GPX4-IN-14
GPX4-IN-14 (compound 2c) is an inhibitor of GPX4, with free radical scavenging activity (maximum scavenging rate is 72.52%) and anti-tumor proliferation activity in vitro. GPX4-IN-14 inhibits GPX4 protein, increases lipid peroxide levels and intracellular Reactive Oxygen Species (ROS) levels, thereby inducing ferroptosis and exerting anti-tumor proliferation effects.
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- Formule: C26H39NO8Se
- Masse moléculaire:572.55
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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GPX4 |
GPX4-IN-14 (100 μM, 30 min) has good free radical scavenging activity with a maximum scavenging rate of 72.52%[1].
GPX4-IN-14 has anti-tumor proliferation activity in SW480, HCT116, HepG2, MCF-7 cells with IC50 of 5.61 μM, 6.59 μM, 18.23 μM, 9.73 μM, and IC50 of LO2 is 11.64 μM[1].
GPX4-IN-14 (3.3, 6.6, 13.2 μM, 24 h) inhibits the GPX4 pathway in HCT116, induces the accumulation of intracellular ROS and lipid ROS in a dose-dependent manner, leading to ferroptosis and inhibiting mitochondrial membrane potential[1].
GPX4-IN-14 (3.3, 6.6, 13.2 μM, 24 h) induces a dose-dependent increase in intracellular iron levels in HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116
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Concentration:3.3, 6.6, 13.2 μM
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Incubation Time:24 h
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Result:Induced significant accumulation of ROS.
Depolarized mitochondrial membrane potential (MMP) in a dose-dependent manner.
Increased lipid ROS levels in a dose-dependent manner.
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Cell Line:HCT116
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Concentration:3.3, 6.6, 13.2 μM
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Incubation Time:24 h
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Result:Inhibited the expression level of GXP4 and increased the expression of FTH1.
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Cell Line:HCT116
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Concentration:3.3, 6.6, 13.2 μM
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Incubation Time:24 h
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Result:Inhibited GXP4 expression level.
Chemical Information
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Masse moléculaire 572.55
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Formule C26H39NO8Se
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SMILES
O=C(CCC(OCCCCCC[Se]C#N)=O)O[C@H]1[C@H](C)[C@@]2([H])[C@]3([C@]4([H])[C@H](C)CC2)[C@](O[C@@](OO3)(C)CC4)([H])O1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPX4-IN-14 Related Classifications
HY-168011 Related Classifications
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