2. Apoptosis
  3. MDM-2/p53
  4. p53 (17-26)

p53 (17-26) is a peptide derived from the P53 MDM2 binding domain, with a Kd of 50 nM for MDM2. p53 (17-26) causes cell lysis by damaging cancer cells and nuclear membranes, and induces cancer cell necrosis. p53 (17-26) exhibits antitumor activity and is applicable to research related to pancreatic cancer.

For research use only. We do not sell to patients.

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p53 (17-26)

p53 (17-26) Chemical Structure

CAS No. : 488118-64-5

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p53 (17-26) Related Antibodies

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Description

p53 (17-26) is a peptide derived from the P53 MDM2 binding domain, with a Kd of 50 nM for MDM2. p53 (17-26) causes cell lysis by damaging cancer cells and nuclear membranes, and induces cancer cell necrosis. p53 (17-26) exhibits antitumor activity and is applicable to research related to pancreatic cancer[1][2].

In Vitro

p53 (17-26) binds tightly to the N-terminal domain of MDM2 (Kd = 50 nM) and induces global conformational changes in the MDM2 domain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

p53 (17-26) Related Antibodies
In Vivo

p53 (17-26) (2 mg; subcutaneous osmotic pump; 14 days) eliminates intraperitoneal xenografted pancreatic cancer cells in nude mice[2].
p53 (17-26) (1-20 mg; subcutaneous osmotic pump; 14 days) dose-dependently inhibits the growth of established subcutaneous xenograft pancreatic cancer in nude mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hsd:Athymic Nu/Nu (7-8 weeks old, 22-24 g, i.p. xenotransplantation of BMRPA1.Tuc3 pancreatic carcinoma cells)[2]
Dosage: 2 mg/mouse
Administration: subcutaneous osmotic pump; constant rate 0.25 μL/hr; 14 days
Result: Prevented ascites or liver metastasis on day 21.
Contained no viable tumor cells in peritoneal lavage fluid, only macrophages and lymphocytes that did not grow in culture.
Animal Model: Hsd:Athymic Nu/Nu (7-8 weeks old, 22-24 g, s.c. xenotransplanted BMRPA1.Tuc3 pancreatic carcinoma cells grown to 40-260 mg before treatment)[2]
Dosage: 20 mg/mouse; 10 mg/mouse; 1 mg/mouse
Administration: subcutaneous osmotic pump; 14 days
Result: Reduced average tumor size.
Inhibited post-treatment tumor growth.
Caused no weight loss or toxicity in treated mice.
Molecular Weight

1251.43

Formula

C60H90N12O17
CAS No.
Sequence

Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu
Sequence Shortening

ETFSDLWKLL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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p53 (17-26) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p53 (17-26)488118-64-5MDM-2/p53MDM2N-terminalp53-binding domainnude micepancreatic carcinoma tumorsnecrosisepithelial cellscancer cellsstem cell differentiationInhibitorinhibitorinhibit

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