19764-30-8
19764-30-8
Chemical Structure
N-Acetyl-R-leucine
Synonym(s): N-Acetyl-D-leucine
- CAS No.: 19764-30-8
- Formula:C8H15NO3
- Molecular Weight:173.21
IUPAC Name: acetyl-D-leucine
InChIKey: WXNXCEHXYPACJF-SSDOTTSWSA-N
SMILES: CC(C)C[C@H](C(O)=O)NC(C)=O
Biological Activity: N-Acetyl-R-leucine is an amino-protecting group N-substituted chiral amino acid. N-Acetyl-R-leucine is a PepT1 and MCT1 inhibitor with IC50 of 0.74 and 11 mM, respectively. N-Acetyl-R-leucine can be used for LysoTracker signaling studies[1][2][3][4].
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N-Acetyl-R-leucine | 99.89% | N-Acetyl-R-leucine is an amino-protecting group N-substituted chiral amino acid. N-Acetyl-R-leucine is a PepT1 and MCT1 inhibitor with IC50 of 0.74 and 11 mM, respectively. N-Acetyl-R-leucine can be used for LysoTracker signaling studies. | ||||||||||||||||||||
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References
- [1]. Wang MZ, et al. Synthesis method of amino protecting group N-substituted chiral amino acid. CN114195684.
- [2]. Churchill GC, et al. Acetylation turns leucine into a drug by membrane transporter switching. Sci Rep. 2021 Aug 4;11(1):15812. [Content Brief]
- [3]. te Vruchte D, et al. Effects of N-acetyl-leucine and its enantiomers in Niemann-Pick disease type C cells. BioRxiv, 2019: 826222.
- [4]. Günther L, et al. N-acetyl-L-leucine accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus. PLoS One. 2015 Mar 24;10(3):e0120891. [Content Brief]
Keywords
