Deoxymikanolide
Deoxymikanolide is an orally active antibacterial agent that inhibits catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activities. Deoxymikanolide increases glycan metabolism, phosphorus metabolism, electric conductivity, intrabacterial reactive oxygen species (ROS) levels, and malondialdehyde (MDA) levels, causes cell shrinkage, cytoplasmic damage, and cell disruption in Ralstonia solanacearum. Deoxymikanolide inhibits Acetic acid-induced writhing in mice. Deoxymikanolide can be used for the research of bacterial wilt.
For research use only. We do not sell to patients.
- CAS No.: 23753-57-3
- Formula: C15H16O5
- Molecular Weight:276.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Deoxymikanolide (15.625-125 mg/L; measured at 2-hour intervals) inhibits the growth of Ralstonia solanacearum race #4 in a concentration-dependent manner, with complete suppression at higher concentrations[1].
Deoxymikanolide (125 mg/L; 2-24 h) induces time-dependent ultrastructural damage to Ralstonia solanacearum race #4, including cell shrinkage, cytoplasmic leakage, and abnormal cell shapes, with complete cytoderm thickening at 24 h[1].
Deoxymikanolide (62.5-125 mg/L; measured every 2 h for 24 h) significantly increases the phosphorus utilization ratio of Ralstonia solanacearum race #4[1].
Deoxymikanolide (62.5-125 mg/L; measured at 5-hour intervals) inhibits the activities of CAT, POD, and SOD in Ralstonia solanacearum race #4, with SOD inhibition rates of 73.50% (62.5 mg/l) and 86.41% (125 mg/L) at 10 min[1].
Deoxymikanolide (62.5-125 mg/L; 24 h) induces significant intracellular ROS accumulation in Ralstonia solanacearum race #4, exceeding levels induced by 340 mg/l H2O2[1].
Deoxymikanolide (62.5-125 mg/L; 24 h post-treatment) increases MDA levels in Ralstonia solanacearum race #4 at 24 h, indicating lipid peroxidation from excessive ROS[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice (male, 20-25 g)[2]
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Dosage:10 mg/kg
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Administration:p.o.
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Result:Reduced acetic acid-induced writhing to 8.5 and produced a 67.3% inhibition of writhing compared to the control group (26.0 writhings).
Chemical Information
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CAS No. 23753-57-3
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Molecular Weight 276.28
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Formula C15H16O5
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SMILES
C=C1[C@]2([H])[C@](OC1=O)([H])C[C@]3([C@@](CCC4=C[C@@]2([H])OC4=O)([H])O3)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Deoxymikanolide Related Classifications
Cat. No.: HY-N13756
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- Deoxymikanolide
- 23753-57-3
- Bacterial
- Reactive Oxygen Species (ROS)
- SOD
- ROS
- mice
- electric conductivity
- MDA
- peroxidase
- CAT
- superoxide dismutase
- phosphorus metabolism
- malondialdehyde
- bacterial wilt
- Mikania micrantha Bunge
- male Swiss mice
- glycan metabolism
- Ralstonia solanacearum race #4
- catalase
- Ralstonia solanacearum
- POD
- intrabacterial reactive oxygen species
- Inhibitor
- inhibitor
- inhibit