N-Acetyl-R-leucine
Based on 1 Customer Validation
N-Acetyl-R-leucine is an amino-protecting group N-substituted chiral amino acid. N-Acetyl-R-leucine is a PepT1 and MCT1 inhibitor with IC50 of 0.74 and 11 mM, respectively. N-Acetyl-R-leucine can be used for LysoTracker signaling studies.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 19764-30-8
- Formula: C8H15NO3
- Molecular Weight:173.21
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
N-Acetyl-R-leucine is not a substrate of LAT1 and PepT1, but is an inhibitor of PepT1 with an IC50 of 0.74 mM[2].
N-Acetyl-R-leucine is a substrate of MCT1 with a Km of 1.0 mM, and an inhibitor of MCT1 with an IC50 of 11 mM[2].
N-Acetyl-R-leucine (1-5 mM; 7 days) shows no apparent dose-dependent effect on LysoTracker signaling in NPC1-deficient Chinese hamster ovary cells, but is statistically significant at higher concentrations (5 mM)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 19764-30-8
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Appearance Solid
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Molecular Weight 173.21
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Formula C8H15NO3
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Color White to off-white
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Synonyms
N-Acetyl-D-leucine
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (577.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[2]. Churchill GC, et al. Acetylation turns leucine into a drug by membrane transporter switching. Sci Rep. 2021 Aug 4;11(1):15812. [Content Brief]
[4]. Günther L, et al. N-acetyl-L-leucine accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus. PLoS One. 2015 Mar 24;10(3):e0120891. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.7733 mL | 28.8664 mL | 57.7327 mL | 144.3318 mL |
| 5 mM | 1.1547 mL | 5.7733 mL | 11.5465 mL | 28.8664 mL | |
| 10 mM | 0.5773 mL | 2.8866 mL | 5.7733 mL | 14.4332 mL | |
| 15 mM | 0.3849 mL | 1.9244 mL | 3.8488 mL | 9.6221 mL | |
| 20 mM | 0.2887 mL | 1.4433 mL | 2.8866 mL | 7.2166 mL | |
| 25 mM | 0.2309 mL | 1.1547 mL | 2.3093 mL | 5.7733 mL | |
| 30 mM | 0.1924 mL | 0.9622 mL | 1.9244 mL | 4.8111 mL | |
| 40 mM | 0.1443 mL | 0.7217 mL | 1.4433 mL | 3.6083 mL | |
| 50 mM | 0.1155 mL | 0.5773 mL | 1.1547 mL | 2.8866 mL | |
| 60 mM | 0.0962 mL | 0.4811 mL | 0.9622 mL | 2.4055 mL | |
| 80 mM | 0.0722 mL | 0.3608 mL | 0.7217 mL | 1.8041 mL | |
| 100 mM | 0.0577 mL | 0.2887 mL | 0.5773 mL | 1.4433 mL |
N-Acetyl-R-leucine Related Classifications
HY-Y1080 Related Classifications
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