2. GPCR/G Protein Neuronal Signaling
  3. Amylin Receptor CGRP Receptor
  4. KBP-336

KBP-336 is a dual amylin and calcitonin receptor agonist (DACRA). KBP-336 exhibits antidiabetic and insulin-sensitizing properties, improves glucose levels, spatial learning, and memory in diabetic rats, and reduces blood glucose. KBP-336 also alleviates pain-like symptoms in osteoarthritis rats. KBP-336 also promotes weight and fat reduction. KBP-336 is useful for research on diabetes, obesity, and arthritis.

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KBP-336

KBP-336 Chemical Structure

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Description

KBP-336 is a dual amylin and calcitonin receptor agonist (DACRA). KBP-336 exhibits antidiabetic and insulin-sensitizing properties, improves glucose levels, spatial learning, and memory in diabetic rats, and reduces blood glucose. KBP-336 also alleviates pain-like symptoms in osteoarthritis rats. KBP-336 also promotes weight and fat reduction. KBP-336 is useful for research on diabetes, obesity, and arthritis[1][2][3].

In Vivo

KBP-336 (4.5 nmol/kg; subcutaneous injection; once every 3 days; 127 days) improves spatial learning and memory deficits and hyperglycemia in diabetic rats and prevents the development of ocular cataracts[1].
KBP-336 (0.5-4.5 nmol/kg; subcutaneous injection; every 72 hours; 6-8 weeks) alleviates pain-like symptoms and reduces body weight and adipose tissue in rats with high-fat diet-induced obesity combined with medial meniscectomy[2].
KBP-336 (4.5 nmol/kg; subcutaneous injection; once every 3 days; 8 weeks) exhibits anti-obesity activity in high-fat diet-induced obese rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zucker Diabetic Fatty Rats (male, 6-7 weeks old, fed Purina Laboratory Diet #5008, left untreated for 3 weeks to develop diabetes)[1]
Dosage: 4.5 nmol/kg
Administration: s.c.; every 3 days; 127 days
Result: Significantly improved spatial learning.
Improved fasting blood glucose levels, reduced tAUC of fasting blood glucose and improved HbA1c levels.
Improved glucose tolerance, preserved plasma insulin levels and prevented eye cataract development.
Animal Model: Sprague Dawley rats (high-fat diet-fed with medial meniscectomy)[2]
Dosage: 0.5 nmol/kg; 1.5 nmol/kg; 4.5 nmol/kg
Administration: s.c.; every 72 hours; 6 and 8 weeks
Result: Significantly increased the 50% paw withdrawal threshold (PWT), indicating relieved pain-like symptoms.
Induced significant weight loss and reduced inguinal and perirenal adipose tissue masses at doses of 1.5 and 4.5 nmol/kg.
Did not affect body weight or fat depots, still effectively alleviated pain at 0.5 nmol/kg dose.
Animal Model: Sprague-Dawley rats (male, 5-6 weeks, high-fat diet)[3]
Dosage: 4.5 nmol/kg
Administration: s.c.; every 3 days; 8 weeks
Result: Significantly reduced body weight and adiposity, improved glucose homeostasis, delayed gastric emptying.
Increased oligomycininduced leak respiration and the activity of citrate synthase and β-hydroxyacetyl-CoA-dehydrogenase.
Molecular Weight

3917.50

Formula

C172H287N43O56S2
Sequence

Ac-Cys-Ala-Ser-Leu-Ser-Thr-Cys-{Aib}-Leu-Gly-Arg-Leu-Ser-Ala-Glu-Leu-His-Lys(AEEA-AEEA-γGlu-C18 diacid)-Ala-Thr-Tyr-Pro-Lys-Thr-Asp-Val-Gly-Ala-Asn-Ala-Pro-NH2
Sequence Shortening

Ac-CASLSTC-{Aib}-LGRLSAELH-Lys(AEEA-AEEA-γGlu-C18 diacid)-ATYPKTDVGANAP-NH2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KBP-336 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KBP-336KBP336KBP 336Amylin ReceptorCGRP ReceptorAMYRCalcitonin gene-related peptide receptorbody weightantinociceptionZucker Diabetic Fatty ratsdiabetesobesityInhibitorinhibitorinhibit

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