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Cat. No.: HY-158023

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DHODH-IN-26

DHODH-IN-26 (compound B2) is a mitochondria-targeting DHODH inhibitor. DHODH-IN-26 shows anticancer activity, triggers the formation of reactive oxygen species (ROS), promots mitochondrial lipid peroxidation, and induces ferroptosis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₄₄H₃₄BrF₂N₂O₃P
분자량:787.63

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DHODH-IN-26 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

DHODH-IN-26 (compound B2) (0.01-100 μM, 72 h) inhibits cell growth of 4T1, B16F10, U251, GL261, SH-SY5Y, U87, and A375 cells^[1].
DHODH-IN-26 (50 and 100 nM) inhibits colony formation in B16F10 and A375 cells^[1].
DHODH-IN-26 (50 and 100 nM, 48 h) decreases the expression of PD-L1 in B16F10 and A375 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

4T1, B16F10, U251, GL261, SH-SY5Y, U87, and A375 cells
Concentration:

0.01, 0.1, 1, 10 and100 μM
Incubation Time:

72 h
Result:

Inhibited cell growth.

Western Blot Analysis^[1]

Cell Line:

B16F10 and A375 cells
Concentration:

50 and 100 nM
Incubation Time:

48 h
Result:

Decreased the expression of PD-L1.

In Vivo

DHODH-IN-26 (compound B2) (intraperitoneal injection, 50 mg/kg for 14 days) inhibits tumor growth in B16F10 xenograft model in C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

B16F10 xenograft model in C57BL/6 mice^[1]
Dosage:

50 mg/kg
Administration:

I.p.; for 14 days
Result:

Reduced tumor volume.

Related Protocols :

Chemical Information

분자량 787.63
화학식 C₄₄H₃₄BrF₂N₂O₃P
SMILES

CC1=C(C2=CC(F)=CC=C2N=C1C3=CC=C(C=C3)C4=CC=C(C=C4F)NC(CC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)=O)C(O)=O.[Br-]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hai Y, et al. A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression. Pharmacol Res. 2024;202:107115. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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