Analgesic sesquiterpene dilactone from Mikania cordata

  • Fitoterapia. 2001 Dec;72(8):919-21. doi: 10.1016/s0367-326x(01)00318-5.
M Ahmed  1 ,  M T Rahman ,  M Alimuzzaman ,  J A Shilpi
Affiliations
  • 1. Department of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh. [email protected]
PMID: 11731117 DOI: 10.1016/s0367-326x(01)00318-5
Abstract

The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three Other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydromikanolide and scandenolide, did not show significant analgesic activity.

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