1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Anti-infection
  2. Reactive Oxygen Species
    Fungal
    Bacterial
  3. Camalexin

Camalexin 

Cat. No.: HY-119502
Handling Instructions

Camalexin is a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production.

For research use only. We do not sell to patients.

Camalexin Chemical Structure

Camalexin Chemical Structure

CAS No. : 135531-86-1

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Description

Camalexin is a phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production[1][2][3].

IC50 & Target

Reactive oxygen species (ROS)[1][2]

In Vitro

Camalexin shows antiproliferative activity against a human breast cancer cell line[2].
For the oomycetes Phytophthora and Pythium Nep1-like proteins (necrosis and ethylene-inducing peptide 1-like proteins) are the initial triggers of Camalexin synthesis and formation of reactive oxygen species (ROS). ROS appear to be of general relevance for Camalexin formation. Chemical induction of ROS, such as by application of acifluorfen, coincided with Camalexin synthesis. In a screen for enhanced susceptibility to Alternaria brassicicola the esa1 mutant is identified, which shows delayed Camalexin induction. Particularly in response to ROS inducing agents reduced Camalexin levels are synthesized. This crucial role for ESA1 is confirmed by the inability of esa1 mutants to synthesize Camalexin in response to Leptosphaeria maculans. An additional mutant that exhibits greatly reduced Camalexin accumulation is ups1, which is isolated on the basis of diminished expression of a tryptophan biosynthetic enzyme[2].

Molecular Weight

200.26

Formula

C₁₁H₈N₂S

CAS No.

135531-86-1

SMILES

C12=C(C=CC=C2)NC=C1C3=NC=CS3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CamalexinReactive Oxygen SpeciesFungalBacterialPhytoalexinantifungalcruciferousantibacterialantiproliferativeanticancerROSInhibitorinhibitorinhibit

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Camalexin
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HY-119502
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