Berberine sulfate
Based on 83 publication(s) in Google Scholar
Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.23%
- No. CAS: 633-66-9
- Fòrmula: C20H19NO8S
- Peso molecular:433.43
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Berberine sulfate
More- Cell Stem Cell. 2025 Mar 20:S1934-5909(25)00084-0. [Abstract]
- Nat Commun. 2025 Jan 2;16(1):212. [Abstract]
- Acta Pharm Sin B. 2025 Sep;15(9):4789-4806. [Abstract]
- Adv Sci (Weinh). 2026 Aug 18:e77174.
- Adv Sci (Weinh). 2026 Mar;13(16):e13310. [Abstract]
- Phytomedicine. 2026 Jan:150:157678. [Abstract]
- Phytomedicine. 2025 Sep 4:148:157233. [Abstract]
- Phytomedicine. 2025 Apr:139:156517. [Abstract]
- Phytomedicine. 2024 Dec:135:156111. [Abstract]
- Phytomedicine. 2024 Jan:123:155247. [Abstract]
- Phytomedicine. 2023 Sep:118:154962. [Abstract]
- J Hazard Mater. 2026 Mar 15:506:141417. [Abstract]
- Acta Pharmacol Sin. 2023 Feb;44(2):332-344. [Abstract]
- NPJ Sci Food. 2025 Feb 4;9(1):16. [Abstract]
- Int J Biol Macromol. 2025 Jun;315(Pt 1):144496. [Abstract]
- Int J Nanomedicine. 2023 Jul 31:18:4347-4363. [Abstract]
- Mol Med. 2024 Dec 20;30(1):251. [Abstract]
- Phytother Res. 2026 Mar;40(3):887-906. [Abstract]
- Free Radic Biol Med. 2025 Dec 16:244:380-394. [Abstract]
- Chin Med. 2025 Nov 17;20(1):190. [Abstract]
- J Med Chem. 2026 Aug 13;69(15):19338-19354.
- J Ethnopharmacol. 2024 Apr 24:324:117829. [Abstract]
- JCI Insight. 2023 Jul 24;8(14):e166306. [Abstract]
- J Ethnopharmacol. 2022 Mar 1:285:114786. [Abstract]
- CNS Neurosci Ther. 2025 Feb;31(2):e70253. [Abstract]
- Biochem Pharmacol. 2021 Jun:188:114576. [Abstract]
- Mech Ageing Dev. 2020 Oct:191:111347. [Abstract]
- Dent Mater. 2026 May;42(5):898-911. [Abstract]
- Inflammopharmacology. 2024 Aug;32(4):2525-2540. [Abstract]
- Anal Chim Acta. 2026 May 12;1412:345649.
- Pharm Biol. 2024 Dec;62(1):53-61. [Abstract]
- Hepatol Commun. 2024 Mar 29;8(4):e0405. [Abstract]
- Int J Mol Sci. 2026 Jan 21;27(2):1063. [Abstract]
- Int Immunopharmacol. 2024 Sep 24;142(Pt B):113227. [Abstract]
- Int Immunopharmacol. 2024 Jul 30:136:112278. [Abstract]
- Int Immunopharmacol. 2024 May 30:133:112036. [Abstract]
- Front Pharmacol. 2023 Apr 18:14:1148611. [Abstract]
- Molecules. 2024 May 14;29(10):2304. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Oct;1871(7):167920. [Abstract]
- Mol Med Rep. 2023 Jan;27(1):17. [Abstract]
- Sci Rep. 2025 Jul 1;15(1):21623. [Abstract]
- Sci Rep. 2022 Oct 17;12(1):17350. [Abstract]
- J Cell Mol Med. 2025 Sep;29(17):e70836. [Abstract]
- Cell Signal. 2025 Jul:131:111732. [Abstract]
- J Inflamm Res. 2025 Aug 21:18:11451-11461. [Abstract]
- Aquacult Nutr. 14 Jul 2022.
- Aquaculture. 15 May 2022, 738055.
- Drug Dev Res. 2026 Feb;87(1):e70223. [Abstract]
- Fish Shellfish Immunol. 2024 Jun:149:109522. [Abstract]
- Microb Pathog. 2025 Dec:209:108114. [Abstract]
- J Pharm Pharmacol. 2022 Sep 1;74(9):1353-1363. [Abstract]
- Toxicol Appl Pharmacol. 2025 Dec:505:117563. [Abstract]
- Appl Biochem Biotechnol. 2024 Aug;196(8):5265-5282. [Abstract]
- Exp Cell Res. 2024 Jun 1;439(1):114094. [Abstract]
- BMC Pharmacol Toxicol. 2023 May 11;24(1):29. [Abstract]
- Exp Cell Res. 2020 Aug 1;393(1):112054. [Abstract]
- Food Chem Toxicol. 2023 May:175:113743. [Abstract]
- Tissue Cell. 2026 Jun:100:103365. [Abstract]
- J Appl Toxicol. 2024 Nov;44(11):1700-1713. [Abstract]
- Fitoterapia. 2026 Sep:193:107388.
- J Bone Miner Metab. 2021 Sep;39(5):748-756. [Abstract]
- Curr Microbiol. 2026 Aug 27;83(10):546.
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- Toxicol In Vitro. 2025 Dec:109:106128. [Abstract]
- Gene. 2022 Mar 30:816:146171. [Abstract]
- Mol Reprod Dev. 2024 Aug;91(8):e23768. [Abstract]
- Arch Oral Biol. 2026 Mar:183:106496. [Abstract]
- J Food Biochem. 2025 Jul 16.
- Mol Genet Genomics. 2026 May 27;301(1):124. [Abstract]
- Oncol Lett. 2025 Dec 1;31(2):62. [Abstract]
- Oncologie. 2023 Mar 10.
- Biol Pharm Bull. 2022 Oct 1;45(10):1444-1451. [Abstract]
- Lett Drug Des Discov. 2025 Dec 13.
- bioRxiv. 2026 Jan 26:2026.01.24.701539. [Abstract]
- Res Sq. 2025 Apr 15.
- Genome Instab Dis. 2025 Mar.
- Biomed Pharmacother. 2024 Jan:170:116012. [Abstract]
- SSRN. 2023 Jan 27.
- Research Square Print. 2022 Aug.
- Research Square Preprint. 2021 Sep.
- Research Square Preprint. 2021 Jun.
- Research Square Preprint. 2021 May.
- Evid Based Complement Alternat Med. 2021 May 4:2021:6688629. [Abstract]
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Actividad biológica
Descripciòn
IC50 & Target
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | IC50 |
>200000 nM
Compound: 1
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Cytotoxicity against african green monkey Vero cells
Cytotoxicity against african green monkey Vero cells
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[PMID: 23167812] |
In Vitro
Berberine sulfate (1.25-160 μM; 72 hours) has potential inhibitory effects on the proliferation of four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29[1].
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Berberine sulfate (1.25-160 μM; 24-72 hours) induces a time- and dose-dependent inhibition of LoVo cell growth[1].
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LoVo cells are exposure to Berberine sulfate (10-80 μM) for 24 h. Cell cycle analysis of 40 μM Berberine-treated LoVo cells by flow cytometry shows accumulation of cells in the G2/M phase[1].
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Berberine sulfate (10-80 μM) suppresses cyclin B1, cdc2 and cdc25c protein expression after 24 h, especially at the dose of 80.0 μM[1].
Berberine hemisulfate exhibits antimicrobial acitivity through inhibition of cell division protein FtsZ, or through DNA/RNA binding and deal thus DNA/RNAdamege[3].
Berberine hemisulfate exhibts anti-inflammatory activity by inhibiting TNF-α and the activation of its downstream pathway AP-1 and NF-kB[4].
Berberine hemisulfate exhibits neuroprotective efficacy by inhibiting the reactive oxygen species (ROS) production and caspase activation, and activatiing the PI3K/Akt signaling pathway, and heme oxygenase-1 (HO-1) expression[5].
Berberine hemisulfate attenuates metabolic diseases through regulations of the lipids composition and inhibition of insulin resistance[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29
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Concentration:1.25, 2.5, 5, 10, 20, 40, 80, and 160 μM
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Incubation Time:72 hours
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Result:Inhibited the proliferation of four cell lines. The IC50 ranged from 40.8±4.1 μM (LoVo) to 98.6±2.9 μM (HCT116).
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Cell Line:Colorectal carcinoma cell lines LoVo
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Concentration:1.25, 2.5, 5, 10, 20, 40, 80, and 160 μM
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Incubation Time:24, 48, 72 hours
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Result:Induced a time- and dose-dependent inhibition of cell growth. By 72 h, 160.0 μM induced 71.1±1.9 % growth inhibitions in LoVo cells.
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Cell Line:LoVo cells
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Concentration:0, 10, 20, 40, or 80 μM
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Incubation Time:24 hours
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Result:Exposure to 40.0 μM induced G2/M-phase cell cycle arrest, an increase in the G2/M-phase population and a progressive decline in the G1 population.
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Cell Line:LoVo cells
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Concentration:10, 20, 40, or 80 μM
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Incubation Time:24 hours
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Result:Suppressed cyclin B1, cdc2 and cdc25c protein expression.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5-week-old BALB/c nu/nu mice with human colorectal adenocarcinoma LoVo xenografts[1]
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Dosage:10, 30, or 50 mg/kg/day
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Administration:Gastrointestinal gavage; for 10 consecutive days
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Result:Showed inhibitory rates of 33.1% and 45.3% at doses of 30 and 50 mg/kg/day.
Chemical Information
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No. CAS 633-66-9
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Appearance Solid
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Peso molecular 433.43
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Fòrmula C20H19NO8S
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Color White to yellow
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SMILES
COC1=C(OC)C2=C[N+]3=C(C(C(CC3)=C4)=CC5=C4OCO5)C=C2C=C1.O=S(O)([O-])=O
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Synonyms
Natural Yellow 18 sulfate
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (83)
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Journal Impact Factor
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Most Recent
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Cell Stem Cell
Vagal pathway activation links chronic stress to decline in intestinal stem cell function. [Abstract]2025 Mar 20:S1934-5909(25)00084-0. PMID: 40120585 -
Nat Commun
Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation. [Abstract]2025 Jan 2;16(1):212. PMID: 39747079
Berberine sulfate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):212. [Abstract]
A549 (1 ×106) cells were subcutaneously inoculated into the right scruff of the female BALB/c nude mouse (n = 8/group). On day 22 after inoculation, mice were given Berberine (p.o.; 40 mg/kg; daily for 12 days) . The tumor volumes on indicated days after gavage were examined
Berberine sulfate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 2;16(1):212. [Abstract]
H1299 cells were treated with or without Berberine (Ber;5 μM; 24 h). Cells were subjected to qPCR (n = 3 independent experiments) analyses.
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Acta Pharm Sin B
Palmitoylated SARM1 targeting P4HA1 promotes collagen deposition and myocardial fibrosis: A new target for anti-myocardial fibrosis. [Abstract]2025 Sep;15(9):4789-4806. PMID: 41049740
Berberine sulfate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Sep;15(9):4789-4806. [Abstract]
The hydroxyproline assay kit was used to detect the secretion of fibroblast collagen in NMCFs by Berberine (BBC; 70 μM）. n=3-4. *P< 0.05, **P< 0.01 vs. CTL #P<0.05, ###P <0.001 vs. TGF-β1.
Berberine sulfate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Sep;15(9):4789-4806. [Abstract]
Immunofluorescence in determining the expression of P4HA1 after treated with Berberine (BBC; p.o.; 20 mg/kg for 7 days ) and Selonsertib (p.o.; 20 mg/kg for 7 days ) in the heart tissue of MI mice. n=3. *P < 0.05, **P < 0.01 vs. Sham, #P < 0.05, ##P < 0.01 vs. MI. Scale bar, 200 µm.
Berberine sulfate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Sep;15(9):4789-4806. [Abstract]
Echocardiographic detection of cardiac function changes in MI mice and treated with Berberine (BBC; p.o.; 20 mg/kg for 7 days ) and Selonsertib (p.o.; 20 mg/kg for 7 days ) . n=3-4. *P < 0.05 vs. Sham, #P < 0.05 vs. MI.
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Adv Sci (Weinh)
2026 Mar;13(16):e13310. PMID: 41589654 -
Phytomedicine
Berberine facilitates alveolar bone regeneration via Ptgs2-mediated dual regulation of osteoblast differentiation and fibroblast inhibition. [Abstract]2026 Jan:150:157678. PMID: 41401587 -
Phytomedicine
Huang-Lian-Jie-Du decoction enhances Capecitabine-Oxaliplatin efficacy via Akkermansia muciniphila and CD8+ T cells in colorectal cancer. [Abstract]2025 Sep 4:148:157233. PMID: 40972261 -
Phytomedicine
Berberine protects against dysentery by targeting both Shigella filamentous temperature sensitive protein Z and host pyroptosis: Resolving in vitro-vivo effect discrepancy. [Abstract]2025 Apr:139:156517. PMID: 39986228 -
Phytomedicine
Swiprosin-1 participates in the berberine-regulated AMPK/MLCK pathway to attenuate colitis-induced tight junction damage. [Abstract]2024 Dec:135:156111. PMID: 39369569 -
Phytomedicine
Modified Hu-lu-ba-wan protects diabetic glomerular podocytes via promoting PKM2-mediated mitochondrial dynamic homeostasis. [Abstract]2024 Jan:123:155247. PMID: 38128393 -
Phytomedicine
2023 Sep:118:154962. PMID: 37506403 -
J Hazard Mater
Ammonia-induced exosomal miRNA disrupts autophagy and promotes lung injury: Therapeutic potential of natural compounds. [Abstract]2026 Mar 15:506:141417. PMID: 41775203 -
Acta Pharmacol Sin
2023 Feb;44(2):332-344. PMID: 35948750 -
NPJ Sci Food
2025 Feb 4;9(1):16. PMID: 39900946 -
Int J Biol Macromol
Berberine@AgNPs@Carboxylated chitosan hydrogel dressing with immunomodulatory and anti-biofilm properties promotes wound repair in drug-resistant bacterial infections. [Abstract]2025 Jun;315(Pt 1):144496. PMID: 40409636 -
Int J Nanomedicine
Combined Therapy of Experimental Autoimmune Uveitis by a Dual-Drug Nanocomposite Formulation with Berberine and Dexamethasone. [Abstract]2023 Jul 31:18:4347-4363. PMID: 37545873 -
Mol Med
Berberine promotes primordial follicle activation and increases ovulated oocyte quantity in aged mice. [Abstract]2024 Dec 20;30(1):251. PMID: 39707173 -
Phytother Res
A Novel Mechanism of Berberine Targeting EIF2AK2 Dimerization Attenuates Methylglyoxal-Induced Endothelial Senescence and Apoptosis. [Abstract]2026 Mar;40(3):887-906. PMID: 41520368 -
Free Radic Biol Med
Redox switch C674 in SERCA2 triggers Ca2+-calcineurin-MCU-Drp1 cascade and pulmonary vascular remodeling. [Abstract]2025 Dec 16:244:380-394. PMID: 41412527 -
Chin Med
Berberine ameliorates high-fat diet-induced metabolic disorders through promoting gut Akkermansia and modulating bile acid metabolism. [Abstract]2025 Nov 17;20(1):190. PMID: 41243097 -
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J Ethnopharmacol
Jiao-tai-wan and its effective component-berberine improve diabetes and depressive disorder through the cAMP/PKA/CREB signaling pathway. [Abstract]2024 Apr 24:324:117829. PMID: 38296172 -
JCI Insight
Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment. [Abstract]2023 Jul 24;8(14):e166306. PMID: 37485875 -
J Ethnopharmacol
Exploring the pathogenesis of type 2 diabetes mellitus intestinal damp-heat syndrome and the therapeutic effect of Gegen Qinlian Decoction from the perspective of exosomal miRNA. [Abstract]2022 Mar 1:285:114786. PMID: 34763043 -
CNS Neurosci Ther
Berberine Alleviates Kainic Acid-Induced Acute Epileptic Seizures in Mice via Reshaping Gut Microbiota-Associated Lipid Metabolism. [Abstract]2025 Feb;31(2):e70253. PMID: 39915895 -
Biochem Pharmacol
Berberine exerts anti-tumor activity in diffuse large B-cell lymphoma by modulating c-myc/CD47 axis. [Abstract]2021 Jun:188:114576. PMID: 33930347 -
Mech Ageing Dev
AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop. [Abstract]2020 Oct:191:111347. PMID: 32882228 -
Dent Mater
Injectable, regenerative and anti-infective PEGylated polyglycerol sebacate-modified calcium phosphate cements triggered by berberine and rhBMP-2 for oral bone defect repair. [Abstract]2026 May;42(5):898-911. PMID: 41633879 -
Inflammopharmacology
Berberine mitigates diclofenac-induced intestinal mucosal mechanical barrier dysfunction through the restoration of autophagy by inhibiting exosome-mediated lncRNA H19. [Abstract]2024 Aug;32(4):2525-2540. PMID: 38758516 -
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Pharm Biol
Berberine decreases S100B generation to regulate gut vascular barrier permeability in mice with burn injury. [Abstract]2024 Dec;62(1):53-61. PMID: 38108311 -
Hepatol Commun
Oxyberberine sensitizes liver cancer cells to sorafenib via inhibiting NOTCH1-USP7-c-Myc pathway. [Abstract]2024 Mar 29;8(4):e0405. PMID: 38573832 -
Int J Mol Sci
Berberine Alleviates Shigella-Induced Dysentery by Regulating Intestinal Barrier and Inflammatory Responses. [Abstract]2026 Jan 21;27(2):1063. PMID: 41596706 -
Int Immunopharmacol
Berberine attenuates neuronal ferroptosis via the AMPK-NRF2-HO-1-signaling pathway in spinal cord-injured rats. [Abstract]2024 Sep 24;142(Pt B):113227. PMID: 39321704 -
Int Immunopharmacol
Berberine enhances the function of intestinal stem cells in healthy and radiation-injured mice. [Abstract]2024 Jul 30:136:112278. PMID: 38815353 -
Int Immunopharmacol
Berberine alleviates neuroinflammation by downregulating NFκB/LCN2 pathway in sepsis-associated encephalopathy: network pharmacology, bioinformatics, and experimental validation. [Abstract]2024 May 30:133:112036. PMID: 38640713 -
Front Pharmacol
Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1. [Abstract]2023 Apr 18:14:1148611. PMID: 37144221 -
Molecules
Discovery of Nine Dipeptidyl Peptidase-4 Inhibitors from Coptis chinensis Using Virtual Screening, Bioactivity Evaluation, and Binding Studies. [Abstract]2024 May 14;29(10):2304. PMID: 38792165 -
Biochim Biophys Acta Mol Basis Dis
Berberine chloride alleviated intestinal inflammation and improved postoperative ileus by regulating macrophage polarization via PI3K/AKT signaling pathway. [Abstract]2025 Oct;1871(7):167920. PMID: 40412730 -
Mol Med Rep
Triptolide promotes ferroptosis by suppressing Nrf2 to overcome leukemia cell resistance to doxorubicin. [Abstract]2023 Jan;27(1):17. PMID: 36453238 -
Sci Rep
Ursolic and oleanolic acids suppress MNNG induced malignant transformation of human gastric mucosal epithelium by regulating the PI3 K/AKT pathway. [Abstract]2025 Jul 1;15(1):21623. PMID: 40594240 -
Sci Rep
Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation. [Abstract]2022 Oct 17;12(1):17350. PMID: 36253427 -
J Cell Mol Med
Berberine Sensitises Breast Cancer Cells to Radiation via the Attenuation of DNA Ligase III. [Abstract]2025 Sep;29(17):e70836. PMID: 40916080 -
Cell Signal
Inhibition of N6-methyladenosine methylation of ASC by berberine ameliorates pyroptosis of renal tubular epithelial cells in acute kidney injury. [Abstract]2025 Jul:131:111732. PMID: 40074191 -
J Inflamm Res
Berberine Inhibits Acne-Related Lipid Secretion and Inflammation by Regulating the hsa-miR-3150a-3p/TP53 Pathway. [Abstract]2025 Aug 21:18:11451-11461. PMID: 40860941 -
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Drug Dev Res
Polydatin Protects Against the Formation of PPE-Induced Abdominal Aortic Aneurysms in Mice by Activating Nuclear Factor Erythroid 2-Related Factor 2. [Abstract]2026 Feb;87(1):e70223. PMID: 41486502 -
Fish Shellfish Immunol
Berberine inhibits SGIV replication by suppressing inflammatory response and oxidative stress. [Abstract]2024 Jun:149:109522. PMID: 38548190 -
Microb Pathog
Berberine inhibits Mycoplasma synoviae infection by suppressing PIK3CA-dependent inflammatory and apoptotic responses in avian macrophages. [Abstract]2025 Dec:209:108114. PMID: 41115537 -
J Pharm Pharmacol
Berberine suppresses the migration and invasion of colon cancer cells by inhibition of lipogenesis through modulation of promyelocytic leukemia zinc finger-mediated sterol-regulatory element binding proteins cleavage-activating protein ubiquitination. [Abstract]2022 Sep 1;74(9):1353-1363. PMID: 35641094 -
Toxicol Appl Pharmacol
Berberine alleviates acute embolism-induced lung inflammation and injury by suppressing miR-22-5p expression and modulating the TLR4/NF-κB signaling pathway. [Abstract]2025 Dec:505:117563. PMID: 40953642 -
Appl Biochem Biotechnol
Berberine Protects Against Dihydrotestosterone-Induced Human Ovarian Granulosa Cell Injury and Ferroptosis by Regulating the Circ_0097636/MiR-186-5p/SIRT3 Pathway. [Abstract]2024 Aug;196(8):5265-5282. PMID: 38153651 -
Exp Cell Res
Berberine increases the killing effect of pirarubicin on HCC cells by inhibiting ATG4B-autophagy pathway. [Abstract]2024 Jun 1;439(1):114094. PMID: 38750718 -
BMC Pharmacol Toxicol
2023 May 11;24(1):29. PMID: 37170144
Berberine sulfate purchased from MedChemExpress. Usage Cited in: BMC Pharmacol Toxicol. 2023 May 11;24(1):29. [Abstract]
Berberine (BBR; 2.5, 5, 10 µM; 48 h) inhibits EGFR phosphorylation in a dose-dependent matter in A431cells.
Berberine sulfate purchased from MedChemExpress. Usage Cited in: BMC Pharmacol Toxicol. 2023 May 11;24(1):29. [Abstract]
Berberine (BBR; 2.5 µM; 10 days) significantly inhibits NCI-H441 colony formation.
Berberine sulfate purchased from MedChemExpress. Usage Cited in: BMC Pharmacol Toxicol. 2023 May 11;24(1):29. [Abstract]
Berberine (BBR; 0.625, 1.25, 2.5, 5, 10 µM; 48 h) inhibits the viability of A431cells in a dose-dependent matter.
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Exp Cell Res
Network-based analysis with primary cells reveals drug response landscape of acute myeloid leukemia. [Abstract]2020 Aug 1;393(1):112054. PMID: 32376287 -
Food Chem Toxicol
Berberine attenuates sunitinib-induced cardiac dysfunction by normalizing calcium regulation disorder via SGK1 activation. [Abstract]2023 May:175:113743. PMID: 36972840 -
Tissue Cell
Overcoming osimertinib resistance in NSCLC: The role of Notch1 pathway inhibition by berberine. [Abstract]2026 Jun:100:103365. PMID: 41687187 -
J Appl Toxicol
Berberine prevents against myocardial injury induced by acute β-adrenergic overactivation in rats. [Abstract]2024 Nov;44(11):1700-1713. PMID: 38981847 -
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J Bone Miner Metab
2021 Sep;39(5):748-756. PMID: 33829324 -
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Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Toxicol In Vitro
Inhibitory potential of phytochemicals on species-specific breast cancer resistance protein transport activity. [Abstract]2025 Dec:109:106128. PMID: 40796067 -
Gene
Pharmacotranscriptomic profiling of resistant triple-negative breast cancer cells treated with lapatinib and berberine shows upregulation of PI3K/Akt signaling under cytotoxic stress. [Abstract]2022 Mar 30:816:146171. PMID: 35026293 -
Mol Reprod Dev
Effect of berberine combined with metformin on autophagy in polycystic ovary syndrome by regulating AMPK/AKT/mTOR pathway. [Abstract]2024 Aug;91(8):e23768. PMID: 39155689 -
Arch Oral Biol
Investigating the mechanism of berberine in inhibiting periodontitis progression using machine learning, molecular docking, and experimental validation. [Abstract]2026 Mar:183:106496. PMID: 41544413 -
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Mol Genet Genomics
Berberine impedes the DNA damage repair to inhibit colorectal cancer by regulating the SOX17/TCF4/PIM3 axis. [Abstract]2026 May 27;301(1):124. PMID: 42201413 -
Oncol Lett
Genome-wide CRISPR screening identifies CLDN1 as a central node in the anticancer mechanisms of berberine and as a therapeutic target in lung cancer. [Abstract]2025 Dec 1;31(2):62. PMID: 41383979 -
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Biol Pharm Bull
Berberine Encapsulated in Exosomes Derived from Platelet-Rich Plasma Promotes Chondrogenic Differentiation of the Bone Marrow Mesenchymal Stem Cells via the Wnt/β-Catenin Pathway. [Abstract]2022 Oct 1;45(10):1444-1451. PMID: 35858798 -
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bioRxiv
Mechanistic Language Modeling and Oxygenated 3D Screening Reveal Berberine and Enzalutamide Synergy in Resistant Prostate Cancer. [Abstract]2026 Jan 26:2026.01.24.701539. PMID: 41659618 -
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Biomed Pharmacother
Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway. [Abstract]2024 Jan:170:116012. PMID: 38113631 -
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Evid Based Complement Alternat Med
2021 May 4:2021:6688629. PMID: 34055022
Solvente y solubilidad
In Vitro:
H2O : 50 mg/mL (115.36 mM; Need ultrasonic)
DMSO : 0.5 mg/mL (1.15 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (286 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Cai Y, et al. Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo. J Nat Med. 2014 Jan;68(1):53-62. [Content Brief]
[2]. Cui HX, et al. Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the Bioavailability. Molecules. 2018 Dec 28;24(1):103. [Content Brief]
[3]. Boberek JM, et al., Genetic evidence for inhibition of bacterial division protein FtsZ by berberine. PLoS One. 2010 Oct 29;5(10):e13745. [Content Brief]
[4]. Remppis A, et al., Rhizoma Coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFkappaB-dependent pathway. Mediators Inflamm. 2010;2010:194896. [Content Brief]
[5]. Bae J, et al., Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1. Mol Cells. 2013 Feb;35(2):151-7. [Content Brief]
[6]. Ye Y, et al., Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Front Pharmacol. 2021 Apr 26;12:653887. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.3072 mL | 11.5359 mL | 23.0718 mL | 57.6794 mL |
| H2O | 5 mM | 0.4614 mL | 2.3072 mL | 4.6144 mL | 11.5359 mL |
| 10 mM | 0.2307 mL | 1.1536 mL | 2.3072 mL | 5.7679 mL | |
| 15 mM | 0.1538 mL | 0.7691 mL | 1.5381 mL | 3.8453 mL | |
| 20 mM | 0.1154 mL | 0.5768 mL | 1.1536 mL | 2.8840 mL | |
| 25 mM | 0.0923 mL | 0.4614 mL | 0.9229 mL | 2.3072 mL | |
| 30 mM | 0.0769 mL | 0.3845 mL | 0.7691 mL | 1.9226 mL | |
| 40 mM | 0.0577 mL | 0.2884 mL | 0.5768 mL | 1.4420 mL | |
| 50 mM | 0.0461 mL | 0.2307 mL | 0.4614 mL | 1.1536 mL | |
| 60 mM | 0.0385 mL | 0.1923 mL | 0.3845 mL | 0.9613 mL | |
| 80 mM | 0.0288 mL | 0.1442 mL | 0.2884 mL | 0.7210 mL | |
| 100 mM | 0.0231 mL | 0.1154 mL | 0.2307 mL | 0.5768 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Berberine sulfate Related Classifications
HY-N0716B Related Classifications
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Keywords
- Berberine
- 633-66-9
- Natural Yellow 18
- Natural Yellow18
- Natural Yellow-18
- Antibiotic
- Topoisomerase
- Autophagy
- Bacterial
- Reactive Oxygen Species (ROS)
- Parasite
- Apoptosis
- PI3K
- Akt
- Caspase
- JNK
- AP-1
- NF-κB
- diabetes mellitus
- type II diabetes
- Alzheimer’s disease
- Parkinson’s disease
- arrhythmia
- atherosclerosis
- hyperlipidemia
- hypertension
- myocarditis
- cardiomyopathy
- heart failure
- RAW264.7
- dopamine
- Inhibitor
- inhibitor
- inhibit