1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Anti-infection
  2. Reactive Oxygen Species
    Fungal
    Bacterial
  3. Camalexin

Camalexin 

Cat. No.: HY-119502 Purity: 98.94%
Handling Instructions

Camalexin is a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production.

For research use only. We do not sell to patients.

Camalexin Chemical Structure

Camalexin Chemical Structure

CAS No. : 135531-86-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 115 In-stock
Estimated Time of Arrival: December 31
25 mg USD 230 In-stock
Estimated Time of Arrival: December 31
50 mg USD 390 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Camalexin is a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production[1][2][3].

IC50 & Target

Reactive oxygen species (ROS)[1][2]

In Vitro

Camalexin shows antiproliferative activity against a human breast cancer cell line[2].
For the oomycetes Phytophthora and Pythium Nep1-like proteins (necrosis and ethylene-inducing peptide 1-like proteins) are the initial triggers of Camalexin synthesis and formation of reactive oxygen species (ROS). ROS appear to be of general relevance for Camalexin formation. Chemical induction of ROS, such as by application of acifluorfen, coincided with Camalexin synthesis. In a screen for enhanced susceptibility to Alternaria brassicicola the esa1 mutant is identified, which shows delayed Camalexin induction. Particularly in response to ROS inducing agents reduced Camalexin levels are synthesized. This crucial role for ESA1 is confirmed by the inability of esa1 mutants to synthesize Camalexin in response to Leptosphaeria maculans. An additional mutant that exhibits greatly reduced Camalexin accumulation is ups1, which is isolated on the basis of diminished expression of a tryptophan biosynthetic enzyme[2].

Molecular Weight

200.26

Formula

C₁₁H₈N₂S

CAS No.

135531-86-1

SMILES

C12=C(C=CC=C2)NC=C1C3=NC=CS3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (624.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9935 mL 24.9675 mL 49.9351 mL
5 mM 0.9987 mL 4.9935 mL 9.9870 mL
10 mM 0.4994 mL 2.4968 mL 4.9935 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (10.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CamalexinReactive Oxygen SpeciesFungalBacterialPhytoalexinantifungalcruciferousantibacterialantiproliferativeanticancerROSInhibitorinhibitorinhibit

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Product name:
Camalexin
Cat. No.:
HY-119502
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