Deoxymikanolide 

Deoxymikanolide is an orally active antibacterial agent that inhibits catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activities. Deoxymikanolide increases glycan metabolism, phosphorus metabolism, electric conductivity, intrabacterial reactive oxygen species (ROS) levels, and malondialdehyde (MDA) levels, causes cell shrinkage, cytoplasmic damage, and cell disruption in Ralstonia solanacearum. Deoxymikanolide inhibits Acetic acid-induced writhing in mice. Deoxymikanolide can be used for the research of bacterial wilt^[1][2].

Deoxymikanolide (15.625-125 mg/L; measured at 2-hour intervals) inhibits the growth of Ralstonia solanacearum race #4 in a concentration-dependent manner, with complete suppression at higher concentrations^[1].
Deoxymikanolide (125 mg/L; 2-24 h) induces time-dependent ultrastructural damage to Ralstonia solanacearum race #4, including cell shrinkage, cytoplasmic leakage, and abnormal cell shapes, with complete cytoderm thickening at 24 h^[1].
Deoxymikanolide (62.5-125 mg/L; measured every 2 h for 24 h) significantly increases the phosphorus utilization ratio of Ralstonia solanacearum race #4^[1].
Deoxymikanolide (62.5-125 mg/L; measured at 5-hour intervals) inhibits the activities of CAT, POD, and SOD in Ralstonia solanacearum race #4, with SOD inhibition rates of 73.50% (62.5 mg/l) and 86.41% (125 mg/L) at 10 min^[1].
Deoxymikanolide (62.5-125 mg/L; 24 h) induces significant intracellular ROS accumulation in Ralstonia solanacearum race #4, exceeding levels induced by 340 mg/l H₂O₂^[1].
Deoxymikanolide (62.5-125 mg/L; 24 h post-treatment) increases MDA levels in Ralstonia solanacearum race #4 at 24 h, indicating lipid peroxidation from excessive ROS^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Deoxymikanolide (10 mg/kg; p.o.) inhibits Acetic acid (HY-Y0319)-induced writhing in male Swiss mice (20-25 g) pain model (with an inhibition rate of 67.3%)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

276.28

C₁₅H₁₆O₅

23753-57-3

C=C1[C@]2([H])[C@](OC1=O)([H])C[C@]3([C@@](CCC4=C[C@@]2([H])OC4=O)([H])O3)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li Y, et al. Deoxymikanolide adversely altered physiology and ultrastructure of Ralstonia solanacearum. Pestic Biochem Physiol. 2021;174:104803.  [Content Brief]

  [2]. Ahmed M, et al. Analgesic sesquiterpene dilactone from Mikania cordata. Fitoterapia. 2001;72(8):919-921.  [Content Brief]