Osteopontin

Osteopontin; Secreted Phosphoprotein 1

Osteopontin (OPN) is a secreted, multifunctional, extracellular matrix (ECM), calcium-binding, glycosylated phosphoprotein that is associated with various normal biological functions and pathological processes. OPN is physiologically produced by a wide range of cells and has been identified in various body fluids, playing a crucial role in bone remodeling and vascularization. OPN is also expressed by multiple immune cells, acting as a chemotactic factor, a mediator of cell activation and cytokine production, and an anti-apoptotic factor, thereby regulating inflammation and immune responses. OPN can be involved in the tumorigenesis of various cancer types, including head and neck squamous cell carcinoma (HNSCC), by promoting cell proliferation, adhesion, invasion, and migration through multiple signaling pathways^[1]^[2].

References:

[1]. El-Zawawy H T, et al. Osteopontin as a marker in thyroid disease: relation to body mass index[J]. Endocrine and Metabolic Science, 2020, 1(1-2): 100049.

[2]. Ghita I, et al. Cytokine profiling in plasma distinguishes the histological inflammatory subtype of head and neck squamous cell carcinoma and a novel regulatory role of osteopontin[J]. Frontiers in oral health, 2022, 3: 993638. [Content Brief]

Osteopontin Related Products (5):

By Effects:	Inhibitors (3) Activator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-146064

OPN-IN-1	Inhibitor	99.98%
OPN-IN-1 is an osteopontin (OPN) expression inhibitor. OPN-IN-1 has potential anti-breast cancer cell metastasis activity and can be used in the study of cancer.

HY-P990116

Anti-Mouse osteopontin/SPP1 Antibody (103D6)	Inhibitor
Anti-Mouse osteopontin/SPP1 Antibody (103D6) is a mouse-derived anti-mouse osteopontin/SPP1 IgG2c κ type antibody inhibitor. Anti-Mouse osteopontin/SPP1 Antibody (103D6) increases cytotoxic T lymphocyte lytic activity and suppresses colon tumor growth. Anti-Mouse osteopontin/SPP1 Antibody (103D6) ameliorates liver injury in common bile duct ligation (CBDL)-induced primary sclerosing cholangitis mice models.

HY-P990795

Anti-Mouse osteopontin/SPP1 Antibody (100D3)	Inhibitor
Anti-Mouse osteopontin/SPP1 Antibody (100D3) is an anti-mouse osteopontin/SPP1 IgG2c monoclonal antibody. Anti-Mouse osteopontin/SPP1 Antibody (100D3) can reverse the inhibition of osteopontin (OPN) on T cells and enhance cytotoxic T lymphocyte (CTL) killing ability. Anti-Mouse osteopontin/SPP1 Antibody (100D3) can improve dentin density. Anti-Mouse osteopontin/SPP1 Antibody (100D3) can be used for researches on cancer and dental related conditions such as colon cancer. The recommend isotype control of Anti-Mouse osteopontin/SPP1 Antibody (100D3): Mouse IgG2c kappa, Isotype Control (HY-P99981).

HY-P11648

SVVYGLR
SVVYGLR is an osteopontin-derived peptide. SVVYGLR can promote the differentiation of fibroblasts into myofibroblast-like cells and promote the production of type III collagen by cardiac fibroblasts. SVVYGLR can activate the adhesion, migration and tubule formation of endothelial cells in vitro. SVVYGLR promotes angiogenesis and wound healing and promotes the migration of dermal fibroblasts and keratinocytes. SVVYGLR can be used for research related to angiogenesis, dermal wounds and bone regeneration.

HY-W404758

Calcium glucoheptonate	Activator
Calcium glucoheptonate is a highly water-soluble calcium supplement. Calcium glucoheptonate can increase the proliferation rate and Calcium intake of MG-63 cells and increase the activity of alkaline phosphatase (ALP). Calcium glucoheptonate can upregulate the expression of osteogenic-related genes and proteins,such as collagen-1, osteocalcin and osteocalcin. Calcium glucoheptonate can be used for the researches of osteoporosis and hypocalcemia.

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