ER-phagy
Endoplasmic reticulum autophagy
ER-phagy (Reticulophagy) is the process by which some regions of the endoplasmic reticulum are degraded by lysosomes. It participates in regulating various stages of tumor cell development and helps to restore cell homeostasis or induce cell apoptosis. ER-phagy regulates tumorigenesis and maintains tumor cell homeostasis through multiple mechanisms including the unfolded protein response, BCL-2 family proteins, and the Caspase pathway.
References:
- [1]. Reggiori F, et al. ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum. Physiol Rev. 2022 Jul 1;102(3):1393-1448. [Content Brief]
- [2]. Zhou H, et al. ER-phagy in the Occurrence and Development of Cancer. Biomedicines. 2022 Mar 18;10(3):707. [Content Brief]
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ER-phagy Related Products (2)
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Pt(II)-NHC complex 2C
0 ImagesCat. No.: HY-175048CAS No.: 3035433-94-1Synonyms: Platinum(II)-N-heterocyclic carbene complex 2CPt(II)-NHC Complex 2C (Platinum(II)-N-Heterocyclic Carbene complex 2C) (Compound 2C) is a platinum(II) complex based on N-heterocyclic carbene (NHC). Pt(II)-NHC Complex 2C is an immunogenic cell death (ICD) inducer that can induce endoplasmic reticulum stress (ERS) in liver cancer cells and produce reactive oxygen species (ROS), ultimately leading to the release of damage-associated molecular patterns (DAMP). Pt(II)-NHC Complex 2C blocks the cell cycle at the S phase and significantly induces cell apoptosis. Pt(II)-NHC Complex 2C shows anti-liver cancer potential in mouse models and activates immune cells in liver injury models.
