OPC 3911

OPC 3911 (up to 30 μM) induces concentration-dependent relaxation of coronary and renal arteries pre-contracted with 30 mM K⁺, with EC₅₀ values of 1.4 μM and 0.87 μM, respectively; however, at the dose of 30 μM, it only induces 42% relaxation of pulmonary arteries pre-contracted with 30 mM K^+[1].
OPC 3911 exerts concentration-dependent relaxation effects on agonist-contracted coronary arteries (EC₅₀ = 0.54 μM), pulmonary arteries (EC₅₀ = 0.39 μM), and renal arteries (EC₅₀ = 0.83 μM)^[1].
OPC 3911 (up to 10 μM) potently relaxes mesenteric arterial segments contracted by Norepinephrine (HY-13715), with an EC₅₀ of 0.51 μM and a maximum relaxation amplitude of 58%^[2].
OPC 3911 potently inhibits the cGMP-inhibited low K_m cAMP phosphodiesterase purified from rat adipose tissue, with an IC₅₀ of 0.042 μM^[2].
OPC 3911 (10 µM) significantly upregulates the protein expression level of osteopontin in primary rat adipocytes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.