2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Phytoene desaturase-IN-1

Phytoene desaturase-IN-1 is a potent phytoene desaturase (PDS) inhibitor (Kd: 65.9 μM) through π−π stacking effect with Phe301 residue. Phytoene desaturase-IN-1 shows broad spectrum of postemergence herbicidal activity. Phytoene desaturase-IN-1 induces PDS mRNA reduction, phytoene and reactive oxygen species (ROS) accumulation in albino leaves. Phytoene desaturase-IN-1 can be used in the area of agricultural production.

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Phytoene desaturase-IN-1 Chemical Structure

Phytoene desaturase-IN-1 Chemical Structure

CAS No. : 2765793-54-0

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10 mg USD 240 In-stock
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Based on 1 publication(s) in Google Scholar

Phytoene desaturase-IN-1 Related Antibodies

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Description

Phytoene desaturase-IN-1 is a potent phytoene desaturase (PDS) inhibitor (Kd: 65.9 μM) through π−π stacking effect with Phe301 residue. Phytoene desaturase-IN-1 shows broad spectrum of postemergence herbicidal activity. Phytoene desaturase-IN-1 induces PDS mRNA reduction, phytoene and reactive oxygen species (ROS) accumulation in albino leaves. Phytoene desaturase-IN-1 can be used in the area of agricultural production[1].

IC50 & Target

Phytoene desaturase (PDS), reactive oxygen species (ROS)[1].
In Vitro

Phytoene desaturase-IN-1 (1b, 375−750 g/ha, 25 days) shows a broad spectrum of herbicidal activity against six kinds of weeds (including ECHCG, DIGSA, SETFA, ABUJU, AMARE, and ECLPR)[1].
Phytoene desaturase-IN-1 (750 g/ha, 14 days) down-regulates PDS mRNA level and induces phytoene accumulation, with the observed albino leaf phenotype[1].
Phytoene desaturase-IN-1 (750 g/ha, 3 days) induces ROS accumulation and regulates ROS-associated enzymes activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phytoene desaturase-IN-1 Related Antibodies

RT-PCR[1]

Cell Line: Albino leaves
Concentration: 750 g/ha
Incubation Time: 14 days
Result: Reduced PDS mRNA level by 30%, thereby limiting the catalytic dehydrogenation process of phytoene and causing phytoene accumulation.
Molecular Weight

427.83

Formula

C18H13ClF3N3O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C(Cl)C=C1)CSC2=NN=C(CO)N2C3=CC=CC(C(F)(F)F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (292.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3374 mL 11.6869 mL 23.3738 mL
5 mM 0.4675 mL 2.3374 mL 4.6748 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3374 mL 11.6869 mL 23.3738 mL 58.4344 mL
5 mM 0.4675 mL 2.3374 mL 4.6748 mL 11.6869 mL
10 mM 0.2337 mL 1.1687 mL 2.3374 mL 5.8434 mL
15 mM 0.1558 mL 0.7791 mL 1.5583 mL 3.8956 mL
20 mM 0.1169 mL 0.5843 mL 1.1687 mL 2.9217 mL
25 mM 0.0935 mL 0.4675 mL 0.9350 mL 2.3374 mL
30 mM 0.0779 mL 0.3896 mL 0.7791 mL 1.9478 mL
40 mM 0.0584 mL 0.2922 mL 0.5843 mL 1.4609 mL
50 mM 0.0467 mL 0.2337 mL 0.4675 mL 1.1687 mL
60 mM 0.0390 mL 0.1948 mL 0.3896 mL 0.9739 mL
80 mM 0.0292 mL 0.1461 mL 0.2922 mL 0.7304 mL
100 mM 0.0234 mL 0.1169 mL 0.2337 mL 0.5843 mL
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Phytoene desaturase-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phytoene desaturase-IN-12765793-54-0Reactive Oxygen SpeciesPDSherbicidephytoene desaturaseperoxidasePODSODweedagricultureInhibitorinhibitorinhibit

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