GPX4-IN-14
GPX4-IN-14 (compound 2c) is an inhibitor of GPX4, with free radical scavenging activity (maximum scavenging rate is 72.52%) and anti-tumor proliferation activity in vitro. GPX4-IN-14 inhibits GPX4 protein, increases lipid peroxide levels and intracellular Reactive Oxygen Species (ROS) levels, thereby inducing ferroptosis and exerting anti-tumor proliferation effects.
For research use only. We do not sell to patients.
- Formula: C26H39NO8Se
- Molecular Weight:572.55
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
GPX4 |
GPX4-IN-14 (100 μM, 30 min) has good free radical scavenging activity with a maximum scavenging rate of 72.52%[1].
GPX4-IN-14 has anti-tumor proliferation activity in SW480, HCT116, HepG2, MCF-7 cells with IC50 of 5.61 μM, 6.59 μM, 18.23 μM, 9.73 μM, and IC50 of LO2 is 11.64 μM[1].
GPX4-IN-14 (3.3, 6.6, 13.2 μM, 24 h) inhibits the GPX4 pathway in HCT116, induces the accumulation of intracellular ROS and lipid ROS in a dose-dependent manner, leading to ferroptosis and inhibiting mitochondrial membrane potential[1].
GPX4-IN-14 (3.3, 6.6, 13.2 μM, 24 h) induces a dose-dependent increase in intracellular iron levels in HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HCT116
-
Concentration:3.3, 6.6, 13.2 μM
-
Incubation Time:24 h
-
Result:Induced significant accumulation of ROS.
Depolarized mitochondrial membrane potential (MMP) in a dose-dependent manner.
Increased lipid ROS levels in a dose-dependent manner.
-
Cell Line:HCT116
-
Concentration:3.3, 6.6, 13.2 μM
-
Incubation Time:24 h
-
Result:Inhibited the expression level of GXP4 and increased the expression of FTH1.
-
Cell Line:HCT116
-
Concentration:3.3, 6.6, 13.2 μM
-
Incubation Time:24 h
-
Result:Inhibited GXP4 expression level.
Chemical Information
-
Molecular Weight 572.55
-
Formula C26H39NO8Se
-
SMILES
O=C(CCC(OCCCCCC[Se]C#N)=O)O[C@H]1[C@H](C)[C@@]2([H])[C@]3([C@]4([H])[C@H](C)CC2)[C@](O[C@@](OO3)(C)CC4)([H])O1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz