Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues

  • Bioorg Med Chem Lett. 2012 Jul 15;22(14):4891-5. doi: 10.1016/j.bmcl.2012.05.007.
Ahmed Kamal  1 ,  J N S R C Murty ,  A Viswanath ,  P Sujitha ,  C Ganesh Kumar
Affiliations
  • 1. Division of Organic Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500607, India. [email protected]
PMID: 22677320 DOI: 10.1016/j.bmcl.2012.05.007
Abstract

In this letter, we describe the first synthesis of two recently isolated Flavones 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone (3a), 5-carboethoxymethyl-4',7-dihydroxyflavone (3b) and their derivatives (3c-t), evaluated for their antimicrobial, antioxidant and Anticancer activities. Most of the synthesized compounds exhibited antimicrobial activity against the tested microbial strains and some of these compounds were found to be more potent as compared to the standard drugs like neomycin and luteolin. Interestingly, some of these synthesized compounds also showed moderate antioxidant property.