TrxR-IN-7
TrxR-IN-7 is a thioredoxin reductase (TrxR) inhibitor with an IC50 of 3.5 μM. TrxR-IN-7 induces reactive oxygen species (ROS) generation and apoptosis in tumor cells. TrxR-IN-7 can be used for the research of liver cancer and breast cancer.
For research use only. We do not sell to patients.
- Formula: C22H21NO3
- Molecular Weight:347.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
TrxR-IN-7 (Compound 14f) potently inhibits isolated TrxR activity with an IC50 of 3.5 μM[1].
TrxR-IN-7 (72 h) inhibits the proliferation of HepG2 cells with an IC50 of 19.45 μM and MCF-7 cells with an IC50 of 28.22 μM[1].
TrxR-IN-7 (12.5-50 μM; 24 h) inhibits intracellular TrxR activity in HepG2 cells in vitro in a concentration-dependent manner following 24 hours of treatment[1].
TrxR-IN-7 (6.25-12.5 μM; 3-12 h) induces ROS generation in HepG2 cells in both concentration- and time-dependent manners, increasing levels of hydrogen peroxide and superoxide anions[1].
TrxR-IN-7 (12.5-50 μM; 24 h) induces both early and late apoptosis in HepG2 cells in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2
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Concentration:12.5 μM; 25 μM; 50 μM
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Incubation Time:24 h
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Result:Caused a concentration-dependent increase in both early and late apoptotic HepG2 cells.
Showed significant increases in apoptotic cells at all tested concentrations compared to the control group.
Chemical Information
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Molecular Weight 347.41
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Formula C22H21NO3
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SMILES
N#CC1=CC=C([C@@]2(O)CCC[C@@]3(C)CC(C(C=C4)=O)=C(C[C@]32[H])C4=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TrxR-IN-7 Related Classifications
HY-172086 Related Classifications
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