2. Apoptosis
  3. MDM-2/p53
  4. p53 (17-26) acetate

p53 (17-26) acetate is a peptide derived from the P53 MDM2 binding domain, with a Kd of 50 nM for MDM2. p53 (17-26) acetate causes cell lysis by damaging cancer cells and nuclear membranes, and induces cancer cell necrosis. p53 (17-26) acetate exhibits antitumor activity and is applicable to research related to pancreatic cancer.

For research use only. We do not sell to patients.

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p53 (17-26) acetate

p53 (17-26) acetate Chemical Structure

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Based on 1 publication(s) in Google Scholar

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p53 (17-26) acetate Related Antibodies

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Description

p53 (17-26) acetate is a peptide derived from the P53 MDM2 binding domain, with a Kd of 50 nM for MDM2. p53 (17-26) acetate causes cell lysis by damaging cancer cells and nuclear membranes, and induces cancer cell necrosis. p53 (17-26) acetate exhibits antitumor activity and is applicable to research related to pancreatic cancer[1][2].

In Vitro

p53 (17-26) acetate binds tightly to the N-terminal domain of MDM2 (Kd = 50 nM) and induces global conformational changes in the MDM2 domain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

p53 (17-26) acetate Related Antibodies
In Vivo

p53 (17-26) (2 mg; subcutaneous osmotic pump; 14 days) acetate eliminates intraperitoneal xenografted pancreatic cancer cells in nude mice[2].
p53 (17-26) (1-20 mg; subcutaneous osmotic pump; 14 days) acetate dose-dependently inhibits the growth of established subcutaneous xenograft pancreatic cancer in nude mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hsd:Athymic Nu/Nu (7-8 weeks old, 22-24 g, i.p. xenotransplantation of BMRPA1.Tuc3 pancreatic carcinoma cells)[2]
Dosage: 2 mg/mouse
Administration: subcutaneous osmotic pump; constant rate 0.25 μL/hr; 14 days
Result: Prevented ascites or liver metastasis on day 21.
Contained no viable tumor cells in peritoneal lavage fluid, only macrophages and lymphocytes that did not grow in culture.
Animal Model: Hsd:Athymic Nu/Nu (7-8 weeks old, 22-24 g, s.c. xenotransplanted BMRPA1.Tuc3 pancreatic carcinoma cells grown to 40-260 mg before treatment)[2]
Dosage: 20 mg/mouse; 10 mg/mouse; 1 mg/mouse
Administration: subcutaneous osmotic pump; 14 days
Result: Reduced average tumor size.
Inhibited post-treatment tumor growth.
Caused no weight loss or toxicity in treated mice.
Molecular Weight

1251.43 (free base)

Formula

C60H90N12O17·xC2HF3O2
Appearance

Solid

Sequence

Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu
Sequence Shortening

ETFSDLWKLL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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p53 (17-26) acetate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p53 (17-26)MDM-2/p53cyclic decapeptidep53Inhibitorinhibitorinhibit

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