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Results for "

Reactive oxygen species (ROS) inducer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Reactive Oxygen Species (ROS) (200) ACSL Family (1) Adrenergic Receptor (1) Akt (11) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (3) AMPK (1) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (1) Antibiotic (14) AP-1 (3) Apoptosis (132) Arenavirus (1) ATF6 (2) Aurora Kinase (1) Autophagy (31) Bacterial (35) Bcl-2 Family (11) Bcr-Abl (2) Biochemical Assay Reagents (3) c-Myc (3) Calcium Channel (4) Carbonic Anhydrase (1) Carnitine Palmitoyltransferase (CPT) (2) Caspase (18) CDK (1) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (8) ClpP (1) COX (5) Cuproptosis (2) Cytochrome P450 (2) DAPK (2) Dihydroorotate Dehydrogenase (1) Disulfidptosis (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (12) Drug Metabolite (3) Endogenous Metabolite (23) Environmental Pollutants (6) Epigenetic Reader Domain (1) ER-phagy (1) ERK (3) Ferroptosis (21) FKBP (1) FLT3 (1) Fluorescent Dye (3) Fungal (17) FXR (2) Glutathione Peroxidase (6) GPR84 (1) GSK-3 (1) HDAC (4) Heme Oxygenase (HO) (4) HIF/HIF Prolyl-Hydroxylase (3) Histone Methyltransferase (3) HSP (3) IAP (1) iGluR (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Insecticide (5) Interleukin Related (3) Isotope-Labeled Compounds (13) JAK (4) JNK (3) Keap1-Nrf2 (12) Lipoxygenase (1) MDM-2/p53 (2) MHC (1) Microtubule/Tubulin (8) Mitochondrial Metabolism (13) Mitophagy (1) Mitosis (1) Mixed Lineage Kinase (2) MMP (7) Monoamine Oxidase (2) mTOR (2) Myosin (2) Na+/K+ ATPase (3) nAChR (1) Necroptosis (4) NF-κB (22) NKCC (1) NO Synthase (6) Nuclear Hormone Receptor 4A/NR4A (1) Nucleoside Antimetabolite/Analog (1) OAT (1) Oxidative Phosphorylation (2) P-glycoprotein (1) P2X Receptor (2) p38 MAPK (6) p62 (2) PANoptosis (1) Paraptosis (1) Parasite (18) PARP (1) PDGFR (2) PDHK (1) PDK-1 (1) PERK (2) Phosphatase (3) Photosensitizer (1) PI3K (10) PPAR (2) Prolyl Endopeptidase (PREP) (2) PROTACs (1) Proteasome (2) Pyroptosis (1) Pyruvate Kinase (1) Quinone Reductase (3) Ras (1) Reference Standards (33) RIP kinase (3) ROR (2) SARS-CoV (2) SOD (6) STAT (2) STING (1) Succinate Dehydrogenase (1) Survivin (1) TGF-beta/Smad (1) Thymidylate Synthase (1) TNF Receptor (4) Toll-like Receptor (TLR) (2) Topoisomerase (12) TrxR (7) VDAC (1) VEGFR (6) Wnt (1) Xanthine Oxidase (1) α-synuclein (1)
By Research Areas:	Cancer (161) Cardiovascular Disease (14) Infection (57) Inflammation/Immunology (66) Metabolic Disease (34) Neurological Disease (29)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Adenosine (1) Nucleoside Analogs (1)

250

Inhibitors & Agonists

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Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: Reactive Oxygen Species (ROS) ROS Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18258

Berberine chloride Maximum Cited Publications 80 Publications Verification Natural Yellow 18 chloride	Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite	Cancer
Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-117433

4-Hydroperoxy cyclophosphamide 10+ Cited Publications	DNA Alkylator/Crosslinker Apoptosis Reactive Oxygen Species (ROS) Drug Metabolite	Inflammation/Immunology
4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases .

HY-N0155

Nobiletin 25+ Cited Publications	ROR Reactive Oxygen Species (ROS) Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce **reactive oxygen species (ROS)** levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

HY-N0052A

Sanguinarine chloride 10+ Cited Publications Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride	Apoptosis Autophagy Bacterial Parasite	Cancer
Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N0716B

Berberine sulfate 75+ Cited Publications Natural Yellow 18 sulfate	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .

HY-N0457

Chicoric acid 2 Publications Verification Cichoric acid; Dicaffeoyltartaric acid	Reactive Oxygen Species (ROS) Apoptosis	Metabolic Disease Inflammation/Immunology
Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces **reactive oxygen species (ROS)** generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects .

HY-17577

Berberine chloride hydrate 70+ Cited Publications Natural Yellow 18 chloride hydrate	Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite	Cancer
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-B0849

Azoxystrobin 3 Publications Verification	Environmental Pollutants Reactive Oxygen Species (ROS) Fungal Apoptosis Bacterial Phosphatase	Infection
Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of **reactive oxygen species (ROS)** and induces cell apoptosis .

HY-135897

Urolithin C 5 Publications Verification	Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite	Metabolic Disease
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca ²⁺ channel opener and enhances Ca ²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates **reactive oxygen species (ROS)** formation .

HY-N1458

Isoschaftoside 1 Publications Verification	Parasite Autophagy p62 Reactive Oxygen Species (ROS)	Infection Metabolic Disease Inflammation/Immunology Cancer
Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit the growth of germinated S. hermonthica radicles. Isoschaftoside reduces **reactive oxygen species (ROS)** and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study .

HY-N0332

Ziyuglycoside II 1 Publications Verification	Reactive Oxygen Species (ROS) Apoptosis	Inflammation/Immunology Cancer
Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect .

HY-N0052

Sanguinarine Sanguinarin; Sanguinarium; Pseudochelerythrine	Apoptosis Autophagy	Cancer
Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N3244

Moracin O 2 Publications Verification	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Moracin O is a 2-arylbenzofuran isolated from the Morus alba Linn. . Moracin O exhibits potent in vitro inhibitory activity against *hypoxia-inducible* factor (HIF-1)*. Moracin O reduces oxygen-glucose deprivation (OGD)-induced* **reactive oxygen species (ROS)** production. Moracin O has neuroprotective and anti-inflammatory effects .

HY-N0716

Berberine Natural Yellow 18	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

HY-119502

Camalexin 3 Publications Verification	Reactive Oxygen Species (ROS) Fungal Bacterial	Infection Cancer
Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce **reactive oxygen species (ROS)** production .

HY-133114

Ezetimibe ketone EZM-K	Keap1-Nrf2 Autophagy	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Ezetimibe ketone is an orall active Nrf2 activator and *ROS* inhibitor. Ezetimibe ketone attenuates H₂O₂-induced reactive oxygen species production and reduces H₂O₂-induced apoptosis in renal tubular epithelial cells. Ezetimibe ketone suppresses renal tubular injury and inflammation .

HY-B1946

Dimethoate 5 Publications Verification	Environmental Pollutants Apoptosis Cholinesterase (ChE) Insecticide Reactive Oxygen Species (ROS)	Inflammation/Immunology
Dimethoate is an organophosphate insecticide and acaricide. Dimethoate is an orally active acetylcholinesterase inhibitor. Dimethoate induces **reactive oxygen species (ROS)*. Dimethoate induces* DNA damage and cell apoptosis in vivo. Dimethoate affect immune system in mice .

HY-W041080

3,5-Di-tert-butylphenol	Fungal Reactive Oxygen Species (ROS) Bacterial	Infection
3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities. 3,5-Di-tert-butylphenol induces accumulation of **reactive oxygen species (ROS)** in C. albicans cells. 3,5-Di-tert-butylphenol also has antibacterial activities .

HY-128784

PK11007	MDM-2/p53 Reactive Oxygen Species (ROS)	Cancer
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing **reactive oxygen species (ROS)** levels .

HY-N1478

Gardenoside 2 Publications Verification	P2X Receptor Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces **reactive oxygen species (ROS)**. Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study .

HY-108992

Deoxynyboquinone	Quinone Reductase Apoptosis Reactive Oxygen Species (ROS)	Cancer
Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation .

HY-150228

MitoCur-1 1 Publications Verification	TrxR	Cancer
MitoCur-1, a curcumin analogue, is an inhibitor of mitochondrial antioxidative thioredoxin reductase 2 (TrxR2). MitoCur-1 has electrophilic and mitochondrial-targeting properties. MitoCur-1 induces reactive oxygen species (ROS) generation, exerts specifically antitumor efficacy .

HY-N2454

β-Elemonic acid	Apoptosis Reactive Oxygen Species (ROS) COX Endogenous Metabolite Prolyl Endopeptidase (PREP)	Inflammation/Immunology Cancer
β-Elemonic acid is a triterpene isolated from Boswellia carterii. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects .

HY-N2208

4-Hydroxylonchocarpin 2 Publications Verification	p38 MAPK Apoptosis Reactive Oxygen Species (ROS)	Infection Metabolic Disease Inflammation/Immunology Cancer
4-Hydroxylonchocarpin is a chalcone compound. 4-Hydroxylonchocarpin enhances the phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin induces **reactive oxygen species (ROS) and apoptosis** in liver cancer cells. 4-Hydroxylonchocarpin has various pharmacological activities, including antibacterial, anticancer, anti-retroviral, anti-tuberculosis, anti-malarial and anti-inflammatory activities .

HY-108551

MG-262 1 Publications Verification Z-Leu-Leu-LeuB(OH)2; ZL3B	Proteasome VEGFR Apoptosis Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Cancer
MG-262 (Z-Leu-Leu-LeuB(OH)2; ZL3B) is a reversible proteasome inhibitor. MG-262 down-regulates VEGF receptor Flt-1. MG-262 inhibits cell growth and induces apoptosis in malignant cells. MG-262 induces **reactive oxygen species (ROS)**. MG-262 can be used for anti-cancer study .

HY-139369

QD394 1 Publications Verification	Reactive Oxygen Species (ROS)	Cancer
QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis .

HY-N3243

Moracin P 2 Publications Verification	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against *hypoxia-inducible* factor (HIF-1)*. Moracin P reduces oxygen-glucose deprivation (OGD)-induced* **reactive oxygen species (ROS)** production. Moracin P has neuroprotective and anti-inflammatory effects .

HY-N6884

Bixin 2 Publications Verification	Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Bixin is an orally active carotenoid found in the seeds of Bixa orellana. Bixin induces apoptosis in cancer cells. Bixin possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and **reactive oxygen species (ROS)** generation .

HY-155554

SCAL-255	Mitochondrial Metabolism Oxidative Phosphorylation Reactive Oxygen Species (ROS) MMP	Cancer
SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with an IC₅₀ of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits oxygen consumption rate (OCR), induces **reactive oxygen species (ROS) production, and reduces MMP**. SCAL-255 can be used in the research of oxidative phosphorylation (OXPHOS)-dependent cancers, such as colorectal cancer (CRC) and acute myeloid leukemia (AML), etc .

HY-W011215

Dihexyl phthalate 1 Publications Verification	Apoptosis Reactive Oxygen Species (ROS)	Inflammation/Immunology
Dihexyl phthalate is one of the commonly used phthalate esters in various plastics and consumer products. Dihexyl phthalate is classified as a priority pollutant and an endocrine disruptor. Dihexyl phthalate can induce reactive oxygen species (ROS) accumulation, promote inflammation, and lead to significant increases in apoptosis and inflammation-related gene expression levels. Dihexyl phthalate can cause testicular atrophy and is a reproductive toxicant .

HY-158412

BT317	Proteasome Apoptosis	Cancer
BT317 is a blood-brain transmissible mitochondrial Lon peptidase I (LonP1) and CT-L proteasome inhibitor. BT317 can increase the production of reactive oxygen species (ROS) and induce apoptosis in astrocytoma cells. BT317 has antitumor activity .

HY-B1946S

Dimethoate-d6	Isotope-Labeled Compounds Insecticide Reactive Oxygen Species (ROS) Apoptosis Cholinesterase (ChE)	Inflammation/Immunology
Dimethoate-d₆ is the deuterium labeled Dimethoate. Dimethoate is an organophosphate insecticide and acaricide. Dimethoate is an orally active acetylcholinesterase inhibitor. Dimethoate induces **reactive oxygen species (ROS)*. Dimethoate induces* DNA damage and cell apoptosis in vivo. Dimethoate affect immune system in mice .

HY-B0849R

Azoxystrobin (Standard)	Reference Standards Fungal Reactive Oxygen Species (ROS) Apoptosis	Infection
Azoxystrobin (Standard) is the analytical standard of Azoxystrobin. This product is intended for research and analytical applications. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of **reactive oxygen species (ROS)** and induces cell apoptosis.

HY-126193

JS-K	NO Synthase Apoptosis Autophagy Reactive Oxygen Species (ROS)	Cancer
JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH. JS-K induces **reactive oxygen species (ROS) to mediate apoptosis*. JS-K induces* autophagy. JS-K inhibits invasion. JS-K has a broad spectrum anti-proliferative activity in cancer cells. JS-K reduces tumor volume and causes necrosis of implanted tumors in mice .

HY-18258R

Berberine chloride (Standard) Natural Yellow 18 chloride (Standard)	Reference Standards Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite	Cancer
Berberine (chloride) (Standard) is the analytical standard of Berberine (chloride). This product is intended for research and analytical applications. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-172086

TrxR-IN-7	TrxR Apoptosis Reactive Oxygen Species (ROS)	Cancer
TrxR-IN-7 is a thioredoxin reductase (TrxR) inhibitor with an IC₅₀ of 3.5 μM. TrxR-IN-7 induces **reactive oxygen species** (ROS) generation and apoptosis in tumor cells. TrxR-IN-7 can be used for the research of liver cancer and breast cancer .

HY-B1946R

Dimethoate (Standard)	Insecticide Reference Standards Reactive Oxygen Species (ROS) Apoptosis Cholinesterase (ChE)	Inflammation/Immunology
Dimethoate (Standard) is the analytical standard of Dimethoate. This product is intended for research and analytical applications. Dimethoate is an organophosphate insecticide and acaricide. Dimethoate is an orally active acetylcholinesterase inhibitor. Dimethoate induces **reactive oxygen species (ROS)*. Dimethoate induces* DNA damage and cell apoptosis in vivo. Dimethoate affect immune system in mice.

HY-157158

TrxR-IN-6	TrxR Apoptosis Reactive Oxygen Species (ROS)	Cancer
TrxR-IN-6 is a thioredoxin reductase (TrxR) inhibitor. TrxR-IN-6 induces **reactive oxygen species** (ROS) accumulation and cell apoptosis. TrxR-IN-6 induces mitochondrial dysfunction, endoplasmic reticulum stress and DNA damage. TrxR-IN-6 can be used for the research of breast cancer, leukemia .

HY-142956

ROS-ERS inducer 1	Reactive Oxygen Species (ROS)	Cancer
ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin .

HY-W728085

CPPD-Q	Bacterial Antibiotic Insecticide Reactive Oxygen Species (ROS)	Infection
CPPD-Q is an antimicrobial agent and insecticide. CPPD-Q has an EC₅₀ of 6.98 mg/L against Vibrio fischeri. At doses of 1 or 10 µg/mL, CPPD-Q exerts its insecticidal effect by inducing the production of reactive oxygen species (ROS) in the intestines of Caenorhabditis elegans .

HY-146350

TrxR-IN-4	TrxR Reactive Oxygen Species (ROS) Apoptosis	Cancer
TrxR-IN-4 is a thioredoxin reductase (TrxR) inhibitor with a rat IC₅₀ of 0.37 μM. TrxR-IN-4 inhibits TrxR activity, elevates **reactive oxygen species** (ROS) and induces apoptosis. TrxR-IN-4 mediates endoplasmic reticulum stress and induces mitochondrial dysfunction. TrxR-IN-4 can be used for the research of hepatocellular carcinoma .

HY-161659

Apoptosis inducer 19	Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species (ROS)	Cancer
Apoptosis inducer 19 (Compound 7g) is an Apoptosis inducer. Apoptosis inducer 19 elevates expression of pro-apoptotic proteins (Bax and caspase-3) and downregulates anti-apoptotic protein (Bcl-2). Apoptosis inducer 19 upregulates cellular **reactive oxygen species** (ROS) levels and disrupts mitochondrial membrane potential (MMP). Apoptosis inducer 19 can be used for triple-negative breast cancer (TNBC) research .

HY-111646

N6-Etheno 2'-deoxyadenosine	Nucleoside Antimetabolite/Analog Endogenous Metabolite	Inflammation/Immunology
N6-Etheno 2'-deoxyadenosine is a reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced DNA oxidation product, used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues .

HY-18258S

Berberine-d6 chloride Natural Yellow 18-d6 chloride	Isotope-Labeled Compounds Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite	Cancer
Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-W724853

Dimethyl tetrasulfide 1,4-Dimethyltetrasulfane	Apoptosis Caspase Reactive Oxygen Species (ROS)	Cancer
Dimethyl tetrasulfide (1,4-Dimethyltetrasulfane) is an apoptosis inducer targeting leukemia cells. Dimethyl tetrasulfide exerts cytotoxic effects through the induction of intracellular reactive oxygen species (ROS) production and activation of caspase-3 enzyme. Dimethyl tetrasulfide is promising for research of cancers, such as leukemia .

HY-176039

TUG-2181	GPR84 Reactive Oxygen Species (ROS)	Inflammation/Immunology
TUG-2181 is an antagonist of GPR84 with an IC₅₀ value of 34 nM. TUG-2181 inhibits GPR84 agonists-induced **reactive species oxygen (ROS)** production and IL-8 release in human neutrophils. TUG-2181 can be used for inflammation and fibrosis study .

HY-173403

TrxR-IN-8	TrxR Reactive Oxygen Species (ROS) Apoptosis	Cancer
TrxR-IN-8 (Compound 6f) is a selective TrxR inhibitor (IC₅₀: 10.2 μM). TrxR-IN-8 induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species (ROS), reducing intracellular thiols, and lowering the glutathione/glutathione ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells .

HY-P10350

PapRIV	NF-κB	Neurological Disease Inflammation/Immunology
PapRIV is an agonist of BV-2 microglial cells, capable of activating microglial cells through an NF-κB-dependent pathway. PapRIV induces the expression of pro-inflammatory cytokines such as IL-6 and TNFα and increases the production of reactive oxygen species (ROS). PapRIV can cross the blood-brain barrier .

HY-P11116

Periplanetasin-2	Bacterial Apoptosis Reactive Oxygen Species (ROS)	Infection
Periplanetasin-2 is an antifungal peptide that induces oxidative stress through the production of **reactive oxygen species (ROS)** and lipid peroxidation. Periplanetasin-2 can also induce apoptosis .

HY-N16417

Elsinochrome C	Apoptosis Reactive Oxygen Species (ROS)	Infection Cancer
Elsinochrome C is a photosensitizer. Elsinochrome C relies on light activation to generate reactive oxygen species (ROS) such as singlet oxygen (1O2), inducing apoptosis or directly disrupting pathogen structures. Elsinochrome C is promising for research of skin cancers, HIV-associated infections, and refractory skin diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18258

Berberine chloride Maximum Cited Publications 80 Publications Verification Natural Yellow 18 chloride	Alkaloids Phellodendron amurense Rupr. Classification of Application Fields Rutaceae Plants Isoquinoline Alkaloids Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite
Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-N0155

Nobiletin 25+ Cited Publications	Flavonoids Neurological Disease Classification of Application Fields Flavones Rutaceae Plants Inflammation/Immunology Disease Research Fields Citrus reticulata Blanco Source Classification	ROR Reactive Oxygen Species (ROS) Apoptosis Autophagy
Nobiletin is a poly-methoxylated flavone from the citrus peel that improves memory loss. Nobiletin is a retinoid acid receptor-related orphan receptors (RORs) agonist. Nobiletin can reduce **reactive oxygen species (ROS)** levels in differentiated C2C12 myotubes and has anti-inflammation and anti-cancer properties, including anti-angiogenesis, anti-proliferation, anti-metastasis and induced apoptosis .

HY-N0052A

Sanguinarine chloride 10+ Cited Publications Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride	Alkaloids Classification of Application Fields Pyridine Alkaloids Sanguinaria canadensis Plants Disease Research Fields Papaveraceae Cancer	Apoptosis Autophagy Bacterial Parasite
Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N0716B

Berberine sulfate 75+ Cited Publications Natural Yellow 18 sulfate	Alkaloids Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .

HY-N0457

Chicoric acid 2 Publications Verification Cichoric acid; Dicaffeoyltartaric acid	other families Classification of Application Fields Anti-aging Other Phenylpropanoids Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Apoptosis
Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces **reactive oxygen species (ROS)** generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects .

HY-N0411

β-Carotene 2 Publications Verification Provitamin A; beta-Carotene	Structural Classification Classification of Application Fields Endocrine diseases Metabolic Disease Plants Endogenous metabolite Food Research Other Terpenoids Immune System Disorder other families Terpenoids Disease markers Pigments Disease Research Fields Cancer Source Classification	Environmental Pollutants Endogenous Metabolite Reactive Oxygen Species (ROS) Apoptosis
β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of **reactive oxygen species (ROS)*, with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces* breast cancer cells apoptosis, with anticancer activities .

HY-17577

Berberine chloride hydrate 70+ Cited Publications Natural Yellow 18 chloride hydrate	Alkaloids Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Plants Isoquinoline Alkaloids Disease Research Fields Source Classification Cancer	Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-N2515

Ginsenoside Rk1 5+ Cited Publications	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-121360

Cylindrospermopsin	Microorganisms Source Classification	DNA/RNA Synthesis Reactive Oxygen Species (ROS)
Cylindrospermopsin, a cyanotoxin, is a polycyclic uracil derivative containing guanidine and sulfate groups, which can inhibit protein synthesis and covalently modify DNA or RNA. Cylindrospermopsin induces hepatocellular hypertrophy, renal cellular hypertrophy, intracellular **reactive oxygen species (ROS)**, DNA strand breaks, mitochondrial hyperpolarisation, ultrastructural damage, and altered gene expression in liver, kidney, and intestinal cells. Cylindrospermopsin can be used in research including hepatocellular carcinoma and water quality testing .

HY-N0316

Mollugin 2 Publications Verification	Monophenols Classification of Application Fields Terpenoids Sesquiterpenes Rubiaceae Phenols Plants Disease Research Fields Rubia cordifolia L. Source Classification Cancer	JAK NF-κB Reactive Oxygen Species (ROS) Apoptosis VEGFR c-Myc
Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway .

HY-N1913

Danshensu 5+ Cited Publications Dan shen suan A; Salvianic acid A	Classification of Application Fields Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Keap1-Nrf2 NF-κB Reactive Oxygen Species (ROS) SARS-CoV Apoptosis
Danshensu (Dan shen suan A), an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC₅₀ of 0.97 μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

HY-W012382

N-Acetyl-L-tyrosine	Human Gut Microbiota Metabolites Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level **reactive oxygen species** (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .

HY-12688A

Succinyl phosphonate trisodium salt 10+ Cited Publications	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Mitochondrial Metabolism Reactive Oxygen Species (ROS) Amyloid-β
Succinyl phosphonate trisodium salt is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate trisodium salt protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate trisodium salt corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate trisodium salt reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate trisodium salt improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate trisodium salt can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease .

HY-N2593

Isorhapontigenin 4 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Gnetum cleistostachyum C. Y. Cheng Phenols Polyphenols Gnetaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2
Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of **reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2** promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes .

HY-135897

Urolithin C 5 Publications Verification	Classification of Application Fields Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Calcium Channel Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca ²⁺ channel opener and enhances Ca ²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates **reactive oxygen species (ROS)** formation .

HY-N1458

Isoschaftoside 1 Publications Verification	Classification of Application Fields Flavones Plants Desmodium uncinatum DC. Infection Flavonoids other families Leguminosae Phenols Polyphenols Disease Research Fields Source Classification Cancer	Parasite Autophagy p62 Reactive Oxygen Species (ROS)
Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit the growth of germinated S. hermonthica radicles. Isoschaftoside reduces **reactive oxygen species (ROS)** and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study .

HY-113110

Cysteinylglycine L-Cysteinylglycine; Cys-Gly; H-Cys-Gly-OH	Natural Products Human Gut Microbiota Metabolites Microorganisms Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Cysteinylglycine (L-Cysteinylglycine; Cys-Gly) is a dipeptide formed by the peptide bond linkage between cysteine (Cysteine) and glycine (Glycine). Cysteinylglycine is an important metabolic intermediate in the human body, mainly derived from the degradation of glutathione (GSH). Cysteinylglycine reduces ferric iron to ferrous iron, drives the redox cycle of iron, generates reactive oxygen species (ROS), stimulates oxidative reactions, induces lipid peroxidation of human plasma LDL lipoproteins, and causes oxidative damage to DNA bases. Cysteinylglycine can be used as a biomarker to evaluate ischemic heart disease, breast cancer and other conditions .

HY-N0332

Ziyuglycoside II 1 Publications Verification	Triterpenes Classification of Application Fields Sanguisorba officinalis Linn. Terpenoids Rosaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Apoptosis
Ziyuglycoside II is a triterpenoid saponin compound extracted from Sanguisorba officinalis L.. Ziyuglycoside II induces reactive oxygen species (ROS) production and apoptosis. Anti-inflammation and anti-cancer effect .

HY-N0052

Sanguinarine Sanguinarin; Sanguinarium; Pseudochelerythrine	Alkaloids Classification of Application Fields Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification Cancer	Apoptosis Autophagy
Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N3244

Moracin O 2 Publications Verification	Neurological Disease Classification of Application Fields Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn. Source Classification	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS)
Moracin O is a 2-arylbenzofuran isolated from the Morus alba Linn. . Moracin O exhibits potent in vitro inhibitory activity against *hypoxia-inducible* factor (HIF-1)*. Moracin O reduces oxygen-glucose deprivation (OGD)-induced* **reactive oxygen species (ROS)** production. Moracin O has neuroprotective and anti-inflammatory effects .

HY-N0716

Berberine Natural Yellow 18	Classification of Application Fields Anti-aging Ranunculaceae Plants Endogenous metabolite Biological Pesticide Research Agricultural Research Alkaloids Coptis chinensis Franch. Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification Cancer	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

HY-136409

N-Decanoyl-L-homoserine lactone C10-HSL	Microorganisms Source Classification	Bacterial Reactive Oxygen Species (ROS)
N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca ²⁺ and reactive oxygen species (ROS), increases the activity of mitogen-activated protein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots .

HY-N0310

Soyasaponin Bb 1 Publications Verification	Triterpenes Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Plants Disease Research Fields Endocrinology Source Classification	Aldose Reductase Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Apoptosis
Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities .

HY-N12257

Antimycin A2 2 Publications Verification	Structural Classification Monophenols Microorganisms Phenols Source Classification	Cytochrome P450 Reactive Oxygen Species (ROS) Apoptosis
Antimycin A2 is a selective inhibitor of the cytochrome b-c1 complex in the mitochondrial electron transport chain. Antimycin A2 disrupts mitochondrial membrane potential and produces reactive oxygen species (ROS) by inhibiting electron transfer between cytochrome b and c. Antimycin A2 has bactericidal and piscicidal activity, as well as tumor cell growth inhibitory effects, and can induce S-phase cell cycle arrest and apoptosis in HeLa cells. Antimycin A2 is suitable for research of cervical cancer and fisheries management. Antimycin A2 can be naturally isolated from the fermentation products of Streptomyces sp. strains .

HY-W015551

trans-2-Decenal (E)-Dec-2-enal	Structural Classification Natural Products Vaccinium vitis-idaea L. Ericaceae Plants Source Classification	Bacterial Reactive Oxygen Species (ROS)
trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici .

HY-119502

Camalexin 3 Publications Verification	Infection Alkaloids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Camelina sativa (L.) Crantz Plants Brassicaceae Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification	Reactive Oxygen Species (ROS) Fungal Bacterial
Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce **reactive oxygen species (ROS)** production .

HY-N6929

Angelic acid 1 Publications Verification	Structural Classification Ketones, Aldehydes, Acids Umbelliferae Plants Echinacea angustifolia DC. Source Classification	Ferroptosis Keap1-Nrf2 Reactive Oxygen Species (ROS)
Angelic acid is a ferroptosis inducer, targeting NRF2 degradation. Angelic acid binds to NRF2 protein and promotes NRF2 degradation via ubiquitination-proteasome pathway, relieves the inhibitory effect of NRF2 on oxidative stress and lipid peroxidation. Then, Angelic acid induces ferroptosis in tumor cells. Angelic acid can enhance the accumulation of intracellular reactive oxygen species (ROS), upregulate ferroptosis-related markers CHAC1 and PTGS2, and synergize with ferroptosis inducers to enhance anti-tumor effects. Angelic acid also has the activity of scavenging UVA-induced ROS in vitro, inhibiting skin fibroblast senescence and extracellular matrix degradation. Angelic Acid helps wound healing with sedative activity .

HY-113410

3-Methylglutaric acid	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Source Classification	Na+/K+ ATPase Mitochondrial Metabolism Reactive Oxygen Species (ROS)
3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na ⁺, K ⁺-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na ⁺, K ⁺-ATPase. 3-Methylglutaric acid can induce **reactive oxygen species** (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration .

HY-N0411R

β-Carotene (Standard) Provitamin A (Standard); beta-Carotene (Standard)	Other Terpenoids Structural Classification Immune System Disorder other families Terpenoids Disease markers Endocrine diseases Plants Endogenous metabolite Cancer Source Classification	Reference Standards Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)
β-Carotene (Standard) is the analytical standard of β-Carotene. This product is intended for research and analytical applications. β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .

HY-W041080

3,5-Di-tert-butylphenol	Infection Monophenols Microorganisms Classification of Application Fields Phenols Disease Research Fields Source Classification	Fungal Reactive Oxygen Species (ROS) Bacterial
3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities. 3,5-Di-tert-butylphenol induces accumulation of **reactive oxygen species (ROS)** in C. albicans cells. 3,5-Di-tert-butylphenol also has antibacterial activities .

HY-N1478

Gardenoside 2 Publications Verification	Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis Source Classification	P2X Receptor Reactive Oxygen Species (ROS)
Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces **reactive oxygen species (ROS)**. Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study .

HY-N2255

Crebanine 4 Publications Verification	Cardiovascular Disease Structural Classification Alkaloids Stephania venosa Classification of Application Fields Other Alkaloids Plants Menispermaceae Inflammation/Immunology Disease Research Fields	Akt Apoptosis NF-κB Reactive Oxygen Species (ROS) p38 MAPK ERK Interleukin Related TNF Receptor NO Synthase nAChR Bacterial
Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC₅₀ of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na ⁺ current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease .

HY-N2374

Eupatorin 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Cruciferae Phenols Polyphenols Isatis tinctoria L. Plants Disease Research Fields Source Classification Cancer	Apoptosis NF-κB MMP Adrenergic Receptor
Eupatorin is an orally active flavonoid with antiproliferative and vasodilatory properties. Eupatorin downregulates the expression levels of NF-κB, MMP9, IL-1β and TNF-α. Eupatorin induces apoptosis, G2/M phase cell cycle arrest, and **reactive oxygen species (ROS) production. Eupatorin modulates the activities of muscarinic receptors and β-adrenergic receptors; inhibits sarcoplasmic reticulum calcium release and calcium channels; and activates the NO/sGC/cGMP pathway, indomethacin-sensitive pathway, and potassium channel pathway. Eupatorin exerts cytotoxic effects on cancer cell lines, and is metabolized by CYP1A1** and CYP1 family enzymes to form metabolites with antiproliferative activity. Eupatorin can be used in research related to breast cancer, hypertension, and leukemia .

HY-N2454

β-Elemonic acid	Triterpenes other families Classification of Application Fields Terpenoids Plants Burseraceae Inflammation/Immunology Disease Research Fields Source Classification Boswellia carterii Cancer	Apoptosis Reactive Oxygen Species (ROS) COX Endogenous Metabolite Prolyl Endopeptidase (PREP)
β-Elemonic acid is a triterpene isolated from Boswellia carterii. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects .

HY-N2208

4-Hydroxylonchocarpin 2 Publications Verification	Classification of Application Fields Metabolic Disease Plants Infection Chalcones Flavonoids Leguminosae Phenols Polyphenols Psoralea corylifolia L. Inflammation/Immunology Disease Research Fields Source Classification	p38 MAPK Apoptosis Reactive Oxygen Species (ROS)
4-Hydroxylonchocarpin is a chalcone compound. 4-Hydroxylonchocarpin enhances the phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin induces **reactive oxygen species (ROS) and apoptosis** in liver cancer cells. 4-Hydroxylonchocarpin has various pharmacological activities, including antibacterial, anticancer, anti-retroviral, anti-tuberculosis, anti-malarial and anti-inflammatory activities .

HY-126848

Diclofenac acyl glucuronide D-1-O-G	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Drug Metabolite SOD COX Reactive Oxygen Species (ROS) OAT
Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, COX-1 inhibitory activity (IC₅₀ = 0.620 μM), and COX-2 inhibitory activity (IC₅₀ = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of OATP2B1. Diclofenac acyl glucuronide induces small intestinal ulcers . Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers .

HY-N2902

Artocarpin	Structural Classification Flavonols Flavonoids Plants Moraceae Source Classification	Reactive Oxygen Species (ROS)
Artocarpin is an orally active apoptosis inducer. Artocarpin targets NF-κB, Erk1/2, p38 MAPK, AktS473, p53, Akt 1 kinase and Akt 2 kinase. Artocarpin induces reactive oxygen species (ROS) production, mediates p53-dependent and p53-independent apoptotic signaling pathways, induces G1-phase cell cycle arrest, and triggers autophagic cell death. Artocarpin exerts cytotoxic and bactericidal effects on cancer cells, reduces bacterial load, and exhibits anti-inflammatory, analgesic and anti-angiogenic activities .

HY-N3243

Moracin P 2 Publications Verification	other families Neurological Disease Classification of Application Fields Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS)
Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against *hypoxia-inducible* factor (HIF-1)*. Moracin P reduces oxygen-glucose deprivation (OGD)-induced* **reactive oxygen species (ROS)** production. Moracin P has neuroprotective and anti-inflammatory effects .

HY-N6884

Bixin 2 Publications Verification	Bixaceae Bixa orellana Linn. Classification of Application Fields Ketones, Aldehydes, Acids Pigments Plants Inflammation/Immunology Disease Research Fields Source Classification Cancer Food Research	Reactive Oxygen Species (ROS) Apoptosis
Bixin is an orally active carotenoid found in the seeds of Bixa orellana. Bixin induces apoptosis in cancer cells. Bixin possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and **reactive oxygen species (ROS)** generation .

HY-W011215

Dihexyl phthalate 1 Publications Verification	Natural Products Pyrus bretschneideri Rehder Rosaceae Plants Source Classification	Apoptosis Reactive Oxygen Species (ROS)
Dihexyl phthalate is one of the commonly used phthalate esters in various plastics and consumer products. Dihexyl phthalate is classified as a priority pollutant and an endocrine disruptor. Dihexyl phthalate can induce reactive oxygen species (ROS) accumulation, promote inflammation, and lead to significant increases in apoptosis and inflammation-related gene expression levels. Dihexyl phthalate can cause testicular atrophy and is a reproductive toxicant .

HY-N1913A

Danshensu sodium 5+ Cited Publications Dan shen suan A sodium; Salvianic acid A sodium	Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants Source Classification	Keap1-Nrf2 NF-κB Reactive Oxygen Species (ROS) SARS-CoV Apoptosis
Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC₅₀ of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

HY-W674241A

4-Ethylphenyl sulfate sodium	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS)
4-Ethylphenyl sulfate sodium is an orally active and brain-penetrant gut microbial metabolite. 4-Ethylphenyl sulfate sodium downregulates Bcl2 expression, upregulates Bax expression, and induces cancer cell apoptosis via the endogenous apoptotic pathway. 4-Ethylphenyl sulfate sodium induces G2/M cell cycle arrest and reactive oxygen species (ROS) production. 4-Ethylphenyl sulfate sodium impairs oligodendrocyte maturation, reduces oligodendrocyte-neuron interactions, decreases axonal myelination levels, and shifts the oligodendrocyte population toward immature precursor cells. 4-Ethylphenyl sulfate sodium alters brain region-specific neural activity and functional connectivity in mice, and correlates with anxiety-like behaviors in mice .

HY-12688

Succinyl phosphonate	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Mitochondrial Metabolism Reactive Oxygen Species (ROS) Amyloid-β
Succinyl phosphonate is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease .

HY-18258R

Berberine chloride (Standard) Natural Yellow 18 chloride (Standard)	Alkaloids Structural Classification Phellodendron amurense Rupr. Rutaceae Plants Isoquinoline Alkaloids Source Classification	Reference Standards Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Antibiotic Endogenous Metabolite Parasite
Berberine (chloride) (Standard) is the analytical standard of Berberine (chloride). This product is intended for research and analytical applications. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-N10113

Verrucarin J 1 Publications Verification Muconomycin B	Infection Natural Products Microorganisms Classification of Application Fields Marine algae Marine natural products Disease Research Fields Source Classification	Apoptosis Arenavirus Fungal Antibiotic Reactive Oxygen Species (ROS)
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC₅₀ of 1.2 ng/mL .

HY-N3027

Soyasaponin Aa 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Metabolic Disease Plants Disease Research Fields Source Classification	PPAR Reactive Oxygen Species (ROS)
Soyasaponin Aa is a soyasaponin that can be found in soy. Soyasaponin Aa suppresses PPARγ transcriptional activity, reduces PPARγ and C/EBPα expression, inhibits adipocyte differentiation and lipid accumulation, and reduces adipogenic marker gene expression. Soyasaponin Aa reduces hydrogen peroxide-induced reactive oxygen species (ROS) production and malondialdehyde levels. Soyasaponin Aa exhibits cellular antioxidant activity. Soyasaponin Aa can be used for the research of obesity .

HY-W041080R

3,5-Di-tert-butylphenol (Standard)	Structural Classification Monophenols Microorganisms Phenols Source Classification	Reference Standards Fungal Reactive Oxygen Species (ROS) Bacterial
3,5-Di-tert-butylphenol (Standard) is the analytical standard of 3,5-Di-tert-butylphenol (HY-W041080). This product is intended for research and analytical applications. 3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities. 3,5-Di-tert-butylphenol induces accumulation of **reactive oxygen species (ROS)** in C. albicans cells. 3,5-Di-tert-butylphenol also has antibacterial activities.

HY-W661499

Orellanine	Structural Classification Natural Products Microorganisms Source Classification	Phosphatase Apoptosis Reactive Oxygen Species (ROS) Caspase
Orellanine, a nephrotoxic alkaloid found in Cortinarius orellanus, is an orally active and selective non-competitive inhibitor of alkaline phosphatase. Orellanine chelates iron, generates **reactive oxygen species** (ROS), induces DNA scission, forms ortho-semiquinone radicals, downregulates antioxidant defenses, and inhibits mitochondrial function. Orellanine induces caspase 8/9-mediated apoptosis. Orellanine inhibits synthesis of proteins, RNA, DNA, and mitochondrial protein synthesis, with metabolic activation required for cell-free protein synthesis inhibition. Orellanine can be used for the research of metastatic clear cell renal cell carcinoma, acute renal failure, chronic renal insufficiency, and kidney damage .

HY-W010203

2-Decanone	Structural Classification Ketones, Aldehydes, Acids Humulus lupulus L. Plants Moraceae Source Classification	Fungal
2-Decanone is an antifungal agent. 2-Decanone inhibits pathogen mycelial growth, spore germination, and appressorium formation. 2-Decanone downregulates spore germination-related genes (MfBmp1) and penetration structure formation genes (MfPls1), inducing reactive oxygen species (ROS) accumulation to trigger mitochondrial damage and subsequent spore apoptosis. 2-Decanone is promising for research of postharvest disease control in fruits and vegetables .

HY-113110A

Cysteinylglycine TFA L-Cysteinylglycine TFA; Cys-Gly TFA; H-Cys-Gly-OH TFA	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Cysteinylglycine (L-Cysteinylglycine; Cys-Gly) TFA is a dipeptide formed by the peptide bond connection of cysteine and glycine. Cysteinylglycine TFA is an important metabolic intermediate in the human body, mainly derived from the degradation of glutathione (GSH). Cysteinylglycine TFA can reduce trivalent iron to divalent iron, driving the redox cycle of iron, generating reactive oxygen species (ROS), stimulating oxidative reactions, inducing lipid peroxidation in human plasma LDL lipoproteins, and causing oxidative damage to DNA base. Cysteinylglycine TFA can be used as a biomarker to assess ischemic heart disease and breast cancer, etc ^[1][2][3][4].

Cat. No.	Product Name	Chemical Structure

HY-B1946S

Dimethoate-d6
Dimethoate-d₆ is the deuterium labeled Dimethoate. Dimethoate is an organophosphate insecticide and acaricide. Dimethoate is an orally active acetylcholinesterase inhibitor. Dimethoate induces **reactive oxygen species (ROS)*. Dimethoate induces* DNA damage and cell apoptosis in vivo. Dimethoate affect immune system in mice .

HY-117433S

4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d₄ is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders .

HY-W012382S

N-Acetyl-L-tyrosine-d3

N-Acetyl-L-tyrosine-d₃ is the deuterated form of N-Acetyl-L-tyrosine (HY-W012382). N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .

HY-N0411S4

β-Carotene-13C10

β-Carotene- ¹³C₁₀ (Provitamin A- ¹³C₁₀) is the ¹³C-labeled β-Carotene (HY-N0411). β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .

HY-18258S

Berberine-d6 chloride
Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties .

HY-W011215S

Dihexyl phthalate-3,4,5,6-d4

Dihexyl phthalate-3,4,5,6-d₄ is the deuterium labeled Dihexyl phthalate-3,4,5,6. Dihexyl phthalate (HY-W011215) is one of the commonly used phthalate esters in various plastics and consumer products. Dihexyl phthalate is classified as a priority pollutant and an endocrine disruptor. Dihexyl phthalate can induce reactive oxygen species (ROS) accumulation, promote inflammation, and lead to significant increases in apoptosis and inflammation-related gene expression levels. Dihexyl phthalate can cause testicular atrophy and is a reproductive toxicant .

HY-107859S

Tris(2-chloroethyl)phosphate-d12

Tris(2-chloroethyl)phosphate-d₁₂ is the deuterium labeled Tris(β-chloroethyl) phosphate. Tris(2-chloroethyl) phosphate is a widely used organic phosphorus flame retardant, mainly used as a plasticizer. Tris(2-chloroethyl) phosphate has orally active hepatotoxicity, inducing an increase in reactive oxygen species (ROS) and calcium ions (Ca²⁺) influx, a decrease in mitochondrial membrane potential (△Ψm), and causing DNA damage and cell apoptosis. Tris(2-chloroethyl) phosphate directly binds to FXR, inducing obesity and the formation of fatty liver in mice. Chloroethyl) phosphate activates the TLR4/NF-κB pathway, triggering liver inflammation.

HY-12040S

Elesclomol-d2

Elesclomol-d₂ (STA-4783-d₂) is a deuterium labeled Elesclomol (HY-12040). Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

HY-B0849S

Azoxystrobin-d4
Azoxystrobin-d₄ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

HY-B0849S1

Azoxystrobin-d3
Azoxystrobin-d₃ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis .

HY-W768895

Sanguinarine chloride-13C,d3

Sanguinarine chloride- ¹³C,d₃ (Sanguinarin chloride- ¹³C,d₃) is the deuterium labeled Sanguinarine chloride (HY-N0052A). Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-113410S

3-Methylglutaric acid-d4

3-Methylglutaric acid-d₄ is the deuterium labeled 3-Methylglutaric acid (HY-113410). 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na ⁺, K ⁺-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na ⁺, K ⁺-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration .

HY-W015551S

trans-2-Decenal-d2

trans-2-Decenal-d₂ ((E)-Dec-2-enal-d₂) is deuterated labeled trans-2-Decenal (HY-W015551). trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici .

HY-W010203S1

2-Decanone-d5-1

2-Decanone-d₅-1 is the deuterium labeled 2-Decanone (HY-W010203). 2-Decanone is an antifungal agent. 2-Decanone inhibits pathogen mycelial growth, spore germination, and appressorium formation. 2-Decanone downregulates spore germination-related genes (MfBmp1) and penetration structure formation genes (MfPls1), inducing reactive oxygen species (ROS) accumulation to trigger mitochondrial damage and subsequent spore apoptosis. 2-Decanone is promising for research of postharvest disease control in fruits and vegetables .

Targets Recommended: Reactive Oxygen Species (ROS) ROS Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16658BG

Z-VAD-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in **reactive oxygen species (ROS)** levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

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