Clavanin A acetate 

Clavanin A acetate is a peptide Antibiotic and membrane permeabilizer. Clavanin A acetate permeabilizes cytoplasmic membranes and unilamellar lipid bilayers, and dissipates membrane potential. Clavanin A acetate inserts into phospholipid monolayers via hydrophobic interactions under physiologically relevant surface pressures. Clavanin A acetate exhibits antibacterial activity against Micrococcus flavus. Clavanin A acetate can be used in studies related to Micrococcus flavus infection^[1].

Clavanin A (starting serial dilution at 500 µg/mL; 24 h) acetate inhibits the growth of Micrococcus flavus (DSM 1790), with an MIC of 4.9 µM^[1].
Clavanin A (0.23 µM) acetate dissipates the membrane potential of intact Micrococcus flavus cells, with inhibition rates reaching 58% and 80% at the concentration of 0.23 µM in two independent experiments^[1].
Clavanin A (1-5 µM; 2 min) acetate permeabilizes DOPC large unilamellar vesicles (LUVs), triggering the release of low-molecular-weight carboxyfluorescein and high-molecular-weight FITC-dextran (9400 Da) in the micromolar concentration range, which indicates a non-specific membrane permeabilization mechanism^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2667.07 (free base)

C₁₃₁H₁₈₄N₃₄O₂₇·xC₂H₄O₂

Solid

White to off-white

Val-Phe-Gln-Phe-Leu-Gly-Lys-Ile-Ile-His-His-Val-Gly-Asn-Phe-Val-His-Gly-Phe-Ser-His-Val-Phe

VFQFLGKIIHHVGNFVHGFSHVF

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. van Kan EJ, et al. Membrane activity of the peptide antibiotic clavanin and the importance of its glycine residues. Biochemistry. 2001;40(21):6398-6405.  [Content Brief]