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  3. Peptide and Derivatives
  4. CLPVASC

CLPVASC is a kidney-targeting cyclic peptide that preferentially distributes to kidney tissue, with utility to enhance kidney targeting of nanocarriers.CLPVASC preferentially distributes to the kidney when displayed on PEG-b-PPS micelles. CLPVASC can be used for the research of acute kidney injury.

For research use only. We do not sell to patients.

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CLPVASC

CLPVASC Chemical Structure

CAS No. : 3106628-26-3

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CLPVASC Related Antibodies

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Description

CLPVASC is a kidney-targeting cyclic peptide that preferentially distributes to kidney tissue, with utility to enhance kidney targeting of nanocarriers.CLPVASC preferentially distributes to the kidney when displayed on PEG-b-PPS micelles. CLPVASC can be used for the research of acute kidney injury[1].

In Vivo

Micelles co-displaying CLPVASC (1% molar ratio) and CYNTTTHRC (1% molar ratio) (17 mg/mL MC; i.v. (retro-orbital route); single dose) show a 3.4-fold higher uptake in the kidneys of mice with ischemia-reperfusion injury than in the contralateral control kidneys, with reduced off-target distribution to other organs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (female, 17.5 to 22.5 weeks old, unilateral renal ischemia-reperfusion injury)[1]
Dosage: MC loaded with 0.3% w/w DiI, displaying CLPVASC at a 1% molar ratio alongside CYNTTTHRC at a 1% molar ratio, at an overall MC concentration of 17 mg/mL
Administration: i.v. (retro-orbital route); single dose
Result: Achieved 3.4-fold higher uptake in the ischemia-reperfusion injured kidney compared to the contralateral control kidney.
Showed 2.3-fold higher uptake in the injured kidney than in the lungs.
Exhibited 67% higher uptake in the injured kidney than that of non-targeted MC.
Molecular Weight

689.84

Formula

C28H47N7O9S2
CAS No.
Sequence

cyclo(Cys-Leu-Pro-Val-Ala-Ser-Cys)
Sequence Shortening

cyclo(CLPVASC)
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CLPVASC Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CLPVASC3106628-26-3cyclo(CLPVASC)Otherskidney-targeting cyclic peptideacute kidney injuryC57BL/6J mice
Inhibitorinhibitorinhibit

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