RES-701-3 peptide TFA
Based on 1 Customer Validation
RES-701-3 peptide TFA is a class II lasso peptide. RES-701-3 peptide TFA can be isolated from the fermentation broth of Streptomyces species. RES-701-3 peptide TFA potently inhibits the binding of ET-1 to ETB, with an IC50 of approximately 5-10 nM. RES-701-3 peptide TFA is applicable to research related to systemic hypertension, myocardial infarction, and myocardial ischemia.
For research use only. We do not sell to patients.
- Formula: C103H115N23O24·xC2H4O2
- Molecular Weight:2059.15 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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ETB ~5-10 nM (IC50) |
Fungal Metabolite |
RES-701-3 peptide TFA potently inhibits the binding of ET-1 to type B endothelin receptor, with an IC50 of approximately 5-10 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 2059.15 (free base)
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Formula C103H115N23O24·xC2H4O2
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Sequence
cyclo(Gly-Asn-Trp-His-Gly-Thr-Ser-Pro-Asp)-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp
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Sequence Shortening
cyclo(GNWHGTSPD)WFFNYYW
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
References
[1]. Oves-Costales D, et al. Identification, Cloning and Heterologous Expression of the Gene Cluster Directing RES-701-3, -4 Lasso Peptides Biosynthesis from a Marine Streptomyces Strain. Mar Drugs. 2020;18(5):238. Published 2020 May 1. [Content Brief]
[2]. Ouyang X, et al. LassoPred: a tool to predict the 3D structure of lasso peptides. Nat Commun. 2025;16(1):5497. Published 2025 Jul 1. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RES-701-3 peptide TFA Related Classifications
HY-P11751A Related Classifications
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- RES-701-3 peptide
- Endogenous Metabolite
- Endothelin Receptor
- Streptomyces coelicolor M1154
- endothelin 1
- Streptomyces albus J1074
- resACB1B2EFD gene cluster
- endothelin type B receptor
- cardiac ischemia
- Streptomyces caniferus CA-271066
- myocardial infarction
- systemic hypertension
- Streptomyces coelicolor M1152
- Inhibitor
- inhibitor
- inhibit