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Cat. No.: HY-P11180

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Clavanin A

Clavanin A is a peptide Antibiotic and membrane permeabilizer. Clavanin A permeabilizes cytoplasmic membranes and unilamellar lipid bilayers, and dissipates membrane potential. Clavanin A inserts into phospholipid monolayers via hydrophobic interactions under physiologically relevant surface pressures. Clavanin A exhibits antibacterial activity against Micrococcus flavus. Clavanin A can be used in studies related to Micrococcus flavus infection.

For research use only. We do not sell to patients.

CAS No.: 185518-51-8
Formula: C₁₃₁H₁₈₄N₃₄O₂₇
Molecular Weight:2667.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Clavanin A Chemical Structure

CAS No.: 185518-51-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Antibiotic Isoforms :

In Vitro

Clavanin A (starting serial dilution at 500 µg/mL; 24 h) inhibits the growth of Micrococcus flavus (DSM 1790), with an MIC of 4.9 µM^[1].
Clavanin A (0.23 µM) dissipates the membrane potential of intact Micrococcus flavus cells, with inhibition rates reaching 58% and 80% at the concentration of 0.23 µM in two independent experiments^[1].
Clavanin A (1-5 µM; 2 min) permeabilizes DOPC large unilamellar vesicles (LUVs), triggering the release of low-molecular-weight carboxyfluorescein and high-molecular-weight FITC-dextran (9400 Da) in the micromolar concentration range, which indicates a non-specific membrane permeabilization mechanism^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 185518-51-8
Molecular Weight 2667.07
Formula C₁₃₁H₁₈₄N₃₄O₂₇
Sequence

Val-Phe-Gln-Phe-Leu-Gly-Lys-Ile-Ile-His-His-Val-Gly-Asn-Phe-Val-His-Gly-Phe-Ser-His-Val-Phe
Sequence Shortening

VFQFLGKIIHHVGNFVHGFSHVF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. van Kan EJ, et al. Membrane activity of the peptide antibiotic clavanin and the importance of its glycine residues. Biochemistry. 2001;40(21):6398-6405. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Clavanin A

All Antibiotic Isoforms