
|
|
Drug Intermediate
|
Others
|
|
Fmoc-(R)-2-(pentenyl)Ala-OH is a peptide intermediate and can be used in peptide synthesis.
|
-
- HY-42757B
-
-
- HY-W109513
-
|
|
Amino Acid Derivatives
|
Inflammation/Immunology
|
|
Boc-Lys(Z)-OH (DCHA) is a involves in synthesis thymosin β4, βg and β6 fragments, and increases E-rosette forming capacity in Lupus Nephritis model. Boc-Lys(Z)-OH (DCHA) involves in synthesis Boc-Lyz-OCH3 and acts as a reagent of peptidyl thrombin inhibitors production .
|
-
- HY-W057434
-
-
- HY-W016423
-
-
- HY-W089292
-
-
- HY-W142039
-
-
- HY-W020826
-
-
- HY-W013293R
-
-
- HY-41912A
-
-
- HY-W004063
-
-
- HY-W048205
-
|
|
Amino Acid Derivatives
|
Others
|
|
N6-Diazo-L-Fmoc-lysine is an active compand and can be used in a variety of chemical studies. N6-Diazo-L-Fmoc-lysine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-P11767
-
|
|
Ferroptosis
Parasite
|
Infection
|
|
NCR247 is a defensin-like nodule cysteine-rich (NCR) peptide and heme chelator. NCR247 induces iron starvation responses in Sinorhizobium meliloti and Medicago truncatula, and supports nitrogenase activity. NCR247 can be used in research related to periodontal disease and toxoplasmosis .
|
-
- HY-P4558A
-
|
|
Dipeptidyl Peptidase
|
Others
|
|
H-Pro-Lys-OH TFA is a dipeptide containing proline and lysine, which can serve as a substrate for iminodipeptidase (prolinase). H-Pro-Lys-OH TFA can also be used for the synthesis of polypeptides .
|
-
- HY-W040705R
-
|
N-Methylanthranilic acid (Standard)
|
Drug Metabolite
Reference Standards
|
Others
|
|
2-(Methylamino)benzoic acid (Standard) is the analytical standard of 2-(Methylamino)benzoic acid. This product is intended for research and analytical applications. 2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver[1].
|
-
- HY-33228
-
-
- HY-122811
-
-
- HY-W003605A
-
|
|
Amino Acid Derivatives
|
Others
|
|
1-Boc-DL-Pyroglutamic acid ethyl ester is a Boc-protected Pyroglutamic acid derivative, can be used for the synthesis of agents or other compounds .
|
-
- HY-119543
-
|
|
Amino Acid Derivatives
|
Others
|
|
O-Succinyl-L-homoserine is a homoserine derivative. O-Succinyl-L-homoserine is an intermediate in the biosynthesis of methionine in Escherichia coli and Salmonella typhimurium .
|
-
- HY-W010811
-
-
- HY-W014700
-
|
H-Gly-Glu-OH; Gly-Glu
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of AChE content and activity. Glycyl-L-glutamic acid doesn’t act directly on AChE synthesis, and may prevent preganglionic neuronal degeneration .
|
-
- HY-W010982
-
-
- HY-W009258
-
-
- HY-W012873
-
-
- HY-79877
-
-
- HY-137416
-
-
- HY-W013779
-
-
- HY-Y1169
-
|
4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate; Fmoc-L-Asp(OtBu)-OH
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is an aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .
|
-
- HY-W012921R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
(R)-Pyrrolidine-2-carboxamide (Standard) is the analytical standard of (R)-Pyrrolidine-2-carboxamide. This product is intended for research and analytical applications. (R)-Pyrrolidine-2-carboxamide is a proline derivative .
|
-
- HY-W106325
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-N-Me-D-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize somatostatin-dopamine chimeric analogs .
|
-
- HY-W009734
-
-
- HY-W013190
-
-
- HY-171746
-
|
4,5,6,7-Tetrafluoro-L-tryptophan
|
nAChR
|
Neurological Disease
|
|
F4-Trp (4,5,6,7-Tetrafluoro-L-tryptophan) is a ligand targeting the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR). F4-Trp is promising for research of neurotransmission, addiction, and related diseases, such as neurological diseases .
|
-
- HY-P11630
-
|
|
Bacterial
|
Cardiovascular Disease
Infection
|
|
ZM-804 is a cationic α-helix antimicrobial peptide. ZM-804 targets bacterial cell membranes. ZM-804 demonstrates antimicrobial activity and prevents the infection of tomato plants by Pst DC3000. ZM-804 inhibits the growth of B. subtilis and E. coli (the same MICs of 41.10 μg/mL). ZM-804 exhibits low hemolytic activity .
|
-
- HY-W009023
-
-
- HY-79123
-
-
- HY-W036160
-
|
|
Amino Acid Derivatives
|
Others
|
|
N-Fmoc-O-ethyl-L-homoserine is an homoserine derivative, can be used in cyclic peptide compounds synthesis, as a reducing reagent .
|
-
- HY-W142151
-
-
- HY-W099578
-
|
Palmitoyl-Glu(OSu)-OBut
|
Drug Intermediate
|
Others
|
|
Pal-Glu(OSu)-OtBu (Palmitoyl-Glu(OSu)-OBut) is an important intermediate in the synthesis process of Liraglutide (HY-P0014) .
|
-
- HY-W002449
-
-
- HY-40118
-
|
Boc-L-proline methyl ester
|
Liposome
|
Others
|
|
Boc-Pro-OMe (Boc-L-proline methyl ester) is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.
|
-
- HY-W048727
-
-
- HY-W037443
-
-
- HY-128675
-
-
- HY-115387
-
-
- HY-W008549
-
-
- HY-W052246
-
-
- HY-W042007
-
-
- HY-P11180A
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Clavanin A acetate is a peptide Antibiotic and membrane permeabilizer. Clavanin A acetate permeabilizes cytoplasmic membranes and unilamellar lipid bilayers, and dissipates membrane potential. Clavanin A acetate inserts into phospholipid monolayers via hydrophobic interactions under physiologically relevant surface pressures. Clavanin A acetate exhibits antibacterial activity against Micrococcus flavus. Clavanin A acetate can be used in studies related to Micrococcus flavus infection .
|
-
- HY-W033132
-
-
- HY-W004114
-
-
- HY-137784
-
|
|
Fluorescent Dye
|
Others
|
|
Boc-Val-Pro-Arg-AMC hydrochloride is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
|
-
- HY-W008061
-
-
- HY-W010785
-
-
- HY-77026
-
-
- HY-111592
-
-
- HY-W007052
-
-
- HY-P11781A
-
|
|
Drug Derivative
|
Cancer
|
|
Cys-HW12 is a random peptide containing an N-terminal cysteine. Cys-HW12 can be coupled via the thiol group of Cys. Cys-HW12 can serve as a control for GE11 (HY-P10128)-conjugated mixed micelles targeting EGFR, and also functions as a cytotoxic agent, cellular uptake inhibitor, and tumor growth inhibitor. Cys-HW12 is applicable to pancreatic cancer-related research .
|
-
- HY-W017551
-
-
- HY-W051093
-
-
- HY-P11647A
-
|
|
Complement System
|
Cancer
|
|
RPARPAR acetate is a CendR tumor-penetrating peptide. RPARPAR acetate directly binds to the NRP-1 and NRP-2 receptors on the surface of tumor cells, triggering cellular internalization, vascular extravasation, and penetration into tumor tissues. RPARPAR acetate serves as an efficient ligand for targeting nanocarriers to NRP-1-positive tumors. RPARPAR acetate is applicable in research on tumor targeting and drug delivery .
|
-
- HY-W016426
-
-
- HY-W008771
-
-
- HY-W008981
-
-
- HY-W013143
-
-
- HY-75401
-
-
- HY-79863
-
|
|
Amino Acid Derivatives
|
Others
|
|
(6S,9S,12S)-Benzyl 12-benzyl-9-isobutyl-2,2-dimethyl-4,7,10-trioxo-6-phenethyl-3-oxa-5,8,11-triazatridecan-13-oate is a phenylalanine derivative .
|
-
- HY-W014375
-
|
(±)-Arginine hydrochloride
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
DL-Arginine ((±)-Arginine) hydrochloride is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells .
|
-
- HY-W010077
-
-
- HY-WAA0253
-
-
- HY-W141960
-
-
- HY-W006923
-
-
- HY-W011992
-
-
- HY-W041984
-
-
- HY-W013293
-
-
- HY-W010962
-
-
- HY-W047799
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Phe(4-CONH2)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a small-sized HTLV-I protease inhibitor with hydrophilicity .
|
-
- HY-W048697
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize analogs of cyclic lanthionine enkephalin, a δ-opioid receptor selective ligand .
|
-
- HY-W009262
-
-
- HY-130189R
-
|
|
Drug Metabolite
Reference Standards
|
Others
|
|
S-Phenylmercapturic acid (Standard) is the analytical standard of S-Phenylmercapturic acid. This product is intended for research and analytical applications. S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay .
|
-
- HY-W007722A
-
-
- HY-W041997
-
-
- HY-W012537
-
-
- HY-164805
-
|
|
Endogenous Metabolite
|
Others
|
|
N-Lactylleucine is an endogenous metabolite that can be identified in patients with the intermediate type of maple syrup urine disease .
|
-
- HY-W018502
-
-
- HY-W011135
-
-
- HY-W009912
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Tyr(Me)-OH is a synthetic amino acid, and can enter into protein in E. coli in response to an amber nonsense codon .
|
-
- HY-W052529
-
-
- HY-W048203
-
-
- HY-W007679
-
-
- HY-W048730
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Phe(4-tBu)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize rOicPaPhe(p-Me)-NH(2) with platelet aggregation activation inhibitory activity .
|
-
- HY-W013286
-
-
- HY-W006093
-
-
- HY-W006064
-
|
(S)-2-Aminopent-4-ynoic acid
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-Aminopent-4-ynoic acid is a synthetic amino acid. (S)-2-Aminopent-4-ynoic acid can be used in synthesis of folate-conjugates and corresponding metal-chelate complexes . (S)-2-Aminopent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W048674
-
|
Fmoc-O-acetyl-L-serine
|
Amino Acid Derivatives
|
Infection
|
|
Fmoc-Ser(Ac)-OH (Fmoc-O-acetyl-L-serine) is a Serine derivative. Fmoc-Ser(Ac)-OH can be used for the preparation of broad-spectrum coronavirus membrane fusion inhibitor .
|
-
- HY-79046
-
|
Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (S)-; Butyric acid, 2-(carboxyamino)-, N-tert-butyl ester, L- (8CI); (2S)-2-(tert-Butoxycarbonylamino)butanoic acid; (2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]butanoic acid
|
Amino Acid Derivatives
|
Others
|
|
Boc-L-2-aminobutanoic acid is an alanine derivative .
|
-
- HY-P1498A
-
-
- HY-W011088
-
-
- HY-W141919
-
-
- HY-W072177
-
-
- HY-59121A
-
|
|
Drug Intermediate
|
Infection
|
|
Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate can be used to synthesis Sofosbuvir (HY-15005) to avoid the production of sofibuvir degradation impurities .
|
-
- HY-W142111
-
-
- HY-W099595
-
-
- HY-W002436
-
-
- HY-W008489
-
-
- HY-W042009A
-
-
- HY-P11771
-
-
- HY-W022657
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Met-OiPr hydrochloride is an Methionine derivative. H-Met-OiPr hydrochloride participates in the synthesis preparation of inhibitors of farnesyl-protein transferase (FTase), and can be used in cancer research .
|
-
- HY-W008922
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-3,3-diphenylalanine is a non-natural D-configuration amino acid derivative protected by Fmoc and commonly used in peptide synthesis research.
|
-
- HY-W012437
-
-
- HY-118174
-
-
- HY-P11641
-
|
|
MMP
|
Inflammation/Immunology
|
|
GCRRGPLGLSLGKRRCG is an MMP13-specific substrate peptide cleaved by MMP13. GCRRGPLGLSLGKRRCG contributes to an MMP13-responsive hydrogel microsphere system that achieves intelligent and controllable drug release in osteoarthritis (OA), decelerates disease progression, and promotes articular cartilage repair. GCRRGPLGLSLGKRRCG can be used for the research of osteoarthritis .
|
-
- HY-W015424R
-
-
- HY-W039112
-
-
- HY-W003903A
-
-
- HY-W013774
-
-
- HY-W051612
-
|
|
Amino Acid Derivatives
|
Others
|
|
DL-Propargylglycine hydrochloride is a Glycine (HY-Y0966) derivative. DL-Propargylglycine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .
|
-
- HY-W016552
-
-
- HY-W010964
-
-
- HY-W419440
-
|
L-Leucine, L-lysyl-
|
Biochemical Assay Reagents
|
Others
|
|
H-Lys-Leu-OH (L-Leucine, L-lysyl-) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W013740
-
-
- HY-W011423
-
-
- HY-W048673
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Phe (4-CONH2)-OH is a protected phenylalanine derivative commonly used in peptide synthesis, and it can be applied in polypeptide research .
|
-
- HY-33466
-
-
- HY-164804
-
-
- HY-30232
-
-
- HY-33319
-
-
- HY-W037120
-
|
|
Amino Acid Derivatives
|
Others
|
|
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-((4-methoxyphenyl)diphenylmethyl)-D-cysteine is a cysteine derivative .
|
-
- HY-W016733
-
|
H-D-Cit-OH
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
D-Citrulline (H-D-Cit-OH) is a stereoisomer of L-citrulline (HY-N0391). D-Citrulline significantly attenuates polymorphonuclear leukocyte (PMN)-induced cardiac contractile dysfunction in the isolated perfused rat heart subjected to ischemia/reperfusion via a non-NO-mediated mechanism .
|
-
- HY-P1894A
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid Protein Precursor 770 (135-155) TFA is a peptide of amyloid precursor protein isoform (APP 770). APP 770 produces Aβ40/42 .
|
-
- HY-W002300
-
-
- HY-W022405
-
-
- HY-78746A
-
|
|
Amino Acid Derivatives
|
Others
|
|
D-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-, (3S,4R,5S)-rel- is a proline derivative .
|
-
- HY-W022250
-
-
- HY-W012497
-
-
- HY-W008432
-
-
- HY-W022444
-
-
- HY-W014919
-
-
- HY-W011359
-
-
- HY-Z0790
-
-
- HY-W012446
-
-
- HY-W141862
-
-
- HY-W014916
-
-
- HY-W036222
-
-
- HY-77021
-
-
- HY-W142062
-
|
Fmoc-(2S,4S)-4-azidoproline
|
Amino Acid Derivatives
|
Others
|
|
cis-Fmoc-Pro(4-N3)-OH is a proline derivative . cis-Fmoc-Pro(4-N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-W008919
-
|
N-Alpha,N-epsilon-di-Boc-L-lysine 4-nitrophenyl ester
|
Amino Acid Derivatives
|
Others
|
|
Boc-Lys(Boc)-Onp (N-Alpha,N-epsilon-di-Boc-L-lysine 4-nitrophenyl ester) is a lysine with a Boc protecting group. Boc-Lys(Boc)-Onp was used as a substrate for a catalyst model to study its enzymatic hydrolysis reaction catalyzed by a copper(II) complex .
|
-
- HY-W141895
-
-
- HY-W039759
-
-
- HY-P11656
-
|
|
mTOR
Beclin1
Autophagy
Atg8/LC3
Reactive Oxygen Species (ROS)
MMP
p38 MAPK
PERK
JNK
Collagen
|
Inflammation/Immunology
|
|
α-Neoendorphin porcine is a peptide. α-Neoendorphin porcine effectively alleviates UVB-induced skin photoaging via activating mTOR-Beclin-1-mediated autophagy, reducing UVB-triggered ROS production, inhibiting the MAPK pathway and MMP activity, and promoting type I procollagen synthesis. α-Neoendorphin porcine exerts anti-aging and anti-wrinkle effects on skin cells. α-Neoendorphin porcine can be used in studies related to skin photoaging .
|
-
- HY-W009119
-
-
- HY-W039947
-
-
![N6-[(2E)-1-Oxo-2-buten-1-yl]-L-lysine](//file.medchemexpress.com/product_pic/hy-w039947.gif)
- HY-W142089
-
-
- HY-W052212
-
-
- HY-W039449
-
-
- HY-W548477
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Lys(Fmoc)-OH hydrochloride is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize diacylated GLP-1 derivatives with antidiabetic activity .
|
-
- HY-W009203
-
|
|
Endogenous Metabolite
Apoptosis
Keap1-Nrf2
Reactive Oxygen Species (ROS)
Ferroptosis
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
L-Cystine dihydrochloride is the dihydrochloride salt form of L-Cystine (HY-N0394). L-Cystine dihydrochloride elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine dihydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine dihydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine dihydrochloride is promising for research of cystinuria and kidney stones
|
-
- HY-W008196
-
-
- HY-P10050
-
|
|
Proteasome
|
Others
|
|
Calpain substrate is the membrane non-permeable fluorogenic calpain substrate and can be used in Calpain enzymatic activity assay .
|
-
- HY-W022404
-
-
- HY-131173
-
-
- HY-Y1789
-
-
- HY-W040124
-
|
|
Amino Acid Derivatives
|
Others
|
|
DL-Propargylglycine is a Glycine (HY-Y0966) derivative . DL-Propargylglycine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W015457
-
-
- HY-W011156
-
|
|
Amino Acid Derivatives
|
Others
|
|
Mpa(Trt) is a 3-mercaptopropionic acid derivative containing a trityl protecting group (Trt) and can be used to synthesize compounds with anti-leukemia activity .
|
-
- HY-W110126
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)hexanoic acid is a lysine derivative .
|
-
- HY-W011075
-
-
- HY-W047845
-
|
|
Amino Acid Derivatives
|
Others
|
|
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-(2-hydroxy-4-methoxybenzyl)glycine is a Glycine (HY-Y0966) derivative .
|
-
- HY-W007722
-
-
- HY-42994
-
-
- HY-W101384
-
-
- HY-W074914
-
-
- HY-W008072
-
-
- HY-I0125
-
-
- HY-W011778
-
-
- HY-W014913
-
-
- HY-W036352
-
-
- HY-W273130
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Glycyl-L-asparagine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W002303
-
-
- HY-W011713
-
-
- HY-P0036D
-
|
|
Drug Derivative
Radionuclide-Drug Conjugates (RDCs)
Somatostatin Receptor
Apoptosis
|
Cancer
|
|
NOTA‑Octreotide is a selective SSTR2‑targeting PET tracer. NOTA‑Octreotide binds specifically to SSTR2 and accumulates in SSTR2‑expressing tissues. NOTA‑Octreotide enables effective imaging of somatostatin receptor‑positive tumors in mice and shows high specific uptake in SSTR2‑expressing organs in healthy rats. NOTA-Octreotide can be used for PET imaging investigation of neuroendocrine tumors. .
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- HY-W101305
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Amino Acid Derivatives
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Others
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|
Fmoc-Pen(Acm)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize chemically modified cyclic peptides containing cell adhesion recognition (CAR) sequences .
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- HY-P11629
-
|
|
Amylin Receptor
CGRP Receptor
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
|
KBP-336 is a dual amylin and calcitonin receptor agonist (DACRA). KBP-336 exhibits antidiabetic and insulin-sensitizing properties, improves glucose levels, spatial learning, and memory in diabetic rats, and reduces blood glucose. KBP-336 also alleviates pain-like symptoms in osteoarthritis rats. KBP-336 also promotes weight and fat reduction. KBP-336 is useful for research on diabetes, obesity, and arthritis .
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-
- HY-W009260
-
-
- HY-134545
-
|
NALA
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
N-Arachidonoyl-L-alanine is an endocannabinoid analog with anti-cancer effects. N- Arachidonoyl-L-alanine kills HNSCC cells through 5-LO-mediated ROS productio .
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-
- HY-W010926
-
-
- HY-P11553B
-
|
|
Radionuclide-Drug Conjugates (RDCs)
CCR
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
DOTA-ECL1i is a conjugate of the CCR2 inhibitor ECL1i (HY-P11553) and DOTA. When radiolabeled with 68Ga, DOTA-ECL1i serves as a PET tracer that targets CCR2 expression. DOTA-ECL1i can be used in research related to pulmonary fibrosis, cardiac injury, abdominal aortic aneurysm inflammation, atherosclerosis, head and neck cancer, and pancreatic cancer .
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-
- HY-B1581
-
-
- HY-41257
-
-
- HY-I0423
-
-
- HY-W013241
-
-
- HY-W017406
-
-
- HY-W016716
-
-
- HY-W005815
-
-
- HY-W013291
-
-
- HY-W012966
-
-
- HY-79861
-
-
- HY-W013940
-
-
- HY-W141961
-
-
- HY-W011750
-
-
- HY-W009328
-
-
- HY-134141
-
|
|
Drug Intermediate
|
Metabolic Disease
|
|
5-Octyl hydrogen L-glutamate is cell-permeable molecule and can be used for synthesizing 5-octyl ester derivatives (5-octyl α-ketoglutarate) .
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-
- HY-113214
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-
- HY-W022281
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-
- HY-Y0967
-
|
N-(Benzyloxycarbonyl)glycine; N-(Carbobenzoxy)glycine; N-(Carbobenzyloxy)glycine; N-(α-Carbobenzoxy)glycine; N-Carboxyglycine N-benzyl ester
|
Amino Acid Derivatives
|
Others
|
|
Z-Glycine is a Glycine (HY-Y0966) derivative .
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-
- HY-169089A
-
|
|
Drug Derivative
|
Cancer
|
|
RP-182-PEG3-K(palmitic acid)-NH2 (Compound 1a) TFA is a fatty acid derivative of the immunomodulatory peptide RP-182. RP-182-PEG3-K(palmitic acid)-NH2 TFA inhibits CD206 high M2-like macrophage (IC50 of 3.2 μM) and induces phagocytosis. RP-182-PEG3-K(palmitic acid)-NH2 TFA exhibits antitumor efficacy in mouse B16 melanoma allografts .
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-
- HY-169089
-
|
|
Drug Derivative
|
Cancer
|
|
RP-182-PEG3-K palmitic acid-NH2 (Compound 1a) is a fatty acid derivative of the immunomodulatory peptide RP-182. RP-182-PEG3-K palmitic acid-NH2 inhibits CD206 high M2-like macrophage (IC50 of 3.2 μM) and induces phagocytosis. RP-182-PEG3-K palmitic acid-NH2 exhibits antitumor efficacy in mouse B16 melanoma allografts .
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-
- HY-P11243
-
|
|
Ephrin Receptor
|
Neurological Disease
|
|
EphA4 agonist compound 23 is a novel EphA4 agonist peptide mimic. EphA4 agonist compound 23 exhibits high affinity, high selectivity, and significant receptor activation ability. EphA4 agonist compound 23 is commonly used in the study of neurodegenerative diseases .
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-
- HY-P10318
-
|
|
GLP Receptor
|
Endocrinology
|
|
SHR-2042 is a selective agonist of the GLP-1 receptor.SHR-2042 improves glycemic control by activating the GLP-1 receptor, enhancing insulin secretion and inhibiting glucagon secretion. SHR-2042 combined with sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) promotes monomerization through the formation of micelles and improves oral absorption efficiency .
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-
- HY-N17580
-
|
|
Renin
|
Cardiovascular Disease
|
|
Lyciumin D acts as an angiotensin-converting enzyme inhibitor and renin inhibitor. Lyciumin D can be used for the research of hypertension .
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-
- HY-P2231
-
|
MEDI0382
|
GCGR
|
Metabolic Disease
|
|
Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D) .
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-
- HY-P2231A
-
|
MEDI0382 acetate
|
GCGR
|
Metabolic Disease
|
|
Cotadutide (MEDI0382) acetate is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide acetate can be used in the research of obesity and type 2 diabetes (T2D) .
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-
- HY-P0014A
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
Liraglutide acetate is the acetate form of Liraglutide (HY-P0014), a glucagon-like peptide-1 (GLP-1) receptor agonist studied in type 2 diabetes .
|
-
- HY-P0014
-
-
- HY-P10869
-
dCNP
1 Publications Verification
|
Natriuretic Peptide Receptor (NPR)
|
Inflammation/Immunology
Cancer
|
|
dCNP binds to NPR-B/C receptor, activates cGMP signaling pathway, and regulates vascular function. dCNP exhibits anti-hypoxia property through downregulation of hypoxia-related genes expressions like HIF1α and HIF2α. dCNP inhibits the induction of tumor stroma and exhibits anti-fibrosis activity. dCNP upregulates CTLs, NK cells, and conventional type 1 dendritic cells in tumors, and activates immune responses .
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-
- HY-P0014B
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
Liraglutide (TFA) is an agonist of glucagon-like peptide 1 receptor (GLP-1). Liraglutide (TFA) can activate GLP-1, leading to the release of insulin in the presence of increased glucose concentration. Liraglutide (TFA) also reduces glucagon secretion in a glucose-dependent manner. Liraglutide (TFA) can be studied in research on type 2 diabetes .
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-
- HY-P10200
-
|
|
Bacterial
|
Infection
|
|
CP7-FP13-2 is a peptide with antivirulence factor and antibacterial activity. CP7-FP13-2 inhibits the formation of Staphylococcus aureus biofilm and has good antibacterial efficacy in mice .
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-
- HY-P1614
-
-
- HY-P2075
-
|
|
Renin
|
Endocrinology
|
|
EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate .
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-
- HY-P11604
-
|
|
Phosphatase
|
Inflammation/Immunology
|
|
C16 acid-I-{Lys (C10 diacid)}-KQELRRIGDEF is a cell-permeable and internalizable PTPN1/2 inhibitor, with IC50 values of 107.6 nM and 3375 nM, respectively. C16 acid-I-{Lys (C10 diacid)}-KQELRRIGDEF restores insulin signaling in HepG2 cells. C16 acid-I-{Lys (C10 diacid)}-KQELRRIGDEF achieves glycemic control in db/db diabetic mice. C16 acid-I-{Lys (C10 diacid)}-KQELRRIGDEF can be used in the research of type 2 diabetes .
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-
- HY-P3291
-
|
ZP7570
|
GCGR
|
Metabolic Disease
|
|
Dapiglutide (ZP7570) is a long-acting glucagon-like peptide-1 receptor 1R (GLP-1R)/Glucagon-like peptide-2 receptor (GLP-2R) dual agonist. Dapiglutide alleviates intestinal dysfunction in a mouse short bowel model and has anti-obesity effects .
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-
- HY-P11233
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
Acmopatide (Compound E-153) is a dual-acting GIP/GLP-1 receptor agonist. Acmopatide is used in anti-diabetic research .
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-
- HY-P11004
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
A3-APO is an antimicrobial peptide. A3-APO has a significant antimicrobial activity by a dual mode of action with both membrane disintegration and intracellular target inhibition. A3-APO can deactivate bacterial toxins and increase the expression of anti-inflammatory cytokines (such as IL-4 and IL-10), without antimicrobial resistance. A3-APO accelerates burn wounds healing in mice infection model of Acinetobacter baumannii and Staphylococcus aureus .
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-
- HY-P0041A
-
-
- HY-P0041
-
-
- HY-P5161
-
-
- HY-P5161A
-
-
- HY-P11586
-
|
|
Amylin Receptor
|
Metabolic Disease
|
|
San45 is a nonselective dual amylin and calcitonin receptor agonist (DACRA) with nonselective potency relative to calcitonin receptor (CTR) and amylin 1 receptor (AMY₁R), and acts as a stabilizer of receptor-ligand complex and prolonged activator of cAMP signaling. San45 carries a conjugated lipid modification that can be used for the research of obesity .
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-
- HY-P2336A
-
|
|
Melanocortin Receptor
|
Cancer
|
|
CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .
|
-
- HY-109166
-
-
- HY-P3462
-
|
|
CGRP Receptor
|
Metabolic Disease
|
|
Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity .
|
-
- HY-P11279
-
|
|
GLP Receptor
GCGR
Neuropeptide Y Receptor
|
Metabolic Disease
|
TC2 is an efficient GIPR-preferring monomeric quadruple agonist that can respectively activate GIPR, GLP-1R, GcgR, and Y2R with IC50 values of 0.47, 2.1, 30, and 55 nM respectively. TC2 exhibits a significant GLP-1R preference, with a significant reduction in β-inhibitory protein 2 (βArr2) recruitment, while maintaining a strong cAMP signal. TC2 can be used for research on obesity and diabetes .
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-
- HY-P3462A
-
|
|
CGRP Receptor
|
Metabolic Disease
|
|
Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies .
|
-
- HY-P10472
-
|
|
GnRH Receptor
|
Endocrinology
|
|
Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .
|
-
- HY-P0014AS
-
-
- HY-P4757
-
|
|
Parasite
|
Others
|
|
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .
|
-
- HY-P0014S2
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Liraglutide- 13C6, 15 TFA is the 13C and 15N labeledLiraglutide(HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .
|
-
- HY-P0014S1
-
|
|
Isotope-Labeled Compounds
GLP Receptor
GCGR
|
Others
|
|
Liraglutide- 13C6, 15 tetraTFA is the 13C and 15N labeled Liraglutide (HY-P0014) . Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .
|
-
- HY-P10271
-
|
NNC0090-2746; MAR709; RO6811135
|
GLP Receptor
|
Metabolic Disease
|
|
RG7697 is a dual agonist for glucagon-like peptide receptor (GLP Receptor) and glucosedependent insulinotropic polypeptide receptor (GIPR), with EC50 of 5 and 3 pM, respectively. RG7697 exhibits antihyperglycemic property .
|
-
- HY-P3143
-
|
|
PD-1/PD-L1
|
Cancer
|
|
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs .
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-
- HY-P3143A
-
|
|
PD-1/PD-L1
|
Cancer
|
|
BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs .
|
-
- HY-P4201
-
|
|
Vasopressin Receptor
|
Cardiovascular Disease
|
|
JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking .
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-
- HY-W010991
-
|
FAPGG
|
Angiotensin-converting Enzyme (ACE)
|
Others
|
|
N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10 -4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system .
|
-
![N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly](//file.medchemexpress.com/product_pic/hy-w010991.gif)
- HY-P10052
-
|
|
VEGFR
|
Cancer
|
|
CBO-P11 specifically binds to receptor of VEGFR-2 and is used as targeting ligand for tumor angiogenesis. CBO-P11 is modified with a nearinfrared cyanine dye bearing an alkyne function, allowing both “click” coupling on azido-modified nanoparticles and fluorescence labelling .
|
-
- HY-P10053
-
|
|
Phospholipase
|
Metabolic Disease
|
|
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .
|
-
- HY-P11431
-
-
- HY-P10051
-
|
|
Ras
Raf
|
Cancer
|
|
Cyclorasin 9A5 is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC50 of 120 nM .
|
-
- HY-148073
-
|
|
Fluorescent Dye
Ser/Thr Protease
|
Others
|
|
MeO-Succ-Arg-Pro-Tyr-AMC TFA is a fluorogenic peptide substrate for chymotrypsin-like proteases that detects protease activity . (measured at 460 nm)
|
-
- HY-P11236
-
-
- HY-P11625
-
|
|
RXFP Receptor
|
Cardiovascular Disease
|
|
R9-13 is a fatty acid-conjugated relaxin and an agonist of LGR7 (RXFP1). R9-13 induces sustained pubic symphysis elongation in estrogen-pretreated mice. R9-13 exhibits long-acting pharmacokinetic profiles in rodents, with in vivo activity lasting up to one week after administration. R9-13 can be used in studies related to acute heart failure .
|
-
- HY-P11273
-
-
- HY-W017444
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(R)-2,4-diamino-4-oxobutanoic acid hydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W142117
-
|
|
Fluorescent Dye
|
Others
|
|
H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM .
|
-
- HY-113560
-
-
- HY-153476
-
|
|
GCGR
GLP Receptor
|
Inflammation/Immunology
|
|
GIP/GLP-1 dual receptor agonist-1 is a GIP/GLP-1 dual receptor agonist. GIP/GLP-1 dual receptor agonist-1 is used in the research of metabolic disorders and fatty liver diseases, including non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD) .
|
-
- HY-153476A
-
|
|
GLP Receptor
GCGR
|
Inflammation/Immunology
|
|
GIP/GLP-1 dual receptor agonist-1 sodium is a GIP/GLP-1 dual receptor agonist. GIP/GLP-1 dual receptor agonist-1 sodium is used in the research of metabolic disorders and fatty liver diseases, including non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD) .
|
-
- HY-P1162
-
-
- HY-P2595
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
SKF 103784 is an vasopressin antagonist with activity against vasopressin. SKF 103784 inhibits the physiological response caused by antidiuretic and is therefore used to study biological processes related to water and salt balance. SKF 103784 can also be used to explore pathological mechanisms related to cardiovascular diseases and endocrine dysfunction .
|
-
- HY-P10910
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
Vensemaglutide is the agonist for glucagon-like peptide 1 (GLP-1) receptor. Vensemaglutide can be used in research of diabetes or other metabolic disorders .
|
-
- HY-P11290
-
-
- HY-P10031A
-
|
|
GLP Receptor
GCGR
|
Metabolic Disease
|
|
SAR441255 TFA is a GLP-1R/GCGR/GIPR agonist, with human EC50 values of 1.03 pM, 1.01 pM, and 0.73 pM, respectively. SAR441255 TFA stimulates receptor activity and drives cAMP accumulation. SAR441255 TFA can be used for the research of type 2 diabetes, obesity .
|
-
- HY-P10031
-
|
|
GLP Receptor
GCGR
|
Metabolic Disease
|
|
SAR441255 is a GLP-1R/GCGR/GIPR agonist, with human EC50 values of 1.03 pM, 1.01 pM, and 0.73 pM, respectively. SAR441255 stimulates receptor activity and drives cAMP accumulation. SAR441255 can be used for the research of type 2 diabetes, obesity .
|
-
- HY-P2434
-
|
|
Somatostatin Receptor
|
Neurological Disease
Metabolic Disease
Cancer
|
|
AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC50: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research .
|
-
- HY-P10272
-
|
PTG-300
|
Ferroportin
|
Others
|
|
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .
|
-
- HY-P5362A
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Somatostatin Receptor
|
Cancer
|
|
NODAGA-LM3 TFA is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC50 = 1.3 nM). NODAGA-LM3 TFA does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 TFA shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. 68Ga-labeled NODAGA-LM3 TFA can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .
|
-
- HY-P5362
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Somatostatin Receptor
|
Neurological Disease
Cancer
|
|
NODAGA-LM3 is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC50 = 1.3 nM). NODAGA-LM3 does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. 68Ga-labeled NODAGA-LM3 can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .
|
-
- HY-105168
-
|
|
Endothelin Receptor
|
Cardiovascular Disease
|
|
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .
|
-
- HY-P11488
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Somatostatin Receptor
PSMA
|
Cancer
|
|
JR11-PEG3-DOTA-PSMA-03 (Compound 2) is an RDC-related compound containing the chelating agent DOTA (HY-W053583), the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-DOTA-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC50 s of 94.0 nM, 81.8 nM, respectively. JR11-PEG3-DOTA-PSMA-03 can be radiolabeled with [ 68Ga]. [ 68Ga] radiolabeled JR11-PEG3-DOTA-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .
|
-
- HY-P11485
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Somatostatin Receptor
PSMA
|
Cancer
|
|
JR11-PEG3-HBED-CC-PSMA-03 (Compound 1) is an RDC-related compound containing the chelating agent HBED-CC, the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-HBED-CC-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC50 s of 59.2 nM, 57.0 nM, respectively. JR11-PEG3-HBED-CC-PSMA-03 can be radiolabeled with [ 68Ga]. [ 68Ga] radiolabeled JR11-PEG3-HBED-CC-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .
|
-
- HY-P10881
-
-
- HY-P4070
-
|
|
Insulin Receptor
|
Metabolic Disease
|
|
Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .
|
-
- HY-P10563
-
|
BHV-1100
|
CD38
|
Cancer
|
|
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-W010991
-
|
FAPGG
|
Fluorescent Dyes
|
|
N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10 -4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system .
|
-
- HY-148073
-
|
|
Fluorescent Dyes
|
|
MeO-Succ-Arg-Pro-Tyr-AMC TFA is a fluorogenic peptide substrate for chymotrypsin-like proteases that detects protease activity . (measured at 460 nm)
|
-
- HY-W142117
-
|
|
Fluorescent Dyes
|
|
H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM .
|
| Cat. No. |
Product Name |
Type |
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-134124
-
|
|
Reactive Oxygen Species (ROS)
|
Metabolic Disease
|
|
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .
|
-
- HY-W008016
-
-
- HY-W008371
-
-
- HY-W008021
-
-
- HY-W048739
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-α-Me-Leu-OH is a leucine derivative with an Fmoc protecting group, which can be used to synthesize peptides with oxytocin receptor agonist activity .
|
-
- HY-W007573
-
-
- HY-W010959
-
-
- HY-W013968
-
-
- HY-W011001
-
-
- HY-W008688
-
-
- HY-W008696
-
-
- HY-P10218
-
|
|
MARCKS
PKC
|
Inflammation/Immunology
Cancer
|
|
MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis .
|
-
- HY-W007056
-
-
- HY-W068839
-
-
- HY-P10218A
-
|
|
MARCKS
PKC
|
Inflammation/Immunology
Cancer
|
|
MANS peptide TFA is the TFA salt form of MANS peptide (HY-P10218). MANS peptide TFA is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis .
|
-
- HY-137950
-
-
- HY-Y1844
-
-
- HY-42709
-
|
Carbobenzoxy-L-valyl-L-alanine
|
Amino Acid Derivatives
|
Cancer
|
|
Z-Val-Ala-OH is a dipeptide derivative of valine and alanine. Z-Val-Ala-OH undergoes cleavage by cathepsin B and other lysosomal proteases to enable payload release following lysosomal internalization. Z-Val-Ala-OH can be used for the research of antibody-drug conjugate (ADC) development[1] .
|
-
- HY-W012713
-
-
- HY-34597
-
|
(S)-p-Bromophenylalanine; L-4-Bromophenylalanine; L-p-Bromophenylalanine; p-Bromo-L-phenylalanine
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-Amino-3-(4-bromophenyl)propanoic acid is a phenylalanine derivative .
|
-
- HY-P10341
-
|
|
GCGR
|
Metabolic Disease
|
|
ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin that has the ability to sustainably improve glycemic control. Additionally, ZP3022 can effectively increase β-cell mass, promote β-cell proliferation, and enhance the function of pancreatic islets. ZP3022 can be used in anti-diabetic research .
|
-
- HY-W014258
-
|
|
Amino Acid Derivatives
|
Others
|
|
(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a Glycine (HY-Y0966) derivative . (R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W016835
-
-
- HY-34738
-
|
3-(Boc-amino)-1-propanol
|
Amino Acid Derivatives
|
Others
|
|
Boc-β-Ala-ol (3-(Boc-amino)-1-propanol) is an alanine derivative with a Boc protecting group at the N-terminus, which can be used to synthesize bioactive peptide mimics, such as Nα-Benzoyl-α-azaornithine phenyl ester, which has trypsin inhibitory activity .
|
-
- HY-W008667
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid hydrate is a glutamic acid derivative .
|
-
- HY-W017501
-
-
- HY-W011003
-
-
- HY-W048703
-
-
- HY-W010830
-
-
- HY-W089229
-
-
- HY-W013874
-
-
- HY-W046355
-
-
- HY-W009117
-
-
- HY-W011722
-
-
- HY-W107585
-
-
- HY-W141859
-
-
- HY-78733
-
-
- HY-60256
-
-
- HY-W019676
-
-
- HY-W003225
-
-
- HY-W010793
-
-
- HY-W009005
-
-
- HY-118349
-
-
- HY-W011324
-
-
- HY-20861
-
-
- HY-W008233
-
-
- HY-W009775
-
-
- HY-W129448
-
-
- HY-W048913
-
|
|
Amino Acid Derivatives
|
Others
|
|
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N2-(2-((5-sulfonaphthalen-1-yl)amino)ethyl)-L-glutamine is a glutamine derivative .
|
-
- HY-W041996
-
- HY-W028991
-
- HY-185057
-
|
S-Lactylglutathione; (R)-S-Lactoylglutathione
|
Drug Metabolite
Glyoxalase (GLO)
|
Inflammation/Immunology
Cancer
|
|
S-D-Lactoylglutathione is a crucial intermediate metabolite of the glyoxalase (Glo) system. S-D-Lactoylglutathione acts as a "bridge molecule" for the conversion of methylglyoxal (MGO) into non-toxic D-lactic acid by continuous catalysis from Glo1 to Glo2, preventing cell damage caused by the accumulation of MGO .
|
- HY-W013751
-
|
N-Fmoc-glycyl-L-valine
|
Drug Intermediate
|
Others
|
|
Fmoc-Gly-Val-OH (N-Fmoc-glycyl-L-valine) is a glycyl valine derivative, can be used for the synthesis of drugs or other compounds .
|
- HY-W041983
-
- HY-W052310
-
- HY-42065
-
- HY-P2689
-
|
|
Peptides
|
Others
|
|
DNP-PLGMWSR is a? fluorogenic substrate for MMP-2 and MMP-9 .
|
- HY-W048830
-
- HY-W005720
-
- HY-W008787
-
- HY-W018620
-
- HY-Y0555
-
- HY-20153
-
- HY-75332
-
|
D-Cbz phenylglycine
|
Amino Acid Derivatives
|
Others
|
|
Z-D-Phg-OH (D-Cbz phenylglycine) is a N-blocked amino acids with Kd values of 390 μM and 323 μM for tBuCQN and tBuCQD, respectively .
|
- HY-W011200
-
- HY-W007842
-
- HY-22062
-
|
Cyclohexaneacetic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (S)-
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Chg-OH is a Glycine (HY-Y0966) derivative .
|
- HY-W014418
-
- HY-W013824
-
- HY-W009392
-
- HY-P10876
-
|
|
Amyloid-β
|
Neurological Disease
|
|
mcK6A1 is an inhibitor for the aggregation of amyloid-β (Aβ), that selectively binds to the 16KLVFFA21 segment of Aβ42, forms an extended β-folded structure, and inhibits the formation of Aβ42 oligomers. mcK6A1 can be used in research of Alzheimer's disease and other amyloid-related diseases .
|
- HY-W051418
-
- HY-79909
-
|
|
Amino Acid Derivatives
|
Others
|
|
L-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-leucyl]-, phenylmethyl ester is a phenylalanine derivative .
|
- HY-79930
-
|
|
Amino Acid Derivatives
|
Others
|
|
D-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-, phenylmethyl ester is a phenylalanine derivative .
|
- HY-W013659
-
- HY-W048701
-
- HY-173459
-
|
|
SARS-CoV
|
Infection
|
|
N-0920 is a potent TMPRSS2 inhibitor with an IC50 of 0.35 nM. N-0920 effectively inhibits SARS-CoV-2 variants EG.5.1 and JN.1 entry in Calu-3 cells, with picomolar EC50s values of 300 pM and 90 pM, respectively .
|
- HY-W021299
-
- HY-W142113
-
- HY-W030573
-
- HY-W016330
-
- HY-W141942
-
- HY-W141771
-
- HY-W065053
-
|
|
Amino Acid Derivatives
|
Others
|
|
trans-N-Methyl-4-methoxyproline is a natural product that can be isolated from the stems of Petiveria alliacea and is also a Proline derivative .
|
- HY-W142081
-
- HY-P11759
-
|
|
Drug Derivative
|
Cancer
|
|
Myr-transportan-Cys is a derivative of the cell-penetrating peptide Transportan (HY-P1732), and its conjugated myristoyl group (Myr) enhances the interaction between the peptide and cell membranes. Myr-transportan-Cys integrates three key delivery functions: nucleic acid condensation, cell penetration, and endosomal escape. Myr-transportan-Cys can form immunostimulatory tandem peptide nanocomplexes (iTPNCs) for encapsulating and delivering immunostimulatory oligonucleotide cargos to tumors .
|
- HY-W051173
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(Methoxycarbonyl)-L-valyl-L-proline is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-P11700
-
|
|
MHC
|
Inflammation/Immunology
|
|
AAPDARETA is a mutated MHC-associated peptide with reduced binding affinity to H-2D b MHC molecules. AAPDARETA activates subsets of mouse main olfactory epithelium sensory neurons and induces Ca 2+ transients .
|
- HY-P3051A
-
|
|
Drug Derivative
|
Infection
Inflammation/Immunology
|
|
CKS-17 (dimer) is the dimer of CKS-17 (HY-P3051). CKS-17 (dimer) can be prepared by introducing a naturally occurring cysteine at the carboxyl terminus and dimerizing via a cysteine-disulfide bond. CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has a highly conserved amino acid sequence present in the transmembrane envelope proteins of numerous animal and human retroviruses. As an immunomodulatory epitope, CKS-17 exhibits inhibitory properties on a variety of immune functions .
|
- HY-P11772
-
|
|
Bacterial
|
Infection
|
|
LBP-14, a peptide, is a synthetic fragment of the LPS (HY-D1056) binding protein (LBP) and is a LPS antagonist. LBP-14 interacts with LPS via electrostatic contacts between arginine/lysine residues and LPS phosphate groups, and hydrophobic contacts between aromatic/aliphatic residues and LPS acyl chains, blocking LPS binding to LBP. LBP-14 moderately inhibits LPS-induced TNF-α formation. LBP-14 can be used for the research of gram-negative sepsis .
|
- HY-P11635
-
|
|
Drug Derivative
MDM-2/p53
|
Cancer
|
|
ATSP-7342 is a negative control analog of ATSP-7041. ATSP-7342 exhibits lower binding affinity to both MDM2 (Ki = 536 nM) and MDMX (Ki >1000 nM), compared with ATSP-7041 .
|
- HY-P11791
-
- HY-W011553R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
Z-Asp(OMe)-OH (Standard) is the analytical standard of Z-Asp(OMe)-OH (HY-W011553). This product is intended for research and analytical applications. Z-Asp(OMe)-OH is an aspartic acid derivative .
|
- HY-P11648
-
|
|
Osteopontin
|
Inflammation/Immunology
Cancer
|
|
SVVYGLR is an osteopontin-derived peptide. SVVYGLR can promote the differentiation of fibroblasts into myofibroblast-like cells and promote the production of type III collagen by cardiac fibroblasts. SVVYGLR can activate the adhesion, migration and tubule formation of endothelial cells in vitro. SVVYGLR promotes angiogenesis and wound healing and promotes the migration of dermal fibroblasts and keratinocytes. SVVYGLR can be used for research related to angiogenesis, dermal wounds and bone regeneration .
|
- HY-P11734
-
|
|
Ser/Thr Protease
|
Others
|
|
Suc-AAPY-pNA is an oligptide compound and protease substrate. Suc-AAPY-pNA undergoes hydrolysis by proteases at the peptide bond between tyrosine and p-nitroaniline, releasing p-nitroaniline with an absorption peak at OD410. Suc-AAPY-pNA functions as a substrate in preclinical assays for measuring activity of acidic, neutral, and alkaline proteases .
|
- HY-P11705
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
PUMA2A is a PUMA BH3-only peptide. PUMA2A can be used as a negative control in Cytochrome C release assays and BH3 profiling. PUMA2A can be used in the research of chronic myeloid leukemia .
|
- HY-P11716
-
|
|
ERK
|
Cancer
|
|
HYD-1 is a D-amino acid tumor cell adhesion peptide. HYD-1 contains overlapping linear peptide elements required for adhesion, migration blocking, and ERK signaling activation. HYD-1 supports adhesion of breast, prostate, ovarian, and pancreatic tumor cells, and shows no effect on tumor cell cycle distribution. HYD-1 can be used for the research of prostate cancer .
|
- HY-P11704
-
|
|
Formyl Peptide Receptor (FPR)
Bacterial
|
Neurological Disease
|
|
f-MKKFRW is a selective mouse formyl peptide receptor 3 (Fpr3) activator and bacterial MgrB-derived peptide motif. f-MKKFRW activates Fpr3 to trigger downstream signaling and calcium responses in Fpr3-expressing cells. f-MKKFRW stimulates a subset of mouse vomeronasal sensory neurons in the accessory olfactory system to evoke calcium responses. f-MKKFRW drives innate avoidance behavior in mice via nasal contact .
|
- HY-P11796
-
- HY-P11811
-
- HY-W040416
-
- HY-W009913
-
- HY-W091734
-
|
|
Amino Acid Derivatives
|
Cardiovascular Disease
Neurological Disease
|
|
Methyl 4-iodo-L-phenylalaninate hydrochloride is a Phenylalaninate derivative. Methyl 4-iodo-L-phenylalaninate hydrochloride can be used for the preparation of factor XI modulators used in the research of thrombotic and thromboembolic. Methyl 4-iodo-L-phenylalaninate hydrochloride can also be used for the synthesis of compounds for the research of amyloid-related diseases, such as Alzheimer’s disease .
|
- HY-W009412R
-
- HY-W011002
-
- HY-W004098
-
- HY-W141791
-
- HY-W009381
-
- HY-P11706
-
|
|
Bcl-2 Family
|
Cancer
|
|
MS-1 peptide is a peptide for BH3 profiling. MS-1 peptide triggers higher depolarization of mitochondrial membrane in melanoma cells pre-treated with Encorafenib (HY-15605). MS1 peptide can be used for the research of BRAF V600E melanoma .
|
- HY-W009203R
-
|
|
Endogenous Metabolite
Apoptosis
Keap1-Nrf2
Reactive Oxygen Species (ROS)
Ferroptosis
Reference Standards
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
L-Cystine (dihydrochloride) (Standard) is the analytical standard of L-Cystine (dihydrochloride) (HY-W009203). This product is intended for research and analytical applications. L-Cystine dihydrochloride is the dihydrochloride salt form of L-Cystine (HY-N0394). L-Cystine dihydrochloride elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine dihydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine dihydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine dihydrochloride is promising for research of cystinuria and kidney stones
|
- HY-W009003
-
- HY-W008958
-
- HY-W105804
-
|
|
Amino Acid Derivatives
Drug Intermediate
|
Others
|
|
Selenocystamine dihydrochloride is a selenocysteine derivative that can be used in the synthesis of other active compounds. Selenocystamine dihydrochloride can also induce the aggregation of amphiphilic p-sulfonatocalixarene to form supramolecular nanoparticles .
|
- HY-P10043
-
|
|
MMP
|
Others
|
|
MMP-1 Substrate is a matrix metalloproteinase-1 (MMP-1) selective substrate that can be used for the fluorometric determination of MMP-1 enzymatic activity .
|
- HY-W010873
-
- HY-P11740
-
|
|
Angiotensin-converting Enzyme (ACE)
Drug Intermediate
|
Others
|
|
VYPFPGPIHN is a precursor peptide of β-casomorphin (HY-P0179) and also an ACE inhibitor (IC50 = 123 μM). VYPFPGPIHN resists hydrolysis by peptidases associated with intestinal cell monolayers, maintaining structural integrity and ACE inhibitory activity. VYPFPGPIHN is not extensively taken up or transported by differentiated intestinal cell monolayers .
|
- HY-W008254
-
- HY-W002326
-
- HY-W008353
-
- HY-W013734
-
- HY-30167
-
|
(R)-2-Amino-3-methyl-butanol
|
Biochemical Assay Reagents
|
Others
|
|
(2R)-2-Amino-3-methylbutan-1-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W050025
-
- HY-W141911
-
- HY-W011322
-
- HY-W141814
-
- HY-W072732
-
- HY-W040686
-
- HY-N2378
-
|
Benzenepropanoic acid, β-amino-α-hydroxy-, hydrochloride, (αR,βS)-
|
Amino Acid Derivatives
|
Others
|
|
(2R,3S)-3-Phenylisoserine hydrochloride is a serine derivative .
|
- HY-W013297
-
- HY-119782
-
|
|
Fluorescent Dye
|
Others
|
|
L-Argininamide is a hydrophilic amino acid derivative and can be used as a compound for ligand binding DNA aptamers. L-Argininamide has the potential for fluorescent aptasensors development .
|
- HY-W010734
-
- HY-W013406
-
- HY-W053531
-
- HY-W013155
-
- HY-W024554
-
- HY-W019205
-
- HY-20561A
-
- HY-W013793
-
- HY-P11646
-
|
|
COX
|
Metabolic Disease
Inflammation/Immunology
|
|
Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities. Brazzein inhibits COX-2 with an IC50 of 12.62 μM. Brazzein exhibits strong antioxidant effects, showing ABTS radical scavenging activity (IC50 = 12.55 μM) . Brazzein shows no antibacterial or antifungal activity. Brazzein can be used for the research of obesity, metabolic disorder, inflammation .
|
- HY-I0102
-
|
|
Amino Acid Derivatives
|
Others
|
|
(2S)-Methyl 2-(2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoate is a valine derivative .
|
- HY-107663
-
|
Pro-Leu-Gly-NH2; Melanostatin
|
Dopamine Receptor
|
Neurological Disease
|
|
MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) .
|
- HY-W012075
-
- HY-77802
-
- HY-W010825
-
- HY-W013373
-
- HY-W010277
-
- HY-79415
-
|
L-Leucine, 4-methyl- (9CI); L-2-Amino-4,4-dimethylpentanoic acid; L-γ-Methylleucine
|
Amino Acid Derivatives
|
Others
|
|
4-Methyl-L-leucine is a Glycine (HY-Y0966) derivative .
|
- HY-P11649
-
|
|
Integrin
VEGFR
|
Cancer
|
|
NYLTHRQ is a peptide. NYLTHRQ specifically blocks the interaction between sVEGFR1-i13 and β1 integrin, and inhibits the activation of VEGFR1 and VEGFR2. NYLTHRQ inhibits cancer cell proliferation. NYLTHRQ can be used in the research of tumors such as lung squamous cell carcinoma .
|
- HY-W011321
-
- HY-W141922
-
- HY-W011280
-
- HY-Y0134
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid is a glutamic acid derivative .
|
- HY-W041866
-
- HY-W017200
-
- HY-W012064
-
- HY-W052408
-
- HY-W016336
-
- HY-W048671
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Thr(TBDMS)-OH is a Threonine derivative. Fmoc-Thr(TBDMS)-OH can be used for the preparation of sugar ligand-tethered functional nucleic acid conjugates for targeted research .
|
- HY-W141985
-
- HY-W040705
-
|
N-Methylanthranilic acid
|
Drug Metabolite
|
Others
|
|
2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver .
|
- HY-W002410
-
- HY-W017256
-
- HY-W013760
-
- HY-W008694
-
- HY-W010965
-
- HY-W010894
-
- HY-W018366
-
- HY-138106
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Cit-OH is citrulline with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as H-Dmt-D-Cit-Aba-b-Ala-NMe-30,50-(CF3)2-Bn and H-Dmt-D-Cit-Aba-b-Ala-NMe-Bn with neurokinin-1 antagonist activity .
|
- HY-W009562
-
- HY-W010591
-
- HY-W008487
-
- HY-W007599
-
|
|
Drug Derivative
|
Cancer
|
|
(S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid is a polypeptide derivative, can be used to synthesis multifunctional amphiphilic peptide dendrimer for non-viral gene delivery in cancer research. (S)-2,6-Bis((tert-butoxycarbonyl)amino)hexanoic acid can be used in the preparation of organic substances that enhance the luminescence intensity of alkaline phosphatase substrates .
|
- HY-W006062
-
- HY-W008395
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Pra-OH is a Glycine (HY-Y0966) derivative . Fmoc-D-Pra-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
- HY-P4096A
-
|
|
Peptides
|
Inflammation/Immunology
|
|
Cys-HAP-1 is a synovium-homing peptide that specifically binds to human and rabbit fibroblast-like synoviocytes, and does not bind to human umbilical vein endothelial cells regardless of TNF-α treatment. Cys-HAP-1 enables targeted drug delivery to inflamed joints after conjugation with liposomes loaded with anti-arthritic agents. Cys-HAP-1 can be used in studies related to adjuvant arthritis .
|
- HY-W009535
-
- HY-W008908
-
- HY-W011553
-
- HY-79709
-
|
|
Amino Acid Derivatives
|
Others
|
|
N-(Methoxycarbonyl)-D-valine methyl ester is an amino acid derivative that can be used for compound synthesis .
|
- HY-P11632
-
|
|
Autophagy
|
Neurological Disease
|
|
YLDLAPL is a sleep-enhancing peptide that can be isolated from truffle albumin hydrolysate. YLDLAPL exhibits sleep-promoting effects via regulation of lysosomal autophagy, neurological activity, tyrosine metabolism, and fatty acid elongation .
|
- HY-W012498
-
- HY-W142083
-
- HY-117141
-
- HY-79132
-
- HY-W801296
-
|
Boc-L-Pyroglutamicacidtert-butylester
|
Peptides
|
Others
|
|
Boc-Pyr-OtBu (Boc-L-Pyroglutamicacidtert-butylester) is a peptide intermediate and can be used in peptide synthesis.
|
- HY-P11577
-
|
|
MMP
Biochemical Assay Reagents
|
Cancer
|
|
TGGGPLGVARGKGGC is a polypeptide that can be specifically cleaved by MMP-9. TGGGPLGVARGKGGC modifies manganese dioxide supraparticles. TGGGPLGVARGKGGC can be used in the research of early cancer diagnosis .
|
- HY-W013678R
-
- HY-W027829
-
- HY-W111214
-
- HY-W141923
-
- HY-W002519
-
- HY-P11703
-
|
|
MHC
|
Others
|
|
TRVLNLGPI is an MHC motif-containing, MHC-independent nonapeptide. TRVLNLGPI is not a product of immune presentation, but a product of renal protein degradation, and its concentration is sufficiently high to be specifically recognized by vomeronasal neurons. The concentration of TRVLNLGPI in mouse urine can be six orders of magnitude higher than that of prototype MHC-dependent peptides .
|
- HY-W142080
-
|
α-Methyltryptophan
|
mTOR
Autophagy
Apoptosis
Amino Acid Derivatives
|
Metabolic Disease
Cancer
|
|
α-Methyl-DL-tryptophan (α-Methyltryptophan), a tryptophan derivative, is a selective SLC6A14 blocker. In estrogen receptor (ER)-positive breast cancer cells, α-Methyl-DL-tryptophan inhibits mTOR and activates autophagy and apoptosis. α-Methyl-DL-tryptophan also has the effect of reducing weight .
|
- HY-W014742
-
- HY-W008866
-
- HY-W012000
-
|
Boc-N-Me-Ile-OH
|
Amino Acid Derivatives
|
Others
|
|
Boc-N-methyl-L-isoleucine (Boc-N-Me-Ile-OH) is a peptide products and can be used as a precursor in organic synthesis and pharmaceuticals .
|
- HY-59135R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
(S)-2-(Methoxycarbonylamino)-3,3-dimethylbutanoic acid (Standard) is the analytical standard of (S)-2-(Methoxycarbonylamino)-3,3-dimethylbutanoic acid. This product is intended for research and analytical applications. (S)-2-(Methoxycarbonylamino)-3,3-dimethylbutanoic acid is a leucine derivative .
|
- HY-W142044
-
- HY-W005014
-
- HY-P11221A
-
|
|
Peptides
|
Cardiovascular Disease
|
|
CLIKKPF acetate is a specific peptide segment. CLIKKPF acetate can bind strongly to phosphatidylserine (PS) on the inner layer of the cell membrane. CLIKKPF acetate can enhance the targeting ability of nanoparticles. CLIKKPF acetate can be used in the research of cardiovascular diseases .
|
- HY-W014786
-
- HY-W008495
-
- HY-W010276
-
- HY-W041857
-
- HY-W141952
-
- HY-76255
-
|
|
Drug Derivative
|
Others
|
|
4-Nitrophenyl (tert-butoxycarbonyl)-L-phenylalaninate is a phenylalanine derivative .
|
- HY-W048918
-
- HY-W009412
-
- HY-I1111
-
- HY-W017788
-
- HY-W016031
-
- HY-W048724
-
- HY-W012871
-
- HY-W008426
-
- HY-43459
-
- HY-20834
-
- HY-Y0168
-
- HY-W011537
-
- HY-W008876
-
- HY-W013686
-
- HY-W015651
-
- HY-W012676
-
- HY-W011074
-
- HY-23053
-
- HY-W010913
-
- HY-W015800
-
|
|
Drug Intermediate
|
Others
|
|
L-Homoserine lactone hydrochloride is the core structural unit of the bacterial quorum-sensing signal molecule N-acyl-L-homoserine lactone (AHLs). As an important intermediate, L-Homoserine lactone hydrochloride acylated derivatives have potent immunosuppressive activity .
|
- HY-W016018
-
- HY-W009345
-
- HY-W009841
-
- HY-W005308
-
|
|
Amino Acid Derivatives
|
Cancer
|
|
N-BOC-DL-serine methyl ester is a Serine derivative. N-BOC-DL-serine methyl ester is used for the synthesis of α,β-dehydro-α-amino acid. N-BOC-DL-serine methyl ester is also used for the synthesis of anti-cancer agent, such as quinazolinone derivative that inhibits PI3K activity, and tricyclic pyrolopyranopyridines that inhibits protein kinase activity .
|
- HY-W283704
-
- HY-W015449
-
- HY-W011054
-
- HY-W088014
-
- HY-W048691
-
- HY-W010924
-
- HY-Z0291
-
|
Isopropyl L-alaninate; L-Alanine 2-propyl ester; L-Alanine isopropyl ester; O-Isopropyl-L-alanine
|
Amino Acid Derivatives
|
Others
|
|
L-Alanine isopropyl ester is an alanine derivative .
|
- HY-W008156R
-
- HY-P1175B
-
|
|
TRP Channel
|
Neurological Disease
|
|
L-R4W2 acetate is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC50 of 0.1 μM. L-R4W2 acetate may act as a potent analgesic .
|
- HY-W008359
-
- HY-124237
-
|
|
Bacterial
|
Others
|
|
N-Octanoyl-DL-homoserine lactone is a member of N-acyl homoserine lactones (AHLs) family, also one of the signal molecule of quorum-sensing (QS) signals. N-Octanoyl-DL-homoserine lactone can regulate the production of siderophores and present positive correlation in Aeromonas sobria strain AS7. N-Octanoyl-DL-homoserine lactone can also regulate the secretion of proteases and stimulate the production of total volatile basic nitrogen (TVB-N) .
|
- HY-W012485
-
- HY-W015946
-
- HY-W014304
-
- HY-W008255
-
- HY-I0393
-
- HY-42066
-
|
S)-3-Amino-4-(benzyloxy)-4-oxobutanoic acid; 1-Benzyl L-aspartate; Aspartic acid 1-benzyl ester; Aspartic acid α-benzyl ester
|
Amino Acid Derivatives
|
Others
|
|
L-Aspartic acid 1-benzyl ester is an aspartic acid derivative .
|
- HY-W007108
-
- HY-Z0438
-
- HY-W011977
-
- HY-139128
-
- HY-76204
-
- HY-W142071
-
- HY-P11708
-
|
|
Integrin
|
Cancer
|
|
Relitegatide is a cyclic peptide with selectivity for the αvβ6 integrin. Relitegatide can be used for the synthesis of Relitegatide brexetan (HY-P11276) .
|
- HY-W013749
-
- HY-75853
-
- HY-W010893
-
- HY-W019032
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with antibacterial activity .
|
- HY-76448
-
- HY-W063269
-
- HY-41912
-
|
N-[(1,1-Dimethylethoxy)carbonyl]-L-norleucine; BOC-L-norleucine; BOC-norleucine; N-(tert-Butoxycarbonyl)norleucine
|
Amino Acid Derivatives
|
Others
|
|
Boc-Nle-OH is a leucine derivative .
|
- HY-W141812
-
- HY-W006069
-
|
|
Protease Activated Receptor (PAR)
|
Others
|
|
H-Phe(3,5-DiF)-OH is a difluorophenylalanines in the L-configuration [L-(F2)Phe]. H-Phe(3,5-DiF)-OH can be incorporated into the thrombin receptor-tethered ligand peptide SFLLRNP to identify the phenyl hydrogens of the Phe-2 residue involved in the CH/π receptor interaction .
|
- HY-W014100
-
- HY-W013198
-
- HY-W002074
-
- HY-W008176
-
- HY-W012381
-
- HY-W011255
-
- HY-W112057
-
- HY-W022138
-
- HY-W011064
-
- HY-W037549
-
- HY-W067478
-
- HY-42356
-
- HY-W008382
-
- HY-W012889R
-
- HY-W012228
-
- HY-W009118
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-5-Ava-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize fatty acid-based dimeric peptides with PSD-95 inhibitory activity .
|
- HY-79908A
-
- HY-W141774
-
|
S-Carboxyethylcysteine
|
Amino Acid Derivatives
|
Metabolic Disease
|
|
S-(2-Carboxyethyl)-L-cysteine (S-Carboxyethylcysteine) is a non-protein (modified) sulfur amino acid. S-(2-Carboxyethyl)-L-cysteine is present in Acacia seed. S-(2-Carboxyethyl)-L-cysteine can affect the seed’s protein use in rats. S-(2-Carboxyethyl)-L-cysteine suppresses the methionine-induced growth rate, and has a negative effect on the plasma amino acid levels in rats .
|
- HY-W008024
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize somatostatin analogs that inhibit neointima formation induced by balloon injury in rats without altering growth hormone release. Fmoc-Dab(Boc)-OH can be used for the synthesis of peptides .
|
- HY-W013769
-
- HY-W141852
-
- HY-W011049
-
- HY-W006063
-
- HY-W010839
-
- HY-W048825
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Ala-Ala-OH is a self-assembling fluorenylmethoxycarbonyl dipeptide, a small amphiphilic building block composed of a dipeptide linked to a fluorenylmethoxycarbonyl (Fmoc) group. Under conditions of pH < 4, Fmoc-Ala-Ala-OH spontaneously assembles to form a nanofiber network, constructing a hydrogel scaffold with a water content exceeding 99% (w/w). The fibers have a diameter of approximately 22 nm, matching the size of extracellular matrix (ECM) components. Fmoc-Ala-Ala-OH supports cell adhesion, proliferation, and maintains of cell phenotype. Fmoc-Ala-Ala-OH's function is to mimic the ECM, providing a 3D growth microenvironment for cells, and Fmoc-Ala-Ala-OH is primarily used in tissue engineering and 3D cell culture, particularly suitable for in vitro culture studies of cells such as chondrocytes[1] .
|
- HY-P1897A
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Fibronectin active fragment control acetate is an active peptide fragment of fibronectin. Fibronectin is a glycoprotein interacting with integrins. Fibronectin active fragment control acetate can be used as a control for Gly-Arg-Gly-Asp-Ser (HY-P0295) .
|
- HY-P11413
-
|
|
Ser/Thr Protease
|
Cardiovascular Disease
|
|
PAI-1 is a plasminogen activator inhibitor. PAI-1 is a member of the Ser Protease inhibitor superfamily with antiprotease activity. PAI-1 is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs) .
|
- HY-W027230
-
- HY-20838
-
- HY-W017069
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(allyloxy)-4-oxobutanoic acid is an aspartic acid derivative .
|
- HY-Y1030
-
|
tert-Butyl (S)-2-amino-3-methylbutanoate hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
tert-Butyl L-valinate hydrochloride is a valine derivative .
|
- HY-42067
-
- HY-W012709
-
- HY-122297A
-
|
|
Peptides
|
Others
|
|
H-Arg-Phe-OH TFA is an amphipathic peptide. H-Arg-Phe-OH TFA has the ability to induce native-like protein aggregation. H-Arg-Phe-OH TFA can induce aggregation of the neutral model protein yeast alcohol dehydrogenase (ADH) .
|
- HY-W011686
-
- HY-W013962
-
- HY-42364
-
- HY-W587803R
-
|
|
Peptides
Reference Standards
|
Metabolic Disease
|
|
Ergosterol (Standard) is the analytical standard of Ergosterol. This product is intended for research and analytical applications. Ergosterol is the primary sterol found in fungi, with antioxidative, anti-proliferative, and anti-inflammatory effects.
|
- HY-P1873B
-
|
|
Ser/Thr Protease
|
Metabolic Disease
|
|
Phosphorylase Kinase β-Subunit Fragment (420-436) acetate is the β-Subunit fragment (peptide 430-436) of phosphorylase kinase. Phosphorylase kinase is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release glucose-1-phosphate from glycogen .
|
- HY-W011073
-
- HY-P11339A
-
|
|
Integrin
|
Cancer
|
|
c-RGD-SH TFA is an Integrin αvβ3 ligand. c-RGD-SH TFA conjugated with core-crosslinked polymeric micelles (CCPM) can be used for synthesis a dual modality nanoparticle probe, and this probe labeled with both Cy7 and 111In can be used for SPECT and NIRF imaging of tumor .
|
- HY-W004864
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-(S)-2-(4-pentenyl) Ala-OH is an Fmoc-protected unnatural amino acid. Fmoc-(S)-2-(4-pentenyl) Ala-OH can be used for polypeptide synthesis, such as NYAD-13 (HY-P10834) .
|
- HY-42448
-
- HY-W015465
-
- HY-113119
-
- HY-W141933
-
- HY-75947
-
- HY-W013652
-
- HY-126169
-
- HY-W036322
-
- HY-W015241
-
- HY-W005226
-
- HY-W042006
-
- HY-W008467
-
- HY-W022823
-
- HY-W048700
-
- HY-129960
-
- HY-W013517
-
- HY-W041988
-
|
|
Bacterial
|
Infection
|
|
Fmoc-Glu-OMe is a glutamic acid derivative. Fmoc-Glu-OMe exhibits significant antibacterial activity and excellent gelation properties in silver nitrate (AgNO3) solution. Fmoc-Glu-OMe promotes wound healing in rat models and eliminates bacteria in MRSA-infected rat wound models. Fmoc-Glu-OMe can be used in studies related to wound infections and MRSA-infected wounds .
|
- HY-W006937
-
|
Boc-p-amino-D-Phe(Fmoc)-OH; Boc-D-phe(4-NH-fmoc)-OH
|
Amino Acid Derivatives
|
Others
|
|
Boc-D-(4-fmoc)-aminophenylalanine (Boc-p-amino-D-Phe(Fmoc)-OH) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with gonadotropin-releasing hormone antagonist activity .
|
- HY-W039758
-
- HY-P11392
-
- HY-30090
-
- HY-34540
-
|
(αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-pyridinepropanoic acid
|
Amino Acid Derivatives
|
Others
|
|
(αS)-α-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-pyridinepropanoic acid is an alanine derivative .
|
- HY-W009244
-
- HY-W005759
-
- HY-35028
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-Glu-Ofm is a peptide. Boc-Glu-Ofm has been used for the synthesis of ester insulin and cyclic peptide mixtures .
|
- HY-W142019
-
- HY-P10065
-
- HY-W021482
-
|
|
Amino Acid Derivatives
Drug Intermediate
|
Others
|
|
(4S)-1-Benzoylcarbonyl-4-fluorobutylproline ((2R,4R)-1-tert-butoxycarbonyl-4-fluoropyrrolidine-2-carboxylic acid) is a derivative of fluorinated proline and can be used as a pharmaceutical intermediate for the synthesis of various active compounds .
|
- HY-W039180
-
- HY-W141889
-
- HY-W011279
-
- HY-101242
-
- HY-W009686
-
- HY-W048829
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-Phe-Gly-OH is a Boc-protected phenylalanyl glycine derivative, can be used for the synthesis of agents or other compounds .
|
- HY-W003318
-
- HY-W001954
-
- HY-W014824
-
- HY-W000795
-
- HY-30216AR
-
|
α-Hydroxyisocaproic acid (Standard)
|
Endogenous Metabolite
Reference Standards
|
Others
|
|
Leucic acid (Standard) is the analytical standard of Leucic acid. This product is intended for research and analytical applications. Leucic acid is an amino acid metabolite .
|
- HY-W012872
-
- HY-22297
-
- HY-W015595
-
|
L-2-Allylglycine hydrochloride
|
Amino Acid Decarboxylase
GABA Receptor
|
Neurological Disease
|
|
L-Allylglycine (L-2-Allylglycine) hydrochloride is an amino acid derivative. L-Allylglycine hydrochloride is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine hydrochloride exhibits convulsant activity .
|
- HY-W009339
-
- HY-Y1801
-
|
L-Aspartic acid β-methyl ester hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
β-Methyl L-aspartate hydrochloride is an aspartic acid derivative .
|
- HY-W013153
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as [desArg 10]HOE 140, which has bradykinin B1 antagonist activity .
|
- HY-W005561
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Dab(Boc)-OMe hydrochloride is an N-terminally protected diaminobutyric acid containing two protecting groups: methoxy (OMe) and tert-butyloxycarbonyl (Boc). H-Dab(Boc)-OMe hydrochloride can be used to synthesize the bifunctional chelator H3Dpaa that can rapidly complex 68Ga under physiological conditions .
|
- HY-W010836
-
- HY-107848
-
- HY-W716776
-
|
|
Drug Intermediate
|
Others
|
|
H-Pro-His-OH is a commonly used amino acid building block in biochemistry and peptide synthesis.
|
- HY-23174
-
- HY-W008999
-
- HY-W141932
-
|
Stearoylglycine; N-Octadecanoylglycine
|
Endogenous Metabolite
|
Others
|
|
N-stearoylglycine is a lipid and has a small ionizable polar headgroup whose charge is pH dependent and whose amide moiety can form H-bonded network between adjacent molecules in ordered films .
|
- HY-W046352
-
- HY-W002301
-
|
|
Amino Acid Derivatives
|
Others
|
|
(2S)-4-(benzyloxy)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-oxobutanoic acid is an aspartic acid derivative .
|
- HY-W053801
-
- HY-W010698
-
- HY-W007620
-
- HY-W141781
-
|
Cystaphos sodium
|
Phosphatase
|
Metabolic Disease
|
|
Cysteamine S-phosphate (Cystaphos) sodium can be hydroIyzed to Cysteamine by human alkaline phosphatases. Cysteamine is an orally active agent for the research of nephropathic cystinosis and an antioxidant .
|
- HY-W013905
-
- HY-Y1144
-
|
N-[(Ethoxycarbonyl)methyl]-N-methylamine hydrochloride; Sacrosine ethyl ester hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
Sarcosine ethyl ester hydrochloride is a Glycine (HY-Y0966) derivative .
|
- HY-W048286
-
- HY-Z0615
-
|
Boc-L-Asp(OBn)-OH
|
Amino Acid Derivatives
|
Others
|
|
(2S)-4-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid is an aspartic acid derivative .
|
- HY-W092202
-
- HY-Y1413
-
- HY-W014000
-
- HY-W047794
-
- HY-P11728
-
|
|
CXCR
Apoptosis
Caspase
Akt
ERK
|
Cancer
|
|
Peptide E5 is an antagonist targeting the CXCR4/CXCL12 axis. Peptide E5 blocks the CXCR4/CXCL12 axis, downregulates CXCR4 expression, and inhibits the phosphorylation of downstream Akt and Erk. Peptide E5 induces apoptosis, suppresses migration and adhesion of breast cancer cells. Peptide E5 inhibits CXCL12-mediated endothelial progenitor cell recruitment, thereby suppressing tumor angiogenesis. Peptide E5 is applicable to relevant research on breast cancer .
|
- HY-W009402
-
- HY-W009892
-
- HY-P11718
-
- HY-W140794
-
- HY-122526
-
- HY-W004101
-
- HY-P11789
-
- HY-W011218
-
- HY-P11202
-
- HY-W022226
-
- HY-W111969
-
- HY-W008256
-
- HY-I0924
-
- HY-78897
-
- HY-W013714
-
- HY-W794670
-
|
|
Aminopeptidase
|
Others
|
|
H-Ala-Pro-Ala-OH, tripeptide, is a substrate for Escherichia coli PepP (Xaa-Pro aminopeptidase). H-Ala-Pro-Ala-OH acts as a nitrogen source for wild-type Escherichia coli .
|
- HY-W008475
-
- HY-P11655
-
|
|
Somatostatin Receptor
|
Neurological Disease
|
|
NOTA-TATE is a somatostatin receptor 2 (SSTR2) binder. NOTA-TATE binds to SSTR2 to enable targeting of SSTR2-positive tumour cells for PET imaging. NOTA-TATE can be used for the research of neuroendocrine tumours .
|
- HY-137529
-
- HY-W005883
-
- HY-P11715
-
|
|
Fluorescent Dye
|
Neurological Disease
|
|
Abz-GFDPFRQ-EDDnp is a fluorogenic substrate for metallothionein oligopeptidase (λex=320 nm, λem=420 nm). Abz-GFDPFRQ-EDDnp is used to determine the enzymatic activity of metallothionein oligopeptidase in tissue extracts and for research on temporal lobe epilepsy .
|
- HY-W008599
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-Amino-3-methyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)butanamide 2,2,2-trifluoroacetate is a valine derivative .
|
- HY-P10063
-
- HY-30230
-
- HY-W018045
-
- HY-159703
-
|
Glutamyl-cysteine; PSSGlu-Cys
|
Endogenous Metabolite
|
Others
|
|
Glu-Cys (Glutamyl-cysteine; PSSGlu-Cys) is a dipeptide composed of L-glutamic acid (HY-14608) and L-cysteine (HY-Y0337) joined by a peptide linkage .
|
- HY-78907
-
- HY-148031
-
|
|
ADC Linker
|
Others
|
|
MC-Ala-Ala-Asn-PAB-PNP is a peptide, can be used to synthesize specifically activated micromolecular target coupling body .
|
- HY-I0517
-
- HY-66024
-
- HY-W097232
-
- HY-W011832
-
- HY-41267
-
- HY-W014303
-
- HY-120731
-
- HY-P1755A
-
|
|
MDM-2/p53
|
Cancer
|
|
p53 (17-26) acetate is a peptide derived from the P53 MDM2 binding domain, with a Kd of 50 nM for MDM2. p53 (17-26) acetate causes cell lysis by damaging cancer cells and nuclear membranes, and induces cancer cell necrosis. p53 (17-26) acetate exhibits antitumor activity and is applicable to research related to pancreatic cancer .
|
- HY-W007578
-
- HY-W014076
-
- HY-W141910
-
- HY-W045221
-
- HY-W012486
-
- HY-W141936
-
- HY-21983
-
|
|
Amino Acid Derivatives
|
Others
|
|
O-Acetyl-N-[(1,1-dimethylethoxy)carbonyl]-L-threonine is a compound containing both an amino group and a carboxyl group.
|
- HY-W061650
-
- HY-P10058
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
cpm-1285m is a cell-permeable mutated peptide analogue of cpm-1285 (Bcl-2 inhibitory peptide). cpm-1285m contains a single substitution of alanine for Leu-151, and exhibits a decrease in Bcl-2 binding affinity with a reduction in IC50 of ∼15-fold. cpm-1285m can be used as a control of cpm-1285 .
|
- HY-W052309
-
- HY-121520
-
- HY-W009503
-
- HY-W009343
-
- HY-20561
-
- HY-P4599B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
H-His-His-OH acetate is an oligopeptide. H-His-His-OH acetate can chelate with Ruthenium (II). H-His-His-OH inhibits the hydrolysis of metal ions at pH 7.4 .
|
- HY-W338516
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-L-Homoarginine hydrochloride is a derivative of amino acid with protecting groups. Fmoc-L-Homoarginine hydrochloride can be used for synthesis of homoarginine containing peptide .
|
- HY-W018849
-
- HY-W010209
-
- HY-W141820
-
- HY-W008273
-
- HY-157248
-
- HY-P11765
-
|
|
Adrenergic Receptor
|
Others
|
|
RESA peptide is a substrate peptide of β-adrenergic receptor kinase (βARK). RESA peptide serves as a substrate for βARK-mediated phosphorylation, and its N-terminal acidic residues enhance phosphorylation efficiency and substrate binding capacity .
|
- HY-W010721
-
- HY-W060779
-
- HY-P4096B
-
|
|
Peptides
|
Inflammation/Immunology
|
|
scHAP-1 is a scrambled HAP-1 peptide, and HAP-1 is a synovial homing peptide. After amino acid sequence scrambling, scHAP-1 still specifically binds to human and rabbit fibroblast-like synoviocytes (FLS), while showing extremely weak binding to human umbilical vein endothelial cells, which proves that it remains an effective FLS-targeting ligand. scHAP-1 can be used in studies related to rheumatoid arthritis .
|
- HY-W037451
-
|
|
Amino Acid Derivatives
|
Others
|
|
Methyl L-leucinate, methyl ester of L-leucine, is an alpha-amino acid ester. Methyl L-leucinate is a derivative of methyl ester and L-leucine, a class of compounds containing both amino and carboxyl groups in the molecule .
|
- HY-W128028
-
- HY-W017404
-
- HY-134445
-
- HY-P11713
-
|
|
EBV
MHC
|
Infection
Cancer
|
|
EBNA3B 399-408 is an immunodominant HLA-A11-restricted cytotoxic T-lymphocyte epitope in EBNA3B. EBNA3B 399-408 can be used in the research of EBV infection, empyema-associated lymphoma, and nasal natural killer cell lymphoma .
|
- HY-W015425
-
- HY-79333
-
- HY-20838A
-
- HY-34611
-
|
N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH
|
Drug Intermediate
ASCT
|
Neurological Disease
Cancer
|
|
Boc-L-2,4-Diaminobutyric acid (N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH) is a versatile synthetic starting material with a cleavable protecting group. Boc-L-2,4-Diaminobutyric acid not only reduces the backbone cleavage rate by protecting the side-chain γ-amino group, but also triggers intramolecular cyclization of self-immolative linkers under acidic cleavage conditions, thus constructing stimuli-responsive materials. Boc-L-2,4-Diaminobutyric acid is also an important building block for bioactive molecules. It can be used in the synthesis of ASCT2 (SLC1A5) inhibitors and carboxynorspermine, and can also serve as an internal standard to support the quantitative detection of specific intracellular amino acids by UPLC-QQQ-MS .
|
- HY-W048215
-
|
|
Amino Acid Derivatives
|
Others
|
|
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl)-L-lysine is a lysine derivative .
|
- HY-115411
-
|
|
NO Synthase
|
Others
|
|
L-Hydroxy arginine acetate is an intermediate in the catabolism of L-arginine. L-Hydroxy arginine acetate is a substrate for NO synthase .
|
- HY-P11791A
-
- HY-W048207
-
- HY-W007408
-
- HY-P11739
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
ZD2 peptide is an EDB-FN-binding peptide with a Kd value of 11 μM. ZD2 peptide binds specifically to the EDB protein fragment of extradomain B fibronectin, a tumor microenvironment biomarker. ZD2 peptide can be conjugated to imaging agents. ZD2 peptide can be used for the research of cancer .
|
- HY-W344383
-
|
|
Ser/Thr Protease
|
Others
|
|
Boc-Phe-Ser-Arg-AMC is a trypsin peptide substrate containing a Boc protecting group. Boc-Phe-Ser-Arg-AMC can be degraded by trypsin, releasing AMC (HY-D0027) which has fluorescence activity. Boc-Phe-Ser-Arg-AMC can be used to assess the activity of trypsin .
|
- HY-W011773
-
- HY-137874
-
|
|
Peptides
|
Metabolic Disease
Cancer
|
|
L-Glutamic γ-monohydroxamate is an antitumor agent, inhibits cell proliferation. L-Glutamic γ-monohydroxamate selectively inhibits the uptake of L-histidine into microvascular endothelial cell. L-Glutamic γ-monohydroxamate, as a vanadium ligand, activates glucose uptake and metabolism, thus decreases the blood glucose levels in vivo .
|
- HY-41650
-
|
(S)-2-((tert-Butoxycarbonyl)amino)-N-methoxy-N-methylpropanamide; (S)-2-(tert-Butoxycarbonylamino)-N-methoxy-N-methylpropionamide
|
Amino Acid Derivatives
|
Others
|
|
Boc-Ala-NMe(OMe) is an alanine derivative .
|
- HY-75949
-
- HY-W141899
-
- HY-W006185
-
- HY-118535
-
- HY-W011614R
-
|
|
Reference Standards
Peptides
|
Others
|
|
L-Arginine ethyl ester dihydrochloride (Standard) is the analytical standard of L-Arginine ethyl ester dihydrochloride. This product is intended for research and analytical applications. L-Arginine ethyl ester dihydrochloride is an arginine derivative .
|
- HY-W010888
-
- HY-W026508
-
- HY-W047901
-
- HY-W007136
-
- HY-W040024
-
- HY-W011021
-
- HY-W008872
-
- HY-79171
-
- HY-78912
-
- HY-W009356
-
|
|
Endogenous Metabolite
Ferroptosis
ROS Kinase
Keap1-Nrf2
Reactive Oxygen Species (ROS)
|
Others
|
|
L-Cystine hydrochloride is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine hydrochloride elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-Cystine hydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine hydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine hydrochloride is promising for research of cystinuria and kidney stones
|
- HY-P10541A
-
|
|
HSP
|
Others
|
|
HSP70/DnaK substrate peptide TFA is a short peptide that the HSP70/DnaK molecular chaperone can bind and act on. HSP70/DnaK substrate peptide TFA can be used to study the mechanism of action of HSP70/DnaK in molecular chaperone function .
|
- HY-107373A
-
- HY-W074889
-
- HY-I0172
-
- HY-P10838A
-
|
|
PD-1/PD-L1
Apoptosis
|
Cancer
|
|
PL120131 acetate is a PD-1 antagonist, can specifically blocking the interaction between PD-1 and PD-L1, thereby effectively inhibiting the PD-1-mediated apoptosis signaling pathway. PL120131 acetate rescues lymphocytes from apoptosis, maintains the survival and activity of T cells, and induces cytotoxic T lymphocytes to exert killing effects and recognize macrophages and dendritic cells. PL120131 acetate can be used in research related to breast cancer and various malignant tumors .
|
- HY-W419989
-
- HY-W022446
-
- HY-W012907
-
- HY-78843
-
- HY-W105634
-
|
|
Endogenous Metabolite
|
Others
|
|
Strombine is a imino acid produced by a dehydrogenase. Strombine is a compound present in the hemolymph that is capable of cryoprotection .
|
- HY-W008926
-
- HY-P11627
-
|
|
Endogenous Metabolite
|
Others
|
|
Cyclo(Pro-Hyp) is a collagen-derived cyclic dipeptide, and its related collagen breakdown product Gly-Pro-Hyp promotes the growth of skin fibroblasts and participates in tissue reconstruction, exhibiting biological activity.
|
- HY-Y0750
-
- HY-P11775A
-
|
|
VEGFR
|
Cardiovascular Disease
|
|
Peptide HRH acetate is a polypeptide that specifically binds to VEGF receptors. Peptide HRH acetate inhibits VEGF-stimulated endothelial cell proliferation. Peptide HRH acetate inhibits angiogenesis and suppresses corneal neovascularization. Peptide HRH acetate can be used in anti-angiogenesis related studies .
|
- HY-W022228
-
- HY-41048
-
- HY-W009682
-
- HY-W142000
-
- HY-W141893
-
- HY-W008079
-
- HY-W002294
-
- HY-W051568
-
- HY-W097054
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-L-cysteic acid is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize triarylsulfonium compounds for radiolabeling of peptides .
|
- HY-W088100
-
|
N-Boc-N'-trityl-D-asparagine; Boc-D-Asn(Trt)-OH
|
Amino Acid Derivatives
|
Cancer
|
|
Boc-N-gamma-trityl-D-asparagin (N-Boc-N'-trityl-D-asparagine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize metastasis-inhibiting or tumor growth-inhibiting metastasis-inhibiting MS derivatives .
|
- HY-W018238
-
- HY-W205320
-
- HY-W097491
-
|
|
Amino Acid Derivatives
|
Others
|
|
L-Methionine sulfone is a sulfonic acid derivative of L-Methionine (HY-N0326). L-Methionine in the presence of a number of oxidizing systems is readily converted to L-Methionine sulfone .
|
- HY-W040723
-
- HY-W004861
-
- HY-W142008
-
- HY-W010957
-
- HY-W040804R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride (Standard) is the analytical standard of 2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrochloride. This product is intended for research and analytical applications.
|
- HY-W010777
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((S)-2-((S)-2-Amino-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanamido)-3-(4-hydroxyphenyl)propanoic acid is a tyrosine derivative .
|
- HY-W002336
-
- HY-136934
-
|
[Boc-Glu(Obzl)]2-Lys-Ome
|
P-glycoprotein
|
Cancer
|
|
Reversin 205 ([Boc-Glu(Obzl)]2-Lys-Ome) is a P-glycoprotein (ABCB1) inhibitor. Reversin 205 is a peptide chemosensitizer .
|
- HY-P10038A
-
|
Myr-FEEERA-OH TFA
|
Integrin
|
Infection
|
|
mP6 (Myr-FEEERA-OH) TFA is a myristoylated peptide. mP6 TFA inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function. mP6 TFA can block the GTP usage of Rac1, Rap1, and Rab7, effectively inhibiting the infection of CHO-A24 cells .
|
- HY-W016425
-
- HY-I0924A
-
|
Methyl (R)-phenylalaninate hydrochloride; Methyl D-phenylalaninate hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
D-Phe-OMe monohydrochloride is a phenylalanine derivative .
|
- HY-20167A
-
|
|
Neurokinin Receptor
|
Cancer
|
|
H-Glu(OtBu)-OtBu hydrochloride is a key intermediate that can be used to synthesize prostate-specific membrane antigen (PSMA) targeting probes. H-Glu(OtBu)-OtBu hydrochloride can reduce nonspecific background binding through negatively charged linkers, improve tumor/background contrast, and can be used in prostate cancer PET/SPECT imaging studies .
|
- HY-W002176
-
- HY-23424
-
- HY-W007615
-
- HY-W008360
-
- HY-W016028
-
- HY-W052227
-
- HY-W050023
-
- HY-W006187
-
|
(Rac)-H-Phg(4-Me)-OH
|
Glutaminase
|
Cancer
|
|
2-Amino-2-(p-tolyl)acetic acid is used for optimizing azide skeleton, and is the intermediate in the synthesis of 1,3, 4-thiadiazole compounds. 1,3,4-thiadiazole compounds exhibit potential anti-cancer activity, and inhibit glutaminase (GLSI) .
|
- HY-P11707
-
|
|
Apoptosis
Bcl-2 Family
|
Inflammation/Immunology
|
|
FS1 peptide is a synthetic BH3 mimetic peptide that shows potential in enhancing NK cell-mediated cancer immunity. FS1 peptide targets anti-apoptotic BCL-2 family proteins, triggers the release of cytochrome c, and thereby promotes apoptosis (Apoptosis). FS1 peptide can be used for NK cell-based immunological research .
|
- HY-W007942
-
- HY-P3756A
-
|
EMP-1 acetate
|
Peptides
|
Cardiovascular Disease
|
|
EPO mimetic peptide-1 (EMP-1) acetate, a 20 amino acid peptide. EPO mimetic peptide-1 acetate stimulates cell proliferation, affects cell cycle and induces the production of reticulocytes in vivo .
|
- HY-W009329
-
- HY-W011210
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Pra-OH is a Glycine (HY-Y0966) derivative . Fmoc-Pra-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
- HY-W038873
-
- HY-W009401
-
- HY-104004A
-
|
Fmoc-Ser-(GlcNAc(Ac)3-beta-D)-OH; Fmoc-Ser[GlcNAc(Ac)3-β-D]-OH; Fmoc-Ser(Ac3AcNH-β-Glc)-OH
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Ser(O-β-D-GlcNAc(OAc)3)-OH is a serine derivative .
|
- HY-W002299
-
|
Boc-D-Leu-OH hydrate
|
Amino Acid Derivatives
|
Neurological Disease
|
|
Boc-D-Leucine monohydrate (Boc-D-Leu-OH hydrate) is an N-Boc-protected form of D-Leucine. D-Leucine is an unnatural isomer of L-Leucine that acts as an auto-inhibitor of lactic streptococci. D-Leucine shows potent anti-seizure effect .
|
- HY-I0630R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
(R)-2-formamido-4-methylpentanoic acid (Standard) is the analytical standard of (R)-2-formamido-4-methylpentanoic acid. This product is intended for research and analytical applications.
|
- HY-W011056
-
- HY-W015987
-
|
Fmoc-NH2
|
Biochemical Assay Reagents
|
Others
|
|
9-Fluorenylmethyl carbamate (Fmoc-NH2) is an amide compound with an Fmoc protecting group, which can be used as a photobase initiator to prepare organosilane-based proton exchange membranes .
|
- HY-W142015
-
- HY-75379
-
- HY-W141770
-
- HY-P11626
-
|
|
Collagen
|
Metabolic Disease
|
|
Cyclo(Ala-Hyp) is an orally effective collagen-derived hydroxyproline-containing cyclic dipeptide that can be isolated from the culture supernatant of Lactobacillus plantarum. Cyclo(Ala-Hyp) has an AUC0-6h of 2.350 μg/mL·h, significantly higher than traditional collagen oligopeptides. Cyclo(Ala-Hyp) can be used in research related to liver and kidney function protection, skin care, and joint health.
|
- HY-W016032
-
- HY-W022630
-
- HY-W022593
-
- HY-W053503
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-3-((tert-Butoxycarbonyl)amino)-3-(3-(trifluoromethyl)phenyl)propanoic acid is a phenylalanine derivative .
|
- HY-W105740
-
- HY-141526
-
- HY-P11643
-
|
|
Angiotensin Receptor
Aminopeptidase
DNA/RNA Synthesis
|
Neurological Disease
|
|
LVV-hemorphin-7 is an Angiotensin IV receptor ligand and IRAP inhibitor (IC50s: 17.6 nM for sheep adrenal IRAP; 5.0 nM for sheep cerebellum IRAP). LVV-hemorphin-7 inhibits the catalytic activity of IRAP. LVV-hemorphin-7 stimulates DNA synthesis. LVV-hemorphin-7 elicits a number of physiological effects, including cellular proliferation and memory enhancement .
|
- HY-W023145
-
- HY-59135
-
- HY-W127783
-
- HY-W041990
-
- HY-W089230
-
|
N,N'-Di-tert-butoxycarbonyl-L-histidine
|
Amino Acid Derivatives
|
Others
|
|
Boc-His(Boc)-OH (N,N'-Di-tert-butoxycarbonyl-L-histidine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize the dodecapeptide α-mating factor of Saccharomyces cerevisiae .
|
- HY-W008086
-
- HY-W010943
-
- HY-P11720
-
|
|
Beta-lactamase
Bacterial
|
Infection
|
|
M104 peptide is an OXA-48 carbapenemase inhibitor and antibiotic potentiator. M104 peptide effectively blocks the binding and active site cavity of OXA-48 . M104 peptide restores Meropenem (HY-13678)’s antibacterial activity against OXA-48-producing Klebsiella pneumoniae. M104 peptide can be used for the research of Carbapenem-resistant Klebsiella pneumoniae infection .
|
- HY-W009534
-
- HY-W010922
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bicyclic peptide tachykinin NK2 antagonists .
|
- HY-W009151
-
- HY-W008971
-
- HY-W015563R
-
|
|
Reference Standards
Peptides
|
Others
|
|
(R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetic acid (Standard) is the analytical standard of (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetic acid. This product is intended for research and analytical applications. (R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetic acid is a Glycine (HY-Y0966) derivative .
|
- HY-W008077
-
- HY-P10059
-
|
|
Peptides
|
Others
|
|
Boc-Val-Gly-Arg-βNA is a colorimetric substrate for plasminogen activator .
|
- HY-W051350
-
- HY-W092107
-
- HY-W017350
-
- HY-P11714
-
|
|
EBV
MHC
|
Infection
Cancer
|
|
EBNA3 246-254 (RYSIFFDYM) is an EBV peptide. EBNA3 246-254 is submitted by HLA-A24. EBNA3 246-254 is amplified in vitro, followed by HLA multimer staining to measure EBV-specific CTLs. EBNA3 246-254 can be used for the research of lung cancer .
|
- HY-41318
-
|
1,2-Pyrrolidinedicarboxylic acid, 2-methyl 1-(phenylmethyl) ester, (S)-; Methyl (S)-N-(benzyloxycarbonyl)prolinate
|
Amino Acid Derivatives
|
Others
|
|
N-Z-L-proline methyl ester is a proline derivative .
|
- HY-W131398
-
- HY-P11652
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Cardiogen is a short biologically active peptide (Ala-Glu-Asp-Arg) that does not bind single-stranded deoxyribooligonucleotides, slightly quenches fluorescence of some double-stranded deoxyribooligonucleotides, strongly quenches fluorescence of methylated and unmethylated λ phage DNA-ethidium bromide complexes .
|
- HY-W008269
-
- HY-W037441
-
- HY-W007223
-
|
D-5-HTP; 5-Hydroxy-D-tryptophan
|
5-HT Receptor
|
Neurological Disease
|
|
D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range .
|
- HY-W017413
-
- HY-Y1824
-
- HY-W101495
-
|
N-Boc-L-leucine monohydrate
|
Amino Acid Derivatives
|
Others
|
|
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .
|
- HY-W009592A
-
|
Glycyltyrosine dihydrate; Gly-Tyr dihydrate; H-Gly-Tyr-OH dihydrate
|
Amino Acid Derivatives
|
Others
|
|
Glycyl-L-tyrosine dihydrate is a synthetic dipeptide that can be used as a food additive for tyrosine supplementation .
|
- HY-76317
-
|
N-Cbz-DL-proline; DL-Cbz-Proline
|
Amino Acid Derivatives
|
Others
|
|
Z-DL-Pro-OH (N-Cbz-DL-proline) is a proline derivative, can be used for the synthesis of agents or other compounds .
|
- HY-W048681
-
- HY-W002038
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(-)-Phenylglycinol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W008887
-
- HY-W008134
-
- HY-W013145
-
- HY-113084
-
|
|
Drug Derivative
|
Metabolic Disease
|
|
L-Cysteine S-sulfate is an S-sulfated derivative of L-cysteine (HY-Y0337). L-Cysteine S-sulfate is the substrate for cystine lyase, it can be used in mass spectrometry and chromatography analyses .
|
- HY-W041986R
-
- HY-P3040A
-
|
|
Peptides
|
Others
|
|
PHI-27 (rat) TFA is a 27 amino acid peptide.PHI-27 (rat) TFA is used to find peptide hormones and other active peptides .
|
- HY-79294
-
- HY-W039756
-
|
NSC 334362
|
Amino Acid Derivatives
|
Others
|
|
Boc-Ala-Ala-OH (NSC 334362) is an Alanine derivative. Boc-Ala-Ala-OH is used in the preparation of anti-bacterial agent .
|
- HY-W012707
-
- HY-W013651
-
- HY-79680
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-(tert-butoxycarbonylamino)-3-(4-carbamoyl-2,6-dimethylphenyl)propanoic acid is a phenylalanine derivative .
|
- HY-W141912
-
- HY-W013906
-
- HY-W008972
-
- HY-W011325
-
- HY-P11662
-
|
|
Peptides
|
Cancer
|
|
NLS peptide is a nuclear localization signal peptide, a short amino acid sequence that can be recognized by nuclear transport machinery (such as the Importin protein complex). NLS peptide can directionally transport the molecules or nanoparticles linked to it into the nucleus, and the N-terminal Cys terminus can be used for subsequent coupling. NLS peptide can be used to construct nucleus-specific imaging probes and nucleus-targeted nanoparticles
|
- HY-79513
-
|
tert-Butyl [(R)-1-(methoxycarbonyl)-2-hydroxyethyl]carbamate
|
Amino Acid Derivatives
|
Others
|
|
(R)-Methyl 2-(tert-butoxycarbonylamino)-3-hydroxypropanoate is a serine derivative .
|
- HY-W141987
-
- HY-W142003
-
- HY-77151
-
- HY-P10038
-
|
Myr-FEEERA-OH
|
Integrin
|
Infection
|
|
mP6 (Myr-FEEERA-OH) is a myristoylated peptide. mP6 inhibits the interaction of Gα13 with integrin β3 without disrupting talin-dependent integrin function. mP6 can block the GTP usage of Rac1, Rap1, and Rab7, effectively inhibiting the infection of CHO-A24 cells .
|
- HY-W011567
-
- HY-W007399
-
- HY-W009970
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
N-Benzylglycine ethyl ester is an N-substituted glycine derivative. N-Benzylglycine ethyl ester is bound to PDB code: 1B41. N-Benzylglycine ethyl ester can be used in Alzheimer's disease research .
|
- HY-P11742
-
|
Ac-GWW(LA)8LWWA-NH2
|
Biochemical Assay Reagents
|
Others
|
|
WALP23 is a synthetic model peptide. WALP23 induces heterogeneity in lipid bilayers, forming stripe-like microdomains in DPPC bilayers. WALP23 can be used to study protein-membrane interactions. WALP23 is also used as a model peptide to determine helical orientation during the association process .
|
- HY-W041076
-
- HY-W013936
-
- HY-W009006
-
- HY-W141934
-
- HY-W131866
-
- HY-Y0029
-
- HY-W042005
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-D-Phe(3,4-DiCl)-OH is D-3,4-Dichlorophenylalanine, a amino acid derivative. H-D-Phe(3,4-DiCl)-OH shows protein synthesis activity .
|
- HY-P11790
-
|
C-Tag peptide
|
Biochemical Assay Reagents
|
Infection
|
|
EPEA tag peptide (C-Tag peptide) is an epitope tag peptide. EPEA tag peptide enables elution of the SpaP EPEA complex. EPEA tag peptide is applicable to research related to bacterial type III secretion systems .
|
- HY-W011116
-
|
H-Leu-Leu-Leu-OH; Trileucine
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((S)-2-((S)-2-Amino-4-methylpentanamido)-4-methylpentanamido)-4-methylpentanoic acid is a leucine derivative .
|
- HY-136197
-
|
|
Ras
|
Cancer
|
|
StRIP16, bioavailable StRIP3 analogue, is a double-stapled peptide which can bind to Rab8a GTPase, with a Kd of 12.7 μM .
|
- HY-145512
-
|
NLT
|
Dopamine Receptor
|
Neurological Disease
|
|
N-(α-Linolenoyl) tyrosine (NLT) is a dopaminergic agonist capable of crossing the blood-brain barrier. N-(α-Linolenoyl) tyrosine increases the level, turnover rate and release amount of dopamine in the striatum. N-(α-Linolenoyl) tyrosine modulates rotational behavior in a rat model with unilateral striatal injury and alleviates excessive blinking symptoms in models induced by dopamine-depleting agents. N-(α-Linolenoyl) tyrosine can be used for research on Parkinson's disease and idiopathic blepharospasm .
|
- HY-W008028
-
- HY-W015533R
-
- HY-W008464
-
- HY-W062304
-
- HY-W047902
-
- HY-148195
-
|
NNZ-2591
|
Biochemical Assay Reagents
|
Neurological Disease
|
|
Ercanetide (NNZ 2591) is a synthetic analogue of a small peptide of cyclic glycine proline (cGP). Ercanetide shows orally active and cross the blood-brain barrier. Ercanetide shows neuroprotective after ischemic brain injury. NNZ 2591 improves motor function in a rat model of Parkinson's disease. Ercanetide has the potential for the research of ischemic brain injury and angelman syndrome .
|
- HY-W101889
-
|
N-Boc-N'-xanthyl-L-glutamine
|
Amino Acid Derivatives
|
Others
|
|
Boc-Gln(Xan)-OH (N-Boc-N'-xanthyl-L-glutamine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize peptides with antigenic activity .
|
- HY-W098273
-
- HY-I0749A
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-Methyl 2-((S)-2-((S)-2-amino-4-phenylbutanamido)-4-methylpentanamido)-3-phenylpropanoate 2,2,2-trifluoroacetate is a phenylalanine derivative .
|
- HY-W141928
-
- HY-W009840
-
- HY-101444A
-
|
MC-207,110 dihydrochloride; Phe-Arg-β-naphthylamide dihydrochloride
|
Bacterial
|
Infection
|
|
PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.
|
- HY-W067360
-
- HY-P11452A
-
|
|
LDLR
|
Endocrinology
|
|
(KKEEE)3K acetate is a kidney-targeting peptide. (KKEEE)3K enters renal tubular cells via megalin receptor-mediated endocytosis. (KKEEE)3K acetate can be used in the research of renal drug delivery .
|
- HY-W040438
-
- HY-W017617
-
- HY-W012921
-
- HY-Y1164
-
- HY-W005295
-
- HY-I0124
-
- HY-W006886
-
|
|
Amino Acid Derivatives
|
Others
|
Fmoc-(R)-2-(7-octenyl) Ala-OH is an unnatural Fmoc-protected amino acid and modification module. Fmoc-(R)-2-(7-octenyl) Ala-OH serves as a key building block for all-hydrocarbon cross-linking modification of antimicrobial peptides, and facilitates the generation of stapled peptide derivatives. When introduced into specific sites of the parent peptide, Fmoc-(R)-2-(7-octenyl) Ala-OH effectively increases the α-helix content of the peptide chain, thereby significantly enhancing its antimicrobial activity and proteolytic stability. Fmoc-(R)-2-(7-octenyl) Ala-OH is widely used in research on bacterial infections and the development of related antimicrobial agents . Stapled peptide is a specially chemically modified polypeptide. It locks the peptide chain into a stable α-helical structure by introducing a "staple"-like chemical bridge (usually an all-carbon backbone) at specific positions of the peptide chain.
|
- HY-W009693
-
- HY-P4613
-
|
|
Drug Derivative
Drug Intermediate
|
Others
|
|
Fmoc-D-allo-Thr-OH is a derivative of D-allothreonine (HY-W001959), which is commonly used as a building block in solid-phase peptide synthesis (SPPS) .
|
- HY-W022220
-
- HY-W008156
-
- HY-101444AR
-
|
MC-207,110 dihydrochloride (Standard); Phe-Arg-β-naphthylamide dihydrochloride (Standard)
|
Bacterial
Reference Standards
|
Infection
|
|
PAβN (dihydrochloride) (Standard) is the analytical standard of PAβN (dihydrochloride) (HY-101444A). This product is intended for research and analytical applications. PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.
|
- HY-W013152
-
- HY-W012791
-
- HY-W016075
-
- HY-Y1166
-
- HY-W000830
-
- HY-W053699
-
- HY-W003903
-
- HY-P11709
-
|
cyclo(CLPVASC)
|
Peptides
|
Metabolic Disease
|
|
CLPVASC is a kidney-targeting cyclic peptide that preferentially distributes to kidney tissue, with utility to enhance kidney targeting of nanocarriers.CLPVASC preferentially distributes to the kidney when displayed on PEG-b-PPS micelles. CLPVASC can be used for the research of acute kidney injury .
|
- HY-137002
-
|
|
Amino Acid Derivatives
Biochemical Assay Reagents
|
Others
|
|
Fmoc-N-Me-Arg(Pbf)-OH is an amino acid derivative containing a guanidinium protecting group on the arginine side chain. Fmoc-N-Me-Arg(Pbf)-OH is used in the synthesis of neurotensin-derived NTS1 ligands for PET imaging .
|
- HY-W019684
-
- HY-W012002
-
- HY-W051937
-
- HY-P11200
-
|
γ-Glutamylasparagine
|
Calcium Channel
|
Neurological Disease
|
|
γ-Glu-Asn (γ-Glutamylasparagine) is a calcium sensing receptor (CaSR) agonist. γ-Glu-Asn is a dipeptide composed of glutamic acid and asparagine .
|
- HY-W099247
-
- HY-41051
-
|
N-tert-Butoxycarbonyl-N-methyl-L-valine; N-tert-Butoxycarbonyl-N-methylvaline
|
Amino Acid Derivatives
|
Others
|
|
(2S)-2-[[(tert-Butoxy)carbonyl](methyl)amino]-3-methylbutanoic acid is a valine derivative .
|
- HY-W023493
-
|
2-Aminopent-4-enoic acid
|
Amino Acid Decarboxylase
|
Neurological Disease
|
|
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine significantly increases mouse brain ornithine decarboxylase (ODC) activity and decreases S-adenosyl-L-methionine decarboxylase (SAM-DC) activity. DL-Allylglycine causes a marked decrease in brain GABA concentration. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .
|
- HY-W009257
-
- HY-W141940
-
- HY-W128037
-
- HY-P10060
-
- HY-P11735
-
|
|
Peptides
|
Others
|
|
Suc-AAPP-pNA is a protease substrate. (Sequence: Suc-Ala-Ala-Pro-Pro-pNA) .
|
- HY-W007020
-
- HY-137946
-
|
|
Aminopeptidase
|
Others
|
|
L-Leucine 4-methoxy-β-naphthylamide hydrochloride is an aminopeptidase M and leucine aminopeptidase substrate .
|
- HY-135113
-
|
|
Amino Acid Derivatives
|
Others
|
|
DL/meso-Lanthionine is a mixture of the racemic mixture (DL-) and meso- isomers of Lanthionine. Lanthionine is a non-protein amino acid composed of two alanine residues cross-linked by a thioether bond and is a structural component of the bacterial cell wall.
|
- HY-W008986
-
- HY-W018865
-
|
(S)-Cysteine methyl ester hydrochloride; Methyl D-cysteinate hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
Methyl D-cysteinate hydrochloride is a cysteine derivative .
|
- HY-78927
-
|
|
Amino Acid Derivatives
|
Others
|
|
N-Boc-L-Prolinal is a proline with a Boc protecting group, which can be used to synthesize biologically active peptide mimetics, such as the synthesis of Dolastatin 10 (HY-15580) analogs with anti-colon cancer activity .
|
- HY-100801A
-
|
|
Peptides
|
Others
|
|
DL-threo-3-Hydroxyaspartic acid is a glutamate uptake inhibitor that can block glutamate transport in cannulated sprague dawley rat .
|
- HY-79919
-
|
|
Amino Acid Derivatives
|
Others
|
|
D-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-D-leucyl]-, phenylmethyl ester is a phenylalanine derivative .
|
- HY-W001158
-
|
Dimethylglycine hydrochloride; DMG hydrochloride; N-Methylsarcosine hydrochloride
|
Endogenous Metabolite
iGluR
Amino Acid Derivatives
|
Neurological Disease
Metabolic Disease
|
|
N,N-Dimethylglycine (Dimethylglycine) hydrochloride, a natural N-methylated glycine, is a nutrient supplement and acts as an NMDAR glycine site partial agonist. N,N-Dimethylglycine hydrochloride is a methyl donor that can improve immunity, act as an antioxidant to prevent oxidative stress, and scavenge excess free radicals. N,N-Dimethylglycine hydrochloride has antidepressant-like and surfactant effects .
|
- HY-138207
-
|
|
Mitochondrial Metabolism
Drug Metabolite
|
Inflammation/Immunology
|
|
N-Oleoyl-L-phenylalanine is a long-chain N-acyl-L-phenylalanine and also a mitochondrial uncoupler. N-Oleoyl-L-phenylalanine uncouples UCP1-independent respiration in mitochondria, thereby helping to regulate glucose homeostasis. As an endogenous metabolite, the level of N-Oleoyl-L-phenylalanine increases in patients with ulcerative colitis after a high-fat diet. N-Oleoyl-L-phenylalanine can be used in studies related to ulcerative colitis .
|
- HY-W010590R
-
- HY-W042478
-
- HY-W007750
-
- HY-W141890R
-
|
|
Reference Standards
Peptides
|
Others
|
|
2-Iodohippuric Acid (Standard) is the analytical standard of 2-Iodohippuric Acid. This product is intended for research and analytical applications. 2-Iodohippuric Acid is a Glycine (HY-Y0966) derivative .
|
- HY-W016948
-
- HY-P11651
-
|
|
Peptides
|
Others
|
|
Livagen is a peptide with an activity of inducer with activity that increases the number of nucleolus organizers per cell and the number of nucleoli per cell. Livagen can be used for the research of nucleolus-related cellular processes .
|
- HY-W042013
-
- HY-78105
-
- HY-W011830
-
- HY-22296
-
- HY-W016256
-
|
|
Bacterial
|
Infection
|
|
L-Methioninamide hydrochloride, a Methionine analogue, is Methionyl-tRNA synthetase inhibitor .
|
- HY-W011223
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoic acid is a phenylalanine derivative .
|
- HY-115393
-
- HY-W043473
-
- HY-P10062
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
Hylambatin, a tachykinin, increases both plasma glucose and plasma insulin, whereas the secretion of glucagon was not affected. Hylambatin can be used in diabetes research .
|
- HY-P4096C
-
|
|
Peptides
|
Inflammation/Immunology
|
|
Cys-scHAP-1 is an N-terminal cysteine-labeled disordered peptide of HAP-1. Cys-scHAP-1 can be used to construct scHAP-1-targeted liposomes, which bind to human and rabbit fibroblast-like synoviocytes and localize to inflamed joints in vivo in a rat adjuvant-induced arthritis model. Cys-scHAP-1 is applicable to arthritis research .
|
- HY-W009770
-
- HY-W019265
-
- HY-P11807
-
|
|
ADC Linker
|
Cancer
|
|
DArg-DLys-DTyr-DTyr-Gly-DTrp is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
- HY-W007354
-
- HY-W048839
-
- HY-W040804
-
- HY-20165
-
- HY-W008529
-
- HY-W016547
-
- HY-W012104
-
- HY-W011178
-
- HY-20897A
-
- HY-W012889
-
- HY-W012159
-
|
H-MET-SER-OH
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
|
Methionylserine (H-MET-SER-OH) is a methionine- and serine-containing dipeptide. Methionylserine binds to and translocation via intestinal di/tri-peptide transporter 1 (hPEPT1) with a Km value of 0.2 mM. Methionylserine inhibits ACE enzyme activity. Methionylserine can be used in the research of hypension .
|
- HY-W008219
-
- HY-W008800
-
- HY-P5897
-
|
|
GnRH Receptor
|
Metabolic Disease
|
|
GnRH antagonist 3 (Compound 11) is a GnRH antagonist with an IC50 of 7 nM. GnRH antagonist 3 can be used in the research of hormone-dependent diseases .
|
- HY-W013638
-
- HY-W011089
-
- HY-W032689
-
- HY-W009088
-
- HY-W010862R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
Fmoc-Lys(Alloc)-OH (Standard) is the analytical standard of Fmoc-Lys(Alloc)-OH (HY-W010862). This product is intended for research and analytical applications. Fmoc-Lys(Alloc)-OH is a lysine derivative.
|
- HY-W007941
-
- HY-W013719
-
- HY-W011203
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-(5-Amino-2-(((benzyloxy)carbonyl)amino)-5-oxopentanamido)acetic acid is a Glycine (HY-Y0966) derivative .
|
- HY-W018850
-
- HY-W089233
-
|
N-Boc-D-glutaMic acid 1-tert-butyl ester
|
Amino Acid Derivatives
|
Others
|
|
Boc-D-Glu-OtBu (N-Boc-D-glutaMic acid 1-tert-butyl ester) is an amino acid derivative with a Boc protecting group, which can be used to synthesize Adamant-1-yl tripeptide with immunostimulatory activity .
|
- HY-W030321
-
- HY-P10057
-
|
|
Apoptosis
|
Cancer
|
|
cpm-1285 induces apoptosis by functionally blocking intracellular Bcl-2 and related death antagonists. cpm-1285 shows strong binding potency to Bcl-2 with an IC50 value of 130 nM. cpm-1285 reduces tumor burden in mice .
|
- HY-W010747
-
- HY-P11187A
-
|
|
Bacterial
Endogenous Metabolite
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Bactofencin A acetate is a class IId bacteriocin and Antibacterial agent. Bactofencin A acetate is produced by Lactobacillus salivarius DPC6502, an isolate derived from the intestine. Bactofencin A acetate exhibits activity against Staphylococcus and Listeria species. Bactofencin A acetate slightly modulates the intestinal flora. Bactofencin A acetate can be used in research related to staphylococcal infections, listerial infections, and mastitis .
|
- HY-W351592
-
|
Boc-S-acetamidomethyl-L-penicillamine
|
Peptides
|
Others
|
|
Boc-Pen(Acm)-OH (Boc-S-acetamidomethyl-L-penicillamine) is a peptide intermediate and can be used in peptide synthesis.
|
- HY-W010729
-
- HY-W125501
-
- HY-Y0028
-
|
N-(tert-Butoxycarbonyl)aspartic acid 1-benzyl ester; N-(tert-Butoxycarbonyl)aspartic acid benzyl ester
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-(tert-Butoxycarbonylamino)succinic acid benzyl ester is an aspartic acid derivative .
|
- HY-W008733
-
- HY-W015279
-
- HY-P11085A
-
|
|
Bacterial
|
Infection
|
|
WLBU2 acetate is a engineered cationic antimicrobial peptide (eCAP) that overcomes the environmental sensitivity of natural antimicrobial peptides (AMPs). WLBU2 acetate exhibits rapid bactericidal effect, with the MIC values of ≤ 10 μM against both Gram-negative and Gram-positive bacteria including MRSA, vancomycin-resistant enterococci, K. pneumoniae, E.aerogenes, E. cloacae, Escherichia coli, et, al. WLBU2 acetate prevents P. aeruginosa biofilm growth and retains its activity in an environment rich in mucus, low pH and high salt concentrations without negative effects on human airway epithelial cells. WLBU2 acetate can be used for the studies of cystic fibrosis (CF) and Pseudomonas aeruginosa infections .
|
- HY-W141801
-
- HY-W343771
-
|
|
Drug Intermediate
|
Others
|
|
H-Tyr-Gly-OH is an amino acid building block commonly used in biochemical and peptide synthesis.
|
- HY-W008064
-
|
Fmoc-L-Citrulline
|
Amino Acid Derivatives
|
Cancer
|
|
Fmoc-Cit-OH (Fmoc-L-Citrulline) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a degradable ADC linker composed of a valine-citrulline (Val-Cit) motif .
|
- HY-W142139
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-Boc-2-amino-5-azido-pentanoic acid (dicyclohexylammonium) is an amino acid derivative, can be used for the synthesis of compounds .
|
- HY-W111382
-
- HY-W013998
-
- HY-Y1091
-
|
|
Endogenous Metabolite
|
Others
|
|
D-Lysine is a useful raw material employed as an analog of lutenizing-hormone-releasing hormone and as a agent carrier in the form of polylysine. D-Lysine decreases renal uptake of radioactivity during scintigraphy and PRRT with low toxicity. D-Lysine not interferes with the natural amino acid metabolic balance .
|
- HY-W018489
-
- HY-W006205
-
- HY-W028793
-
- HY-W008370
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Z-Hyp-OMe is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-20582
-
- HY-P11203
-
- HY-W005117
-
- HY-W141845
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-3-(3-quinolyl)-DL-Ala-OH is a Boc-protected quinolyl Alanine derivative, can be used to synthesis compounds.
|
- HY-W009762
-
- HY-W012487
-
- HY-W011126
-
- HY-W009038
-
- HY-79288
-
|
(S)-2-[(tert-Butoxycarbonyl)amino]-3-(3-fluorophenyl)propionic acid; tert-Butoxycarbonyl-L-3-fluorophenylalanine
|
Amino Acid Derivatives
|
Others
|
|
(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3-fluorophenyl)propionic acid is a phenylalanine derivative .
|
- HY-P10945A
-
- HY-W048334
-
- HY-W330469
-
- HY-W013210
-
- HY-60265
-
- HY-32688
-
- HY-P10999A
-
|
P55 acetate
|
Drug Derivative
Biochemical Assay Reagents
|
Others
|
|
INF7TAT-P55 acetate (P55 acetate) is a polypeptide derived from INF7TAT (HY-P11000) with G1K, G20L and Y22N mutations. INF7TAT-P55 acetate serves as a delivery carrier to deliver preassembled CRISPR ribonucleases into cells for genome editing .
|
- HY-W022796
-
- HY-79404A
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-beta-t-butyl-d-alanine is an intermediate, can be used in the synthesis of peptides and other amino acids .
|
- HY-W010366
-
- HY-W012706
-
- HY-W013664
-
|
|
PROTAC Linkers
|
Cancer
|
|
Glycyl-l-serine is a PROTAC linker composed of glycine and serine. Glycyl-l-serine can be used in the synthesis of PROTACs, such as FPP29 (HY-P11228) .
|
- HY-W015424
-
- HY-44070
-
- HY-W001037
-
- HY-77894
-
- HY-W008560
-
- HY-W019683
-
- HY-W096171
-
|
3-Hydroxy-D-tyrosine
|
Carboxypeptidase
|
Infection
Neurological Disease
|
|
D-Dopa (3-Hydroxy-D-tyrosine) is a potent, orally active, non-competitive and allosteric inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 200 nM. D-Dopa elevates brain dopamine and produce turning behavior in rats. D-Dopa inhibit severe fever with thrombocytopenia syndrome (SFTS) virus infection. D-Dopa can be used for neurological disease and virus infection research .
|
- HY-W142162
-
- HY-W141795
-
- HY-W002588
-
- HY-W053701
-
|
|
Amino Acid Derivatives
|
Others
|
|
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-((5-(dimethylamino)naphthalen-1-yl)sulfonyl)-L-lysine is a lysine derivative .
|
- HY-W009477
-
- HY-W018050
-
- HY-W048680
-
- HY-59260
-
- HY-W040803
-
- HY-W014553
-
- HY-W039102
-
|
|
Amino Acid Derivatives
|
Cancer
|
|
N-Fmoc-N,O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells .
|
- HY-W005846
-
- HY-W009144
-
- HY-79131
-
- HY-W048668
-
- HY-W002237
-
- HY-Z0615R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
(2S)-4-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid (Standard) is the analytical standard of (2S)-4-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoic acid. This product is intended for research and analytical applications.
|
- HY-W008297
-
- HY-79271
-
|
Butanamide, 2-amino-N,3,3-trimethyl-, (S)-; (S)-2-Amino-N-methyl-3,3-dimethylbutanamide; L-tert-Leucine methylamide; L-tert-Leucine-N-methylamide
|
Amino Acid Derivatives
|
Others
|
|
S-tert-Leucine N-methylamide is a leucine derivative .
|
- HY-W337644
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-L-Homoarg(Et)2-OH hydrochloride is a derivative of amino acid with protecting groups. Fmoc-L-Dap(Boc,Me)-OH can be used for synthesis of homoarginine containing peptide .
|
- HY-W141945
-
- HY-W013416
-
- HY-P5121B
-
|
|
Peptides
|
Cardiovascular Disease
|
|
γ-Fibrinogen 377-395 scrambled TFA is a control peptide that forms a structure similar to that of γ-Fibrinogen 377-395 TFA (HY-P5121A) but possesses a scrambled sequence in the target-binding region.
|
- HY-W010955
-
|
NSC 334018
|
Carboxypeptidase
|
Others
|
|
Z-Phe-Leu-OH (NSC 334018) is a dipeptide acid. Z-Phe-Leu-OH undergoes hydrolysis by carboxypeptidase Y to release L-leucine. Z-Phe-Leu-OH acts as a substrate to assay carboxypeptidase Y peptidase activity .
|
- HY-W142107
-
- HY-W011154
-
- HY-N7831
-
- HY-W004153
-
- HY-P11785
-
|
|
Claudin
|
Cancer
|
|
Cpe30 MT2 is a short peptide that binds tightly junction protein Claudin‑4 (CLDN4) with high affinity, with a Kd value of 1.97 nM. Cpe30 MT2 can be used for the synthesis of PET molecular imaging probes targeting pancreatic cancer .
|
- HY-151641
-
|
|
Biochemical Assay Reagents
|
Others
|
|
3-Azido-L-alanine is an aliphatic functionalized amino acid with side chain lengths of up to four carbons . 3-Azido-L-alanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
- HY-116073
-
|
|
Acyltransferase
|
Infection
Cancer
|
|
L-Penicillamine is an orally active serine palmitoyltransferase (SPT) inhibitor. L-Penicillamine inactivates the PLP cofactor by forming adducts, thereby inhibiting SPT activity and reducing sphingolipid biosynthesis. L-Penicillamine not only blocks tumor access to vitamin B6, but also stabilizes the human papillomavirus 16 E6 oncoprotein monomer and inhibits its polymerization, exhibiting a unique anticancer mechanism. L-Penicillamine effectively delays the growth of Sarcoma-180, induces tumor necrosis and prolongs survival (though long-term use may lead to Pyridoxine (HY-B1328) deficiency and weight loss) .
|
- HY-W013292
-
- HY-W142009
-
- HY-41121
-
|
Boc-Ala-OH
|
Amino Acid Derivatives
|
Cancer
|
|
Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma .
|
- HY-I0775
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-methyl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoate is a phenylalanine derivative .
|
- HY-Y1250
-
|
Fmoc-glycine
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds .
|
- HY-W039695
-
- HY-W018386
-
- HY-W214058
-
|
(S)-N-Acetyl-2-naphthylalanine
|
Biochemical Assay Reagents
|
Others
|
|
Ac-2-Nal-OH ((S)-N-Acetyl-2-naphthylalanine), the S-enantiomer of N-Acetyl-2-naphthylalanine, is used as a biochemical assay reagent .
|
- HY-106187B
-
|
|
|
Cancer
|
|
MART-1 (27-35) (human) (TFA) is the amino acid fragment spanning positions 27 to 35 of the MART-1 protein, and it represents an immunogenic epitope recognizable by HLA-A2-restricted melanoma-specific tumor-infiltrating lymphocytes (TILs). MART-1 (27-35) (human) (TFA) can be used in studies related to melanoma .
|
- HY-W036329
-
- HY-W129587
-
- HY-W011186
-
- HY-W008183
-
- HY-W009403
-
- HY-W105884
-
- HY-W010197
-
- HY-W044620
-
- HY-P11751A
-
|
|
Endogenous Metabolite
Endothelin Receptor
|
Cardiovascular Disease
Infection
|
|
RES-701-3 peptide TFA is a class II lasso peptide. RES-701-3 peptide TFA can be isolated from the fermentation broth of Streptomyces species. RES-701-3 peptide TFA potently inhibits the binding of ET-1 to ETB, with an IC50 of approximately 5-10 nM. RES-701-3 peptide TFA is applicable to research related to systemic hypertension, myocardial infarction, and myocardial ischemia .
|
- HY-W045072
-
- HY-W044285
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-4-Aph(cBm)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active peptide mimetics, such as Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph/4Amf(P)-D4Aph/D4Amf(Q)-Leu-ILys-Pro-DAla-NH2 with gonadotropin-releasing hormone (GnRH) antagonist activity .
|
- HY-W013300
-
- HY-P3869A
-
|
[D-Arg2]Dermorphin-(1-4) amide TFA
|
Peptides
|
Neurological Disease
|
|
Lumekefamide TFA ([D-Arg2]Dermorphin-(1-4) amide TFA) is a N-terminal shorter peptide amide of [D-Arg2]dermorphin with the hypothermic effect. Lumekefamide shows analgesic activity and degradation in soluble mouse liver and brain extracts .
|
- HY-W042057
-
- HY-W009472
-
- HY-W007798
-
- HY-W022255
-
|
D-Fmoc-glutamic acid
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Glu-OH (D-Fmoc-glutamic acid) is a derivative of glutamate, can be used to prepare supramolecular hydrogels .
|
- HY-W720703
-
|
|
Drug Intermediate
|
Others
|
|
H-Ser-Val-OH is a commonly used amino acid building block in biochemistry and peptide synthesis.
|
- HY-W017499
-
- HY-W010835
-
|
Boc-S-trityl-D-cysteine
|
Amino Acid Derivatives
|
Others
|
|
Boc-D-Cys(Trt)-OH (Boc-S-trityl-D-cysteine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize the bicyclic depsipeptide histone deacetylase inhibitor spirocysteine .
|
- HY-41309
-
- HY-W009204
-
- HY-W009085
-
- HY-W048733
-
- HY-131894
-
- HY-W002235
-
- HY-W008446
-
|
|
Amino Acid Derivatives
|
Others
|
|
(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid is a proline derivative .
|
- HY-W008997
-
- HY-76205
-
- HY-W141975
-
- HY-Y1080
-
|
N-Acetyl-D-leucine
|
Amino Acid Derivatives
Monocarboxylate Transporter
|
Endocrinology
|
|
N-Acetyl-R-leucine is an amino-protecting group N-substituted chiral amino acid. N-Acetyl-R-leucine is a PepT1 and MCT1 inhibitor with IC50 of 0.74 and 11 mM, respectively. N-Acetyl-R-leucine can be used for LysoTracker signaling studies .
|
- HY-20838B
-
- HY-W015177
-
- HY-W010028
-
- HY-W006093R
-
- HY-W010984
-
- HY-W036324
-
- HY-W008383
-
- HY-W014373
-
- HY-W022134
-
- HY-77635
-
- HY-W008942
-
- HY-W004083
-
- HY-W072598
-
- HY-WAA0112
-
|
|
Amino Acid Derivatives
|
Others
|
|
Ethyl 2-((2-((tert-butoxycarbonyl)amino)ethyl)amino)acetate hydrochloride is a Glycine (HY-Y0966) derivative .
|
- HY-W012214
-
- HY-W002578
-
- HY-W142119
-
|
|
Ser/Thr Protease
|
Neurological Disease
|
|
α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine .
|
- HY-W036333
-
- HY-121705
-
- HY-W142161
-
|
Fmoc-MeHis(Trt)-OH
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-N-Me-His(Trt)-OH (Fmoc-MeHis(Trt)-OH) is an Amino acid derivative containing a carboxyl group. Fmoc-N-Me-His(Trt)-OH can be used for the synthesis of Fmoc-MeHis (Trt)-Leu-OH and N-methyl peptides .
|
- HY-W026072
-
- HY-W040417
-
|
|
PI3K
|
Others
|
|
Boc-L-cyclobutylglycine is a Boc-protected L-cyclic amino acid and synthetic intermediate in the preparation of purinyl quinazolinone PI3Kδ inhibitors .
|
- HY-W008527
-
- HY-W013678
-
- HY-P11638
-
|
|
Mitochondrial Metabolism
|
Neurological Disease
Inflammation/Immunology
|
|
Mitochondrial-targeted peptide BP29 is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 can be used for the research of Friedreich's ataxia .
|
- HY-23122
-
- HY-W141815
-
- HY-W048828
-
- HY-P10929
-
|
|
Drug Intermediate
|
Others
|
|
Fmoc-Lys(tBuO-Ara-Glu(AEEA-AEEA)-OtBu)-OH is a drug intermediate in the synthesis of Tirzepatide. Tirzepatide is a dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor (GLP-1R) agonist .
|
- HY-P11784
-
|
|
Peptides
|
Others
|
|
p5RHH is an acid-activated membrane-lytic peptide derived from melittin. p5RHH, as a siRNA delivery vector, initiates synchronous disassembly of nanocomplexes and endosome lysis in response to acidic pH, and triggers the release of siRNA into the cytoplasm following macropinocytosis .
|
- HY-W039763
-
- HY-77132
-
- HY-W012519
-
- HY-W011337
-
- HY-W018628
-
- HY-77757
-
- HY-W142140
-
|
N-Methylvaline
|
Amino Acid Derivatives
|
Others
|
|
N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability .
|
- HY-W015450
-
|
D-Alanyl-D-alanine; H-D-Ala-D-Ala-OH
|
Endogenous Metabolite
|
Others
|
|
D-Ala-D-Ala is a bacterial endogenous metabolite. D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase .
|
- HY-141447
-
|
α-N-Carbobenzoxy-L-lysine thiobenzyl ester monohydrochloride
|
Amino Acid Derivatives
|
Others
|
|
Z-LYS-SBZL (monohydrochloride) is a lysine derivative .
|
- HY-W014505
-
- HY-W057465
-
- HY-W004064
-
- HY-P2089
-
|
|
MMP
|
Others
|
|
Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm .
|
- HY-W050785
-
- HY-30231
-
- HY-W141786
-
|
|
Amino Acid Derivatives
|
Others
|
|
Magnesium L-glutamate is a cysteine derivative. Magnesium L-glutamate s a flavor enhancer used to reduce the amount of salt needed in meat products .
|
- HY-W013163
-
- HY-W011026
-
- HY-W142023
-
- HY-P11805
-
|
|
ADC Linker
|
Cancer
|
|
Gly-Gly-DTyr-Gly-Gly is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
- HY-W002481
-
- HY-23861
-
|
Fmoc-N,N-dimethyl-L-Glutamine
|
Amino Acid Derivatives
|
Others
|
|
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N5,N5-dimethyl-L-glutamine is a glutamine derivative .
|
- HY-W008182
-
- HY-W077223
-
- HY-W008075
-
- HY-W052493
-
- HY-W011913
-
- HY-W009794
-
- HY-30216A
-
|
α-Hydroxyisocaproic acid
|
Drug Metabolite
Hydroxycarboxylic Acid Receptor (HCAR)
AMPK
ERK
|
Metabolic Disease
Inflammation/Immunology
|
|
Leucic acid (α-Hydroxyisocaproic acid) is an orally active end-product of the microbial metabolism of leucine. Leucic acid can bind to HCAR2, alters AMPK and ERK1/2 phosphorylation status, suppresses lipid synthesis, promotes catabolism, reduces adiposity, enhances lean mass and exercise capacity. Leucic acid suppresses pro-inflammatory cytokine secretion, inflammation-related gene mRNA expression. Leucic acid decreases basal protein synthesis, attenuates myotube atrophy. Leucic acid can be used for the research of obesity .
|
- HY-Y0007
-
|
L-Alanine, N-carboxy-, N-benzyl ester (6CI,7CI); (S)-2-(Benzyloxycarbonylamino)propanoic acid
|
Amino Acid Derivatives
|
Others
|
|
N-[(Benzyloxy)carbonyl]-L-alanine is an alanine derivative .
|
- HY-15400
-
- HY-W008029
-
- HY-W048693
-
- HY-20167
-
- HY-W041864
-
- HY-W042002
-
- HY-W142035
-
- HY-I0591R
-
- HY-W072147
-
|
Fmoc-L-Ser-OMe
|
Amino Acid Derivatives
Drug Intermediate
|
Others
|
|
Fmoc-Ser-OMe (Fmoc-L-Ser-OMe) is an Fmoc-protected L-serine methyl ester and also a solid-phase peptide synthesis intermediate. Fmoc-Ser-OMe is linked to Ellman resin via its hydroxyl side chain. Fmoc-Ser-OMe is used in peptide synthesis .
|
- HY-W141821
-
- HY-W009648
-
- HY-W011472
-
- HY-W013123
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Phe(4-CF3)-OH is Phenylalanine derivative. Fmoc-D-Phe(4-CF3)-OH can be used for the research of peptide inhibitors of protein-protein interactions .
|
- HY-W000843
-
- HY-P10056
-
|
Human ezrin peptide (324-337)
|
HIV
HCV
HPV
Influenza Virus
Interleukin Related
|
Infection
Inflammation/Immunology
|
|
HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases .
|
- HY-W562116
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-Lys(ivdde)-OH is a derivative of amino acid. Boc-Lys(ivdde)-OH can be used for synthesis of lysine containing peptide .
|
- HY-14743
-
|
SCV 07; Gamma-D-glutamyl-L-tryptophan
|
Bacterial
STAT
|
Infection
Inflammation/Immunology
Cancer
|
|
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .
|
- HY-W014097
-
- HY-W142169
-
|
Formyl-L-histidine
|
Aminoacyl-tRNA Synthetase
|
Others
|
|
N-Formyl-L-histidine shows binding affinity to histidyl-tRNA synthetase with a Ki value of 4.6 μM. N-Formyl-L-histidine shows a competitive inhibition against L-histidine ammonia-lyase, inhibits urocanic acid formation from L-histidine with a Ki value of 4.26 mM .
|
- HY-W099254
-
- HY-W017255
-
|
L-R-(3-Thieyl)glycie; L-α-3-Thieylglycie
|
Amino Acid Derivatives
|
Others
|
|
(S)-3-Thienylglycine (L-R-(3-Thieyl)glycie; L-α-3-Thieylglycie) is aamino acids and their derivatives.
|
- HY-I1107
-
- HY-P10458
-
|
Human/rat 5-LO (130-149)
|
Lipoxygenase
|
Others
|
|
5-Lipoxygenase blocking peptide (Human/rat 5-LO 130-149) is a specific sequence fragment of 5-lipoxygenase (5-LOX), which can be utilized to prepare an antibody against 5-LOX .
|
- HY-75331
-
- HY-79295
-
|
N-BOC-3-Fluoro-D-phenylalanine; N-tert-Butoxycarbonyl-3-fluoro-D-phenylalanine
|
Amino Acid Derivatives
|
Others
|
|
N-BOC-3-Fluoro-D-phenylalanine is a phenylalanine derivative .
|
- HY-W092111
-
- HY-P11782
-
|
|
GSK-3
CDK
Apoptosis
|
Cancer
|
|
GTGKT is a CAGE inhibitor. GTGKT binds to CAGE and blocks the binding of CAGE to GSK3β. GTGKT alters the localization of CAGE and inhibits the binding of CAGE to the promoter sequence of Cyclin D1. GTGKT enhances the Apoptotic effect of anticancer agents. GTGKT reduces the expression of Cyclin D1. GTGKT decreases the tumorigenic potential of melanoma and hepatocellular carcinoma cells .
|
- HY-W010838
-
- HY-W015233
-
- HY-W012030
-
- HY-W036320
-
|
|
Amino Acid Derivatives
|
Others
|
|
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-Nw-((4-methoxy-2,3,6-trimethylphenyl)sulfonyl)-N2-methyl-L-arginine is an arginine derivative .
|
- HY-W002450
-
|
|
Drug Derivative
|
Cardiovascular Disease
|
|
L-Cyclohexylalanine is an amino acid derivative. L-Cyclohexylalanine modifies an atrial natriuretic peptide, regulates homeostasis of body fluid and blood pressure homeostasis and vasodilation activity .
|
- HY-W042008
-
- HY-41631
-
|
(S)-Ethyl-N-Boc-pyroglutamate
|
Amino Acid Derivatives
Drug Intermediate
|
Others
|
|
Boc-Pyr-Oet ((S)-Ethyl-N-Boc-pyroglutamate) is a derivative of L-Pyroglutamic acid (HY-76082). Boc-Pyr-Oet can be used for the synthesis of agents or other compounds.
|
- HY-W067091
-
- HY-138815
-
|
|
Glycosidase
|
Metabolic Disease
|
|
(S)-N-(1H-Indole-3-acetyl)tryptophan (compound 4a) is a Tryptophan derivative that weakly inhibits β-D-glucosidase .
|
- HY-W041992
-
- HY-W048831
-
- HY-79165
-
- HY-W053705
-
- HY-W040432
-
- HY-W027251
-
- HY-W050803
-
- HY-W098059
-
- HY-W009124
-
- HY-I0591
-
- HY-W008633
-
- HY-W012906
-
|
L-2-Allylglycine
|
Amino Acid Decarboxylase
GABA Receptor
|
Neurological Disease
|
|
L-Allylglycine (L-2-Allylglycine) is an amino acid derivative. L-Allylglycine is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine exhibits convulsant activity .
|
- HY-Y1856
-
- HY-P11770
-
|
|
Microtubule/Tubulin
|
Others
|
|
α-Tubulin (residues 440-451) (α-Tubulin Tail) is a Microtubule growth inhibitor. α-Tubulin (residues 440-451) transiently interacts with the longitudinal polymerization interface of α-tubulin, regulating the apparent association and dissociation rates of tubulin at the microtubule growing end. α-Tubulin (residues 440-451) inhibits microtubule growth .
|
- HY-W009284
-
- HY-23185
-
- HY-W142073
-
|
7-Methyltryptophan
|
Amino Acid Derivatives
|
Infection
|
|
7-Methyl-DL-tryptophan (7-Methyltryptophan) is an amino acid derivative, which is a key precursor for biosynthesis of many non-ribosomal peptide antibiotics. 7-Methyl-DL-tryptophan plays an important role in synthesis of high-efficiency antibacterial agents and analogues thereof .
|
- HY-W008996
-
- HY-W142086
-
- HY-W003222
-
|
|
Drug Intermediate
|
Metabolic Disease
|
|
N-tert-Boc-cis-4-fluoro-L-proline (Compound 11) is a drug intermediate for the synthesis of 4-fluoropyrrolidine-2-carbonitrile DPP-4 inhibitor. N-tert-Boc-cis-4-fluoro-L-proline can be used to study type 2 diabetes .
|
- HY-W042001
-
- HY-W008685
-
- HY-W009630
-
- HY-P11699
-
|
|
|
Inflammation/Immunology
|
|
AAPDNRETF is a dominant minor histocompatibility antigen presented by H-2D b， which antigen is expressed in C57BL/6 mice and can be recognized by T cells from C3H.SW mice, thereby inducing a strong immune response. AAPDNRETF can induce graft-versus-host disease in irradiated C57BL/6 recipient mice via transfer of sensitized T lymphocytes. AAPDNRETF is applicable to the research of graft-versus-host disease .
|
- HY-W003985
-
- HY-W141842
-
- HY-42938
-
- HY-P11201
-
- HY-W587803
-
- HY-W030771
-
- HY-W111211
-
- HY-W007706
-
- HY-W010927
-
- HY-W012133
-
- HY-W142047
-
- HY-W145762
-
- HY-W009343R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
(S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoic acid (Standard) is the analytical standard of (S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoic acid. This product is intended for research and analytical applications. (S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoic acid is an alanine derivative .
|
- HY-77519R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
N-(4-Cyanophenyl)glycine (Standard) is the analytical standard of N-(4-Cyanophenyl)glycine. This product is intended for research and analytical applications. N-(4-Cyanophenyl)glycine is a Glycine (HY-Y0966) derivative .
|
- HY-P11738
-
|
|
Peptides
|
Endocrinology
|
|
Murine ZP3 peptide (330-342) is a zona pellucida 3 polypeptide fragment with the amino acid sequence NSSSSQFQIHGPR. Murine ZP3 peptide (330-342) induces autoimmune premature ovarian failure (POF). Murine ZP3 peptide (330-342) can be used for the research of premature ovarian failure .
|
- HY-W141918
-
- HY-P11774
-
|
|
Integrin
|
Cancer
|
|
HYNIC-3P-RGD2 is a dimeric cyclic RGD peptide with high binding affinity for integrin αvβ3 (IC50 = 33 nM). HYNIC-3P-RGD2 acts as a precursor molecule for radiotracers and is used to detect tumor angiogenesis .
|
- HY-W009321
-
- HY-W048722
-
|
Fmoc-D-2-Thienylalanine
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Thi-OH (Fmoc-D-2-Thienylalanine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize AS-Z-P with thrombin inhibitory activity .
|
- HY-P10061
-
|
|
Cathepsin
|
Cancer
|
|
Cathepsin K inhibitor 4 is a potent carbohydrazide Cathepsin K inhibitor with IC50s of 13 nM, 269 nM, 296 nM for human, rat, mouse Cathepsin K, respectively .
|
- HY-Y0555A
-
|
N-(Benzyloxycarbonyl)-D-leucine; N-Carbobenzoxy-D-leucine; N-Carbobenzyloxy-D-leucine; NSC 523826
|
Amino Acid Derivatives
|
Others
|
|
D-N-(Benzyloxycarbonyl)leucine is a leucine derivative .
|
- HY-W007875
-
- HY-113214R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
3,5-Diiodo-L-tyrosine (Standard) is the analytical standard of 3,5-Diiodo-L-tyrosine. This product is intended for research and analytical applications. 3,5-Diiodo-L-tyrosine is a tyrosine derivative .
|
- HY-W016340
-
- HY-W650842
-
|
|
Caspase
|
Cancer
|
|
Boc-Asp(OBzl)-CMK is an inhibitor for IL-1 converting enzyme (ICE, caspase1). Boc-Asp(OBzl)-CMK prevents death of CHP100 neuroblastoma cell, and IL-1β release elicited by the viral coat protein .
|
- HY-114932
-
- HY-W019263
-
- HY-W061614
-
|
|
Amino Acid Derivatives
|
Others
|
|
(4R)-1-Boc-4-fluoro-D-proline is an amino acid derivative that can be used for preparation of peptidomimetics, dihydropyridopyrimidines and pyridopyrimidines .
|
- HY-100047
-
|
|
Taste Receptor
|
Others
|
|
Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .
|
- HY-W009049
-
- HY-W129194
-
- HY-P11736
-
|
|
NF-κB
|
Metabolic Disease
|
|
mcIRBP-9 is an orally active NF-κB inhibitor. mcIRBP-9 reduces the levels of TNF-α, IL-1β and TGF-β1 in renal tissues, and decreases LPS-induced IL-1β production. mcIRBP-9 can be used in research related to diabetic nephropathy and type 2 diabetes mellitus .
|
- HY-W011165
-
|
Lysyllysine dihydrochloride
|
Peptides
|
Others
|
|
L-Lysyl-L-lysine (Lysyllysine) dihydrochloride is an enzyme cleavable basic amino acid. L-Lysyl-L-lysine dihydrochloride can be used for delivering multiple biologically active peptides .
|
- HY-W016035
-
- HY-W011019
-
- HY-W142126
-
- HY-W044573
-
- HY-W015449R
-
- HY-W015231
-
- HY-W014917
-
- HY-79417
-
|
Carbamic acid, [(1S)-1-[(methoxymethylamino)carbonyl]-3-methylbutyl]-, 1,1-dimethylethyl ester (9CI); Carbamic acid, [1-[(methoxymethylamino)carbonyl]-3-methylbutyl]-, 1,1-dimethylethyl ester, (S)-
|
Amino Acid Derivatives
|
Others
|
|
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide is a leucine derivative .
|
- HY-W010712
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-His(Trt)-OH is a histidine derivative with a trityl (Trt) group protecting the His side chain. Fmoc-His(Trt)-OH also has an Fmoc group protecting the α-NH2 group. Fmoc-His(Trt)-OH can be used in solid-phase peptide synthesis to prevent racemization and byproduct formation. Fmoc-His(Trt)-OH acts as a protected histidine precursor in solid-phase peptide synthesis (SPPS), participating in peptide chain construction through amide bond formation. Fmoc-His(Trt)-OH can be precisely incorporated into the target peptide sequence, ensuring correct peptide chain synthesis and reducing impurity formation. Fmoc-His(Trt)-OH is mainly used in the solid-phase synthesis research of pharmaceutical peptides and bioactive peptides, and is particularly suitable for the preparation of peptide drugs requiring precise control of histidine configuration .
|
- HY-W015359
-
- HY-W042016
-
- HY-45894
-
|
Semaglutide side chain
|
GLP Receptor
|
Metabolic Disease
Inflammation/Immunology
|
|
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu is an intermediate in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist Semaglutide (HY-114118). tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu exhibits a strong binding affinity to albumin and can be used to modify SN38 prodrugs to improve tumor distribution .
|
- HY-W047788
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Dab(Boc)-OH is an amino acid derivative with a Boc protecting group, which can be used to synthesize methotrexate (MTX) analogs with antitumor and antifolate activities .
|
- HY-W009379
-
- HY-W011342
-
- HY-P11701
-
|
|
MHC
|
Others
|
|
SEIDLILGY is a nonapeptide identified as a peptide ligand derived from mouse major histocompatibility complex class I (MHC). SEIDLILGY serves as a tool chemical stimulant for the specific activation of sensory neurons expressing the particular vomeronasal receptor (V2rf2) .
|
- HY-W011444
-
- HY-W014238
-
- HY-W019028
-
- HY-W141990
-
- HY-W008995
-
- HY-W141962
-
- HY-W013810
-
- HY-P11650
-
|
|
p38 MAPK
JNK
|
Cardiovascular Disease
|
|
HE4-1 leech peptide is a p38 MAPK inhibitor with an additional c-Jun N-terminal kinase (JNK) inhibitory role. HE4-1 leech peptide suppresses macrophage migration, and does not significantly affect macrophage immunological activities including phagocytic ability, lysozyme activity, and expression levels of most inflammatory factors. HE4-1 leech peptide can be used for the research of atherosclerosis .
|
- HY-P11800A
-
|
|
Exosomes
MMP
|
Inflammation/Immunology
|
|
GPLGVRGC is a cysteine-tagged variant of GPLGVRG (HY-P11800). GPLGVRGC is hydrolyzable by MMP13. GPLGVRGC mediates the disassembly of micelle-exosome systems, enhances chondrocyte endocytosis, and promotes responsive system uptake. GPLGVRGC confers targeted delivery and responsive release properties to micelle-exosome systems. GPLGVRGC is applicable to the research of osteoarthritis .
|
- HY-Y1875
-
- HY-34346
-
|
[[[Hydrazino]carbonyl]methyl]carbamic acid tert-butyl ester; tert-Butyl (2-hydrazinyl-2-oxoethyl)carbamate; tert-Butyl (2-hydrazinyl-2-oxoethyl)carbamate
|
Amino Acid Derivatives
|
Others
|
|
tert-Butyl (2-hydrazinyl-2-oxoethyl)carbamate is a Glycine (HY-Y0966) derivative .
|
- HY-P11638A
-
|
|
Mitochondrial Metabolism
|
Neurological Disease
Inflammation/Immunology
|
|
Mitochondrial-targeted peptide BP29 acetate is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 acetate protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 acetate prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 acetate can be used for the research of Friedreich's ataxia .
|
- HY-W141930
-
- HY-P11741
-
|
|
Exosomes
Biochemical Assay Reagents
|
Neurological Disease
|
|
BV2 is a delivery peptide that binds to BVES, with a Ka of 2.03 μM for the BVES target. BV2 specifically binds to the extracellular domain of BVES, achieving muscle homing and cellular internalization via caveolae-mediated endocytosis. When BV2 is modified on the surface of exosomes by PMO, it enhances dystrophin restoration in the peripheral muscles and myocardium of dystrophin-deficient mice. BV2 is applicable to research related to Duchenne muscular dystrophy and muscle atrophy .
|
- HY-W019599
-
|
L-PCPA
|
5-HT Receptor
Tryptophan Hydroxylase
|
Neurological Disease
|
|
4-Chloro-L-phenylalanine (L-PCPA) is a tryptophan hydroxylase inhibitor targeting TPH1 and TPH2, with the activity of blocking serotonin biosynthesis. 4-Chloro-L-phenylalanine reduces the levels of serotonin and its metabolites in the brain without impairing the survival of serotonergic neurons. 4-Chloro-L-phenylalanine enhances anhedonic, depression-like and anxiety-like behaviors in mice with depleted noradrenergic and dopaminergic neurons. 4-Chloro-L-phenylalanine acts as a decarboxylation substrate for aromatic L-amino acid decarboxylase from Bacillus atrophaeus. 4-Chloro-L-phenylalanine can be used in studies related to Parkinson's disease .
|
- HY-P11088A
-
- HY-20841
-
|
(S)-2-((tert-Butoxycarbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid; Boc-4-Pyranoyl-Gly-OH
|
Amino Acid Derivatives
|
Others
|
|
Boc-(2S)-Gly-4-pyranoyl ((S)-2-((tert-Butoxycarbonyl)amino)-2-(tetrahydro-2H-pyran-4-yl)acetic acid) is an amino-terminally protected glycine derivative that can be used to synthesize dipeptidyl peptidase IV with antidiabetic activity .
|
- HY-W008179
-
- HY-W048677
-
- HY-P5407A
-
|
|
SARS-CoV
Angiotensin-converting Enzyme (ACE)
|
Infection
Cancer
|
|
HD5 TFA is an innate immune effector peptide and SARS-CoV Inhibitor. HD5 TFA binds to the ligand-binding domain of angiotensin-converting enzyme-2 (ACE2) via multiple hydrogen bonds to competitively block the receptor, shielding it from viral recognition. HD5 TFA can be used for the research of COVID-19, HPV16 infection, epithelial ovarian cancer, small-cell lung cancer, and colon cancer .
|
- HY-W009197
-
- HY-W014663
-
- HY-41912B
-
|
Boc-D-Nle-OH; N-BOC-D-norleucine
|
Amino Acid Derivatives
|
Others
|
|
Boc-D-norleucine (Boc-D-Nle-OH) is a leucine derivative that can be used for peptide synthesis .
|
- HY-W040441
-
- HY-P11810
-
|
|
GnRH Receptor
Neuropeptide FF Receptor
|
Metabolic Disease
|
|
GUB08248 is a full GPR10 agonist and a partial NPFF2R agonist, with EC50 values of 0.5 nM and 2.5 nM, respectively. GUB08248 inhibits food intake and induces sustained weight loss. GUB08248 can be used in obesity-related research .
|
- HY-P0281B
-
|
TAT(47-57) acetate; HIV-1 TAT protein (47-57) acetate
|
HIV
|
Infection
|
|
TAT (TAT(47-57)) acetate is derived from the transactivator of transcription (TAT) of human immunodeficiency virus-1 (HIV-1) and is a cell-penetrating peptide. TAT acetate can increase the yields and the solubility of heterologous proteins .
|
- HY-W013844
-
- HY-14743R
-
|
SCV 07 (Standard); Gamma-D-glutamyl-L-tryptophan (Standard)
|
Bacterial
STAT
Reference Standards
|
Infection
Inflammation/Immunology
Cancer
|
|
Golotimod (Standard) is the analytical standard of Golotimod. This product is intended for research and analytical applications. Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .
|
- HY-W048911
-
- HY-W008379
-
- HY-W012705
-
- HY-P11764
-
- HY-P2682
-
|
|
MMP
|
Metabolic Disease
|
|
MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a matrix metalloproteinase-8 (MMP-8) fluorogenic substrate. MMP-8/MMP-26 Fluorogenic substrate can be used for the research of atherosclerosis, pulmonary fibrosis, and sepsis .
|
- HY-B1732R
-
|
DLPA (Standard); NSC 9959 (Standard)
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
DL-3-Phenylalanine (Standard) is the analytical standard of DL-3-Phenylalanine. This product is intended for research and analytical applications. DL-3-Phenylalanine is a phenylalanine derivative .
|
- HY-W012003
-
- HY-138126
-
|
|
Peptides
|
Others
|
|
Dansyl-Tyr-Val-Gly is a substrate of peptidylglycine monooxygenase (PHM), with a KD of 22 μM for PHM. Dansyl-Tyr-Val-Gly can be used to investigate the catalytic mechanism, kinetics and inactivation characteristics of PHM .
|
- HY-N0473A
-
- HY-W011004
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-4-Amino-5-(((S)-1-(((S)-1-carboxy-2-phenylethyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-5-oxopentanoic acid is a phenylalanine derivative .
|
- HY-W026894
-
- HY-W038703
-
- HY-W015230
-
- HY-W011892
-
- HY-W111226
-
|
|
Amyloid-β
Amino Acid Derivatives
|
Cardiovascular Disease
Neurological Disease
|
|
Fmoc-His (3-Me)-OH is a histidine derivative with a methylated imidazole group. Fmoc-His (3-Me)-OH can be used for the synthesis of the chemically modified tripeptide His (3-methyl)-Arg-Trp (H (3-Me)-RW). Fmoc-His (3-Me)-OH serves as a resin in Fmoc solid-phase synthesis for the generation of the His-(3-Me)-Gly-Lys peptide. Fmoc-His (3-Me)-OH is a building block for the synthesis of NAHIS02-(p-Met). Fmoc-His (3-Me)-OH can be applied in research related to Alzheimer's disease .
|
- HY-W008140
-
- HY-P10005A
-
- HY-W141907
-
- HY-W014259
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a Glycine (HY-Y0966) derivative . (S)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
- HY-W016342
-
- HY-W141885
-
- HY-W013162
-
- HY-W011713R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
(4-Aminobenzoyl)-L-glutamic acid (Standard) is the analytical standard of (4-Aminobenzoyl)-L-glutamic acid. This product is intended for research and analytical applications. (4-Aminobenzoyl)-L-glutamic acid is a glutamic acid derivative .
|
- HY-Y1167
-
- HY-W048217
-
- HY-W013185
-
- HY-P10064
-
|
|
Peptides
|
Others
|
|
Akt Substrate (Akt/SKG substrate) is a 7 amino acid synthetic peptide suitable as a substrate for Akt .
|
- HY-W013048
-
- HY-W018717
-
- HY-P11578A
-
|
|
Peptides
|
Metabolic Disease
|
|
CKGGRAKDC (linear) TFA is an adipose tissue homing peptide. CKGGRAKDC (linear) TFA binds to vasculature-enriched prohibitin in adipose tissue to enable selective tissue targeting. CKGGRAKDC (linear) TFA can be used to selective delivery of cargos to adipose tissues .
|
- HY-W007986
-
- HY-113014
-
- HY-W041867
-
- HY-W007931
-
- HY-W010997
-
- HY-W101772
-
- HY-W012485R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
H-D-Phe(4-Cl)-OH (Standard) is the analytical standard of H-D-Phe(4-Cl)-OH. This product is intended for research and analytical applications. H-D-Phe(4-Cl)-OH is a phenylalanine derivative .
|
- HY-W011606
-
- HY-66026
-
- HY-W010732
-
- HY-79676
-
- HY-W002236
-
- HY-W029652
-
- HY-W010931
-
- HY-W041991
-
- HY-W101935
-
|
N-Boc-D-arginine hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
N-Boc-D-Arg hydrochloride (N-Boc-D-arginine hydrochloride) is an amino acid derivative with a Boc protecting group, which can be used to synthesize desmopressin with the effects of improving nocturia, urinary incontinence and enuresis .
|
- HY-W040734
-
- HY-134852
-
- HY-W140881
-
- HY-139006
-
|
|
TRP Channel
|
Neurological Disease
|
|
N-oleoyl-glutamine is a PM20D1-regulated N-acyl amino acids (NAAs). N-oleoyl-glutamine is a transient receptor potential (TRP) antagonist .
|
- HY-W010974
-
- HY-41257A
-
- HY-W025811
-
- HY-W009322
-
- HY-W005913
-
- HY-W141881
-
|
|
Environmental Pollutants
Biochemical Assay Reagents
HSV
|
Infection
|
|
N-lauroylsarcosine is an anionic surfactant. N-lauroylsarcosine has antiviral activity against HSV-2 strain 333 and HSV-1 strain F. N-lauroylsarcosine synergistically increases skin permeability with 25-50% ethanol. N-lauroylsarcosine can be used to study HSV-2 infection .
|
- HY-Z0424
-
|
Methyl (2S)-2-(tert-butoxycarbonylamino)-3-iodopropanoate; Methyl (S)-2-[(tert-butoxycarbonyl)amino]-3-iodopropanoate
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-[(tert-Butoxycarbonyl)amino]-3-iodopropionic acid methyl ester is an alanine derivative .
|
- HY-79106
-
|
[1,1'-Biphenyl]-4-propanoic acid, α-amino-, (S)-; 4-Biphenylyl-L-alanine; 4-Phenyl-L-phenylalanine; Biphenylalanine
|
Amino Acid Derivatives
|
Others
|
|
L-Biphenylalanine is a phenylalanine derivative .
|
- HY-W010386
-
- HY-W022227
-
- HY-W011081
-
- HY-79775
-
- HY-W419374
-
|
|
Amino Acid Derivatives
|
Others
|
|
ivDde-Lys(Fmoc)-OH is a derivative of amino acid with protecting groups. ivDde-Lys(Fmoc)-OH can be used for peptide synthesis .
|
- HY-P11637
-
|
|
Fluorescent Dye
|
Neurological Disease
|
|
Mitochondrial-targeted peptide BP19 is a fluorescent probe for the selective measurement of labile iron in the mitochondriairon. Mitochondrial-targeted peptide BP19 exhibits iron-selective sensing activity with mitochondrial accumulation, reduced fluorescence in iron-loaded cells, and fluorescence reinstatement upon iron chelation. Mitochondrial-targeted peptide BP19 evaluates mitochondrial labile iron levels in cultured fibroblasts with Friedreich's ataxia .
|
- HY-W007618
-
- HY-P10768B
-
|
|
PACAP Receptor
|
Inflammation/Immunology
|
|
Ro 25-1553 acetate is a selective VIP2 receptor (VPAC2 receptor) agonist. Ro 25-1553 acetate exhibits bronchodilatory effects on tracheal smooth muscle contractions induced by nerve stimulation or Carbachol (HY-B1208). Ro 25-1553 acetate produces a superimposed effect when combined with Formoterol and Salmeterol (HY-14302). Ro 25-1553 acetate can be used for the study of bronchoconstriction .
|
- HY-Z0711
-
- HY-Y1394
-
- HY-W050493
-
- HY-W040801
-
- HY-W042010
-
- HY-P1544A
-
|
|
Calcium Channel
PKA
Endogenous Metabolite
Adenylate Cyclase
|
Neurological Disease
Metabolic Disease
|
|
Cerebellin TFA is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation. Cerebellin TFA stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway. Cerebellin TFA reduces insulin secretion from pancreatic islets under high-glucose conditions. Cerebellin TFA also regulates synaptic structure formation and controls catecholamine secretion in peripheral tissues. Cerebellin TFA can be used in neurological research .
|
- HY-W017150
-
- HY-P10945B
-
|
|
Radionuclide-Drug Conjugates (RDCs)
FAP
|
Cancer
|
|
Cys-FAP targeting peptide for FXX489 TFA is the polypeptide part of Unlabeled FXX489 (HY-P10944). Unlabeled FXX489 is a fibroblast activation protein (FAP)-targeting ligand .
|
- HY-W016749
-
- HY-W010794
-
- HY-W009110
-
- HY-W017254
-
- HY-W048209
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Lys(Palmitoyl)-OH is a Fmoc-amino acid with long alkyl chains. Fmoc-Lys(Palmitoyl)-OH can be used for peptide synthesis .
|
- HY-N7403
-
- HY-W009911
-
- HY-P11647
-
|
|
Complement System
|
Cancer
|
|
RPARPAR is a CendR tumor-penetrating peptide. RPARPAR directly binds to the NRP-1 and NRP-2 receptors on the surface of tumor cells, triggering cellular internalization, vascular extravasation, and penetration into tumor tissues. RPARPAR serves as an efficient ligand for targeting nanocarriers to NRP-1-positive tumors. RPARPAR is applicable in research on tumor targeting and drug delivery .
|
- HY-W010499
-
|
|
Biochemical Assay Reagents
|
Others
|
|
H-D-Homoser-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-79404
-
|
L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl- (9CI); (S)-2-(tert-Butoxycarbonylamino)-4,4-dimethylpentanoic acid
|
Amino Acid Derivatives
|
Others
|
|
N-(Tert-Butoxycarbonyl)-L-neopentylglycine is a Glycine (HY-Y0966) derivative .
|
- HY-W011155
-
- HY-W014405
-
- HY-59121
-
- HY-W013870
-
- HY-W005143
-
- HY-W012098
-
- HY-W010930
-
|
|
Amino Acid Derivatives
|
Others
|
|
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-chlorophenyl)propanoic acid is a phenylalanine derivative .
|
- HY-P5107A
-
|
LMWP acetate; TDSP5 acetate
|
VEGFR
|
Cancer
|
|
Low molecular weight protamine acetate (LMWP acetate;TDSP5 acetate) is a truncated arginine-rich protamine peptide, which also acts as an antidote for heparin/low molecular weight heparin and a cell-penetrating delivery vector. Low molecular weight protamine acetate neutralizes heparin-induced anticoagulant activities, including aPTT, anti-Xa and anti-IIa activities. Low molecular weight protamine acetate translocates across mammalian cell membranes, delivers conjugated impermeable molecules through tumor tissues, enhances the skin permeability of conjugated epidermal growth factor, and accelerates wound healing when conjugated with epidermal growth factor. Low molecular weight protamine acetate retains the in vitro cell proliferation activity of conjugated EGF, and also enables site-specific conjugation with peptides or proteins via genetic recombination. Low molecular weight protamine acetate can be used in studies related to colon cancer, skin wounds and diabetic skin wounds .
|
- HY-W090626
-
- HY-W007720
-
- HY-W100942
-
- HY-W141946
-
- HY-120791A
-
|
L-Lysyl-L-lysine trihydrochloride
|
Drug Intermediate
|
Others
|
|
Lysyllysine (L-Lysyl-L-lysine) trihydrochloride is a dipeptide composed of two L-lysine amino acids linked together. Lysyllysine trihydrochloride is often used as an enzyme cleavage linker for connecting bioactive peptides, or as a component of more complex antibacterial agents .
|
- HY-W007766
-
- HY-W010249
-
- HY-W010714
-
- HY-W011701
-
- HY-Y1636
-
- HY-W009631
-
- HY-W042000
-
- HY-W022447
-
- HY-W013305
-
- HY-I0377
-
- HY-P11797
-
|
|
Transmembrane Glycoprotein
|
Cardiovascular Disease
|
|
EP9 is a 7-amino acid peptide targeting CD63. EP9 binds specifically to the extracellular region of CD63, including a groove in the large extracellular loop (EC2) or the extracellular end of CD63’s central cavity, triggering endocytosis of decorated nanoemulsions/liposomes into cells. EP9 promotes cellular uptake of decorated nanoemulsions/liposomes into activated cardiac fibroblasts and epicardial stromal cells via caveolae and/or clathrin-coated pits. EP9 can be used for the research of myocardial infarction, cardiac fibrosis .
|
- HY-W142133
-
- HY-W013118
-
- HY-P11639
-
|
|
Biochemical Assay Reagents
|
Others
|
|
ppTG21 is an endosomolytic agent and inducer. ppTG21 can facilitate endosomal escape of Cas9-2lig-1NLS and Cas9-ASGPrL ribonucleoproteins (RNPs) to enable receptor-facilitated, cell-type specific gene editing in cancer cells without electroporation or transfection reagents. ppTG21 can be used for the research of gene editing .
|
- HY-W011458
-
|
|
Amino Acid Derivatives
|
Others
|
|
3,5-Dinitro-L-tyrosine sodium is a tyrosine derivative. 3,5-Dinitro-L-tyrosine sodium as artificial substrate, has zero activity relative to tyrosine as a substrate for tyrosine aminotransferase .
|
- HY-W011391A
-
- HY-W010156
-
- HY-79648
-
- HY-W141879
-
- HY-W048199
-
- HY-W015340
-
- HY-W010837
-
- HY-W011983
-
- HY-P11773
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Integrin
|
Others
|
|
3P-RGD2 is a dimeric cyclic RGD (Arg-Gly-Asp) peptide. When radiolabeled with 99mTc, 3P-RGD2 serves as a selective radiotracer for integrin αvβ3. When radiolabeled with 99mTc, 3P-RGD2 enables single-photon emission computed tomography imaging of integrin αvβ3 .
|
- HY-W009320
-
- HY-W008386
-
- HY-W016424
-
- HY-W212029
-
- HY-W141810
-
|
H-Phe(4-NH2)-OH hydrochloride
|
Endogenous Metabolite
|
Others
|
|
4-Amino-L-phenylalanine (H-Phe(4-NH2)-OH) hydrochloride is an endogenous metabolite.
|
- HY-W055811
-
- HY-P11806
-
|
|
ADC Linker
|
Cancer
|
|
DLeu-DTyr-Gly-DTrp-Gly-DTyr-DTrp is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
- HY-79130
-
|
Benzeneacetic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (S)-; (S)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]phenylethanoic acid; (S)-N-Fmoc-α-phenylglycine; N-9-Fluorenylmethoxycarbonyl-L-phenylglycine
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-(S)-phenylglycine is a Glycine (HY-Y0966) derivative .
|
- HY-W010871
-
- HY-W012908
-
|
|
Biochemical Assay Reagents
|
Infection
Cancer
|
|
DL-Proline is a racemic mixture of D-Proline and L-Prolin. DL-Proline is a cyclic imino acid with a five-membered ring structure. DL-Proline is a key structural unit in peptide synthesis. DL-Proline can stabilize the β-turn conformation and affect the secondary structure of the peptide. DL-Proline has biological activities such as regulating peptide conformation and enhancing the stability of cyclic peptides. DL-Proline can be used to study diseases related to peptide structure and function, such as cancer and bacterial infection .
|
- HY-W005891
-
- HY-W012379
-
- HY-W141949
-
- HY-W012572A
-
|
|
Mitochondrial Metabolism
Bacterial
|
Infection
Metabolic Disease
|
|
D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu 2+) .
|
- HY-P11416
-
|
|
Integrin
|
Cardiovascular Disease
|
|
Ac-RGDS-NH2, a tetrapeptide, is an integrin antagonist. Ac-RGDS-NH2 competitively binds to the GPIIb/IIIa receptor (Ki = 4.2 μM), inhibiting the binding of fibrinogen to platelets and thereby effectively suppressing platelet aggregation. Ac-RGDS-NH2 can be used for research on thrombosis .
|
- HY-W018077
-
- HY-W142025
-
- HY-W011993
-
- HY-W008559
-
- HY-W141986
-
- HY-34663
-
|
(2R)-2-(tert-Butoxycarbonylamino)-2-phenylethanoic acid; (R)-2-((tert-Butoxycarbonyl)amino)-2-phenylacetic acid; (R)-2-[(tert-Butoxycarbonyl)amino]-2-phenylacetic acid
|
Amino Acid Derivatives
|
Others
|
|
(αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzeneacetic acid is a Glycine (HY-Y0966) derivative .
|
- HY-W002170
-
- HY-W013280
-
- HY-W010862
-
- HY-P3501A
-
|
NX-1207 TFA
|
Apoptosis
|
Cancer
|
|
Fexapotide (NX-1207) TFA induces apoptosis selectively, reducing prostate volume at a cellular level. Fexapotide can be used in lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) research .
|
- HY-W017202
-
- HY-79862
-
- HY-100047R
-
|
|
Taste Receptor
Reference Standards
|
Others
|
|
Nα,Nα-Bis(carboxymethyl)-L-lysine (Standard) is the analytical standard of Nα,Nα-Bis(carboxymethyl)-L-lysine (HY-100047). This product is intended for research and analytical applications. Nα,Nα-Bis(carboxymethyl)-L-lysine is a competitive inhibitor of bitter taste receptor 4, with an IC50 of 59 nM. Nα,Nα-Bis(carboxymethyl)-L-lysine can be used in bitter receptors related study .
|
- HY-W088097
-
- HY-P5750
-
|
|
Peptides
|
Neurological Disease
|
|
Hypertrehalosemic neuropeptide (Nauphoeta cinerea) is a neuropeptide in the adipokinetic hormone/red pigment-concentrating hormone (AKH/RPCH) family, and can stimulate the synthesis of trehalose .
|
- HY-W008269R
-
- HY-P11108A
-
|
|
NF-κB
Apoptosis
TNF Receptor
Caspase
|
Inflammation/Immunology
Cancer
|
|
RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (Kd = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 acetate induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 high TAMs. RP-182 acetate has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 acetate is used in pancreatic cancer and melanoma research .
|
- HY-W013864
-
- HY-W008869
-
- HY-W729138
-
|
|
ADC Linker
|
Others
|
|
Fmoc-D-homoArg(Et)2-OH (hydrochloride) is a Fmoc-protected derivative of D-Homoarginine (HArg) that renders peptides and proteins resistant to proteolysis by trypsin. Fmoc-D-homoArg(Et)2-OH (hydrochloride) can be used as a cleavable ADC linker to synthesize antibody-drug conjugates (ADCs) .
|
- HY-W005144
-
- HY-W091365
-
|
N-Boc-N'-xanthyl-L-asparagine
|
Amino Acid Derivatives
|
Others
|
|
Boc-Asn(Xan)-OH (N-Boc-N'-xanthyl-L-asparagine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize locust fat growth hormone .
|
- HY-I1044
-
- HY-I0115
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((S)-2-Cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid is a valine derivative .
|
- HY-Y1153
-
|
CarnoSyn; Ethyl 3-aminopropanoate hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
Ethyl 3-aminopropionate hydrochloride is an alanine derivative .
|
- HY-W053678
-
- HY-W002302
-
- HY-77801
-
- HY-W048332
-
- HY-W141779
-
- HY-W007706R
-
- HY-W010324
-
- HY-66025
-
- HY-W142171
-
- HY-P11781
-
|
|
Drug Derivative
|
Cancer
|
|
HW12 is a random peptide containing an N-terminal cysteine and is not an EGFR ligand. HW12 can serve as a control for GE11 (HY-P10128)-conjugated mixed micelles targeting EGFR. HW12 is applicable to pancreatic cancer-related research .
|
- HY-I0917
-
- HY-W003605
-
|
N-Boc-D-pyroglutamic acid ethyl ester
|
Biochemical Assay Reagents
|
Others
|
|
Boc-D-Pyr-Oet (N-Boc-D-pyroglutamic acid ethyl ester) is used as a biochemical assay reagent .
|
- HY-W016319
-
- HY-105305A
-
|
ABT-719 acetate; AP-214 acetate
|
Melanocortin Receptor
|
Endocrinology
|
|
Modimelanotide (ABT-719) acetate is an α-melanocyte-stimulating hormone analog. Modimelanotide acetate has high specific binding ability to melanocortin receptors (MCR1, 3, 4, 5). Modimelanotide acetate possesses anti-inflammatory and organ-protective effects. Modimelanotide acetate can be used in the research of diseases such as acute kidney injury .
|
- HY-60040
-
- HY-P60234A
-
|
|
Dipeptidyl Peptidase
GLP Receptor
|
Metabolic Disease
|
|
AGFAGDDAPR is a bioactive peptide that is a competitive and orally effective inhibitor of dipeptidyl peptidase-IV (DPP-IV). AGFAGDDAPR can enhance the level of GLP-1 in the body by inhibiting DPP-IV, thereby stimulating insulin secretion, improving β-cell function, and inhibiting abnormal proliferation of α-cells, exerting anti-diabetic effects. AGFAGDDAPR can be used for research on type 2 diabetes .
|
- HY-W008022
-
- HY-W016012
-
|
H-Glu-Glu-OH; Glutamyl-glutamic acid
|
Amino Acid Derivatives
|
Others
|
|
Glu-Glu is a glutamic acid derivative containing amino and carboxyl groups. Glu-Glu is an analogs of acidic tripeptide and can contribute to calcium absorption .
|
- HY-W009908
-
- HY-W006152
-
- HY-W010946
-
- HY-W043423
-
- HY-W050444
-
- HY-W011931
-
- HY-W032681
-
- HY-W009211
-
- HY-W419324
-
- HY-W011167
-
- HY-P3918
-
|
|
p38 MAPK
|
Others
|
|
EGF-R (661-681) T669 Peptide is a MAPK substrate that can used to measure MAPK catalytic activity .
|
- HY-78008
-
- HY-P11633
-
|
|
Autophagy
|
Neurological Disease
|
|
YLRPEGDW is an orally active sleep-promoting peptide. YLRPEGDW upregulates Autophagy-related genes, increase Autophagy activity. YLRPEGDW could improve Caffeine-induced sleep reduction .
|
- HY-W048708
-
- HY-19821
-
- HY-W051351
-
- HY-W014329
-
- HY-W024485
-
|
|
SARS-CoV
Drug Derivative
|
Infection
|
|
SARS-CoV-2-IN-86 (Compound 2734589) is SARS-CoV-2 methyltransferases nsp14 and nsp16 inhibitor, Andrographolide (HY-N0191) derivative. SARS-CoV-2-IN-86 has low toxicity, and according to toxicity analysis, the predicted LD50 is 700 mg/kg .
|
- HY-W019714
-
- HY-P5502A
-
|
|
Influenza Virus
MHC
|
Infection
Inflammation/Immunology
|
|
Influenza NP (311-325) TFA is an Influenza A nucleoprotein peptide. Influenza NP (311-325) TFA is a class II restricted epitope. Influenza NP (311-325) Influenza NP (311-325) TFA fused to OVA protein can be used for immunological response studies .
|
- HY-W013144
-
- HY-W104862
-
|
4-NH2-d-Phe
|
CXCR
|
Inflammation/Immunology
|
|
4-Amino-D-phenylalanine ([D-Phe(4-NH2)), a cyclic pentapeptide, inhibits CXCL12 binding to CXCR4 in FC131, with an IC50 of 0.1 μM .
|
- HY-W014168
-
- HY-W142092
-
|
|
Bacterial
Endogenous Metabolite
|
Others
|
|
N-Acetyl-DL-serine is a hydrophobic amino acid that is synthesized in the body and can be found as a free form or as a salt with malonate, phosphate, or acetate. N-Acetyl-DL-serine has antimicrobial activity against Bacillus cereus and Staphylococcus aureus. N-Acetyl-DL-serine has also been used for the immobilization of DNA fragments on solid surfaces and can be used for protein synthesis and optical detection of DNA strands .
|
- HY-W046071
-
|
|
Drug Intermediate
|
Others
|
|
N-Boc-trans-4-fluoro-L-proline is a non-natural amino acid substitute used to construct monoclonal antibodies that specifically target the seed conformation of tau protein .
|
- HY-W011354
-
- HY-W041986
-
- HY-77630
-
- HY-W141835
-
- HY-W013735
-
- HY-W013781
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Boc-Glu(OBzl)-OH (Compound 9) is a glutamic acid derivative commonly used in Boc SPPS. Glutamic acid residues increase the hydrophilicity of the polypeptide and play an important structural and receptor binding role .
|
- HY-W101377
-
- HY-Y1661
-
- HY-W048704
-
|
|
Amino Acid Derivatives
|
Others
|
|
N2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N6-((4-methoxyphenyl)diphenylmethyl)-L-lysine is a lysine derivative .
|
- HY-20897AR
-
- HY-W012967
-
- HY-W012850
-
- HY-W013622
-
- HY-W013407
-
|
|
Tyrosine Hydroxylase
Thyroid Hormone Receptor
|
Neurological Disease
|
|
α-Methyltyrosine methyl ester hydrochloride is an orally active and competitive tyrosine hydroxylase inhibitor. α-Methyltyrosine methyl ester hydrochloride can inhibit the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride causes kidney damage and urethral calculi in rats. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research .
|
- HY-I0109
-
- HY-W011000
-
- HY-115411A
-
|
|
NO Synthase
|
Others
|
|
L-Hydroxy arginine dihydrochloride is an intermediate in the catabolism of L-arginine, and is a substrate for NO synthase .
|
- HY-P11143A
-
|
|
Interleukin Related
Liposome
|
Cancer
|
|
IL4RPep-1 acetate is an interleukin-4 receptor (IL-4R) binding agent. IL4RPep-1 acetate preferentially binds to cells with high levels of IL-4R expression compared to those with low levels of expression. IL4RPep-1-labeled liposomes containing Doxorubicin (HY-15142A) are internalized by cells more efficiently. IL4RPep-1-labeled liposomes accumulate more effectively within H226 tumors .
|
- HY-Y0978
-
- HY-65000
-
- HY-78906
-
- HY-W040067
-
- HY-W098060
-
- HY-W011652
-
- HY-W010958
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-cyanophenyl)propanoic acid is a phenylalanine derivative .
|
- HY-W013239
-
- HY-W016427
-
- HY-W013108
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxycarbonyl)amino)phenyl)propanoic acid is a phenylalanine derivative .
|
- HY-W005388
-
- HY-W141858
-
|
Indoleacetylalanine; IAA-ala
|
Amino Acid Derivatives
|
Others
|
|
N-(3-Indolylacetyl)-L-alanine (Indoleacetylalanine) is an indoleacetylamino acid. N-(3-Indolylacetyl)-L-alanine appears to increase callus growth and reduces the ability of growths to differentiate into shoots of Phalaenopsis orchids .
|
- HY-113064
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .
|
- HY-W141963
-
- HY-W008326
-
- HY-76205R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid (Standard) is the analytical standard of 2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid. This product is intended for research and analytical applications. 2-(tert-butoxycarbonylamino)-3-phenylpropanoic acid is a phenylalanine derivative .
|
- HY-W010788
-
- HY-W142120
-
- HY-Y0533
-
|
L-Aspartic acid β-tert-butyl ester; β-tert-Butyl L-aspartate
|
Amino Acid Derivatives
|
Others
|
|
L-Aspartic acid 4-tert-butyl ester is an aspartic acid derivative .
|
- HY-W011137
-
|
|
Drug Derivative
|
Others
|
|
(S)-4-Nitrophenyl 4-amino-2-((tert-butoxycarbonyl)amino)-4-oxobutanoate is an asparagine derivative .
|
- HY-W048283
-
- HY-W010590
-
- HY-W050782
-
- HY-Y0749A
-
|
Glutamic acid, dimethyl ester, hydrochloride, D-
|
Amino Acid Derivatives
|
Others
|
|
Dimethyl D-glutamate hydrochloride is a glutamic acid derivative .
|
- HY-W011488
-
- HY-W016555
-
- HY-W092115
-
- HY-32687A
-
- HY-Y0920
-
- HY-77519
-
- HY-P11775
-
|
|
VEGFR
|
Cardiovascular Disease
|
|
Peptide HRH is a polypeptide that specifically binds to VEGF receptors. Peptide HRH inhibits VEGF-stimulated endothelial cell proliferation. Peptide HRH inhibits angiogenesis and suppresses corneal neovascularization. Peptide HRH can be used in anti-angiogenesis related studies .
|
- HY-W001210
-
- HY-P11280A
-
|
|
Melanocortin Receptor
|
Cancer
|
|
PRAME peptide (425-433) acetate is a proteasome-degraded peptide derived from the cancer-testis antigen PRAME (Preferentially Expressed Antigen in Melanoma). PRAME peptide (425-433) acetate is restricted by HLA-A*02:01 and can serve as a target for bispecific T cell engager therapy in the context of major histocompatibility complex I presentation. PRAME peptide (425-433) acetate shows application potential in various malignant tumors and is widely suitable for research related to solid tumors, melanoma, ovarian cancer, endometrial cancer, and lung cancer (including lung adenocarcinoma and lung squamous cell carcinoma). PRAME peptide (425-433) acetate can be used to explore disease of triple-negative breast cancer, diffuse large B-cell lymphoma, and head and neck squamous cell carcinoma .
|
- HY-W016339
-
- HY-W002416
-
- HY-W130212
-
|
|
Amino Acid Derivatives
|
Others
|
|
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-(trifluoromethyl)phenyl)propanoic acid is a phenylalanine derivative .
|
- HY-W011201
-
- HY-W013154
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Tic-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bioactive peptide mimetics, such as the biotinylated derivative of the opioid receptor antagonist TIPP .
|
- HY-P3343
-
|
|
Estrogen Receptor/ERR
|
Endocrinology
|
|
hFSH-β-(33-53) is a polypeptide corresponding to residues 33-53 of hFSH-β, and also a follicle-stimulating hormone (FSH) antagonist. hFSH-β-(33-53) stimulates basal estradiol synthesis in cells. hFSH-β-(33-53) prolongs vaginal estrus in mice with normal estrous cycles .
|
- HY-W010745
-
- HY-W050494
-
- HY-W041985
-
- HY-W008389
-
- HY-B1732
-
- HY-201283A
-
- HY-W011374
-
- HY-W053702
-
- HY-P10704A
-
|
|
Integrin
|
Cancer
|
|
C16Y acetate is a short peptide and an inhibitor of integrins αvβ3 and α5β1. C16Y acetate acts on the cell membrane and exerts its anticancer activity by inhibiting angiogenesis .
|
- HY-W142030
-
- HY-P11768
-
|
|
Bombesin Receptor
|
Cancer
|
|
AMBA is a gastrin-releasing peptide receptor (GRPR, BB2, BRS-2) ligand. AMBA binds to GRPR with high specificity and high affinity, and undergoes receptor-mediated endocytosis, which retains the conjugated radiometal in target cells. AMBA is applicable for the research of prostate cancer .
|
- HY-W002169
-
- HY-W013850
-
- HY-W015897
-
- HY-W090421
-
- HY-43973
-
- HY-W011903
-
- HY-W011703
-
- HY-W003499
-
- HY-60264
-
- HY-P11781B
-
|
|
Drug Derivative
|
Cancer
|
|
Cys-HW12 TFA is a random peptide containing an N-terminal cysteine and derivative of HW12 (HY-P11781). Cys-HW12 TFA can be coupled via the thiol group of Cys. Cys-HW12 TFA can serve as a control for GE11 (HY-P10128)-conjugated mixed micelles targeting EGFR, and also functions as a cytotoxic agent, cellular uptake inhibitor, and tumor growth inhibitor. Cys-HW12 TFA is applicable to pancreatic cancer-related research .
|
- HY-W142115
-
- HY-W014599
-
- HY-124081
-
|
|
Apoptosis
|
Metabolic Disease
|
|
N-Oleoyl-L-Serine is an endogenous amide of long-chain fatty acids with ethanolamine (N-acyl amides). N-Oleoyl-L-Serine is a lipid regulator of bone remodeling and stimulates osteoclast apoptosis. N-Oleoyl-L-Serine can be used for antiosteoporotic drug discovery development .
|
- HY-W141788
-
|
|
Bacterial
|
Infection
|
|
N-Butyryl-DL-homocysteine thiolactone is an N-acyl homoserine lactone (AHL) analogue. AHLs are potent inhibitors of biofilm formation and virulence factors, and has been used for degrading microbial communities, reducing bacterial pathogenicity .
|
- HY-W011278
-
- HY-W008544
-
- HY-W015450R
-
|
D-Alanyl-D-alanine (Standard); H-D-Ala-D-Ala-OH (Standard)
|
Reference Standards
Endogenous Metabolite
|
Others
|
|
D-Ala-D-Ala (Standard) is the analytical standard of D-Ala-D-Ala. This product is intended for research and analytical applications. D-Ala-D-Ala is a bacterial endogenous metabolite. D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase .
|
- HY-W041862
-
- HY-P11812
-
- HY-W011084
-
- HY-W010775
-
- HY-W003991
-
- HY-W008113
-
- HY-P11769
-
|
|
CGRP Receptor
|
Cancer
|
|
RM2 is a GRPr antagonist. RM2 selectively binds to GRPr, blocks agonist-induced receptor internalization, and inhibits agonist-triggered intracellular calcium mobilization. RM2 can be used in studies related to prostate cancer .
|
- HY-W009502
-
- HY-W051299
-
- HY-I1061
-
- HY-P10587B
-
|
JNJ-77242113 (hydrochloride); JNJ-2113 (hydrochloride); PN-235 (hydrochloride)
|
Interleukin Related
STAT
IFNAR
|
Inflammation/Immunology
|
|
Icotrokinra (JNJ-77242113) hydrochloride is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra hydrochloride inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC50=5.6 pM) and inhibits IL-23-induced interferon IFN-γ production in NK cells with an IC50 of 18.4 pM. Icotrokinra hydrochloride exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra hydrochloride can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease .
|
- HY-W022223
-
- HY-126809
-
|
Bz-PFR-pNA
|
Kallikrein
Ser/Thr Protease
Parasite
Factor Xa
|
Others
|
|
Bz-Pro-Phe-Arg-pNA (Bz-PFR-pNA) is a chromogenic peptide substrate for plasma and glandular Kallikrein, cysteine proteinase (Cruzipain) and Trypsin. Bz-Pro-Phe-Arg-pNA can be used in Factor XII assay .
|
- HY-W035886
-
- HY-I0630
-
- HY-W013207
-
- HY-34519
-
|
L-Tyrosine tert-butyl ester; tert-Butyl (S)-2-amino-3-(4-hydroxyphenyl)propanoate; tert-Butyl L-tyrosinate
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid tert-butyl ester is a tyrosine derivative .
|
- HY-W012255
-
- HY-78824
-
|
|
Peptides
|
Others
|
|
Glycine, N-[(1,1-dimethylethoxy)carbonyl]thio-L-phenylalanyl-, methyl ester (compound 3b) is a polypeptide compound containing sulfamide, can be used to synthesis peptide-agent coupling compounds .
|
- HY-W010895
-
- HY-59140
-
- HY-W009337
-
- HY-P11776
-
- HY-W012220
-
- HY-W008486
-
- HY-W008522
-
- HY-W010976
-
- HY-139093
-
|
APAP-Cys
|
Drug Derivative
|
Others
|
|
Paracetamol-cysteine is a Paracetamol (HY-66005)-cysteine Paracetamol protein (HY-139093A) adduct (PPA), which is formed when Paracetamol is oxidized to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) .
|
- HY-W010209R
-
- HY-W013726
-
|
|
Biochemical Assay Reagents
Amino Acid Derivatives
|
Others
|
|
Fmoc-Phe(4-Br)-OH is a widely used amino acid derivative. Fmoc-Phe(4-Br)-OH can be used in the synthesis of compounds and for the study of protein-protein interactions and the development of biomaterials. Fmoc-Phe(4-Br)-OH can be used in peptide synthesis to incorporate phenylalanine bromide into the peptide chain .
|
- HY-W102709
-
- HY-W012451
-
- HY-W018062
-
- HY-W012139
-
- HY-W025807
-
- HY-W035914
-
- HY-W141955
-
- HY-76962
-
- HY-W129585
-
- HY-W013923
-
- HY-W092110
-
- HY-W013097
-
|
|
Amino Acid Derivatives
|
Others
|
|
Boc-Arg(di-Z)-OH can be used for the synthesis of amino acid. Boc-Arg(di-Z)-OH can be used for the research of inhibitors for processing proteinases. Boc-Arg(di-Z)-OH is coupled via the mixed anhydride (MA) with HGlu(OBzl)-Lys(Z)-Arg(Z,Z)-CH2Cl .
|
- HY-W130397
-
|
|
Drug Derivative
|
Others
|
|
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-4-oxo-4-(tritylamino)butanoic acid is an asparagine derivative .
|
- HY-W142156
-
- HY-Y0735
-
- HY-41060
-
- HY-W022536
-
- HY-W002173
-
- HY-W011020
-
- HY-W141817
-
- HY-W018650
-
- HY-W012137
-
- HY-W141944
-
- HY-W021790
-
- HY-W269700
-
|
L-Isoleucyl-L-leucine
|
Drug Intermediate
|
Neurological Disease
|
|
Ile-Leu-OH (L-Isoleucyl-L-leucine) is a hydrophobic dipeptide fragment and is a component of the neurotensin C-terminal heptapeptide Pro-Arg-Arg-Pro-Tyr-Ile-LeuOH .
|
- HY-W724905
-
|
γ-Glu-Ile; H-γ-Glu-Ile-OH
|
Amino Acid Derivatives
|
Others
|
|
gamma-Glutamylisoleucine (γ-Glu-Ile; H-γ-Glu-Ile-OH) is a dipeptide composed of γ-glutamic acid and isoleucine, and it is also a degradation product of macromolecular proteins after proteolysis .
|
- HY-W014048
-
- HY-W010758
-
- HY-34470
-
- HY-W099255
-
- HY-W011199
-
- HY-W008867
-
- HY-W011915
-
- HY-W041999
-
- HY-W097163
-
- HY-79708A
-
|
Methyl (R)-2-amino-3-methylbutanoate hydrochloride; Methyl D-valinate hydrochloride; NSC 22921
|
Amino Acid Derivatives
|
Others
|
|
O-Methyl-D-valine (hydrochloride) is a valine derivative .
|
- HY-W053550
-
- HY-W008731
-
- HY-W014692
-
|
N-t-Boc-amino-D-alanine; Boc-D-Dap-OH
|
Amino Acid Derivatives
|
Others
|
|
Boc-D-2,3-diaminopropionic acid (N-t-Boc-amino-D-alanine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize a potent NMDA receptor glycine site agonist with GluN2 subunit-specific activity .
|
- HY-W014406
-
- HY-W010724
-
- HY-W040333
-
- HY-100838
-
|
L-CCG III
|
EAAT
|
Neurological Disease
|
|
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na +-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes .
|
- HY-W004110
-
- HY-W142093
-
- HY-W010249R
-
- HY-77584
-
|
|
Amino Acid Derivatives
|
Others
|
|
(2S,4R)-1-((S)-2-((tert-butoxycarbonyl)amino)non-8-enoyl)-4-hydroxypyrrolidine-2-carboxylic acid is a proline derivative .
|
- HY-33259
-
- HY-W008261
-
- HY-134450
-
- HY-W011443
-
- HY-W077219
-
|
Boc-Arg(Mtr)-OH
|
Amino Acid Derivatives
|
Others
|
|
Boc-L-Arg(Mtr)-OH (Boc-Arg(Mtr)-OH) is an amino acid derivative with a Boc protecting group, which can be used to synthesize peptides with antithrombotic activity .
|
- HY-22002
-
- HY-W291634
-
- HY-W022137
-
- HY-P3730A
-
|
|
CDK
|
Cancer
|
|
Cdk2/Cyclin Inhibitory Peptide I (Tat-LFG) acetate, a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner .
|
- HY-42069
-
- HY-W010880
-
- HY-W111209
-
- HY-Y0754
-
- HY-W345421
-
- HY-W141789
-
- HY-W008308
-
- HY-P11277
-
|
|
Peptides
|
Cancer
|
|
Pocuvotide satetraxetan is an anticancer agent. Pocuvotide satetraxetan labeled with 177Lu can be used for imaging diagnosis .
|
- HY-79128
-
- HY-W141831
-
- HY-W141863
-
- HY-30167A
-
|
(S)-2-Amino-3-methyl-butanol
|
Biochemical Assay Reagents
|
Others
|
|
L-Valinol ((S)-2-Amino-3-methyl-butanol) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W109214
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-L-Dap(Boc,Me)-OH is a derivative of amino acid with protecting groups. Fmoc-L-Dap(Boc,Me)-OH can be used for synthesis of diaminopropionic acid containing peptide .
|
- HY-W018741
-
- HY-P2278A
-
- HY-W128408
-
- HY-W011033
-
- HY-134161
-
|
|
Peptides
|
Metabolic Disease
|
|
DL-α-(Difluoromethyl)arginine is an potent, enzyme-activated and irreversible arginine decarboxylases inhibitor. DL-α-(Difluoromethyl)arginine blocks the arginine decarboxylase activity of E.coli and Pseudomonas aeruginosa in vivo .
|
- HY-134449
-
- HY-W041987
-
- HY-42354
-
|
(R)-2-Cyclohexyl-2-aminoethanoic acid; D-Cyclohexylglycine; D-α-Aminocyclohexaneacetic acid
|
Amino Acid Derivatives
|
Others
|
|
D-α-Aminocyclohexylacetic acid is a Glycine (HY-Y0966) derivative .
|
- HY-W041989
-
- HY-W142163
-
- HY-W015926
-
- HY-W048718
-
|
Fmoc-D-α-t-butylglycine
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Tle-OH (Fmoc-D-α-t-butylglycine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize chelating agents that can form a single stereoisomer-enriched form after coordination with metal centers .
|
- HY-P10046
-
|
|
Vasopressin Receptor
|
Metabolic Disease
|
|
[Deamino-Pen1,Val4,D-Arg8]-vasopressin (AVP-A) is an arginine-vasopressin (AVP) antagonist. AVP-A can significantly lower plasma aldosterone concentration in rats. AVP-A can be used for the research of the growth and steroidogenic capacity of rat adrenal zona glomerulosa .
|
- HY-W015533
-
- HY-W141927
-
- HY-W013780
-
- HY-W141948
-
- HY-W013460
-
- HY-W016363
-
- HY-W041982
-
- HY-W012883
-
- HY-I0519
-
- HY-N7403R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
3-Phenylpropionylglycine (Standard) is the analytical standard of 3-Phenylpropionylglycine. This product is intended for research and analytical applications. 3-Phenylpropionylglycine is a Glycine (HY-Y0966) derivative .
|
- HY-W008977
-
- HY-W745139
-
- HY-W012138
-
- HY-P11702
-
|
|
Bacterial
|
Others
|
|
f-MFFINTLTL is a formylated nonapeptide and a natural ligand from mitochondria or bacteria. f-MFFINTLTL serves as a tool chemical stimulant for the specific activation of sensory neurons expressing the specific vomeronasal receptor (V2rf2) .
|
- HY-134935
-
- HY-W009215
-
|
L-Met-L-Ala-L-Ser
|
Amino Acid Derivatives
|
Others
|
|
H-Met-Ala-Ser-OH (L-Met-L-Ala-L-Ser) is a tripeptide. H-Met-Ala-Ser-OH can act as a formyl receptor .
|
- HY-W009008
-
- HY-W010770
-
- HY-W022471
-
- HY-W013182
-
- HY-P10036
-
|
|
PKG
|
Others
|
|
G-Subtide is a G-substrate peptide localized in Purkinje cells of the cerebellum. G-Subtide has little activity distinct from background and is a preferentially phosphorylated peptide substrate of recombinant PfPKG2 protein .
|
- HY-W010850
-
- HY-P10055
-
|
PSMA-1
|
PSMA
|
Cancer
|
|
PSMA-1 is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells. PSMA-1 is selected and polyarginine sequences R6 or R9 were added at the C terminus to generate the CTPs. FITC labeling of the peptide with an aminohexanoic acid (Ahx) linker at the N terminus produced FITC-PSMA-1，to track PSMA binding on PCa cells .
|
- HY-W018528
-
- HY-W013201
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-1-((S)-2-Amino-4-methylpentanoyl)pyrrolidine-2-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:1) is a proline derivative .
|
- HY-W141880
-
- HY-W013083
-
- HY-W008530
-
- HY-W010719
-
- HY-W010782
-
- HY-114118C
-
|
|
GLP Receptor
Insulin Receptor
α-synuclein
Apoptosis
p38 MAPK
Autophagy
Bcl-2 Family
|
Neurological Disease
Metabolic Disease
Cancer
|
|
Semaglutide sodium is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide sodium promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide sodium also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide sodium has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide sodium can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .
|
- HY-W016996
-
- HY-W016731
-
- HY-W013745
-
- HY-W008178
-
- HY-Y0749
-
|
Dimethyl (S)-2-aminopentanedioate hydrochloride; Dimethyl L-glutamate hydrochloride; Dimethyl glutamate hydrochloride
|
Amino Acid Derivatives
|
Others
|
|
Glutamic acid dimethyl ester hydrochloride is a glutamic acid derivative .
|
- HY-W013322
-
- HY-W018847
-
|
|
Drug Intermediate
|
Others
|
|
Fmoc-(R)-2-(pentenyl)Ala-OH is a peptide intermediate and can be used in peptide synthesis.
|
- HY-42757B
-
- HY-W109513
-
|
|
Amino Acid Derivatives
|
Inflammation/Immunology
|
|
Boc-Lys(Z)-OH (DCHA) is a involves in synthesis thymosin β4, βg and β6 fragments, and increases E-rosette forming capacity in Lupus Nephritis model. Boc-Lys(Z)-OH (DCHA) involves in synthesis Boc-Lyz-OCH3 and acts as a reagent of peptidyl thrombin inhibitors production .
|
- HY-W057434
-
- HY-W016423
-
- HY-W089292
-
- HY-W142039
-
- HY-W020826
-
- HY-W013293R
-
- HY-41912A
-
- HY-W004063
-
- HY-W048205
-
|
|
Amino Acid Derivatives
|
Others
|
|
N6-Diazo-L-Fmoc-lysine is an active compand and can be used in a variety of chemical studies. N6-Diazo-L-Fmoc-lysine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
- HY-P11767
-
|
|
Ferroptosis
Parasite
|
Infection
|
|
NCR247 is a defensin-like nodule cysteine-rich (NCR) peptide and heme chelator. NCR247 induces iron starvation responses in Sinorhizobium meliloti and Medicago truncatula, and supports nitrogenase activity. NCR247 can be used in research related to periodontal disease and toxoplasmosis .
|
- HY-P4558A
-
|
|
Dipeptidyl Peptidase
|
Others
|
|
H-Pro-Lys-OH TFA is a dipeptide containing proline and lysine, which can serve as a substrate for iminodipeptidase (prolinase). H-Pro-Lys-OH TFA can also be used for the synthesis of polypeptides .
|
- HY-W040705R
-
|
N-Methylanthranilic acid (Standard)
|
Drug Metabolite
Reference Standards
|
Others
|
|
2-(Methylamino)benzoic acid (Standard) is the analytical standard of 2-(Methylamino)benzoic acid. This product is intended for research and analytical applications. 2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver[1].
|
- HY-33228
-
- HY-122811
-
- HY-W003605A
-
|
|
Amino Acid Derivatives
|
Others
|
|
1-Boc-DL-Pyroglutamic acid ethyl ester is a Boc-protected Pyroglutamic acid derivative, can be used for the synthesis of agents or other compounds .
|
- HY-119543
-
|
|
Amino Acid Derivatives
|
Others
|
|
O-Succinyl-L-homoserine is a homoserine derivative. O-Succinyl-L-homoserine is an intermediate in the biosynthesis of methionine in Escherichia coli and Salmonella typhimurium .
|
- HY-W010811
-
- HY-W014700
-
|
H-Gly-Glu-OH; Gly-Glu
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of AChE content and activity. Glycyl-L-glutamic acid doesn’t act directly on AChE synthesis, and may prevent preganglionic neuronal degeneration .
|
- HY-W010982
-
- HY-W009258
-
- HY-W012873
-
- HY-79877
-
- HY-137416
-
- HY-W013779
-
- HY-Y1169
-
|
4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate; Fmoc-L-Asp(OtBu)-OH
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is an aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis .
|
- HY-W012921R
-
|
|
Amino Acid Derivatives
Reference Standards
|
Others
|
|
(R)-Pyrrolidine-2-carboxamide (Standard) is the analytical standard of (R)-Pyrrolidine-2-carboxamide. This product is intended for research and analytical applications. (R)-Pyrrolidine-2-carboxamide is a proline derivative .
|
- HY-W106325
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-N-Me-D-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize somatostatin-dopamine chimeric analogs .
|
- HY-W009734
-
- HY-W013190
-
- HY-171746
-
|
4,5,6,7-Tetrafluoro-L-tryptophan
|
nAChR
|
Neurological Disease
|
|
F4-Trp (4,5,6,7-Tetrafluoro-L-tryptophan) is a ligand targeting the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR). F4-Trp is promising for research of neurotransmission, addiction, and related diseases, such as neurological diseases .
|
- HY-P11630
-
|
|
Bacterial
|
Cardiovascular Disease
Infection
|
|
ZM-804 is a cationic α-helix antimicrobial peptide. ZM-804 targets bacterial cell membranes. ZM-804 demonstrates antimicrobial activity and prevents the infection of tomato plants by Pst DC3000. ZM-804 inhibits the growth of B. subtilis and E. coli (the same MICs of 41.10 μg/mL). ZM-804 exhibits low hemolytic activity .
|
- HY-W009023
-
- HY-79123
-
- HY-W036160
-
|
|
Amino Acid Derivatives
|
Others
|
|
N-Fmoc-O-ethyl-L-homoserine is an homoserine derivative, can be used in cyclic peptide compounds synthesis, as a reducing reagent .
|
- HY-W142151
-
- HY-W099578
-
|
Palmitoyl-Glu(OSu)-OBut
|
Drug Intermediate
|
Others
|
|
Pal-Glu(OSu)-OtBu (Palmitoyl-Glu(OSu)-OBut) is an important intermediate in the synthesis process of Liraglutide (HY-P0014) .
|
- HY-W002449
-
- HY-40118
-
|
Boc-L-proline methyl ester
|
Liposome
|
Others
|
|
Boc-Pro-OMe (Boc-L-proline methyl ester) is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.
|
- HY-W048727
-
- HY-W037443
-
- HY-128675
-
- HY-115387
-
- HY-P10054
-
|
|
Peptides
|
Others
|
|
SGKtide is used as an SGK(Serum and glucocorticoid-inducible kinase) substrate .
|
- HY-W008549
-
- HY-W052246
-
- HY-W042007
-
- HY-P11180A
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Clavanin A acetate is a peptide Antibiotic and membrane permeabilizer. Clavanin A acetate permeabilizes cytoplasmic membranes and unilamellar lipid bilayers, and dissipates membrane potential. Clavanin A acetate inserts into phospholipid monolayers via hydrophobic interactions under physiologically relevant surface pressures. Clavanin A acetate exhibits antibacterial activity against Micrococcus flavus. Clavanin A acetate can be used in studies related to Micrococcus flavus infection .
|
- HY-W033132
-
- HY-W004114
-
- HY-137784
-
|
|
Fluorescent Dye
|
Others
|
|
Boc-Val-Pro-Arg-AMC hydrochloride is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
|
- HY-W008061
-
- HY-W010785
-
- HY-77026
-
- HY-111592
-
- HY-W007052
-
- HY-P11781A
-
|
|
Drug Derivative
|
Cancer
|
|
Cys-HW12 is a random peptide containing an N-terminal cysteine. Cys-HW12 can be coupled via the thiol group of Cys. Cys-HW12 can serve as a control for GE11 (HY-P10128)-conjugated mixed micelles targeting EGFR, and also functions as a cytotoxic agent, cellular uptake inhibitor, and tumor growth inhibitor. Cys-HW12 is applicable to pancreatic cancer-related research .
|
- HY-W017551
-
- HY-W051093
-
- HY-P11647A
-
|
|
Complement System
|
Cancer
|
|
RPARPAR acetate is a CendR tumor-penetrating peptide. RPARPAR acetate directly binds to the NRP-1 and NRP-2 receptors on the surface of tumor cells, triggering cellular internalization, vascular extravasation, and penetration into tumor tissues. RPARPAR acetate serves as an efficient ligand for targeting nanocarriers to NRP-1-positive tumors. RPARPAR acetate is applicable in research on tumor targeting and drug delivery .
|
- HY-W016426
-
- HY-W008771
-
- HY-W008981
-
- HY-W013143
-
- HY-75401
-
- HY-79863
-
|
|
Amino Acid Derivatives
|
Others
|
|
(6S,9S,12S)-Benzyl 12-benzyl-9-isobutyl-2,2-dimethyl-4,7,10-trioxo-6-phenethyl-3-oxa-5,8,11-triazatridecan-13-oate is a phenylalanine derivative .
|
- HY-W014375
-
|
(±)-Arginine hydrochloride
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
DL-Arginine ((±)-Arginine) hydrochloride is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells .
|
- HY-W010077
-
- HY-WAA0253
-
- HY-W141960
-
- HY-W141891
-
|
|
Peptides
|
Others
|
|
N-(2-Cyanoethyl)glycine is a Glycine (HY-Y0966) derivative .
|
- HY-W006923
-
- HY-W011992
-
- HY-W041984
-
- HY-W013293
-
- HY-W010962
-
- HY-W047799
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Phe(4-CONH2)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize a small-sized HTLV-I protease inhibitor with hydrophilicity .
|
- HY-W048697
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize analogs of cyclic lanthionine enkephalin, a δ-opioid receptor selective ligand .
|
- HY-W009262
-
- HY-130189R
-
|
|
Drug Metabolite
Reference Standards
|
Others
|
|
S-Phenylmercapturic acid (Standard) is the analytical standard of S-Phenylmercapturic acid. This product is intended for research and analytical applications. S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay .
|
- HY-W007722A
-
- HY-W041997
-
- HY-W012537
-
- HY-164805
-
|
|
Endogenous Metabolite
|
Others
|
|
N-Lactylleucine is an endogenous metabolite that can be identified in patients with the intermediate type of maple syrup urine disease .
|
- HY-W018502
-
- HY-W011135
-
- HY-W009912
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Tyr(Me)-OH is a synthetic amino acid, and can enter into protein in E. coli in response to an amber nonsense codon .
|
- HY-W052529
-
- HY-W048203
-
- HY-W007679
-
- HY-W048730
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Phe(4-tBu)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize rOicPaPhe(p-Me)-NH(2) with platelet aggregation activation inhibitory activity .
|
- HY-W013286
-
- HY-W006093
-
- HY-W006064
-
|
(S)-2-Aminopent-4-ynoic acid
|
Amino Acid Derivatives
|
Others
|
|
(S)-2-Aminopent-4-ynoic acid is a synthetic amino acid. (S)-2-Aminopent-4-ynoic acid can be used in synthesis of folate-conjugates and corresponding metal-chelate complexes . (S)-2-Aminopent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
- HY-W048674
-
|
Fmoc-O-acetyl-L-serine
|
Amino Acid Derivatives
|
Infection
|
|
Fmoc-Ser(Ac)-OH (Fmoc-O-acetyl-L-serine) is a Serine derivative. Fmoc-Ser(Ac)-OH can be used for the preparation of broad-spectrum coronavirus membrane fusion inhibitor .
|
- HY-79046
-
|
Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (S)-; Butyric acid, 2-(carboxyamino)-, N-tert-butyl ester, L- (8CI); (2S)-2-(tert-Butoxycarbonylamino)butanoic acid; (2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]butanoic acid
|
Amino Acid Derivatives
|
Others
|
|
Boc-L-2-aminobutanoic acid is an alanine derivative .
|
- HY-P1498A
-
- HY-W011088
-
- HY-W141919
-
- HY-W072177
-
- HY-59121A
-
|
|
Drug Intermediate
|
Infection
|
|
Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate can be used to synthesis Sofosbuvir (HY-15005) to avoid the production of sofibuvir degradation impurities .
|
- HY-W142111
-
- HY-W099595
-
- HY-W002436
-
- HY-W008489
-
- HY-W042009A
-
- HY-P11771
-
- HY-W022657
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Met-OiPr hydrochloride is an Methionine derivative. H-Met-OiPr hydrochloride participates in the synthesis preparation of inhibitors of farnesyl-protein transferase (FTase), and can be used in cancer research .
|
- HY-W008922
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-D-3,3-diphenylalanine is a non-natural D-configuration amino acid derivative protected by Fmoc and commonly used in peptide synthesis research.
|
- HY-W012437
-
- HY-118174
-
- HY-P11641
-
|
|
MMP
|
Inflammation/Immunology
|
|
GCRRGPLGLSLGKRRCG is an MMP13-specific substrate peptide cleaved by MMP13. GCRRGPLGLSLGKRRCG contributes to an MMP13-responsive hydrogel microsphere system that achieves intelligent and controllable drug release in osteoarthritis (OA), decelerates disease progression, and promotes articular cartilage repair. GCRRGPLGLSLGKRRCG can be used for the research of osteoarthritis .
|
- HY-W015424R
-
- HY-W039112
-
- HY-W003903A
-
- HY-W013774
-
- HY-W051612
-
|
|
Amino Acid Derivatives
|
Others
|
|
DL-Propargylglycine hydrochloride is a Glycine (HY-Y0966) derivative. DL-Propargylglycine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .
|
- HY-W016552
-
- HY-W010964
-
- HY-W419440
-
|
L-Leucine, L-lysyl-
|
Biochemical Assay Reagents
|
Others
|
|
H-Lys-Leu-OH (L-Leucine, L-lysyl-) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W013740
-
- HY-W011423
-
- HY-W048673
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Phe (4-CONH2)-OH is a protected phenylalanine derivative commonly used in peptide synthesis, and it can be applied in polypeptide research .
|
- HY-33466
-
- HY-164804
-
- HY-30232
-
- HY-33319
-
- HY-W037120
-
|
|
Amino Acid Derivatives
|
Others
|
|
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-((4-methoxyphenyl)diphenylmethyl)-D-cysteine is a cysteine derivative .
|
- HY-W016733
-
|
H-D-Cit-OH
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
D-Citrulline (H-D-Cit-OH) is a stereoisomer of L-citrulline (HY-N0391). D-Citrulline significantly attenuates polymorphonuclear leukocyte (PMN)-induced cardiac contractile dysfunction in the isolated perfused rat heart subjected to ischemia/reperfusion via a non-NO-mediated mechanism .
|
- HY-P1894A
-
|
|
Amyloid-β
|
Neurological Disease
|
|
β-Amyloid Protein Precursor 770 (135-155) TFA is a peptide of amyloid precursor protein isoform (APP 770). APP 770 produces Aβ40/42 .
|
- HY-W002300
-
- HY-W022405
-
- HY-78746A
-
|
|
Amino Acid Derivatives
|
Others
|
|
D-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-, (3S,4R,5S)-rel- is a proline derivative .
|
- HY-W022250
-
- HY-W012497
-
- HY-W008432
-
- HY-W022444
-
- HY-W014919
-
- HY-W011359
-
- HY-Z0790
-
- HY-W012446
-
- HY-W141862
-
- HY-W014916
-
- HY-W036222
-
- HY-77021
-
- HY-W142062
-
|
Fmoc-(2S,4S)-4-azidoproline
|
Amino Acid Derivatives
|
Others
|
|
cis-Fmoc-Pro(4-N3)-OH is a proline derivative . cis-Fmoc-Pro(4-N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
- HY-W008919
-
|
N-Alpha,N-epsilon-di-Boc-L-lysine 4-nitrophenyl ester
|
Amino Acid Derivatives
|
Others
|
|
Boc-Lys(Boc)-Onp (N-Alpha,N-epsilon-di-Boc-L-lysine 4-nitrophenyl ester) is a lysine with a Boc protecting group. Boc-Lys(Boc)-Onp was used as a substrate for a catalyst model to study its enzymatic hydrolysis reaction catalyzed by a copper(II) complex .
|
- HY-W141895
-
- HY-W039759
-
- HY-P11656
-
|
|
mTOR
Beclin1
Autophagy
Atg8/LC3
Reactive Oxygen Species (ROS)
MMP
p38 MAPK
PERK
JNK
Collagen
|
Inflammation/Immunology
|
|
α-Neoendorphin porcine is a peptide. α-Neoendorphin porcine effectively alleviates UVB-induced skin photoaging via activating mTOR-Beclin-1-mediated autophagy, reducing UVB-triggered ROS production, inhibiting the MAPK pathway and MMP activity, and promoting type I procollagen synthesis. α-Neoendorphin porcine exerts anti-aging and anti-wrinkle effects on skin cells. α-Neoendorphin porcine can be used in studies related to skin photoaging .
|
- HY-W009119
-
- HY-W039947
-
- HY-W142089
-
- HY-W052212
-
- HY-W039449
-
- HY-W548477
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Lys(Fmoc)-OH hydrochloride is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize diacylated GLP-1 derivatives with antidiabetic activity .
|
- HY-W009203
-
|
|
Endogenous Metabolite
Apoptosis
Keap1-Nrf2
Reactive Oxygen Species (ROS)
Ferroptosis
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
L-Cystine dihydrochloride is the dihydrochloride salt form of L-Cystine (HY-N0394). L-Cystine dihydrochloride elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine dihydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine dihydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine dihydrochloride is promising for research of cystinuria and kidney stones
|
- HY-P11636
-
|
|
Peptides
|
Inflammation/Immunology
|
|
TRP-1(106-130) is a peptide sequence derived from tyrosinase-related protein 1 (TRP-1), which can be used to specifically activate and amplify T cells that recognize this antigen sequence .
|
- HY-W008196
-
- HY-P10050
-
|
|
Proteasome
|
Others
|
|
Calpain substrate is the membrane non-permeable fluorogenic calpain substrate and can be used in Calpain enzymatic activity assay .
|
- HY-W022404
-
- HY-131173
-
- HY-Y1789
-
- HY-W040124
-
|
|
Amino Acid Derivatives
|
Others
|
|
DL-Propargylglycine is a Glycine (HY-Y0966) derivative . DL-Propargylglycine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
- HY-W015457
-
- HY-W011156
-
|
|
Amino Acid Derivatives
|
Others
|
|
Mpa(Trt) is a 3-mercaptopropionic acid derivative containing a trityl protecting group (Trt) and can be used to synthesize compounds with anti-leukemia activity .
|
- HY-W110126
-
|
|
Amino Acid Derivatives
|
Others
|
|
(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)hexanoic acid is a lysine derivative .
|
- HY-W011075
-
- HY-W047845
-
|
|
Amino Acid Derivatives
|
Others
|
|
N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-(2-hydroxy-4-methoxybenzyl)glycine is a Glycine (HY-Y0966) derivative .
|
- HY-W007722
-
- HY-42994
-
- HY-W101384
-
- HY-W074914
-
- HY-W008072
-
- HY-I0125
-
- HY-W011778
-
- HY-W014913
-
- HY-W036352
-
- HY-W273130
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Glycyl-L-asparagine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W002303
-
- HY-W011713
-
- HY-P0036D
-
|
|
Drug Derivative
Radionuclide-Drug Conjugates (RDCs)
Somatostatin Receptor
Apoptosis
|
Cancer
|
|
NOTA‑Octreotide is a selective SSTR2‑targeting PET tracer. NOTA‑Octreotide binds specifically to SSTR2 and accumulates in SSTR2‑expressing tissues. NOTA‑Octreotide enables effective imaging of somatostatin receptor‑positive tumors in mice and shows high specific uptake in SSTR2‑expressing organs in healthy rats. NOTA-Octreotide can be used for PET imaging investigation of neuroendocrine tumors. .
|
- HY-W101305
-
|
|
Amino Acid Derivatives
|
Others
|
|
Fmoc-Pen(Acm)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize chemically modified cyclic peptides containing cell adhesion recognition (CAR) sequences .
|
- HY-D0844F
-
|
N,N-Biotinyl glutathione disulfide TFA; Biotin-GSSG TFA
|
Peptides
|
Others
|
|
Biotin-glutathione oxidized TFA ((N,N-Biotinyl glutathione disulfide TFA; Biotin-GSSG TFA) is an inducer of protein S-glutathionylation and a detection probe for S-glutathionylated proteins. Biotin-glutathione oxidized TFA forms protein-glutathione disulfide adducts, mimics components of oxidative stress, and drives protein S-glutathionylation. Biotin-glutathione oxidized TFA enables the labeling, detection, localization and purification of proteins susceptible to S-glutathionylation .
|
- HY-P11629
-
|
|
Amylin Receptor
CGRP Receptor
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
|
KBP-336 is a dual amylin and calcitonin receptor agonist (DACRA). KBP-336 exhibits antidiabetic and insulin-sensitizing properties, improves glucose levels, spatial learning, and memory in diabetic rats, and reduces blood glucose. KBP-336 also alleviates pain-like symptoms in osteoarthritis rats. KBP-336 also promotes weight and fat reduction. KBP-336 is useful for research on diabetes, obesity, and arthritis .
|
- HY-W009260
-
- HY-134545
-
|
NALA
|
Reactive Oxygen Species (ROS)
|
Cancer
|
|
N-Arachidonoyl-L-alanine is an endocannabinoid analog with anti-cancer effects. N- Arachidonoyl-L-alanine kills HNSCC cells through 5-LO-mediated ROS productio .
|
- HY-W010926
-
- HY-P11553B
-
|
|
Radionuclide-Drug Conjugates (RDCs)
CCR
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
DOTA-ECL1i is a conjugate of the CCR2 inhibitor ECL1i (HY-P11553) and DOTA. When radiolabeled with 68Ga, DOTA-ECL1i serves as a PET tracer that targets CCR2 expression. DOTA-ECL1i can be used in research related to pulmonary fibrosis, cardiac injury, abdominal aortic aneurysm inflammation, atherosclerosis, head and neck cancer, and pancreatic cancer .
|
- HY-B1581
-
- HY-41257
-
- HY-I0423
-
- HY-W013241
-
- HY-W017406
-
- HY-W016716
-
- HY-W005815
-
- HY-W013291
-
- HY-W012966
-
- HY-79861
-
- HY-W013940
-
- HY-W141961
-
- HY-W011750
-
- HY-W009328
-
- HY-134141
-
|
|
Drug Intermediate
|
Metabolic Disease
|
|
5-Octyl hydrogen L-glutamate is cell-permeable molecule and can be used for synthesizing 5-octyl ester derivatives (5-octyl α-ketoglutarate) .
|
- HY-113214
-
- HY-W022281
-
- HY-Y0967
-
|
N-(Benzyloxycarbonyl)glycine; N-(Carbobenzoxy)glycine; N-(Carbobenzyloxy)glycine; N-(α-Carbobenzoxy)glycine; N-Carboxyglycine N-benzyl ester
|
Amino Acid Derivatives
|
Others
|
|
Z-Glycine is a Glycine (HY-Y0966) derivative .
|
- HY-169089A
-
|
|
Drug Derivative
|
Cancer
|
|
RP-182-PEG3-K(palmitic acid)-NH2 (Compound 1a) TFA is a fatty acid derivative of the immunomodulatory peptide RP-182. RP-182-PEG3-K(palmitic acid)-NH2 TFA inhibits CD206 high M2-like macrophage (IC50 of 3.2 μM) and induces phagocytosis. RP-182-PEG3-K(palmitic acid)-NH2 TFA exhibits antitumor efficacy in mouse B16 melanoma allografts .
|
- HY-169089
-
|
|
Drug Derivative
|
Cancer
|
|
RP-182-PEG3-K palmitic acid-NH2 (Compound 1a) is a fatty acid derivative of the immunomodulatory peptide RP-182. RP-182-PEG3-K palmitic acid-NH2 inhibits CD206 high M2-like macrophage (IC50 of 3.2 μM) and induces phagocytosis. RP-182-PEG3-K palmitic acid-NH2 exhibits antitumor efficacy in mouse B16 melanoma allografts .
|
- HY-P11243
-
|
|
Ephrin Receptor
|
Neurological Disease
|
|
EphA4 agonist compound 23 is a novel EphA4 agonist peptide mimic. EphA4 agonist compound 23 exhibits high affinity, high selectivity, and significant receptor activation ability. EphA4 agonist compound 23 is commonly used in the study of neurodegenerative diseases .
|
- HY-P10318
-
|
|
GLP Receptor
|
Endocrinology
|
|
SHR-2042 is a selective agonist of the GLP-1 receptor.SHR-2042 improves glycemic control by activating the GLP-1 receptor, enhancing insulin secretion and inhibiting glucagon secretion. SHR-2042 combined with sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) promotes monomerization through the formation of micelles and improves oral absorption efficiency .
|
- HY-N17580
-
|
|
Renin
|
Cardiovascular Disease
|
|
Lyciumin D acts as an angiotensin-converting enzyme inhibitor and renin inhibitor. Lyciumin D can be used for the research of hypertension .
|
- HY-P2231
-
|
MEDI0382
|
GCGR
|
Metabolic Disease
|
|
Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D) .
|
- HY-P2231A
-
|
MEDI0382 acetate
|
GCGR
|
Metabolic Disease
|
|
Cotadutide (MEDI0382) acetate is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide acetate can be used in the research of obesity and type 2 diabetes (T2D) .
|
- HY-P0014A
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
Liraglutide acetate is the acetate form of Liraglutide (HY-P0014), a glucagon-like peptide-1 (GLP-1) receptor agonist studied in type 2 diabetes .
|
- HY-P0014
-
- HY-P10869
-
dCNP
1 Publications Verification
|
Natriuretic Peptide Receptor (NPR)
|
Inflammation/Immunology
Cancer
|
|
dCNP binds to NPR-B/C receptor, activates cGMP signaling pathway, and regulates vascular function. dCNP exhibits anti-hypoxia property through downregulation of hypoxia-related genes expressions like HIF1α and HIF2α. dCNP inhibits the induction of tumor stroma and exhibits anti-fibrosis activity. dCNP upregulates CTLs, NK cells, and conventional type 1 dendritic cells in tumors, and activates immune responses .
|
- HY-P4837
-
|
|
Peptides
|
Others
|
|
Ac-Lys-D-Ala-D-lactic acid is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
|
- HY-P0014B
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
Liraglutide (TFA) is an agonist of glucagon-like peptide 1 receptor (GLP-1). Liraglutide (TFA) can activate GLP-1, leading to the release of insulin in the presence of increased glucose concentration. Liraglutide (TFA) also reduces glucagon secretion in a glucose-dependent manner. Liraglutide (TFA) can be studied in research on type 2 diabetes .
|
- HY-P10200
-
|
|
Bacterial
|
Infection
|
|
CP7-FP13-2 is a peptide with antivirulence factor and antibacterial activity. CP7-FP13-2 inhibits the formation of Staphylococcus aureus biofilm and has good antibacterial efficacy in mice .
|
- HY-P1614
-
- HY-P2075
-
|
|
Renin
|
Endocrinology
|
|
EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate .
|
- HY-P11604
-
|
|
Phosphatase
|
Inflammation/Immunology
|
|
C16 acid-I-{Lys (C10 diacid)}-KQELRRIGDEF is a cell-permeable and internalizable PTPN1/2 inhibitor, with IC50 values of 107.6 nM and 3375 nM, respectively. C16 acid-I-{Lys (C10 diacid)}-KQELRRIGDEF restores insulin signaling in HepG2 cells. C16 acid-I-{Lys (C10 diacid)}-KQELRRIGDEF achieves glycemic control in db/db diabetic mice. C16 acid-I-{Lys (C10 diacid)}-KQELRRIGDEF can be used in the research of type 2 diabetes .
|
- HY-P3291
-
|
ZP7570
|
GCGR
|
Metabolic Disease
|
|
Dapiglutide (ZP7570) is a long-acting glucagon-like peptide-1 receptor 1R (GLP-1R)/Glucagon-like peptide-2 receptor (GLP-2R) dual agonist. Dapiglutide alleviates intestinal dysfunction in a mouse short bowel model and has anti-obesity effects .
|
- HY-P11233
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
Acmopatide (Compound E-153) is a dual-acting GIP/GLP-1 receptor agonist. Acmopatide is used in anti-diabetic research .
|
- HY-P11004
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
A3-APO is an antimicrobial peptide. A3-APO has a significant antimicrobial activity by a dual mode of action with both membrane disintegration and intracellular target inhibition. A3-APO can deactivate bacterial toxins and increase the expression of anti-inflammatory cytokines (such as IL-4 and IL-10), without antimicrobial resistance. A3-APO accelerates burn wounds healing in mice infection model of Acinetobacter baumannii and Staphylococcus aureus .
|
- HY-P0041A
-
- HY-P0041
-
- HY-P5161
-
- HY-P5161A
-
- HY-P11586
-
|
|
Amylin Receptor
|
Metabolic Disease
|
|
San45 is a nonselective dual amylin and calcitonin receptor agonist (DACRA) with nonselective potency relative to calcitonin receptor (CTR) and amylin 1 receptor (AMY₁R), and acts as a stabilizer of receptor-ligand complex and prolonged activator of cAMP signaling. San45 carries a conjugated lipid modification that can be used for the research of obesity .
|
- HY-P2336A
-
|
|
Melanocortin Receptor
|
Cancer
|
|
CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .
|
- HY-109166
-
- HY-P3462
-
|
|
CGRP Receptor
|
Metabolic Disease
|
|
Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity .
|
- HY-P11279
-
|
|
GLP Receptor
GCGR
Neuropeptide Y Receptor
|
Metabolic Disease
|
TC2 is an efficient GIPR-preferring monomeric quadruple agonist that can respectively activate GIPR, GLP-1R, GcgR, and Y2R with IC50 values of 0.47, 2.1, 30, and 55 nM respectively. TC2 exhibits a significant GLP-1R preference, with a significant reduction in β-inhibitory protein 2 (βArr2) recruitment, while maintaining a strong cAMP signal. TC2 can be used for research on obesity and diabetes .
|
- HY-P3462A
-
|
|
CGRP Receptor
|
Metabolic Disease
|
|
Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies .
|
- HY-P10472
-
|
|
GnRH Receptor
|
Endocrinology
|
|
Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .
|
- HY-P0014AS
-
- HY-P4757
-
|
|
Parasite
|
Others
|
|
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .
|
- HY-P0014S2
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Liraglutide- 13C6, 15 TFA is the 13C and 15N labeledLiraglutide(HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .
|
- HY-P0014S1
-
|
|
Isotope-Labeled Compounds
GLP Receptor
GCGR
|
Others
|
|
Liraglutide- 13C6, 15 tetraTFA is the 13C and 15N labeled Liraglutide (HY-P0014) . Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .
|
- HY-P10271
-
|
NNC0090-2746; MAR709; RO6811135
|
GLP Receptor
|
Metabolic Disease
|
|
RG7697 is a dual agonist for glucagon-like peptide receptor (GLP Receptor) and glucosedependent insulinotropic polypeptide receptor (GIPR), with EC50 of 5 and 3 pM, respectively. RG7697 exhibits antihyperglycemic property .
|
- HY-P3143
-
|
|
PD-1/PD-L1
|
Cancer
|
|
BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs .
|
- HY-P3143A
-
|
|
PD-1/PD-L1
|
Cancer
|
|
BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs .
|
- HY-P4201
-
|
|
Vasopressin Receptor
|
Cardiovascular Disease
|
|
JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking .
|
- HY-W010991
-
|
FAPGG
|
Angiotensin-converting Enzyme (ACE)
|
Others
|
|
N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10 -4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system .
|
- HY-P10052
-
|
|
VEGFR
|
Cancer
|
|
CBO-P11 specifically binds to receptor of VEGFR-2 and is used as targeting ligand for tumor angiogenesis. CBO-P11 is modified with a nearinfrared cyanine dye bearing an alkyne function, allowing both “click” coupling on azido-modified nanoparticles and fluorescence labelling .
|
- HY-P11415
-
|
|
Peptides
|
Cancer
|
|
GX1 is a tumor-homing peptide, and its amino acid sequence is CGNSNPKSC. GX1 can specifically target the vascular endothelial cells of gastric cancer and can be used as a specific imaging probe for gastric cancer angiogenesis .
|
- HY-P10053
-
|
|
Phospholipase
|
Metabolic Disease
|
|
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .
|
- HY-P11431
-
- HY-P10051
-
|
|
Ras
Raf
|
Cancer
|
|
Cyclorasin 9A5 is an 11-residue cell-permeable cyclic peptide that orthosterically inhibits the Ras-Raf protein interaction with an IC50 of 120 nM .
|
- HY-148073
-
|
|
Fluorescent Dye
Ser/Thr Protease
|
Others
|
|
MeO-Succ-Arg-Pro-Tyr-AMC TFA is a fluorogenic peptide substrate for chymotrypsin-like proteases that detects protease activity . (measured at 460 nm)
|
- HY-P11236
-
- HY-P11625
-
|
|
RXFP Receptor
|
Cardiovascular Disease
|
|
R9-13 is a fatty acid-conjugated relaxin and an agonist of LGR7 (RXFP1). R9-13 induces sustained pubic symphysis elongation in estrogen-pretreated mice. R9-13 exhibits long-acting pharmacokinetic profiles in rodents, with in vivo activity lasting up to one week after administration. R9-13 can be used in studies related to acute heart failure .
|
- HY-P11273
-
- HY-W017444
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(R)-2,4-diamino-4-oxobutanoic acid hydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W142117
-
|
|
Fluorescent Dye
|
Others
|
|
H-Asp(AMC)-OH, a amino acid derivative, is a fluorescent dye. H-Asp(AMC)-OH dose not inhibit glycine transport at a concentration of 0.25 mM .
|
- HY-P10381
-
|
|
Peptides
|
Others
|
|
palm11-TTDS-PrRP31 is a strong agonist of GPR10 (EC50: 84 pM). palm11-TTDS-PrRP31 has long-lasting anorexigenic effects .
|
- HY-113560
-
- HY-153476
-
|
|
GCGR
GLP Receptor
|
Inflammation/Immunology
|
|
GIP/GLP-1 dual receptor agonist-1 is a GIP/GLP-1 dual receptor agonist. GIP/GLP-1 dual receptor agonist-1 is used in the research of metabolic disorders and fatty liver diseases, including non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD) .
|
- HY-153476A
-
|
|
GLP Receptor
GCGR
|
Inflammation/Immunology
|
|
GIP/GLP-1 dual receptor agonist-1 sodium is a GIP/GLP-1 dual receptor agonist. GIP/GLP-1 dual receptor agonist-1 sodium is used in the research of metabolic disorders and fatty liver diseases, including non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD) .
|
- HY-P1162
-
- HY-P2595
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
SKF 103784 is an vasopressin antagonist with activity against vasopressin. SKF 103784 inhibits the physiological response caused by antidiuretic and is therefore used to study biological processes related to water and salt balance. SKF 103784 can also be used to explore pathological mechanisms related to cardiovascular diseases and endocrine dysfunction .
|
- HY-P10910
-
|
|
GLP Receptor
|
Metabolic Disease
|
|
Vensemaglutide is the agonist for glucagon-like peptide 1 (GLP-1) receptor. Vensemaglutide can be used in research of diabetes or other metabolic disorders .
|
- HY-P11290
-
- HY-P0046
-
|
GHK; Tripeptide-1
|
Peptides
|
Neurological Disease
Inflammation/Immunology
|
|
Glycyl-L-histidyl-L-lysine is a tripeptide consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance .
|
- HY-P10031A
-
|
|
GLP Receptor
GCGR
|
Metabolic Disease
|
|
SAR441255 TFA is a GLP-1R/GCGR/GIPR agonist, with human EC50 values of 1.03 pM, 1.01 pM, and 0.73 pM, respectively. SAR441255 TFA stimulates receptor activity and drives cAMP accumulation. SAR441255 TFA can be used for the research of type 2 diabetes, obesity .
|
- HY-P10031
-
|
|
GLP Receptor
GCGR
|
Metabolic Disease
|
|
SAR441255 is a GLP-1R/GCGR/GIPR agonist, with human EC50 values of 1.03 pM, 1.01 pM, and 0.73 pM, respectively. SAR441255 stimulates receptor activity and drives cAMP accumulation. SAR441255 can be used for the research of type 2 diabetes, obesity .
|
- HY-P2434
-
|
|
Somatostatin Receptor
|
Neurological Disease
Metabolic Disease
Cancer
|
|
AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC50: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research .
|
- HY-P10272
-
|
PTG-300
|
Ferroportin
|
Others
|
|
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .
|
- HY-P5362A
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Somatostatin Receptor
|
Cancer
|
|
NODAGA-LM3 TFA is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC50 = 1.3 nM). NODAGA-LM3 TFA does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 TFA shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. 68Ga-labeled NODAGA-LM3 TFA can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .
|
- HY-P5362
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Somatostatin Receptor
|
Neurological Disease
Cancer
|
|
NODAGA-LM3 is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC50 = 1.3 nM). NODAGA-LM3 does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. 68Ga-labeled NODAGA-LM3 can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors .
|
- HY-105168
-
|
|
Endothelin Receptor
|
Cardiovascular Disease
|
|
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .
|
- HY-P11488
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Somatostatin Receptor
PSMA
|
Cancer
|
|
JR11-PEG3-DOTA-PSMA-03 (Compound 2) is an RDC-related compound containing the chelating agent DOTA (HY-W053583), the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-DOTA-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC50 s of 94.0 nM, 81.8 nM, respectively. JR11-PEG3-DOTA-PSMA-03 can be radiolabeled with [ 68Ga]. [ 68Ga] radiolabeled JR11-PEG3-DOTA-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .
|
- HY-P11485
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Somatostatin Receptor
PSMA
|
Cancer
|
|
JR11-PEG3-HBED-CC-PSMA-03 (Compound 1) is an RDC-related compound containing the chelating agent HBED-CC, the JR11 peptide (SSTR2 antagonist), and the PSMA ligand. JR11-PEG3-HBED-CC-PSMA-03 shows SSTR2-binding affinities and PSMA-binding affinities, with IC50 s of 59.2 nM, 57.0 nM, respectively. JR11-PEG3-HBED-CC-PSMA-03 can be radiolabeled with [ 68Ga]. [ 68Ga] radiolabeled JR11-PEG3-HBED-CC-PSMA-03 can be used in diagnostic studies of neuroendocrine differentiated prostate cancer .
|
- HY-P10881
-
- HY-P4070
-
|
|
Insulin Receptor
|
Metabolic Disease
|
|
Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .
|
- HY-105055
-
|
|
Peptides
|
Cancer
|
|
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .
|
- HY-P10563
-
|
BHV-1100
|
CD38
|
Cancer
|
|
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-P0014S1
-
|
|
|
Liraglutide- 13C6, 15 tetraTFA is the 13C and 15N labeled Liraglutide (HY-P0014) . Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .
|
-
-
- HY-P0014AS
-
|
|
|
Liraglutide-d8 tetraTFA is deuterium labeled Liraglutide (HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .
|
-
-
- HY-P0014S2
-
|
|
|
Liraglutide- 13C6, 15 TFA is the 13C and 15N labeledLiraglutide(HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .
|
-
-
- HY-P11431
-
|
|
|
Cyclo(Gly-Pro) is a cyclic dipeptide. Cyclo(Gly-Pro) can be derived from the Nterminus of the IGF-1. Cyclo(Gly-Pro) attenuates nociceptive behaviour and inflammatory response in mice .
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W040124
-
|
|
|
Alkynes
|
|
DL-Propargylglycine is a Glycine (HY-Y0966) derivative . DL-Propargylglycine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W011210
-
|
|
|
Alkynes
|
|
Fmoc-Pra-OH is a Glycine (HY-Y0966) derivative . Fmoc-Pra-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W048205
-
|
|
|
Azide
|
|
N6-Diazo-L-Fmoc-lysine is an active compand and can be used in a variety of chemical studies. N6-Diazo-L-Fmoc-lysine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-W006064
-
|
(S)-2-Aminopent-4-ynoic acid
|
|
Alkynes
|
|
(S)-2-Aminopent-4-ynoic acid is a synthetic amino acid. (S)-2-Aminopent-4-ynoic acid can be used in synthesis of folate-conjugates and corresponding metal-chelate complexes . (S)-2-Aminopent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W008395
-
|
|
|
Alkynes
|
|
Fmoc-D-Pra-OH is a Glycine (HY-Y0966) derivative . Fmoc-D-Pra-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W142062
-
|
Fmoc-(2S,4S)-4-azidoproline
|
|
Azide
|
|
cis-Fmoc-Pro(4-N3)-OH is a proline derivative . cis-Fmoc-Pro(4-N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-W014258
-
|
|
|
Alkynes
|
|
(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a Glycine (HY-Y0966) derivative . (R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-151641
-
|
|
|
Azide
|
|
3-Azido-L-alanine is an aliphatic functionalized amino acid with side chain lengths of up to four carbons . 3-Azido-L-alanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-W014259
-
|
|
|
Alkynes
|
|
(S)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a Glycine (HY-Y0966) derivative . (S)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
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