2. Immunology/Inflammation
  3. COX
  4. Brazzein

Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities.

Brazzein inhibits COX-2 with an IC50 of 12.62 μM. Brazzein exhibits strong antioxidant effects, showing ABTS radical scavenging activity (IC50 = 12.55 μM). Brazzein shows no antibacterial or antifungal activity. Brazzein can be used for the research of obesity, metabolic disorder, inflammation.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Brazzein

Brazzein Chemical Structure

CAS No. : 178359-31-4

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Brazzein Related Antibodies

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COX COX-1 COX-2 COX-3

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Description

Brazzein is a functional sweetener with antioxidant, anti-inflammatory, and anti-allergic activities.

Brazzein inhibits COX-2 with an IC50 of 12.62 μM. Brazzein exhibits strong antioxidant effects, showing ABTS radical scavenging activity (IC50 = 12.55 μM). Brazzein shows no antibacterial or antifungal activity. Brazzein can be used for the research of obesity, metabolic disorder, inflammation[1][2].
IC50 & Target[1]

COX-2

12.62 μM (IC50)

In Vitro

Brazzein (15-30 μM) shows strong ABTS radical scavenging activity with an IC50 of 12.55 μM in cell-free conditions[1].
Brazzein (15-30 μM; 30 min) shows weaker DPPH radical scavenging activity compared to ABTS, with an IC50 > 30 μM in cell-free conditions[1].
Brazzein (3-25 μM) inhibits human COX-2 activity with an IC50 of 12.62 μM in cell-free conditions[1].
Brazzein (1–15 μM) shows weak anti-inflammatory activity in RAW 264.7 cells, with an IC50 > 15 μM for NO production inhibition[1].
Brazzein (1-15 μM) has no cytotoxic effect on RAW 264.7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Brazzein Related Antibodies
Molecular Weight

6473.18

Formula

C276H410N76O89S8
CAS No.
Sequence

Glp-Asp-Lys-Cys-Lys-Lys-Val-Tyr-Glu-Asn-Tyr-Pro-Val-Ser-Lys-Cys-Gln-Leu-Ala-Asn-Gln-Cys-Asn-Tyr-Asp-Cys-Lys-Leu-Asp-Lys-His-Ala-Arg-Ser-Gly-Glu-Cys-Phe-Tyr-Asp-Glu-Lys-Arg-Asn-Leu-Gln-Cys-Ile-Cys-Asp-Tyr-Cys-Glu-Tyr (disulfide bridge:Cys4-Cys52,Cys16-Cys37,Cys22-Cys47,Cys26-Cys49)
Sequence Shortening

Glp-DKCKKVYENYPVSKCQLANQCNYDCKLDKHARSGECFYDEKRNLQCICDYCEY (disulfide bridge:Cys4-Cys52,Cys16-Cys37,Cys22-Cys47,Cys26-Cys49)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Brazzein Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brazzein178359-31-4COXCyclooxygenasemast cell degranulationRAW 264.7 cellsCOX-2inflammatory responsesβ-hexosaminidaseprostaglandin biosynthesiscyclooxygenase-2RBL-2H3 cellsallergic responsesobesityInhibitorinhibitorinhibit

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