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Cat. No.: HY-P11709

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CLPVASC

(Synonyms: cyclo(CLPVASC))

CLPVASC is a kidney-targeting cyclic peptide that preferentially distributes to kidney tissue, with utility to enhance kidney targeting of nanocarriers.CLPVASC preferentially distributes to the kidney when displayed on PEG-b-PPS micelles. CLPVASC can be used for the research of acute kidney injury.

For research use only. We do not sell to patients.

CAS No.: 3106628-26-3
Formula: C₂₈H₄₇N₇O₉S₂
Molecular Weight:689.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CLPVASC Chemical Structure

CAS No.: 3106628-26-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

Micelles co-displaying CLPVASC (1% molar ratio) and CYNTTTHRC (1% molar ratio) (17 mg/mL MC; i.v. (retro-orbital route); single dose) show a 3.4-fold higher uptake in the kidneys of mice with ischemia-reperfusion injury than in the contralateral control kidneys, with reduced off-target distribution to other organs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (female, 17.5 to 22.5 weeks old, unilateral renal ischemia-reperfusion injury)^[1]
Dosage:

MC loaded with 0.3% w/w DiI, displaying CLPVASC at a 1% molar ratio alongside CYNTTTHRC at a 1% molar ratio, at an overall MC concentration of 17 mg/mL
Administration:

i.v. (retro-orbital route); single dose
Result:

Achieved 3.4-fold higher uptake in the ischemia-reperfusion injured kidney compared to the contralateral control kidney.
Showed 2.3-fold higher uptake in the injured kidney than in the lungs.
Exhibited 67% higher uptake in the injured kidney than that of non-targeted MC.

Chemical Information

CAS No. 3106628-26-3
Molecular Weight 689.84
Formula C₂₈H₄₇N₇O₉S₂
Synonyms

cyclo(CLPVASC)
Sequence

cyclo(Cys-Leu-Pro-Val-Ala-Ser-Cys)
Sequence Shortening

cyclo(CLPVASC)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bishop BY, et al. Enabling organ- and injury-specific nanocarrier targeting via surface-functionalized PEG-b-PPS micelles for acute kidney injury. Nanoscale Horiz. 2025 Nov 17;10(12):3423-3432. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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