Radical-regulating and antiviral properties of ascorbic acid and its derivatives

  • Bioorg Med Chem Lett. 2012 Apr 1;22(7):2424-7. doi: 10.1016/j.bmcl.2012.02.022.
Sviatoslav D Brinkevich  1 ,  Eugene I Boreko ,  Olga V Savinova ,  Natalia I Pavlova ,  Oleg I Shadyro
Affiliations
  • 1. Department of Chemistry of the Belarusian State University, Nezavisimosti Av., 4, 220030, Minsk, Belarus.
PMID: 22390834 DOI: 10.1016/j.bmcl.2012.02.022
Abstract

The ability of ascorbic acid and a number of its derivatives to suppress replication of Herpes simplex virus type I was investigated in human rhabdomyosarcoma cell line. In parallel, interaction of the test compounds with carbon- and oxygen-centered radicals formed on radiolysis of hydroxyl-containing organic compounds was studied using the steady state radiolysis method. It has been shown that 2-O-glycoside of ascorbic acid, displaying marked Antiviral properties against Herpes simplex virus type I, is also capable of inhibiting fragmentation and recombination reactions of α-hydroxyl-containing carbon-centered radicals while not affecting processes involving oxygen-centered radicals.