ER-phagy

Endoplasmic reticulum autophagy

ER-phagy (Reticulophagy) is the process by which some regions of the endoplasmic reticulum are degraded by lysosomes. It participates in regulating various stages of tumor cell development and helps to restore cell homeostasis or induce cell apoptosis. ER-phagy regulates tumorigenesis and maintains tumor cell homeostasis through multiple mechanisms including the unfolded protein response, BCL-2 family proteins, and the Caspase pathway.

References:

[1]. Reggiori F, et al. ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum. Physiol Rev. 2022 Jul 1;102(3):1393-1448. [Content Brief]

[2]. Zhou H, et al. ER-phagy in the Occurrence and Development of Cancer. Biomedicines. 2022 Mar 18;10(3):707. [Content Brief]

ER-phagy Related Products (2):

By Effects:	Inhibitor (1) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-175048

Pt(II)-NHC complex 2C	Inducer
Pt(II)-NHC Complex 2C (Platinum(II)-N-Heterocyclic Carbene complex 2C) (Compound 2C) is a platinum(II) complex based on N-heterocyclic carbene (NHC). Pt(II)-NHC Complex 2C is an immunogenic cell death (ICD) inducer that can induce endoplasmic reticulum stress (ERS) in liver cancer cells and produce reactive oxygen species (ROS), ultimately leading to the release of damage-associated molecular patterns (DAMP). Pt(II)-NHC Complex 2C blocks the cell cycle at the S phase and significantly induces cell apoptosis. Pt(II)-NHC Complex 2C shows anti-liver cancer potential in mouse models and activates immune cells in liver injury models.

HY-170884

ICD inducer-1	Inhibitor
ICD inducer-1 (Compound Re1) is an effective immunogenic cell death (ICD) inducer that can target the endoplasmic reticulum (ER) and block ER-phagy at the late stages. ICD inducer-1 is promising for research of cancers.

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