2. Peptides
  3. Peptide and Derivatives
  4. scHAP-1

scHAP-1 is a scrambled HAP-1 peptide, and HAP-1 is a synovial homing peptide. After amino acid sequence scrambling, scHAP-1 still specifically binds to human and rabbit fibroblast-like synoviocytes (FLS), while showing extremely weak binding to human umbilical vein endothelial cells, which proves that it remains an effective FLS-targeting ligand. scHAP-1 can be used in studies related to rheumatoid arthritis.

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scHAP-1

scHAP-1 Chemical Structure

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Other Forms of scHAP-1:

scHAP-1 Related Antibodies

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Description

scHAP-1 is a scrambled HAP-1 peptide, and HAP-1 is a synovial homing peptide. After amino acid sequence scrambling, scHAP-1 still specifically binds to human and rabbit fibroblast-like synoviocytes (FLS), while showing extremely weak binding to human umbilical vein endothelial cells, which proves that it remains an effective FLS-targeting ligand. scHAP-1 can be used in studies related to rheumatoid arthritis[1].

In Vivo
Animal Model: Wistar rats (female; adjuvant-induced arthritis model)[1]
Dosage: 0.5 mg drug/0.5 ml/250 g rat/day
Administration: i.v.; two consecutive days
Result: Showed a 9-fold increase in fluorescence signal in arthritic joints compared to unaffected joints in the same animals at 3 hours post-injection.
Molecular Weight

1335.47

Formula

C60H90N18O17
Sequence

Ala-Leu-Ser-Gln-Ala-Phe-Arg-His-Ala-Phe-Thr-Ser
Sequence Shortening

ALSQAFRHAFTS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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scHAP-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

scHAP-1scHAP1scHAP 1OthersHUVECsTNF-αinflamed rat adjuvant-induced arthritis jointsrheumatoid arthritishuman fibroblast-like synovial cellshFLSrabbit fibroblast-like synovial cellsadjuvant-induced arthritisrFLShuman umbilical vein endothelial cellsInhibitorinhibitorinhibit

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