OPC 3911 

OPC 3911 is a highly selective inhibitor of cGMP-inhibited cAMP phosphodiesterase (cGI-PDE/PDE3) and a vasodilator, with an IC₅₀ of 0.042 μM against rat cGI-PDE. OPC 3911 upregulates the expression of Osteopontin. OPC 3911 mediates vasodilation of arterial smooth muscle, induces vasodilatory responses in isolated rat arteriovenous tissues, and exhibits additive vasodilatory effects with Isoprenaline (HY-108353) and Forskolin (HY-15371). OPC 3911 can be used in studies related to congestive heart failure and insulin resistance^[1][2][3].

OPC 3911 (up to 30 μM) induces concentration-dependent relaxation of coronary and renal arteries pre-contracted with 30 mM K⁺, with EC₅₀ values of 1.4 μM and 0.87 μM, respectively; however, at the dose of 30 μM, it only induces 42% relaxation of pulmonary arteries pre-contracted with 30 mM K^+[1].
OPC 3911 exerts concentration-dependent relaxation effects on agonist-contracted coronary arteries (EC₅₀ = 0.54 μM), pulmonary arteries (EC₅₀ = 0.39 μM), and renal arteries (EC₅₀ = 0.83 μM)^[1].
OPC 3911 (up to 10 μM) potently relaxes mesenteric arterial segments contracted by Norepinephrine (HY-13715), with an EC₅₀ of 0.51 μM and a maximum relaxation amplitude of 58%^[2].
OPC 3911 potently inhibits the cGMP-inhibited low K_m cAMP phosphodiesterase purified from rat adipose tissue, with an IC₅₀ of 0.042 μM^[2].
OPC 3911 (10 µM) significantly upregulates the protein expression level of osteopontin in primary rat adipocytes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

374.48

C₂₁H₃₀N₂O₄

76470-87-6

O=C1NC2=CC=C(OCCCC(=O)N(CCO)C3CCCCC3)C=C2CC1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lindgren S, et al. Effects of selective phosphodiesterase inhibitors on isolated coronary, lung and renal arteries from man and rat. Acta physiologica Scandinavica. 1991 May;142(1):77-82.  [Content Brief]

  [2]. Lindgren S, et al. Relaxant effects of the selective phosphodiesterase inhibitors milrinone and OPC 3911 on isolated human mesenteric vessels. Pharmacology & toxicology. 1989 May;64(5):440-5.  [Content Brief]

  [3]. Omar B, et al. Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B. Biochem Biophys Res Commun. 2012 Sep 7;425(4):812-7.  [Content Brief]