2. Metabolic Enzyme/Protease Anti-infection Apoptosis Immunology/Inflammation NF-κB
  3. Endogenous Metabolite Fungal Heme Oxygenase (HO) Apoptosis Reactive Oxygen Species (ROS)
  4. Dankasterone A

Dankasterone A is a secondary metabolite. Dankasterone A can be derived from the Fungus Talaromyces purpurogenu. Dankasterone A upregulates HO-1 protein expression, induces Apoptosis, induces excessive ROS production. Dankasterone A has anti-cancer activity against prostate cancer.

For research use only. We do not sell to patients.

Dankasterone A

Dankasterone A Chemical Structure

CAS No. : 244303-77-3

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Dankasterone A Related Antibodies

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HO-1 HO-2

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Description

Dankasterone A is a secondary metabolite. Dankasterone A can be derived from the Fungus Talaromyces purpurogenu. Dankasterone A upregulates HO-1 protein expression, induces Apoptosis, induces excessive ROS production. Dankasterone A has anti-cancer activity against prostate cancer[1].

IC50 & Target[1]

Fungal Metabolite

 

HO-1

 

In Vitro

Dankasterone A (72 h) dose-dependently inhibits viability of PC-3 and 22Rv1 prostate cancer cells with IC50 values of 5.10 μM and 3.41 μM, respectively[1].
Dankasterone A (2.5-10 μM; 48 h) dose-dependently increases HO-1 protein expression in PC-3 and 22Rv1 prostate cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dankasterone A Related Antibodies
Molecular Weight

424.62

Formula

C28H40O3
CAS No.
SMILES

C[C@@]12[C@]3(C(CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(C)C)=O)[C@@](CC1)([H])[C@@]4(C(C(C3)=O)=CC(CC4)=O)C
Structure Classification
Initial Source

endolichenic fungus Pleosporales sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dankasterone A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dankasterone A244303-77-3Endogenous MetaboliteFungalHeme Oxygenase (HO)ApoptosisReactive Oxygen Species (ROS)Heme Oxygenasezebrafish xenograft tumor modelHeme oxygenase-1 (HO-1)apoptosis inducerprostate cancer cellsoxidative stress inducercell proliferation inhibitor22Rv1normal prostate epithelial cellsPC-3reactive oxygen species (ROS)Inhibitorinhibitorinhibit

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