DHODH-IN-26
DHODH-IN-26 (compound B2) is a mitochondria-targeting DHODH inhibitor. DHODH-IN-26 shows anticancer activity, triggers the formation of reactive oxygen species (ROS), promots mitochondrial lipid peroxidation, and induces ferroptosis.
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- Formule: C44H34BrF2N2O3P
- Masse moléculaire:787.63
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
DHODH-IN-26 (compound B2) (0.01-100 μM, 72 h) inhibits cell growth of 4T1, B16F10, U251, GL261, SH-SY5Y, U87, and A375 cells[1].
DHODH-IN-26 (50 and 100 nM) inhibits colony formation in B16F10 and A375 cells[1].
DHODH-IN-26 (50 and 100 nM, 48 h) decreases the expression of PD-L1 in B16F10 and A375 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:4T1, B16F10, U251, GL261, SH-SY5Y, U87, and A375 cells
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Concentration:0.01, 0.1, 1, 10 and100 μM
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Incubation Time:72 h
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Result:Inhibited cell growth.
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Cell Line:B16F10 and A375 cells
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Concentration:50 and 100 nM
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Incubation Time:48 h
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Result:Decreased the expression of PD-L1.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B16F10 xenograft model in C57BL/6 mice[1]
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Dosage:50 mg/kg
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Administration:I.p.; for 14 days
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Result:Reduced tumor volume.
Chemical Information
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Masse moléculaire 787.63
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Formule C44H34BrF2N2O3P
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SMILES
CC1=C(C2=CC(F)=CC=C2N=C1C3=CC=C(C=C3)C4=CC=C(C=C4F)NC(CC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)=O)C(O)=O.[Br-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DHODH-IN-26 Related Classifications
HY-158023 Related Classifications
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