2. Others Membrane Transporter/Ion Channel
  3. Amino Acid Derivatives Monocarboxylate Transporter
  4. N-Acetyl-R-leucine

N-Acetyl-R-leucine  (Synonyms: N-Acetyl-D-leucine)

Cat. No.: HY-Y1080 Purity: 99.89%
COA
SDS
Handling Instructions Technical Support

N-Acetyl-R-leucine is an amino-protecting group N-substituted chiral amino acid. N-Acetyl-R-leucine is a PepT1 and MCT1 inhibitor with IC50 of 0.74 and 11 mM, respectively. N-Acetyl-R-leucine can be used for LysoTracker signaling studies.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

N-Acetyl-R-leucine

N-Acetyl-R-leucine 화학구조

CAS No. : 19764-30-8

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
25 g 해외재고보유
100 g 해외재고보유
500 g 해외재고보유
> 100 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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N-Acetyl-R-leucine Related Antibodies

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  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

N-Acetyl-R-leucine is an amino-protecting group N-substituted chiral amino acid. N-Acetyl-R-leucine is a PepT1 and MCT1 inhibitor with IC50 of 0.74 and 11 mM, respectively. N-Acetyl-R-leucine can be used for LysoTracker signaling studies[1][2][3][4].

In Vitro

N-Acetyl-R-leucine is not a substrate of LAT1 and PepT1, but is an inhibitor of PepT1 with an IC50 of 0.74 mM[2].
N-Acetyl-R-leucine is a substrate of MCT1 with a Km of 1.0 mM, and an inhibitor of MCT1 with an IC50 of 11 mM[2].
N-Acetyl-R-leucine (1-5 mM; 7 days) shows no apparent dose-dependent effect on LysoTracker signaling in NPC1-deficient Chinese hamster ovary cells, but is statistically significant at higher concentrations (5 mM)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Acetyl-R-leucine Related Antibodies
In Vivo

N-Acetyl-R-leucine (24 mg per rat; i.v.; once a day) has no significant effect on the compensation of nystagmus and postural imbalance scores in rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

173.21

화학식

C8H15NO3
CAS No.
Appearance

Solid

Color

White to off-white

Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (577.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7733 mL 28.8664 mL 57.7327 mL
5 mM 1.1547 mL 5.7733 mL 11.5465 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.89%

SDS (396 KB)

COA (248 KB) HNMR (161 KB) RP-HPLC (211 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.7733 mL 28.8664 mL 57.7327 mL 144.3318 mL
5 mM 1.1547 mL 5.7733 mL 11.5465 mL 28.8664 mL
10 mM 0.5773 mL 2.8866 mL 5.7733 mL 14.4332 mL
15 mM 0.3849 mL 1.9244 mL 3.8488 mL 9.6221 mL
20 mM 0.2887 mL 1.4433 mL 2.8866 mL 7.2166 mL
25 mM 0.2309 mL 1.1547 mL 2.3093 mL 5.7733 mL
30 mM 0.1924 mL 0.9622 mL 1.9244 mL 4.8111 mL
40 mM 0.1443 mL 0.7217 mL 1.4433 mL 3.6083 mL
50 mM 0.1155 mL 0.5773 mL 1.1547 mL 2.8866 mL
60 mM 0.0962 mL 0.4811 mL 0.9622 mL 2.4055 mL
80 mM 0.0722 mL 0.3608 mL 0.7217 mL 1.8041 mL
100 mM 0.0577 mL 0.2887 mL 0.5773 mL 1.4433 mL
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N-Acetyl-R-leucine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Acetyl-R-leucine19764-30-8N-Acetyl-D-leucineAmino Acid DerivativesMonocarboxylate Transporterhamsterovary cellsratInhibitorinhibitorinhibit

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N-Acetyl-R-leucine
Cat. No.:
HY-Y1080
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