2. Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Membrane Transporter/Ion Channel Neuronal Signaling Apoptosis
  3. Reactive Oxygen Species (ROS) Calcium Channel Apoptosis Endogenous Metabolite
  4. L-Ascorbic acid

L-Ascorbic acid (L-Ascorbate) (GMP) is Ascorbic acid (HY-B0166) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Ascorbic acid is an inhibitor of Cav 3.2 channels.

For research use only. We do not sell to patients.

L-Ascorbic acid

L-Ascorbic acid Chemical Structure

CAS No. : 50-81-7

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Ascorbic acid:

L-Ascorbic acid Related Antibodies

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Human Endogenous Metabolite Microbial Metabolite

  • Biological Activity

  • Purity & Documentation

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Description

L-Ascorbic acid (L-Ascorbate) (GMP) is Ascorbic acid (HY-B0166) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Ascorbic acid is an inhibitor of Cav 3.2 channels[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 100 μM
Compound: L-ASA
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31586832]
CFPAC-1 IC50
> 100 μM
Compound: L-ASA
Antiproliferative activity against human CFPAC-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human CFPAC-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31586832]
Erythrocyte EC50
119.87 μg/mL
Compound: Ascorbic acid
Antioxidant activity in erythrocytes assessed as inhibition of hemolysis
Antioxidant activity in erythrocytes assessed as inhibition of hemolysis
[PMID: 22677320]
Erythrocyte EC50
96.625 μg/mL
Compound: Ascorbic acid
Hemolysis of human erythrocytes after 30 mins by spectrophotometry
Hemolysis of human erythrocytes after 30 mins by spectrophotometry
[PMID: 23811092]
HCT-116 IC50
> 100 μM
Compound: L-ASA
Antiproliferative activity against human HCT116cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT116cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31586832]
HEK293 EC50
0.5 nM
Compound: Ascorbic acid
Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay
Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay
[PMID: 19243956]
HEK293 EC50
156 μM
Compound: 54670067
Substrate uptake and inhibition of the Na(+)/L-Ascorbic Acid Transporter 1 (SVCT1, SLC23A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC23A1 cells (PubChem AID: 1794810)
Substrate uptake and inhibition of the Na(+)/L-Ascorbic Acid Transporter 1 (SVCT1, SLC23A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC23A1 cells (PubChem AID: 1794810)
10.5281/zenodo.7360349
HFF IC50
> 100 μM
Compound: L-ASA
Cytotoxicity against human HFF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HFF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31586832]
HL-60 IC50
0.01 μM
Compound: Vitamin C
Antioxidant activity in human HL60 cells assessed as inhibition of relative oxygen species generation by DCFH-DA method
Antioxidant activity in human HL60 cells assessed as inhibition of relative oxygen species generation by DCFH-DA method
[PMID: 19555121]
HL-60 IC50
10.2 μM
Compound: Vitamin C
Antioxidant activity in human HL60 cells assessed as inhibition of TPA-stimulated hydrogen peroxide induced DCFH-DA oxidation by fluorometric microplate assay
Antioxidant activity in human HL60 cells assessed as inhibition of TPA-stimulated hydrogen peroxide induced DCFH-DA oxidation by fluorometric microplate assay
[PMID: 16562834]
HL-60 IC50
9.7 μM
Compound: Vitamin C
Antioxidant activity against TPA-induced ROS production in human HL60 cells by 2',7'-dichlorodihydrofluorescein diacetate cellular-based assay
Antioxidant activity against TPA-induced ROS production in human HL60 cells by 2',7'-dichlorodihydrofluorescein diacetate cellular-based assay
[PMID: 12762791]
HeLa IC50
> 100 μM
Compound: L-ASA
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31586832]
HepG2 IC50
> 100 μM
Compound: L-ASA
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31586832]
J774.A1 IC50
> 100 μM
Compound: AA
Antiinflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based analysis
Antiinflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based analysis
[PMID: 33422907]
MCF7 IC50
> 100 μM
Compound: L-ASA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31586832]
RD EC50
> 2270 μM
Compound: AA
Antiviral activity against Herpes simplex virus type 1 infected in human RD cells assessed as inhibition of virus-induced cytopathic effect
Antiviral activity against Herpes simplex virus type 1 infected in human RD cells assessed as inhibition of virus-induced cytopathic effect
[PMID: 22390834]
SW-620 IC50
> 100 μM
Compound: L-ASA
Antiproliferative activity against human SW620 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human SW620 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31586832]
In Vitro

L-Ascorbic acid (GMP) (25-200 μg/mL) induces chondrogenic differentiation of adipose-derived mesenchymal stem cells[1].
L-Ascorbic acid (GMP) (250 μM; 10 d) induces osteogenic differentiation of mesenchymal stem cells (MSCs)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Ascorbic acid Related Antibodies
Molecular Weight

176.12

Formula

C6H8O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-Ascorbic acid Related Classifications

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  • Dilution Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Ascorbic acid (GMP)50-81-7L-Ascorbate (GMP)Vitamin C (GMP)Reactive Oxygen Species (ROS)Calcium ChannelApoptosisEndogenous MetaboliteCa2+ channelsCa channelsGMPosteogenicchondrogenic differentiationmesenchymal stem cellsInhibitorinhibitorinhibit

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